公开(公告)号：US09326870B2

公开(公告)日：2016-05-03

申请号：US12766480

申请日：2010-04-23

申请人： Joseph Berglund ,  Justin Peterson

发明人： Joseph Berglund ,  Justin Peterson

IPC分类号： A61F2/06 ,  A61F2/86 ,  A61F2/07 ,  A61F2/852 ,  A61F2/90 ,  A61F2/82 ,  A61F2/848

CPC分类号： A61F2/86 ,  A61F2/07 ,  A61F2/852 ,  A61F2/90 ,  A61F2002/825 ,  A61F2002/8483 ,  A61F2210/0004 ,  A61F2220/0016 ,  A61F2230/0054 ,  A61F2250/0031 ,  A61F2250/0063

摘要： A hybrid stent prosthesis including a biodegradable tubular body, a first non-biodegradable self-expanding ring coupled to a proximal end of the biodegradable body, and a second non-biodegradable self-expanding ring coupled to a distal end of the biodegradable body. The hybrid stent includes a mechanism for longitudinally compressing the tubular body to increase the radial or hoop strength thereof. The longitudinally compressing mechanism may be protruding elements coupled to and extending radially outward from the hybrid stent or elastomeric compression bands or tethers extending between the non-biodegradable rings. The compression bands may be pre-connected to both non-biodegradable rings prior to stent delivery, or may be connected to one non-biodegradable ring prior to insertion and connected to the other non-biodegradable ring in situ.

摘要翻译： 一种混合支架假体，包括可生物降解的管状体，联接到生物可降解体的近端的第一不可生物降解的自膨胀环，以及联接到可生物降解的身体的远端的第二不可生物降解的自膨胀环。 混合支架包括用于纵向压缩管状体以增加其径向或环向强度的机构。 纵向压缩机构可以是从混合支架或弹性体压缩带或在不可生物降解的环之间延伸的系绳的径向向外的突出元件。 在支架输送之前，压缩带可以预先连接到不可生物降解的环上，或者可以在插入之前连接到一个不可生物降解的环，并且原位连接到另一个不可生物降解的环。

公开(公告)号：US20130284310A1

公开(公告)日：2013-10-31

申请号：US13457398

申请日：2012-04-26

申请人： Justin Peterson ,  James Mitchell ,  Abby Schlichting ,  Nate Glucklich ,  Joseph Berglund ,  Ya Guo

发明人： Justin Peterson ,  James Mitchell ,  Abby Schlichting ,  Nate Glucklich ,  Joseph Berglund ,  Ya Guo

IPC分类号： B65B1/04

CPC分类号： A61F2/91 ,  A61F2/82 ,  A61F2240/00 ,  A61F2250/0068 ,  A61L31/16 ,  A61L2420/02

摘要： Methods and apparatus are disclosed for filling a therapeutic substance or drug within a hollow wire that forms a stent. The stent is placed within a chamber housing a fluid drug formulation. During filling, the chamber is maintained at or near the vapor-liquid equilibrium of the solvent of the fluid drug formulation. To fill the stent, a portion of the stent is placed into contact with the fluid drug formulation until a lumenal space defined by the hollow wire is filled with the fluid drug formulation via capillary action. After filling is complete, the stent is retracted such that the stent is no longer in contact with the fluid drug formulation. The solvent vapor pressure within the chamber is reduced to evaporate a solvent of the fluid drug formulation. A wicking means may control transfer of the fluid drug formulation into the stent.

摘要翻译： 公开了用于在形成支架的中空丝内填充治疗物质或药物的方法和装置。 将支架放置在容纳流体药物制剂的腔室内。 在填充期间，室被保持在或接近流体药物制剂的溶剂的气液平衡。 为了填充支架，将支架的一部分放置成与流体药物制剂接触，直到由空心线限定的腔空间通过毛细作用填充流体药物制剂。 填充完成后，支架缩回，使得支架不再与流体药物制剂接触。 室内的溶剂蒸气压降低以蒸发流体药物制剂的溶剂。 芯吸装置可以控制流体药物制剂转移到支架中。

公开(公告)号：US08052737B2

公开(公告)日：2011-11-08

申请号：US12435738

申请日：2009-05-05

申请人： Joseph Berglund

发明人： Joseph Berglund

IPC分类号： A61F2/82

CPC分类号： A61B17/12109 ,  A61B17/12022 ,  A61B17/12036 ,  A61B17/12159 ,  A61B17/12177 ,  A61B17/12186 ,  A61B17/1219 ,  A61B17/12195 ,  A61B2017/00004 ,  A61B2017/00898 ,  A61F2/91 ,  A61F2002/068 ,  A61F2230/0054 ,  A61F2250/0031

摘要： An implantable flow restrictor plug is disclosed that is disposed within a deployed endoluminal prosthesis to initially restrict, then gradually restore blood flow through the prosthesis after an angioplasty procedure. Upon initial deployment, the plug has a tubular biodegradable body defining a blood flow lumen therethrough that is sized to effectively reduce the amount of blood flow exiting the prosthesis. An inner surface of the body erodes or biodegrades in vivo to enlarge the plug lumen, thereby gradually restoring blood flow through the prosthesis until blood flow is unimpeded through the prosthesis, i.e., blood flow through the vessel is fully restored. The flow restrictor plug may be attached to the endoluminal prosthesis to be delivered and deployed therewith, or may be formed within a previously deployed prosthesis.

