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公开(公告)号：US20240238445A1
公开(公告)日：2024-07-18
申请号：US18552290
申请日：2022-07-08
申请人： NEURACLE SCIENCE CO., LTD. , KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION , KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION, SEJONG CAMPUS
发明人： Jae Young SEONG , Youngjoo BYUN , Hoyun KWAK , Sitaek OH , Min-Hyeok LEE , Yongwoo JEONG , Nui HA , Eun-Ho CHO , Suhyun LEE , Sang-Myeong LEE , Yerim LEE , Eun Bee CHO , Jae Keun LEE , Han-Byul KIM , Soon-gu KWON
IPC分类号： A61K48/00 , A61K31/055 , A61K31/085 , A61K31/136 , A61K31/137 , A61K38/08 , A61K38/10 , A61K38/17 , A61K45/06 , A61K47/64 , A61P25/02 , A61P25/28 , C12N5/0793
CPC分类号： A61K48/005 , A61K31/055 , A61K31/085 , A61K31/136 , A61K31/137 , A61K38/08 , A61K38/10 , A61K38/1709 , A61K45/06 , A61K47/64 , A61P25/02 , A61P25/28 , C12N5/0619
摘要： The present disclosure provides mimic molecules that are capable of specifically targeting a FAM19A5 protein, and thereby, inhibiting, reducing, and/or dissociating the interaction between members of the LRRC4 protein family and the FAM19A5 protein. The present disclosure also provides methods for promoting neurite outgrowth, by administering a mimic molecule described herein.
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2.发明公开公开(公告)号：US20240212800A1
公开(公告)日：2024-06-27
申请号：US18544488
申请日：2023-12-19
申请人： LumanLab Inc. , Korea University Research and Business Foundation , Korea University Research and Business Foundation, Sejong Campus
发明人： Jae Hyun LIM , Chul Hyun CHO , Seung Pil PACK
CPC分类号： G16H10/20 , A61B5/16 , G16H50/20 , G16H50/30 , A61B2503/06
摘要： An electronic device and a method to assess a mental health state of an adolescent by using a survey formed based on an artificial intelligence (AI). The method comprises: collecting physical information of a user through a pre-installed application, verifying survey questions regarding a mental health depending on the physical information, and verifying answers to the verified survey questions through the application; forming additional survey questions after having verified the answers and calculating a prediction rate of an appearance of symptoms of a mental illness regarding the additional survey questions by using AI models; verifying a set of survey questions including a plurality of sub-questions depending on the calculated prediction rate; outputting the verified set of survey questions through the application; outputting result data by adjusting the prediction rate; and transmitting the outputted result data.
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公开(公告)号：US20220289657A1
公开(公告)日：2022-09-15
申请号：US17637565
申请日：2020-08-21
申请人： KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION, SEJONG CAMPUS , KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
发明人： Youngjoo BYUN , Hee Deung PARK , Sangjin NAM , Sang-Hyun SON , So Young HAM , Han Shin KIM
IPC分类号： C07C49/255 , C07C49/248 , C07C49/235 , A61K31/12 , A61P31/04
摘要： The present invention relates to a 4-gingerol derivative compound, or a racemate, isomer, or pharmaceutically acceptable salt thereof, the compound being capable of inhibiting biofilm formation and production of virulence factors. The 4-gingerol derivative compound according to the present invention has binding affinity to RhlR and corresponding RhlR antagonism activity that are significantly improved, and therefore can effectively inhibit biofilm formation and production of virulence factors. Furthermore, various bacterial infectious diseases caused by biofilms can be fundamentally prevented or treated by using a pharmaceutical composition comprising the 4-gingerol derivative compound, or a racemate, isomer, or pharmaceutically acceptable salt thereof as an active ingredient.
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公开(公告)号：US20200283364A1
公开(公告)日：2020-09-10
申请号：US16632592
申请日：2018-07-19
申请人： Korea University Research and Business Foundation, Sejong Campus , Korea University Research and Business Foundation
发明人： Youngjoo BYUN , Hee-Deung PARK , Sang-Hyun SON , Eunji CHA , So-Young HAM , Hyunsuk CHOI
IPC分类号： C07C49/255 , C07C49/245 , A61P31/04
摘要： The present invention relates to a gingerol derivative having inhibitory activity against biofilm formation and a pharmaceutical composition for preventing or treating infections caused by biofilms including the gingerol derivative as an active ingredient. The gingerol derivative of the present invention exhibits significantly improved binding affinity for LasR and inhibitory activity against biofilm formation. Therefore, the gingerol derivative of the present invention can act on various membrane surfaces where biofilms tend to form and can effectively inhibit the formation of the corresponding biofilms. In addition, the use of the pharmaceutical composition according to the present invention can fundamentally prevent or treat a variety of infections caused by biofilms due to the presence of the gingerol derivative in the pharmaceutical composition.
