摘要:
The present invention relates to compounds which are 1,2-dihydro-4-hydroxy-2-oxo-quinoline-3-carboxanilides, their thieno-pyridone analogs, and prodrugs thereof. This invention specifically relates to such derivatives containing an N-hydrogen in the carboxanilide moiety and which exhibit modulating activity towards the aromatic hydrocarbon receptor (AhR), and, specifically, also to prodrugs thereof. The present invention also relates to use of said compounds as a medicament, and for the treatment of cancer, autoimmune disorders and other disorders with an immunological component, and a pharmaceutical composition comprising one or more of said compounds and a method of treatment.
摘要:
The present invention relates to novel compounds which are 7α-substituted 17-alkylene-16α-hydroxy steroidal estrogens. This invention specifically relates to estrogen derivatives which contain 7α-substituents and which exhibit anti-estrogenic properties. The present invention also relates to use of said compounds as a medicament, and for the treatment of estrogen dependent disorders, a pharmaceutical composition comprising one or more of said compounds and a method of treatment.
摘要:
The present invention relates to novel heterocyclic compounds, to methods for their preparation, to compositions containing them, and to methods and use for clinical treatment of medical conditions which may benefit from immunomodulation, including rheumatoid arthritis, multiple sclerosis, diabetes, asthma, transplantation, systemic lupus erythematosis and psoriasis. More particularly the present invention relates to novel heterocyclic compounds, which are CD80 antagonists capable of inhibiting the interactions between CD80 and CD28.
摘要:
The invention provides compounds of general formula (I) wherein Q, R, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要:
The present invention relates to compounds which are 1,2-dihydro-4-hydroxy-2-oxo-quinoline-3-carboxanilides, their thieno-pyridone analogs, and prodrugs thereof. This invention specifically relates to such derivatives containing an N-hydrogen in the carboxanilide moiety and which exhibit modulating activity towards the aromatic hydrocarbon receptor (AhR), and, specifically, also to prodrugs thereof. The present invention also relates to use of said compounds as a medicament, and for the treatment of cancer, autoimmune disorders and other disorders with an immunological component, and a pharmaceutical composition comprising one or more of said compounds and a method of treatment.
摘要:
A reformer reactor is provided for converting hydrocarbon fuel into hydrogen rich gas by auto-thermal reaction process having a cylindrically shaped and double walled, housing with two side faces forming a reaction chamber of the reformer. Additionally, a fuel inlet is provided in one of the two side faces for providing hydrocarbon fuels into the reaction chamber, wherein further a fuel preheating means is provided which preheats the hydrocarbon fuel before the hydrocarbon fuel enters the reaction chamber.
摘要:
A method and system for the systematic evaluation and rating of technical equipment using a data processing device (20), which works together with at least one data memory (21) and has an input (22) and display device (23), in which, step-by-step for the particular technical equipment, at least one first data set having economically relevant input parameters and at least one second data set having technically relevant input parameters are detected and/or established. For each data set, through knowledge-based predetermined numerical and/or logical linkages and knowledge-based predetermined weighting factors specific to the equipment, the established input parameters are brought together into an economic evaluation parameter FIx and a technical evaluation parameter RIx, respectively, and from the established evaluation parameters, through knowledge-based predetermined numerical linkages and weighting factors, a single overall resulting evaluation parameter EIx is determined.
摘要:
Compounds are described that are prodrugs to active compounds that modulate a muscarinic receptor. In some cases, the compounds are prodrugs to N-desmethylclozapine. The compounds may be used to treat neuropsychiatric disorders.
摘要:
Compounds of formula (I) are modulators of STAT6 signal pathway activity, and can be used in the treatment of atopic dermatitis, urticaria, allergic asthma, allergic rhinitis, a food allergy, allergic conjunctivitis, hayfever, bullous pemphigoid, industrial sensitization, chronic rejection of transplants or COPD
摘要:
The invention provides compounds of general formula (I) wherein Q, R, R2, R4, R5, R6, R7 and R8 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy