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公开(公告)号：US08957203B2
公开(公告)日：2015-02-17
申请号：US13459403
申请日：2012-04-30
申请人： Sheldon Hiebert , Ramkumar Rajamani , Li-Qiang Sun , Eric Mull , Eric P. Gillis , Michael S. Bowsher , Qian Zhao , Nicholas A. Meanwell , Kishore V. Renduchintala , Kandhasamy Sarkunam , Pulicharla Nagalakshmi , P. V. K. Suresh Babu , Paul Michael Scola
发明人： Sheldon Hiebert , Ramkumar Rajamani , Li-Qiang Sun , Eric Mull , Eric P. Gillis , Michael S. Bowsher , Qian Zhao , Nicholas A. Meanwell , Kishore V. Renduchintala , Kandhasamy Sarkunam , Pulicharla Nagalakshmi , P. V. K. Suresh Babu , Paul Michael Scola
IPC分类号： C07D225/00 , C07D295/00 , C07D245/00 , C07D225/04 , C07D487/00 , C07D487/04 , C07K5/083 , C07K5/08 , A61K38/20 , A61K38/21 , A61K45/06 , A61K31/13 , A61K31/4745 , A61K31/7056 , A61K38/00
CPC分类号： C07K5/0823 , A61K31/13 , A61K31/4745 , A61K31/7056 , A61K38/00 , A61K38/06 , A61K38/2013 , A61K38/204 , A61K38/2053 , A61K38/21 , A61K38/212 , A61K45/06 , C07D487/04 , C07K5/0804 , C07K5/0827 , A61K2300/00
摘要： Hepatitis C virus inhibitors having the general formula (I) are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
摘要翻译： 公开了具有通式（I）的丙型肝炎病毒抑制剂。 还公开了包含化合物的组合物和使用该化合物抑制HCV的方法。
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公开(公告)号：US08741884B2
公开(公告)日：2014-06-03
申请号：US13086704
申请日：2011-04-14
申请人： Tao Wang , Zhiwei Yin , Zhongxing Zhang , Annapurna Pendri , Guo Li , Samuel Gerritz , Weixu Zhai , Paul Michael Scola , Li-Qiang Sun , Eric Mull
发明人： Tao Wang , Zhiwei Yin , Zhongxing Zhang , Annapurna Pendri , Guo Li , Samuel Gerritz , Weixu Zhai , Paul Michael Scola , Li-Qiang Sun , Eric Mull
IPC分类号： A61K31/33 , C07D487/00
CPC分类号： C07D498/06
摘要： The disclosure provides compounds of formula I, including pharmaceutically acceptable salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.
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公开(公告)号：US20120093766A1
公开(公告)日：2012-04-19
申请号：US13086036
申请日：2011-04-13
申请人： Tao Wang , Annapurna Pendri , Zhongxing Zhang , Weixu Zhai , Guo Li , Samuel Gerritz , Paul Michael Scola , Li-Qiang Sun , Qian Zhao , Eric Mull
发明人： Tao Wang , Annapurna Pendri , Zhongxing Zhang , Weixu Zhai , Guo Li , Samuel Gerritz , Paul Michael Scola , Li-Qiang Sun , Qian Zhao , Eric Mull
IPC分类号： A61K31/53 , C07D498/08 , A61K38/13 , A61K38/20 , A61P31/14 , C07D487/08 , A61K38/21
CPC分类号： C07D487/08 , C07D498/08
摘要： The disclosure provides compounds of formula I, including pharmaceutically acceptable salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.
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公开(公告)号：US20110086858A1
公开(公告)日：2011-04-14
申请号：US12904264
申请日：2010-10-14
申请人： Tao Wang , Annapurna Pendri , Zhongxing Zhang , Weixu Zhai , Guo Li , Samuel Gerritz , Paul Michael Scola , Li-Qiang Sun , Qian Zhao , Eric Mull
发明人： Tao Wang , Annapurna Pendri , Zhongxing Zhang , Weixu Zhai , Guo Li , Samuel Gerritz , Paul Michael Scola , Li-Qiang Sun , Qian Zhao , Eric Mull
IPC分类号： A61K31/53 , C07D245/00 , C07D267/00 , A61P31/14
CPC分类号： C07D487/08 , C07D498/08
摘要： The disclosure provides compounds of formula I, including pharmaceutically acceptable salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.
摘要翻译： 本公开提供式I化合物，包括药学上可接受的盐，以及使用该化合物的组合物和方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。
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5.发明申请公开(公告)号：US20060063760A1
公开(公告)日：2006-03-23
申请号：US10554390
申请日：2004-04-16
申请人： Yamin Wang , Maio Dai , Holia Hatoum-Mokdad , Zhengqiu Hong , Harold Kluender , Gaetan Ladouceur , Tindy Li , Derek Lowe , Eric Mull , Tatiana Shelekhin , Roger Smith , Wai Wong
发明人： Yamin Wang , Maio Dai , Holia Hatoum-Mokdad , Zhengqiu Hong , Harold Kluender , Gaetan Ladouceur , Tindy Li , Derek Lowe , Eric Mull , Tatiana Shelekhin , Roger Smith , Wai Wong
IPC分类号： A61K31/54 , A61K31/537 , A61K31/445 , A61K31/495 , A61K31/4172
CPC分类号： C07C259/06 , C07C311/08 , C07C311/29 , C07C317/32 , C07C2602/08 , C07D209/14 , C07D209/16 , C07D209/26 , C07D213/38 , C07D213/53 , C07D215/12 , C07D265/30 , C07D307/52 , C07D307/81 , C07D333/58 , C07D403/12 , C07D413/12
摘要： This invention relates to a compound of Formula (I) and its use in treating hyper-proliferative disorders.
