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公开(公告)号：US20140328857A1
公开(公告)日：2014-11-06
申请号：US14294935
申请日：2014-06-03
IPC分类号： C07K16/30 , A61N5/10 , A61K47/48 , A61K39/395 , A61K45/06
CPC分类号： C07K16/30 , A61K38/00 , A61K39/39558 , A61K45/06 , A61K47/6851 , A61K2039/505 , A61N5/10 , C07K14/70532 , C07K16/2827 , C07K2317/77 , G01N33/57492 , G01N2333/70503
摘要： The invention provides the identification and characterization of disease and cancer-associated antigen, RAAG10. The invention also provides a family of monoclonal antibodies that bind to antigen RAAG10, methods of diagnosing and treating various human cancers and diseases that express RAAG10.
摘要翻译： 本发明提供疾病和癌症相关抗原RAAG10的鉴定和表征。 本发明还提供了与抗原RAAG10结合的单克隆抗体家族，诊断和治疗表达RAAG10的各种人类癌症和疾病的方法。
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公开(公告)号：US08361475B2
公开(公告)日：2013-01-29
申请号：US12687512
申请日：2010-01-14
申请人： Jennie P. Mather , Deryk T. Loo
发明人： Jennie P. Mather , Deryk T. Loo
IPC分类号： A61K39/00 , A61K39/395
CPC分类号： G01N33/57484 , A61K2039/505 , C07K16/28 , C07K16/30 , C07K16/40 , C07K2317/73 , C07K2317/77 , G01N33/574 , G01N33/57492 , G01N2333/705 , G01N2333/96486
摘要： The invention provides the identification and characterization of a disease and cancer-associated antigen, KID24. The invention also provides modulators of KID24, including a family of monoclonal antibodies that bind to antigen KID24, and methods of diagnosing and treating various human cancers and diseases with KID24.
摘要翻译： 本发明提供了疾病和癌症相关抗原KID24的鉴定和表征。 本发明还提供KID24的调节剂，包括与抗原KID24结合的单克隆抗体家族，以及用KID24诊断和治疗各种人类癌症和疾病的方法。
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公开(公告)号：US20120110682A1
公开(公告)日：2012-05-03
申请号：US13348479
申请日：2012-01-11
申请人： Jennie P. Mather , Peter F. Young
发明人： Jennie P. Mather , Peter F. Young
CPC分类号： A01K67/0271 , A01K2227/10 , A01K2227/105 , A01K2227/30 , A01K2267/03 , A61K49/0008
摘要： The invention relates to the use of fetal tissues to generate a tissue model in a non-human animal. The tissue model comprises target tissues allowed to progress through development in vivo in a non-human host in order to obtain tissues having a mature phenotype that can be used to assess toxicity and/or efficacy of an agent.
摘要翻译： 本发明涉及胎儿组织在非人动物中产生组织模型的用途。 组织模型包括允许在非人宿主体内通过体内发育进展的靶组织，以获得可用于评估药物的毒性和/或功效的具有成熟表型的组织。
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公开(公告)号：US07718774B2
公开(公告)日：2010-05-18
申请号：US11937470
申请日：2007-11-08
申请人： Jennie P. Mather , Tony W. Liang
发明人： Jennie P. Mather , Tony W. Liang
IPC分类号： C07K16/30 , A61K39/395 , G01N33/53
CPC分类号： G01N33/57484 , A61K2039/505 , C07K16/2827 , C07K16/30 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/77
摘要： The invention provides the identification and characterization of disease and cancer-associated antigen, TES7. The invention also provides a family of monoclonal antibodies that bind to antigen TES7, methods of diagnosing and treating various human cancers and diseases that express TES7.
摘要翻译： 本发明提供疾病和癌症相关抗原TES7的鉴定和表征。 本发明还提供了结合抗原TES7的单克隆抗体家族，诊断和治疗表达TES7的各种人类癌症和疾病的方法。
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公开(公告)号：US07687242B2
公开(公告)日：2010-03-30
申请号：US11331717
申请日：2006-01-12
申请人： Jennie P. Mather , Deryk T. Loo
发明人： Jennie P. Mather , Deryk T. Loo
IPC分类号： G01N33/574 , C12P21/08 , C07K16/00
CPC分类号： C07K16/3038 , A61K2039/505 , C07K16/40 , G01N33/57407 , G01N33/57484 , G01N33/57492
摘要： The invention provides the identification and characterization of disease and cancer-associated antigen, KID31. The invention also provides a family of monoclonal antibodies that bind to antigen KID31, methods of diagnosing and treating various human cancers and diseases that express KID31.
