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1.发明申请PACAP SIGNALING PATHWAY MODULATORS FOR TREATING INFLAMMATORY SKIN DISEASES HAVING A NEUROGENIC COMPONENT, NOTABLY ROSACEA, AND COMPOSITIONS COMPRISED THEREOF 审中-公开用于治疗具有神经细胞成分，非特异性ROSACEA及其组合物的炎症性皮肤疾病的PACAP信号途径调节剂公开(公告)号：US20110229423A1
公开(公告)日：2011-09-22
申请号：US13054769
申请日：2009-07-17
IPC分类号： A61K31/713 , G01N33/566 , C12Q1/68 , C07H21/02 , A61P29/00 , A61P17/10 , A61P17/02 , A61P17/00 , A61P31/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P31/10 , A61P23/00 , A61P37/08 , A61P39/06 , A61P37/06 , A61P17/08 , A61P17/12 , A61Q17/04 , A61P3/02
CPC分类号： G01N33/6881 , A61K9/0014 , A61K38/00 , G01N2500/04 , G01N2800/20 , G01N2800/202
摘要： Modulators of specific PACAP receptors are useful for treating inflammatory skin diseases having a neurogenic component, and more particularly rosacea and/or facial erythema, compositions containing these and screening methods are described for identifying PACAP signaling pathway modulators.
摘要翻译： 特异性PACAP受体的调节剂可用于治疗具有神经源成分的炎性皮肤疾病，更具体地，涉及红斑痤疮和/或面部红斑，含有这些和组合物的组合物和筛选方法用于鉴定PACAP信号通路调节剂。
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公开(公告)号：US20140221231A1
公开(公告)日：2014-08-07
申请号：US14129679
申请日：2012-06-25
申请人： Martin Steinhoff
发明人： Martin Steinhoff
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： A method is described that uses ROR gamma t, or ROR alpha to diagnose rosacea and/or to screen inhibitors of Th17 differentiation, notably in inhibiting ROR gamma t or ROR alpha. Also described is a method of using these screened inhibitors in rosacea treatment.
摘要翻译： 描述了一种使用RORγt或RORα来诊断酒渣鼻和/或筛选Th17分化抑制剂的方法，特别是抑制RORγt或RORα。 还描述了在酒渣鼻治疗中使用这些筛选的抑制剂的方法。
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公开(公告)号：US20130017969A1
公开(公告)日：2013-01-17
申请号：US13516834
申请日：2010-12-16
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： Markers for rosacea among the chemokines and cytokines and their receptors, selected from interleukin 8 (IL-8), CXCL1, CXCL2, CXCL3 and CXCL5, the CXCR1 receptor and the CXCR2 receptor are described. Also described, is a method for the diagnosis of rosacea.
摘要翻译： 描述了选自白介素8（IL-8），CXCL1，CXCL2，CXCL3和CXCL5，CXCR1受体和CXCR2受体的趋化因子和细胞因子及其受体中的红斑痤疮的标志物。 还描述了用于诊断酒渣鼻的方法。
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公开(公告)号：US20140349866A1
公开(公告)日：2014-11-27
申请号：US14129809
申请日：2012-06-25
申请人： Martin Steinhoff
发明人： Martin Steinhoff
CPC分类号： G01N33/6869 , C12Q1/6883 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/6863 , G01N33/6893 , G01N2800/202 , G01N2800/52 , G01N2800/60
摘要： Methods are described for using genes crucial in TH17 differentiation, IL-12Rbeta 1/IL-23R, CCR6, BATF, AHR, STAT3 and IRF4 as new markers for rosacea. Also described, are methods of their use to diagnose rosacea, to screen inhibitors of Th17 differentiation. In particular, method are described for inhibiting at least one of these genes and using the screened inhibitors in rosacea treatment.
摘要翻译： 描述了使用在TH17分化，IL-12Rβ1/ IL-23R，CCR6，BATF，AHR，STAT3和IRF4中关键的基因作为红斑痤疮的新标记物的方法。 还描述了它们用于诊断酒渣鼻的方法，以筛选Th17分化的抑制剂。 具体地，描述了抑制这些基因中的至少一种并且在酒渣鼻治疗中使用筛选的抑制剂的方法。
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公开(公告)号：US20140031341A1
公开(公告)日：2014-01-30
申请号：US13997110
申请日：2011-12-19
申请人： Jerome Aubert , Martin Steinhoff
发明人： Jerome Aubert , Martin Steinhoff
IPC分类号： A61K31/55 , A61K31/357 , A61K31/496 , A61K31/506 , A61K31/538 , A61K31/4439 , A61K31/416 , A61K31/4725 , A61K31/4188 , A61K31/165 , A61K31/451
CPC分类号： A61K31/55 , A61K31/165 , A61K31/167 , A61K31/357 , A61K31/416 , A61K31/4188 , A61K31/4439 , A61K31/451 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/513 , A61K31/517 , A61K31/538 , C12Q1/6883 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , G01N33/6872
摘要： An in vitro method of screening candidate compounds for the preventive or curative treatment of rosacea is described. The method can include determining the capacity of a compound to modulate the expression or activity of the Transient Receptor Potential (TRPs), as well as the use of modulators of the expression or activity of this transcription factor for the treatment of rosacea. The method can also include in vitro diagnosis or prognosis of this pathology.
摘要翻译： 描述了筛选用于预防或治疗酒渣鼻的候选化合物的体外方法。 该方法可以包括确定化合物调节瞬时受体电位（TRP）的表达或活性的能力，以及使用该转录因子的表达或活性的调节剂来治疗酒渣鼻。 该方法还可以包括这种病理学的体外诊断或预后。
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公开(公告)号：US10370714B2
公开(公告)日：2019-08-06
申请号：US14129679
申请日：2012-06-25
申请人： Martin Steinhoff
发明人： Martin Steinhoff
IPC分类号： C12Q1/68 , C12Q1/6883
摘要： A method is described that uses ROR gamma t, or ROR alpha to diagnose rosacea and/or to screen inhibitors of Th17 differentiation, notably in inhibiting ROR gamma t or ROR alpha. Also described is a method of using these screened inhibitors in rosacea treatment.
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公开(公告)号：US20140024725A1
公开(公告)日：2014-01-23
申请号：US13997134
申请日：2011-12-19
申请人： Jéróme Aubert , Martin Steinhoff
发明人： Jéróme Aubert , Martin Steinhoff
CPC分类号： A61K45/00 , G01N33/50 , G01N33/6872 , G01N2800/20
摘要： An in vitro method of screening candidate compounds for the preventive or curative treatment of rosacea is described. The method can include determining the capacity of a compound to modulate the expression or activity of the Transient Receptor Potential (TRP) cation channel, subfamily A, member 1(TRPA1), as well as the use of modulators of the expression or activity of this transcription factor for the treatment of rosacea. The method can also include in vitro diagnosis or prognosis of this pathology.
摘要翻译： 描述了筛选用于预防或治疗酒渣鼻的候选化合物的体外方法。 该方法可以包括测定化合物调节瞬时受体电位（TRP）阳离子通道，亚族A，成员1（TRPA1）的表达或活性的能力，以及使用这种表达或活性的调节剂 用于治疗红斑痤疮的转录因子。 该方法还可以包括这种病理学的体外诊断或预后。
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