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1.发明申请SOLID PHARMACEUTICAL COMPOSITION COMPRISING 1-(4-CHLOROANILINO)-4-(4-PYRIDYLMETHYL)PHTHALAZINE AND A PH MODIFIER 审中-公开包含1-（4-氯苯胺基）-4-（4-吡啶基甲基）苯乙胺和PH修饰剂的固体药物组合物公开(公告)号：US20100280035A1
公开(公告)日：2010-11-04
申请号：US12063046
申请日：2006-08-21
申请人： Dieter Becker , Nicoletta Loggia , Barbara Lückel , Andrea Kramer , Stefanie Siepe , Angelika Ries
发明人： Dieter Becker , Nicoletta Loggia , Barbara Lückel , Andrea Kramer , Stefanie Siepe , Angelika Ries
IPC分类号： A61K31/502 , A61P9/00
CPC分类号： A61K9/1617 , A61K9/1676 , A61K9/2013 , A61K9/2086 , A61K9/282 , A61K9/2886 , A61K9/5015 , A61K9/5042 , A61K9/5084 , A61K31/502
摘要： The present invention concerns pharmaceutical compositions comprising the pH dependent drug compound 1-(4-chloroanilino)-4-(4-pyridylmethyl)phthalazine and a pH modifier.
摘要翻译： 本发明涉及包含pH依赖性药物化合物1-（4-氯苯胺基）-4-（4-吡啶基甲基）酞嗪和pH调节剂的药物组合物。
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2.发明授权
公开(公告)号：US5858603A
公开(公告)日：1999-01-12
申请号：US967280
申请日：1997-11-07
申请人： Dieter Becker , Jurgen Graumann
发明人： Dieter Becker , Jurgen Graumann
CPC分类号： G03F3/10
摘要： A support material for making color test prints in the analog proof system, in which the support material has a layer comprising a hydrophobic binder or binder mixture and a pigment mixture containing hollow micro-balls.
摘要翻译： 用于在模拟证明系统中制作彩色测试印刷品的支撑材料，其中支撑材料具有包含疏水性粘合剂或粘合剂混合物的层和含有中空微球的颜料混合物。
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3.发明授权Use of 9-anthrylalkyl compounds as derivatization reagents for separation and detection purposes 失效使用9-蒽基烷基化合物作为分离和检测目的的衍生化试剂
公开(公告)号：US5128120A
公开(公告)日：1992-07-07
申请号：US650868
申请日：1991-02-05
申请人： Hans-Dieter Becker , Stefan Einarsson , Andrzej Grzegorczyk , Bjorn Josefsson , Stig S. Lagerkvist , Per L. Moller , Domingo Sanchez , Johan H. Sorensen
发明人： Hans-Dieter Becker , Stefan Einarsson , Andrzej Grzegorczyk , Bjorn Josefsson , Stig S. Lagerkvist , Per L. Moller , Domingo Sanchez , Johan H. Sorensen
IPC分类号： C07D207/16 , A61K49/00 , C07B57/00 , C07B63/02 , C07C33/18 , C07C67/00 , C07C69/96 , C07C201/00 , C07C205/43 , C07C227/40 , C07C229/36 , C07C241/00 , C07C247/20 , C07C247/22 , C07C281/02 , C07D207/404 , C07D207/416 , C07D255/02
CPC分类号： C07C69/96 , C07C227/34 , C07C33/18 , C07C2103/24 , Y10S435/968 , Y10T436/142222 , Y10T436/143333 , Y10T436/173845 , Y10T436/203332 , Y10T436/204998
摘要： New 9-anthrylalkyl compounds having the general formula ##STR1## wherein R is hydrogen or an alkyl group, whereby, however, not more than one of the groups R is an alkyl group; R.sub.1 is hydrogen, lower alkyl, halogen or nitro; n is an integer of from 1 to 7, whereby, however, the total number of carbon atoms in the group --CHR--(CHR).sub.n -- does not exceed 8; and X is halogen, an azide group or a succinimidyl group.The new compounds are prepared from 9-anthrylalcohols which are reacted with a compound X--CO--X wherein X is a halogen, and then optionally with compounds giving azide or succinimidyl group. The compounds are used as derivatization reagents for separation and detection purposes.Intermediates for preparation of the above defined 9-anthrylalkyl compounds wherein one R is an alkyl group are 9-anthrylalcohols with the group --CHR--(CHR).sub.n --OH, wherein one R is an alkyl group.