摘要翻译： 公开了一种植入式限流塞，其被布置在部署的腔内假体内，以初始限制，然后在血管成形术程序之后逐渐恢复通过假体的血流。 在初次部署时，塞子具有限定穿过其中的血流腔的管状可生物降解体，其尺寸设计成有效地减少离开假体的血流量。 身体的内表面在体内侵蚀或生物降解以扩大塞子腔，从而逐渐恢复通过假体的血流，直到通过假体畅通血流，即通过血管的血流完全恢复。 流量限制器塞子可以附接到被输送和展开的腔内假体，或者可以在预先展开的假体中形成。

公开(公告)号：US20100286758A1

公开(公告)日：2010-11-11

申请号：US12435738

申请日：2009-05-05

申请人： Joseph Berglund

发明人： Joseph Berglund

IPC分类号： A61F2/06

CPC分类号： A61B17/12109 ,  A61B17/12022 ,  A61B17/12036 ,  A61B17/12159 ,  A61B17/12177 ,  A61B17/12186 ,  A61B17/1219 ,  A61B17/12195 ,  A61B2017/00004 ,  A61B2017/00898 ,  A61F2/91 ,  A61F2002/068 ,  A61F2230/0054 ,  A61F2250/0031

摘要： An implantable flow restrictor plug is disclosed that is disposed within a deployed endoluminal prosthesis to initially restrict, then gradually restore blood flow through the prosthesis after an angioplasty procedure. Upon initial deployment, the plug has a tubular biodegradable body defining a blood flow lumen therethrough that is sized to effectively reduce the amount of blood flow exiting the prosthesis. An inner surface of the body erodes or biodegrades in vivo to enlarge the plug lumen, thereby gradually restoring blood flow through the prosthesis until blood flow is unimpeded through the prosthesis, i.e., blood flow through the vessel is fully restored. The flow restrictor plug may be attached to the endoluminal prosthesis to be delivered and deployed therewith, or may be formed within a previously deployed prosthesis.

摘要翻译： 公开了一种植入式限流塞，其被布置在部署的腔内假体内，以初始限制，然后在血管成形术程序之后逐渐恢复通过假体的血流。 在初次部署时，塞子具有限定穿过其中的血流腔的管状可生物降解体，其尺寸设计成有效地减少离开假体的血流量。 身体的内表面在体内侵蚀或生物降解以扩大塞子腔，从而逐渐恢复通过假体的血流，直到通过假体畅通血流，即通过血管的血流完全恢复。 流量限制器塞子可以附接到被输送和展开的腔内假体，或者可以在预先展开的假体中形成。

公开(公告)号：US07815962B2

公开(公告)日：2010-10-19

申请号：US11690000

申请日：2007-03-22

申请人： Joseph Berglund

发明人： Joseph Berglund

IPC分类号： A61L33/00 ,  B05D3/02 ,  B05D3/10 ,  A61F2/06

CPC分类号： A61L31/16 ,  A61L31/10 ,  A61L2300/606

摘要： A stent includes a stent framework and a coating disposed on the stent framework. The coating includes an inner surface and an outer surface. The coating has a circumferential therapeutic concentration zone near the inner surface and a circumferential washed zone near the outer surface.

摘要翻译： 支架包括支架框架和设置在支架框架上的涂层。 涂层包括内表面和外表面。 涂层在内表面附近具有圆周处理浓度区域和靠近外表面的周边洗涤区域。

公开(公告)号：US20090269480A1

公开(公告)日：2009-10-29

申请号：US12244167

申请日：2008-10-02

申请人： Joseph Berglund

发明人： Joseph Berglund

IPC分类号： B05D5/00 ,  B05D1/02

CPC分类号： A61L27/54 ,  A61B2017/00893 ,  A61L17/145 ,  A61L27/34 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/602 ,  A61L2420/02 ,  B05D1/025 ,  B05D2401/90

摘要： Described herein are implantable medical devices that can be coated with polymers and/or bioactive agents with the aid of supercritical fluids and methods for coating the devices. The medical devices described herein can have at least a portion of their surface made of or formed from a porous material. The supercritical fluids are used as a carrier for the bioactive agents described. Once the bioactive agents are carried to the medical device surface, they are sequestered there, preferably in the pores. The supercritical fluid is sprayed onto the medical devices achieving precipitation of the fluid. If appropriate conditions are used in the area of precipitation, bioactive agents can penetrate into the pores of the medical device before coming out of solution and expanding.

