公开(公告)号：US20110195930A1

公开(公告)日：2011-08-11

申请号：US13125582

申请日：2009-11-06

申请人： Takahiro Haga ,  Masayuki Morita ,  Kazuhisa Kiriyama ,  Kumiko Azuma

发明人： Takahiro Haga ,  Masayuki Morita ,  Kazuhisa Kiriyama ,  Kumiko Azuma

IPC分类号： A01N55/10 ,  C07D401/06 ,  A01N43/40 ,  C07F7/18 ,  C07D401/14 ,  A01P7/00

CPC分类号： C07D401/12

摘要： To provide a novel pesticide. The present invention provides a pesticide which contains, as an active ingredient, novel pyridine derivative represented by the formula (I) or its salt: wherein R1 is alkyl, cycloalkyl, alkoxyalkyl or OR3; R2 is 1H-1,2,4-triazol-1-yl which may be substituted, 1H-imidazol-1-yl which may be substituted, 1H-1,2,3-triazol-1-yl which may be substituted, or 4H-1,2,4-triazol-4-yl which may be substituted; X is alkyl which may be substituted, cycloalkyl which may be substituted, halogen, nitro, etc.; R3 is alkyl which may be substituted, cycloalkyl which may be substituted, alkenyl which may be substituted, alkynyl which may be substituted, etc.; m is an integer of from 1 to 4.

摘要翻译： 提供一种新型农药。 本发明提供了含有作为活性成分的由式（I）表示的新型吡啶衍生物或其盐的农药：其中R1是烷基，环烷基，烷氧基烷基或OR3; R2是可以被取代的1H-1,2,4-三唑-1-基，可以被取代的1H-咪唑-1-基，可以被取代的1H-1,2,3-三唑-1-基， 或可被取代的4H-1,2,4-三唑-4-基; X为可被取代的烷基，可被取代的环烷基，卤素，硝基等; R3是可被取代的烷基，可被取代的环烷基，可被取代的链烯基，可被取代的炔基等; m为1〜4的整数。

公开(公告)号：US20100179172A1

公开(公告)日：2010-07-15

申请号：US12666171

申请日：2008-06-20

申请人： Masayuki Morita ,  Kazuhiro Yamamoto ,  Toshihiko Ueki ,  Kumiko Azuma ,  Taku Hamamoto

发明人： Masayuki Morita ,  Kazuhiro Yamamoto ,  Toshihiko Ueki ,  Kumiko Azuma ,  Taku Hamamoto

IPC分类号： A01N43/60 ,  C07D213/24 ,  A01N43/40 ,  C07D401/12 ,  C07D413/12 ,  A01N43/80 ,  C07D417/12 ,  C07D409/12 ,  C07D405/12

CPC分类号： A01N43/40 ,  A01N43/50 ,  A01N43/60 ,  A01N43/713 ,  A01N43/80 ,  C07D213/38 ,  C07D213/61 ,  C07D213/64 ,  C07D213/70 ,  C07D213/89 ,  C07D401/12 ,  C07D401/14 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

摘要： A novel pesticide is provided. The present invention provides a pesticide containing, as an active ingredient, an N-phenyl-methanamine derivative represented by the formula (I) or its salt: wherein R1 is alkyl which may be substituted, etc.; each of R2, R3, R4 and R6 which are independent of one another, is hydrogen, halogen, alkyl which may be substituted, etc.; R5 is haloalkyl or halogen; each of R7 and R8 which are independent of each other, is hydrogen, cyano, alkyl, etc.; R9 is alkyl, cycloalkyl, etc.; m is from 0 to 1 and n is from 0 to 4.