摘要翻译： 具有通式“IMAGE”的新的9-蒽基烷基化合物，其中R是氢或烷基，其中R不多于一个是烷基; R1是氢，低级烷基，卤素或硝基; n为1〜7的整数，但-CHR-（CHR）n-基团中的碳原子总数不超过8; X为卤素，叠氮基或琥珀酰亚胺基。 新化合物由与蒽化合物X-CO-X反应的9-蒽醇制备，其中X为卤素，然后任选与化合物反应，得到叠氮化物或琥珀酰亚胺基。 该化合物用作分离和检测目的的衍生试剂。 制备其中一个R为烷基的上述定义的9-蒽基烷基化合物的中间体是具有基团-CHR-（CHR）n -OH的9-蒽基，其中一个R为烷基。
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4.发明授权Toothpaste active against plaque comprising a copper compound and a silica polishing agent 失效对包含铜化合物和二氧化硅抛光剂的斑块有活性的牙膏
公开(公告)号：US4332791A
公开(公告)日：1982-06-01
申请号：US252405
申请日：1981-04-09
申请人： Helmut Raaf , Dieter Becker , Franz Frosch , Helmut Harth , Helmar R. Wagner
发明人： Helmut Raaf , Dieter Becker , Franz Frosch , Helmut Harth , Helmar R. Wagner
IPC分类号： A61K8/00 , A61K8/19 , A61K8/21 , A61K8/25 , A61K8/33 , A61K8/36 , A61K8/365 , A61K8/42 , A61K8/44 , A61K33/34 , A61Q11/00 , A61K7/16 , A61K7/18 , A61K7/24
摘要： This invention relates to a novel toothpaste and more particularly, to a new toothpaste which includes a silica polishing agent and at least one copper compound. This toothpaste has proven effective against plaque formation on teeth but does not exhibit any of the side effects of the prior art formulations such as discoloring.
摘要翻译： 本发明涉及一种新型牙膏，更具体地说，涉及一种新的牙膏，其包括二氧化硅抛光剂和至少一种铜化合物。 这种牙膏已被证明对牙齿上的斑块形成是有效的，但不表现出现有技术制剂如变色的任何副作用。
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5.发明申请Apparatus and Method for Creating a Program For Computer-controlled Machines 审中-公开用于创建计算机控制机器程序的装置和方法公开(公告)号：US20140115561A1
公开(公告)日：2014-04-24
申请号：US13992197
申请日：2011-12-07
IPC分类号： G06F9/44
CPC分类号： G06F8/31 , G05B19/0426 , G05B19/408 , G05B2219/13119 , G05B2219/23266 , G05B2219/36243
摘要： A method for creating a program for controlling the operation of a computer-controlled machine includes providing a conversion program for converting a first program in a programming language into an executable second program in a machine language, writing a first program in the first programming language, and converting the first program using the conversion program into an executable second program in the machine language.
摘要翻译： 一种用于创建用于控制计算机控制机器的操作的程序的方法，包括提供一种用于将编程语言中的第一程序转换为机器语言的可执行的第二程序的转换程序，以第一编程语言编写第一程序， 以及使用所述转换程序将所述第一程序转换成机器语言的可执行的第二程序。
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6.发明申请PHARMACEUTICAL COMPOSITIONS, DOSAGE FORMS AND NEW FORMS OF THE COMPOUND OF MULA (I), AND METHODS OF USE THEREOF 有权药物组合物，剂型和多形式化合物的新形式（I）及其使用方法公开(公告)号：US20130252979A1
公开(公告)日：2013-09-26
申请号：US13990632
申请日：2011-12-05
申请人： Ulrich Meier , Nicole Bieri , Dieter Becker , Julien Taillemite , Marie-Pierre Filliot , Tanja Meister
发明人： Ulrich Meier , Nicole Bieri , Dieter Becker , Julien Taillemite , Marie-Pierre Filliot , Tanja Meister
IPC分类号： A61K31/517 , A61K45/06 , C07D409/12
CPC分类号： A61K31/517 , A61K45/06 , C07D409/12
摘要： The present invention relates to a novel crystalline anhydrous form of [(5-chlorothiophene-2-ylsulfonylcarbamoyl)-(4-(6-fluoro-7-(methylamino)-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)phenyl)amide, potassium salt, and its use in the treatment or prevention of a condition or a disorder with platelet ADP receptor inhibition, in particular, P2Y12 inhibition, in animals, particularly humans. It also relates processes for making such a novel crystalline form. The present invention also relates to a solid, oral for mulation of this novel crystalline form, its preparation and use thereof.