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公开(公告)号：US11964935B2
公开(公告)日：2024-04-23
申请号：US16632592
申请日：2018-07-19
申请人： Korea University Research and Business Foundation, Sejong Campus , Korea University Research and Business Foundation
发明人： Youngjoo Byun , Hee-Deung Park , Sang-Hyun Son , Eunji Cha , So-Young Ham , Hyunsuk Choi
IPC分类号： C07C49/255 , A61P31/04 , C07C49/245
CPC分类号： C07C49/255 , A61P31/04 , C07C49/245
摘要： The present invention relates to a gingerol derivative having inhibitory activity against biofilm formation and a pharmaceutical composition for preventing or treating infections caused by biofilms including the gingerol derivative as an active ingredient. The gingerol derivative of the present invention exhibits significantly improved binding affinity for LasR and inhibitory activity against biofilm formation. Therefore, the gingerol derivative of the present invention can act on various membrane surfaces where biofilms tend to form and can effectively inhibit the formation of the corresponding biofilms. In addition, the use of the pharmaceutical composition according to the present invention can fundamentally prevent or treat a variety of infections caused by biofilms due to the presence of the gingerol derivative in the pharmaceutical composition.
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公开(公告)号：US11298534B2
公开(公告)日：2022-04-12
申请号：US16235498
申请日：2018-12-28
申请人： KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION , Korea University Research and Business Foundation, Sejong Campus
发明人： Hoon Jai Chun , Jung Hwa Hong , Dong Geun Sul , Bora Keum , Eun Sun Kim , Hyuk Soon Choi , Seung Han Kim
摘要： A stimulator for a digestive organ includes a case, a substrate member disposed in the case, and an electrode member connected to the substrate member and extending to protrude outwardly from the case. The electrode member may have a shape of a wire and may be configured to provide an electrical stimulation in a state of being inserted and fixed at a predetermined location within a digestive organ.
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公开(公告)号：US20190321631A1
公开(公告)日：2019-10-24
申请号：US16235498
申请日：2018-12-28
申请人： KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION , KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
发明人： Hoon Jai Chun , Jung Hwa Hong , Dong Geun Sul , Bora Keum , Eun Sun Kim , Hyuk Soon Choi , Seung Han Kim
摘要： A stimulator for a digestive organ includes a case, a substrate member disposed in the case, and an electrode member connected to the substrate member and extending to protrude outwardly from the case. The electrode member may have a shape of a wire and may be configured to provide an electrical stimulation in a state of being inserted and fixed at a predetermined location within a digestive organ.
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8.发明公开公开(公告)号：US20240346790A1
公开(公告)日：2024-10-17
申请号：US18634813
申请日：2024-04-12
发明人： Hyunwoo KIM , Sihyeon KIM , Jin-Young PARK , Sang Hyeok LEE
CPC分类号： G06T19/20 , G06T5/70 , G06T7/11 , G06T2219/2016
摘要： The present disclosure relates to a three-dimensional (3D) data augmentation method using a weighted local transformation and an apparatus for the same. More specifically, the present disclosure relates to a method and apparatus of significantly augmenting 3D data required to improve the performance of an artificial intelligence model with only limited 3D data by applying a non-rigid transformation to local part(s) of the 3D data.
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9.发明公开公开(公告)号：US20240340020A1
公开(公告)日：2024-10-10
申请号：US18471437
申请日：2023-09-21
发明人： Chulwoo KIM , Soohoo PARK , Yohan CHOI , Chang Joo KIM
CPC分类号： H03M1/462 , H03M1/1245
摘要： Disclosed is an analog-to-digital conversion device. The analog-to-digital conversion device includes a signal generating unit that generates a plurality of comparison voltages based on an analog input voltage and generates a plurality of comparison results of the plurality of comparison voltages based on a sampling period, a calculation unit that skips a comparison result generated by a comparison voltage having a smallest difference between the analog input voltages among the plurality of comparison voltages from the plurality of comparison results and generates an end of comparison based on a remaining plurality of comparison results, and a SAR logic unit that generates a digital signal corresponding to the end of comparison and stores information for each bit of the digital signal.
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公开(公告)号：US12102464B2
公开(公告)日：2024-10-01
申请号：US17763103
申请日：2020-12-15
发明人： Byung Duk Ahn , In Seok Song , Yoon-Ji Kim , Jae Gul Choo , Jin Hee Kim , Tae Sung Kim
CPC分类号： A61B6/505 , A61B6/463 , A61B6/469 , A61B6/5217 , A61B6/54 , G06T7/0012 , G06T7/64 , G06T2207/10116 , G06T2207/20081 , G06T2207/20101 , G06T2207/30012
摘要： Disclosed are a bone age estimation method and a bone age estimation apparatus. The bone age estimation method may comprise the steps of: extracting a region of interest including a cervical spine region from a lateral cephalometric radiographic image obtained by imaging a subject's cervical spine, by using a first deep learning model; extracting landmarks from the extracted region of interest by using a second deep learning model; calculating a landmark numerical value on the basis of the extracted landmarks; and providing maturity information of a maturation stage of the cervical spine on the basis of the calculated landmark numerical value.
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