摘要翻译： 提供了一种新型农药。 本发明提供含有式（I）所示的N-苯基 - 甲胺衍生物或其盐的农药，其中R1为可被取代的烷基等; 彼此独立的R 2，R 3，R 4和R 6各自为氢，卤素，可被取代的烷基等; R5是卤代烷基或卤素; R 7和R 8各自独立地为氢，氰基，烷基等; R9是烷基，环烷基等; m为0〜1，n为0〜4。

公开(公告)号：US20100160326A1

公开(公告)日：2010-06-24

申请号：US12305664

申请日：2007-07-20

申请人： Hirohiko Kimura ,  Masayuki Morita ,  Kazuhiro Yamamoto ,  Toshihiko Ueki ,  Kumiko Azuma ,  Taku Hamamoto

发明人： Hirohiko Kimura ,  Masayuki Morita ,  Kazuhiro Yamamoto ,  Toshihiko Ueki ,  Kumiko Azuma ,  Taku Hamamoto

IPC分类号： A01N43/86 ,  C07D213/02 ,  A01N43/40 ,  C07D215/12 ,  A01N43/42 ,  C07D265/30 ,  C07D233/96 ,  A01N43/54 ,  C07D241/20 ,  A01N43/60 ,  A01P7/00

CPC分类号： C07D213/85 ,  A01N43/40 ,  A01N43/42 ,  A01N43/54 ,  A01N43/56 ,  A01N43/60 ,  A01N43/78 ,  A01N43/80 ,  A01N43/82 ,  A01N43/84 ,  A01N43/90 ,  C07D213/74 ,  C07D213/80 ,  C07D213/82 ,  C07D213/84 ,  C07D401/14 ,  C07D405/14 ,  C07D411/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

摘要： A novel pesticide is provided. The present invention provides a pesticide containing, as an active ingredient, a pyridyl-methanamine derivative represented by the formula (I) or its salt: wherein R1 is hydrogen, alkyl, alkenyl, alkynyl, aryl, a heterocyclic group, etc.; each of R2 and R3 which are independent of each other, is hydrogen, halogen, cyano, nitro, alkyl, cycloalkyl, alkenyl, alkynyl, aryl, a heterocyclic group, etc.; R4 is trifluoromethyl or chlorodifluoromethyl; R5 is hydrogen, halogen, cyano, nitro, alkyl, etc.; each of R6 and R7 which are independent of each other, is hydrogen, cyano, alkyl, haloalkyl, etc.; R8 is alkyl, cycloalkyl, alkoxyalkyl, alkoxyalkoxyalkyl, hydroxyalkyl, halogen, haloalkyl, cyano, nitro, etc.; and n is an integer of from 0 to 4.

摘要翻译： 提供了一种新型农药。 本发明提供含有式（I）表示的吡啶基 - 甲胺衍生物或其盐的农药：其中R1是氢，烷基，烯基，炔基，芳基，杂环基等; R 2和R 3各自独立地为氢，卤素，氰基，硝基，烷基，环烷基，烯基，炔基，芳基，杂环基等。 R4是三氟甲基或氯二氟甲基; R5是氢，卤素，氰基，硝基，烷基等; R 6和R 7各自独立地为氢，氰基，烷基，卤代烷基等; R8是烷基，环烷基，烷氧基烷基，烷氧基烷氧基烷基，羟基烷基，卤素，卤代烷基，氰基，硝基等; n为0〜4的整数。

公开(公告)号：US07632865B2

公开(公告)日：2009-12-15

申请号：US10588859

申请日：2005-02-16

申请人： Fuminori Kato ,  Hirohiko Kimura ,  Kiyoshi Tamai ,  Kazuhiro Yamamoto ,  Mitsuo Sano ,  Shinya Mori ,  Takashi Okada ,  Toshihiko Ueki ,  Kumiko Azuma

发明人： Fuminori Kato ,  Hirohiko Kimura ,  Kiyoshi Tamai ,  Kazuhiro Yamamoto ,  Mitsuo Sano ,  Shinya Mori ,  Takashi Okada ,  Toshihiko Ueki ,  Kumiko Azuma

IPC分类号： A61K31/165 ,  C07C327/42

CPC分类号： C07D239/34 ,  C07C233/66 ,  C07C233/69 ,  C07C233/71 ,  C07C233/78 ,  C07C323/42 ,  C07C327/48 ,  C07C2603/74 ,  C07D213/83 ,  C07D239/42