摘要翻译： 本发明涉及[（5-氯噻吩-2-基磺酰基氨基甲酰基） - （4-（6-氟-7-（甲基氨基）-2,4-二氧代-1,2-二氢喹唑啉-3（ 4H） - 基）苯基）酰胺钾盐，以及其在动物，特别是人中治疗或预防血小板ADP受体抑制，特别是P2Y12抑制的病症或病症的用途。 它还涉及制备这种新型结晶形式的方法。 本发明还涉及这种新型结晶形式的固体口服，其制备及其用途。
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7.发明申请PHARMACEUTICAL COMPOSITION AND DOSAGE FORMS OF ELINOGREL AND METHODS OF USE THEREOF 审中-公开药物组合物及其用量及其使用方法公开(公告)号：US20130165459A1
公开(公告)日：2013-06-27
申请号：US13521906
申请日：2011-01-12
申请人： Juan Wang , Chandir Ramani , Joe Lambing , Christine Ye , Elizabeth Vadas , Julian Taillemite , Marie-Pierre Filliot , Dieter Becker
发明人： Juan Wang , Chandir Ramani , Joe Lambing , Christine Ye , Elizabeth Vadas , Julian Taillemite , Marie-Pierre Filliot , Dieter Becker
CPC分类号： A61K9/2054 , A61K9/1623 , A61K9/2009 , A61K9/2013 , A61K9/2027 , A61K9/2095 , A61K31/64
摘要： The present invention is concerned with a solid delivery form of elinogrel for the treatment of thrombosis which is notable for its multi-pH dissolution, immediate release and improved pharmacokinetic properties and stability in storage. The delivery and dosage form is a solid, oral formulation comprising: a) at least about 15% by weight elinogrel or a pharmaceutically acceptable salt thereof relative to the total weight of the overall pharmaceutical composition, and b) at least one pharmaceutically acceptable carrier. A further aspect of the present invention concerns the preparation and use of such a formulation.
摘要翻译： 本发明涉及用于治疗血栓形成的固体递送形式，其对于其多pH溶解，立即释放和改善的药代动力学性质和储存稳定性是显着的。 递送和剂型是固体口服制剂，其包含：a）相对于总体药物组合物的总重量，至少约15重量％的依依格雷或其药学上可接受的盐，和b）至少一种药学上可接受的载体。 本发明的另一方面涉及这种制剂的制备和用途。
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公开(公告)号：US20100197804A1
公开(公告)日：2010-08-05
申请号：US12758145
申请日：2010-04-12
IPC分类号： A61K31/137 , C07C211/30 , A61P31/10
CPC分类号： A61K9/2009 , A61K31/137
摘要： Pharmaceutical compositions for oral administration comprising terbinafine, a buffering component and a disintegrant. The compositions show rapid disintegration and having taste-masking properties.
摘要翻译： 用于口服给药的药物组合物，包括特比萘芬，缓冲组分和崩解剂。 组合物显示快速崩解并具有掩味性质。
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公开(公告)号：US07635453B2
公开(公告)日：2009-12-22
申请号：US12352356
申请日：2009-01-12
申请人： Horst Dieter Becker , Xaver Einsle
发明人： Horst Dieter Becker , Xaver Einsle
CPC分类号： G01N1/2813 , G01N1/312 , Y10T436/11 , Y10T436/110833
摘要： The invention relates to a device and a method for wetting objects with a liquid by means of a system for carrying a specimen slide that is disposed at a distance from a platform. To reduce liquid consumption, the specimen slide is raised or lowered relative to the platform by means of a system.
摘要翻译： 本发明涉及一种通过用于承载设置在离平台一定距离处的试样滑块的系统来润湿物体的装置和方法。 为了减少液体消耗，试样滑块通过系统相对于平台升高或降低。
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公开(公告)号：US20090117611A1
公开(公告)日：2009-05-07
申请号：US12352356
申请日：2009-01-12
申请人： Horst Dieter Becker , Xaver Einsle
发明人： Horst Dieter Becker , Xaver Einsle
CPC分类号： G01N1/2813 , G01N1/312 , Y10T436/11 , Y10T436/110833
摘要： The invention relates to a device and a method for wetting objects with a liquid by means of a system for carrying a specimen slide that is disposed at a distance from a platform. To reduce liquid consumption, the specimen slide is raised or lowered relative to the platform by means of a system.
摘要翻译： 本发明涉及一种通过用于承载设置在离平台一定距离处的试样滑块的系统来润湿物体的装置和方法。 为了减少液体消耗，试样滑块通过系统相对于平台升高或降低。
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