摘要翻译： 本发明涉及式（I）化合物及其在治疗高增殖性疾病中的用途。
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公开(公告)号：US08586584B2
公开(公告)日：2013-11-19
申请号：US12904264
申请日：2010-10-14
申请人： Tao Wang , Annapurna Pendri , Zhongxing Zhang , Weixu Zhai , Guo Li , Samuel Gerritz , Paul Michael Scola , Li-Qiang Sun , Qian Zhao , Eric Mull
发明人： Tao Wang , Annapurna Pendri , Zhongxing Zhang , Weixu Zhai , Guo Li , Samuel Gerritz , Paul Michael Scola , Li-Qiang Sun , Qian Zhao , Eric Mull
IPC分类号： A61K31/53 , C07D251/72 , C07D487/00
CPC分类号： C07D487/08 , C07D498/08
摘要： The disclosure provides compounds of formula I, including pharmaceutically acceptable salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.
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公开(公告)号：US08445490B2
公开(公告)日：2013-05-21
申请号：US13086036
申请日：2011-04-13
申请人： Tao Wang , Annapurna Pendri , Zhongxing Zhang , Weixu Zhai , Guo Li , Samuel Gerritz , Paul Michael Scola , Li-Qiang Sun , Qian Zhao , Eric Mull
发明人： Tao Wang , Annapurna Pendri , Zhongxing Zhang , Weixu Zhai , Guo Li , Samuel Gerritz , Paul Michael Scola , Li-Qiang Sun , Qian Zhao , Eric Mull
IPC分类号： A61K31/53 , C07D251/18
CPC分类号： C07D487/08 , C07D498/08
摘要： The disclosure provides compounds of formula I, including pharmaceutically acceptable salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.
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公开(公告)号：US20120213729A1
公开(公告)日：2012-08-23
申请号：US13210776
申请日：2011-08-16
申请人： Li-Qiang Sun , Eric Mull , Qian Zhao , Tao Wang , Zhongxing Zhang , Paul Michael Scola
发明人： Li-Qiang Sun , Eric Mull , Qian Zhao , Tao Wang , Zhongxing Zhang , Paul Michael Scola
IPC分类号： A61K31/53 , A61K38/21 , A61K38/13 , A61K31/541 , A61K31/5377 , C07D403/04 , C07D413/12 , C07D251/52 , C07D403/12 , C07D401/14 , C07D401/12 , A61P31/14 , A61K38/20 , C07D417/12
CPC分类号： C07D251/52 , A61K31/53 , A61K45/06 , C07D401/04 , C07D401/12 , C07D403/12 , A61K2300/00
摘要： The disclosure provides compounds of formula I, including pharmaceutically acceptable salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.
摘要翻译： 本公开提供式I化合物，包括药学上可接受的盐，以及使用该化合物的组合物和方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。
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9.发明申请1, 8-Naphthyridine derivatives and their use to treat diabetes and related disorders 审中-公开1,8-萘啶衍生物及其用于治疗糖尿病和相关疾病的用途公开(公告)号：US20060189609A1
公开(公告)日：2006-08-24
申请号：US11409536
申请日：2006-04-21
申请人： Yamin Wang , William Bullock , David Gunn , Qingjie Liu , Sidney Liang , Donglei Liu , Steven Magnuson , Tindy Li , Eric Mull , Jill Wood , Ning Qi
发明人： Yamin Wang , William Bullock , David Gunn , Qingjie Liu , Sidney Liang , Donglei Liu , Steven Magnuson , Tindy Li , Eric Mull , Jill Wood , Ning Qi
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/4745 , C07D471/02
CPC分类号： A61K45/06 , A61K31/44 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D471/04 , A61K2300/00
摘要： The invention relates generally to naphthyridine derivatives of the formula wherein one of U, X, Y and Z is nitrogen and the others are C—R, where R is hydrogen or a substituent. More specifically, the invention relates to 1,8-naphthyridine derivatives and pharmaceutical compositions containing such derivatives. Methods of the invention comprise administration of a naphthyridine derivative of the invention for the treatment of diabetes and related disorders.
摘要翻译： 本发明一般涉及下式的萘啶衍生物，其中U，X，Y和Z中的一个为氮，其余为C-R，其中R为氢或取代基。 更具体地，本发明涉及1,8-萘啶衍生物和含有这些衍生物的药物组合物。 本发明的方法包括施用本发明的萘啶衍生物用于治疗糖尿病和相关疾病。
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公开(公告)号：US08765944B2
公开(公告)日：2014-07-01
申请号：US13210776
申请日：2011-08-16
申请人： Li-Qiang Sun , Eric Mull , Qian Zhao , Tao Wang , Zhongxing Zhang , Paul Michael Scola
发明人： Li-Qiang Sun , Eric Mull , Qian Zhao , Tao Wang , Zhongxing Zhang , Paul Michael Scola
IPC分类号： C07D251/52 , A61K31/53 , A61P31/12
CPC分类号： C07D251/52 , A61K31/53 , A61K45/06 , C07D401/04 , C07D401/12 , C07D403/12 , A61K2300/00
摘要： The disclosure provides compounds of formula I, including pharmaceutically acceptable salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.
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