摘要翻译： 本发明提供疾病和癌症相关抗原KID31的鉴定和表征。 本发明还提供了结合抗原KID31的单克隆抗体家族，诊断和治疗表达KID31的各种人类癌症和疾病的方法。
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6.发明授权RAAG10 cell surface target and a family of antibodies recognizing that target 有权RAAG10细胞表面靶标和识别该靶标的一系列抗体公开(公告)号：US07527969B2
公开(公告)日：2009-05-05
申请号：US10600802
申请日：2003-06-19
IPC分类号： C12N1/20
CPC分类号： C07K16/30 , A61K38/00 , A61K39/39558 , A61K45/06 , A61K47/6851 , A61K2039/505 , A61N5/10 , C07K14/70532 , C07K16/2827 , C07K2317/77 , G01N33/57492 , G01N2333/70503
摘要： The invention provides the identification and characterization of disease and cancer-associated antigen, RAAG10. The invention also provides a family of monoclonal antibodies that bind to antigen RAAG10, methods of diagnosing and treating various human cancers and diseases that express RAAG10.
摘要翻译： 本发明提供疾病和癌症相关抗原RAAG10的鉴定和表征。 本发明还提供了与抗原RAAG10结合的单克隆抗体家族，诊断和治疗表达RAAG10的各种人类癌症和疾病的方法。
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公开(公告)号：US07208308B2
公开(公告)日：2007-04-24
申请号：US09903640
申请日：2001-07-11
申请人： Avi Ashkenazi , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Giang Gao , Hanspeter Gerber , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Ivar J. Kljavin , Jennie P. Mather , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Timothy A. Stewart , Daniel Tumas , P. Mickey Williams , William I. Wood
发明人： Avi Ashkenazi , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Giang Gao , Hanspeter Gerber , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Ivar J. Kljavin , Jennie P. Mather , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Timothy A. Stewart , Daniel Tumas , P. Mickey Williams , William I. Wood
IPC分类号： C12N9/48
CPC分类号： C07K14/47 , G01N33/68 , G01N2333/485
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US07148038B2
公开(公告)日：2006-12-12
申请号：US10272835
申请日：2002-10-16
申请人： Jennie P. Mather
发明人： Jennie P. Mather
IPC分类号： C12P21/08
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/2896 , C07K2317/73 , C07K2317/77
摘要： Provided herein is disclosure about the development and characterization of an antibody (mPA7) which binds to antigen CD46 which is present on a variety of human cancers from ovary, breast, lung, prostate, colon, kidney, and pancreas. Methods of diagnosing and treating various cancers by using antibodies such as mPA7 directed against this antigen are also disclosed.
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公开(公告)号：US06653287B1
公开(公告)日：2003-11-25
申请号：US09660590
申请日：2000-09-13
IPC分类号： A61K3817
CPC分类号： C07K16/244 , A61K38/12 , A61K39/3955 , A61K2300/00
摘要： A leukemia inhibitory factor antagonist, alone or in combination with an endothelin antagonist, may be used for treatment of heart failure. The antagonist(s) are administered in a chronic fashion, in therapeutically effective amounts, to achieve this purpose.
摘要翻译： 单独或与内皮素拮抗剂组合的白血病抑制因子拮抗剂可用于治疗心力衰竭。 拮抗剂以治疗有效量以慢性方式施用以达到该目的。
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公开(公告)号：US06635468B2
公开(公告)日：2003-10-21
申请号：US09907794
申请日：2001-07-17
申请人： Avi Ashkenazi , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Ivar J. Kljavin , Jennie P. Mather , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Timothy A. Stewart , Daniel Tumas , P. Mickey Williams , William I. Wood
发明人： Avi Ashkenazi , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Ivar J. Kljavin , Jennie P. Mather , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Timothy A. Stewart , Daniel Tumas , P. Mickey Williams , William I. Wood
IPC分类号： C12N121
CPC分类号： C07K14/47 , C07K14/705 , C07K2319/00
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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