摘要翻译： 这里描述的是可以借助超临界流体和用于涂覆装置的方法用聚合物和/或生物活性剂涂覆的可植入医疗装置。 本文所述的医疗装置可以具有由多孔材料制成或由多孔材料形成的表面的至少一部分。 超临界流体用作所述生物活性剂的载体。 一旦生物活性剂被运送到医疗器械表面，它们就被隔离在那里，优选在孔中。 将超临界流体喷射到医疗装置上，实现流体的沉淀。 如果在沉淀区域使用合适的条件，生物活性剂可以在溶出和膨胀之前渗透到医疗器械的孔中。

公开(公告)号：US20080233267A1

公开(公告)日：2008-09-25

申请号：US11690000

申请日：2007-03-22

申请人： Joseph Berglund

发明人： Joseph Berglund

IPC分类号： A61L33/00

CPC分类号： A61L31/16 ,  A61L31/10 ,  A61L2300/606

摘要： A stent includes a stent framework and a coating disposed on the stent framework. The coating includes an inner surface and an outer surface. The coating has a circumferential therapeutic concentration zone near the inner surface and a circumferential washed zone near the outer surface.

摘要翻译： 支架包括支架框架和设置在支架框架上的涂层。 涂层包括内表面和外表面。 涂层在内表面附近具有圆周处理浓度区域和靠近外表面的周边洗涤区域。

公开(公告)号：US20100256738A1

公开(公告)日：2010-10-07

申请号：US12419531

申请日：2009-04-07

申请人： Joseph Berglund

发明人： Joseph Berglund

IPC分类号： A61F2/82

CPC分类号： A61F2/91 ,  A61F2002/068 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2230/0067

摘要： An implantable flow restrictor device is disclosed for initially restricting, then gradually restoring blood flow through a body vessel after an interventional procedure. A self-expanding annular member having a constricted diameter gives the device a frustoconical configuration that reduces blood flow therethrough upon initial deployment at a treatment site. The annular member is constricted by a plurality of linkages that operate to allow the annular member to gradually expand, thereby transforming the flow restrictor device to a cylindrical configuration that allows unimpeded blood flow therethrough. In one embodiment, expansion of the annular member is achieved via biodegradation of the linkages. In another embodiment, expansion of the annular member is achieved via creep deformation of the linkages. The flow restrictor device may be attached to an endoluminal prosthesis, or may be a separate complementary component that is delivered during an interventional procedure.

公开(公告)号：US20100125323A1

公开(公告)日：2010-05-20

申请号：US12271465

申请日：2008-11-14

申请人： Joseph Berglund ,  Matthew J. Birdsall ,  Lesley Crookall

发明人： Joseph Berglund ,  Matthew J. Birdsall ,  Lesley Crookall

IPC分类号： A61F2/06

CPC分类号： A61L31/148 ,  A61F2/88 ,  A61F2/95 ,  A61F2002/9517 ,  A61F2002/9665 ,  A61F2220/0016

摘要： The coil stent delivery system and method of use includes a stent delivery system including a coil stent; a housing, the housing having a receiver defining a receiver chamber and a sheath defining a sheath lumen, the receiver chamber being in communication with the sheath lumen; and a screw assembly, the screw assembly having a shaft, a helical screw disposed about a distal portion of the shaft, and a drive operably coupled to the shaft. The shaft is disposed in the receiver chamber and the sheath lumen, the helical screw is disposed in the sheath, and the coil stent is disposed about the shaft in the receiver chamber and engages the helical screw. Rotation of the drive moves the coil stent through the sheath lumen.

摘要翻译： 线圈支架输送系统和使用方法包括支架输送系统，其包括线圈支架; 壳体，其具有限定了接收器室的接收器和限定护套管腔的护套，所述接收器腔室与鞘管腔连通; 和螺钉组件，所述螺钉组件具有轴，设置在所述轴的远侧部分周围的螺旋形螺钉以及可操作地联接到所述轴的驱动器。 轴设置在接收器腔室和护套管腔中，螺旋形螺钉设置在护套中，线圈支架围绕接收器腔室中的轴设置并与螺旋形螺钉接合。 驱动器的旋转将线圈支架移动通过鞘管。

公开(公告)号：US20090024209A1

公开(公告)日：2009-01-22

申请号：US11780702

申请日：2007-07-20

申请人： Feridun Ozdil ,  Joseph Berglund

发明人： Feridun Ozdil ,  Joseph Berglund

IPC分类号： A61F2/06

CPC分类号： A61F2/88 ,  A61F2210/0004 ,  A61F2250/003 ,  A61F2250/0035 ,  A61F2250/0068

摘要： An implantable device capable of delivering drugs is disclosed. An example of the device is a stent that comprises at least one hypotube having a lumen and one or more pores. The lumen of the hypotube is configured to retain drugs that can be eluted through the one or more pores after deployment at a treatment site.

摘要翻译： 公开了一种能够输送药物的可植入装置。 该装置的实例是包括至少一个具有内腔和一个或多个孔的海波管的支架。 海波管的管腔被配置为保留在处置部位展开后可以通过一个或多个孔洗脱的药物。