摘要:
The invention relates to an injection device comprising a housing, a container holder arranged within said housing, the container holder being configured for accommodating a medicament container having a needle attached to one end thereof and a stopper sealingly and slidable arranged inside the medicament container at the other end thereof, a drive unit comprising a plunger rod and plunger drive means, the plunger drive means being slidable arranged in relation to the plunger rod, being rotationally locked to the plunger rod and being rotatable in relation to the housing, said drive unit further comprising a first energy accumulating member arranged in the interior of the housing of the injection device and adapted to accumulate and store energy, wherein said plunger drive means is operationally associated with said first energy accumulating member, wherein the plunger drive means is releasable such that due to an output torque from said first energy accumulating member, the plunger drive means are allowed to be rotated and the plunger rod is urged towards the proximal end of the injection device whereby an injection is performed, and a rotary injection indication mechanism configured for indicating to the user the progress of the injection, wherein the rotary injection indication mechanism comprises a signalling member and a drive mechanism for rotationally driving said signalling member, said signalling member being coupled to said drive mechanism, said drive mechanism being coupled to said plunger drive means at the distal end of said plunger drive means, said rotary injection indication mechanism being arranged such that the progress of injection is shown through at least one opening provided at least in a distal end surface of the housing.
摘要:
The present invention relates to sealing means made of a plastically deformable material for mechanical sealing of hollow hoses (2) of elastic material by means of an appliance having at least two jaws, at least one of which is movable towards and away from the other and which, when moving towards each other, crimp the sealing means against the hose (2) for contamination-tight sealing of the same, the sealing means (20) comprises at least one sealing member (4, 4′; 44, 44′; 64, 64′; 74, 74′; 84), which has two opposite ends and an opening (40, 40′) that extends between said ends to allow the at least one sealing member to be slipped onto the hose (2) to be sealed.The present invention also relates to a kit comprising a sealing means and an appliance for sealing of hollow hoses and to a method for mechanical sealing of hollow hoses.
摘要:
The present invention relates to an industrial fabric, in particular press fabric or transfer belt, for use in a papermaking machine. The industrial fabric includes a porous composite structure, having a batt fiber structure and particulate polymeric material. The batt fiber structure has an upper surface and a lower surface extending parallel to the upper surface and spaced from the upper surface along a thickness direction extending perpendicular to the upper and lower surface. The particulate polymeric material is partly fused together and bonded with fibers extending on at least one of the surfaces of the batt fiber structure and with fibers inside the batt fiber structure such that the polymeric material partly impregnates fibers of the batt structure and partly fills interstices between fibers of the batt structure to form the porous composite structure. Further in accordance with the present invention, the composite structure has a varying amount of polymeric material in the batt fiber structure along at least a section of the thickness direction of the batt fiber structure. The present invention further provides a method of making same.
摘要:
The present invention relates to a method of making cutting tools comprising a substrate having a hard phase and a binder phase, the method comprising forming green powder compacts using powder metallurgical techniques, charging the green powder compacts, placed on one or several trays, in a furnace and sintering the green powder compacts wherein the furnace comprises an insulation package, at least three individually controlled heating elements located inside the insulation package including a vertical heating element, an upper horizontal heating element arranged in an upper part of the furnace, and a lower horizontal heating element arranged in a lower part of the furnace, wherein operating the at least three heating elements such that an average controlled cooling rate from a sintering temperature down to at least a solidification temperature of the binder phase is 0.1-4.0° C./min, and a sintering furnace operable to obtain a controlled cooling rate.
摘要:
A scanner arrangement which is designed to scan only one part at a time in order to permit scanning results of a model or die-shaped unit consisting of two or more parts which can be joined together or taken apart and which can have different longitudinal inclination axes and/or configurations. The scanner has, for each respective part, a support member adjustable with different inclinations in order to adapt the respective part's longitudinal inclination axis to a longitudinal displacement movement effected by the scanner's contour-sensing member relative to the supported part at the same time as the contour-sensing member is set at an angle with respect to a rotation axis for the part. The support member is designed to movably support the respective part and a unit with a grid surface and to be adjustably arranged with the same inclination as the part in question and a selected height position. After contour sensing and removal of the respective part, the scanner is designed to rescan a portion which is located on the grid surface and which is continuous with the respective part's position in space. The grid pattern is designed to indicate unique positions • for the data thus scanned. The scanner or a computer unit connected to it transforms, by means of an algorithm, the positions corresponding to the positions which are present in the model or. the die-shaped unit and which, in subsequent signal or data generation, form the basis for the dental bridge structure. By means of the invention, it is readily possible to use one-part scanners to scan dental objects with several parts, without the scanner functions having to be reconfigured. The handling principles for model and tool production can be retained, likewise the handling in the computer environment in the manufacture of the dental product. Costs can be kept low, and precision requirements and speed of production can be maintained.
摘要:
A CVD-coated cutting tool insert with improved toughness properties having the ability to withstand high temperatures without sacrificing edge line security is disclosed. The insert coating comprises a TiCxNy-layer with a low tensile stress level of 50-500 MPa and an α-Al2O3-layer with a high surface smoothness with a mean Ra
摘要翻译:公开了具有改进的韧性的具有能够承受高温但不牺牲边缘线安全性的CVD涂层的切削刀具刀片。 插入涂层包括具有50-500MPa的低拉伸应力水平和α-Al 2 O 3的TiC x N z N层 具有高表面光滑度的平均Ra <0.12μm的AFM技术测定的层3,其通过对涂层进行强力的湿式喷砂操作获得。
摘要:
The present invention describes oligosaccharide sequences, which are specifically expressed by human tumors. The present invention is related to a method of determining an oligosaccharide sequence, which comprises a tumor specific terminal N-acetylglucosamine residue, in a biological sample, the presence of said sequence in said sample being an indication of the presence of cancer. The present invention provides antigenic substances comprising said oligosaccharide sequences in a polyvalent form and it further provides diagnostic agents, pharmaceutical compositions and cancer vaccines comprising said oligosaccharide sequences or substances binding to said oligosaccharide sequences. The present invention is also related to methods for the treatment of cancer.
摘要:
An injection device having an elongated body, including a container with medicament, elements for connecting a needle to the container, actuating elements capable of injecting a dose of medicament upon activation, activating elements capable of activating the actuating elements, a needle shield arranged to the body and slidable between an extended and a retracted position in relation to the body. The needle shield is designed and arranged such that, upon penetration of the needle into a patient, when moved to its retracted position, acts on the activating elements, which in turn activates the actuating elements and injects a dose.
摘要:
The present application describes a binding epitope to Helicobacter pylori, namely substances comprising the oligosaccharide sequence -Gal(Nac)r2$g(b)4Glc(A)q2(Nac)r3-, and the use thereof in pharmaceutical and nutritional compositions for the treatment of conditions due to the presence of Helicobacter pylori in a subject, e.g. gastritis, gastric ulcers, gastric adenocarcinoma, liver disease, pancreatic disease, skin disease, heart disease, autoimmune diseases and sudden infant death syndrome. The invention is also directed to the use of the receptor for diagnostics of Helicobacter pylori, to a method of producing chondroitin oligosaccharides from chondroitin sulphates, and a method for production of amidated glucuronic acid comprising oligosaccharides and monosaccharides from glucuronic acid comprising polysaccharides.