摘要： To provide cytokine production inhibitors useful as preventive or therapeutic medicines for diseases accompanied by hyperactivated immune functions.A cytokine production inhibitor containing, as an active ingredient, a thioamide compound represented by the formula (I) or a salt thereof: wherein A is N, NO, C—NO2 or C—CN; Hal is a halogen; M1 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, heterocyclyl, amino, O, S, SO or SO2; M2 is amino, O, S or a single bond; R1 is a halogen, alkyl or the like; each of R2, R3, R4 and R5 is independently H, alkyl or the like; R6 is a halogen, alkyl or the like; Cy is cycloalkyl, cycloalkenyl, aryl or heterocyclyl; each of k, p and q is independently an integer of from 0 to 3; and r is an integer of from 0 to 5.

摘要翻译： 提供可用作预防或治疗药物的细胞因子产生抑制剂，用于伴有过度活化的免疫功能的疾病。 1.一种细胞因子产生抑制剂，含有作为活性成分的式（I）所示的硫代酰胺化合物或其盐：其中A为N，NO，C-NO 2或C-CN; 卤素是卤素; M 1是烷基，烯基，炔基，环烷基，环烯基，芳基，杂环基，氨基，O，S，SO或SO 2; M2是氨基，O，S或单键; R1是卤素，烷基等; R2，R3，R4和R5各自独立地为H，烷基等; R6是卤素，烷基等; Cy是环烷基，环烯基，芳基或杂环基; k，p和q各自独立地为0〜3的整数; r为0〜5的整数。

公开(公告)号：US20070219215A1

公开(公告)日：2007-09-20

申请号：US10588859

申请日：2005-02-16

申请人： Fuminori Kato ,  Hirohiko Kimura ,  Kiyoshi Tamai ,  Kazuhiro Yamamoto ,  Mitsuo Sano ,  Shinya Mori ,  Takashi Okada ,  Toshihiko Ueki ,  Kumiko Azuma

发明人： Fuminori Kato ,  Hirohiko Kimura ,  Kiyoshi Tamai ,  Kazuhiro Yamamoto ,  Mitsuo Sano ,  Shinya Mori ,  Takashi Okada ,  Toshihiko Ueki ,  Kumiko Azuma

IPC分类号： A61K31/496 ,  A61K31/16 ,  A61K31/44 ,  C07D213/00 ,  C07D401/00 ,  C07C327/02 ,  A61K31/445

CPC分类号： C07D239/34 ,  C07C233/66 ,  C07C233/69 ,  C07C233/71 ,  C07C233/78 ,  C07C323/42 ,  C07C327/48 ,  C07C2603/74 ,  C07D213/83 ,  C07D239/42

摘要： To provide cytokine production inhibitors useful as preventive or therapeutic medicines for diseases accompanied by hyperactivated immune functions. A cytokine production inhibitor containing, as an active ingredient, a thioamide compound represented by the formula (I) or a salt thereof: wherein A is N, NO, C—NO2 or C—CN; Hal is a halogen; M1 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, heterocyclyl, amino, O, S, SO or SO2; M2 is amino, O, S or a single bond; R1 is a halogen, alkyl or the like; each of R2, R3, R4 and R5 is independently H, alkyl or the like; R6 is a halogen, alkyl or the like; Cy is cycloalkyl, cycloalkenyl, aryl or heterocyclyl; each of k, p and q is independently an integer of from 0 to 3; and r is an integer of from 0 to 5.

摘要翻译： 提供可用作预防或治疗药物的细胞因子产生抑制剂，用于伴有过度活化的免疫功能的疾病。 含有式（I）所示的硫代酰胺化合物或其盐作为活性成分的细胞因子产生抑制剂：其中A为N，NO，C-NO 2或C-CN; 卤素是卤素; M 1是烷基，烯基，炔基，环烷基，环烯基，芳基，杂环基，氨基，O，S，SO或SO 2。 M 2是氨基，O，S或单键; R 1是卤素，烷基等; R 2，R 3，R 4和R 5各自独立地为H，烷基等; R 6是卤素，烷基等; Cy是环烷基，环烯基，芳基或杂环基; k，p和q各自独立地为0〜3的整数; r为0〜5的整数。