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    MODULATORS OF ACETYL-COENZYME A ACYLTRANSFERASE 1 OR 2 IN THE TREATMENT OF ACNE, OF SEBORRHOEIC DERMATITIS OR OF HYPERSEBORRHOEA
    2.
    发明申请
    MODULATORS OF ACETYL-COENZYME A ACYLTRANSFERASE 1 OR 2 IN THE TREATMENT OF ACNE, OF SEBORRHOEIC DERMATITIS OR OF HYPERSEBORRHOEA 审中-公开
    乙酰苯胺的调节剂ACYLTRANSFERASE 1或2治疗ACNE，SEBORRHOEIC DERMATITIS或者HYPERSEBORRHOEA

    公开(公告)号：US20110150773A1

    公开(公告)日：2011-06-23

    申请号：US12991060

    申请日：2009-05-07

    申请人： Jérôme Aubert ,  Michel Rivier ,  Johannes Voegel

    发明人： Jérôme Aubert ,  Michel Rivier ,  Johannes Voegel

    IPC分类号： A61K49/00 ,  G01N33/53 ,  C12Q1/68 ,  A61K39/395 ,  C07H21/00 ,  C12N9/10 ,  A61P17/08 ,  A61P17/10

    CPC分类号： G01N33/6893 ,  G01N2333/91057 ,  G01N2500/10 ,  G01N2800/20

    摘要： An in vitro method for screening for candidate compounds for the preventive or curative treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea, includes determining the ability of a compound to modulate the expression or the activity of acetyl-coenzyme A acyltransferase 1 (ACAA1) or of acetyl-coenzyme A acyltransferase 2 (ACAA2), and also utilizes modulators of the expression or of the activity of either of these enzymes, for the treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea; methods for the in vitro diagnosis of or in vitro prognosis for these pathologies are also featured.

    摘要翻译： 用于筛选候选化合物用于预防或治疗痤疮，脂溢性皮炎或与过度脂蛋白相关的皮肤病症的体外方法包括测定化合物调节乙酰辅酶A酰基转移酶1的表达或活性的能力 （ACAA1）或乙酰辅酶A酰基转移酶2（ACAA2），并且还利用这些酶的表达或活性的调节剂用于治疗痤疮，脂溢性皮炎或与过度脂蛋白相关的皮肤病症; 还提出了这些病理学的体外诊断或体外预后的方法。

    GOS2 MODULATORS IN THE TREATMENT OF ACNE, OF SEBORRHOEIC DERMATITIS OR OF HYPERSEBORRHOEA
    4.
    发明申请
    GOS2 MODULATORS IN THE TREATMENT OF ACNE, OF SEBORRHOEIC DERMATITIS OR OF HYPERSEBORRHOEA 审中-公开
    GOS2调节剂治疗ACNE，SEBORRHOEIC DERMATITIS或者HYPERSEBORRHOEA

    公开(公告)号：US20110263677A1

    公开(公告)日：2011-10-27

    申请号：US12990995

    申请日：2009-05-07

    申请人： Jérôme Aubert ,  Isabelle Carlavan ,  Johannes Voegel

    发明人： Jérôme Aubert ,  Isabelle Carlavan ,  Johannes Voegel

    IPC分类号： A61K31/713 ,  C12Q1/68 ,  A61P17/08 ,  C07H21/02 ,  C07H21/04 ,  G01N33/566 ,  C12Q1/02

    CPC分类号： C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158

    摘要： An in vitro or in vivo method for screening for candidate compounds for the preventive or curative treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea, includes determining the ability of a compound to modulate the expression or the activity of G0/G1 switch protein 2 (GOS2), and also utilizes modulators of the expression or of the activity of this protein, for the treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea; methods for the in vitro diagnosis of or in vitro prognosis for these pathologies are also featured.

    摘要翻译： 用于筛选候选化合物用于预防或治疗痤疮，脂溢性皮炎或与过度脂蛋白相关的皮肤病症的体外或体内方法包括测定化合物调节G0 / G1的表达或活性的能力 开关蛋白2（GOS2），并且还利用这种蛋白质的表达或活性的调节剂，用于治疗痤疮，脂溢性皮炎或与超球囊相关的皮肤疾病; 还提出了这些病理学的体外诊断或体外预后的方法。

    Corrective methodology for processing results of transcriptome experiments obtained by differential analysis
    8.
    发明申请
    Corrective methodology for processing results of transcriptome experiments obtained by differential analysis 失效
    通过差异分析获得的转录组实验处理结果的纠正方法

    公开(公告)号：US20100057369A1

    公开(公告)日：2010-03-04

    申请号：US12457730

    申请日：2009-06-19

    申请人： Paul Fogel ,  Didier Zugaj ,  Jean-Marc Le Goff ,  Jérôme Aubert ,  Sophie Deret

    发明人： Paul Fogel ,  Didier Zugaj ,  Jean-Marc Le Goff ,  Jérôme Aubert ,  Sophie Deret

    IPC分类号： G06F19/00

    CPC分类号： G06F19/20 ,  G06F19/24

    摘要： A corrective method for processing results of transcriptome experiments obtained by differential analysis includes the following steps: obtaining the results of the level of expression of genes under a reference condition, and calculating the mean level of expression of each of such genes; obtaining the results of the level of expression of such genes under a treatment condition, and calculating the mean level of expression for each of such genes; calculating the modulation coefficient for the level of expression for each of such genes; calculating a p-value associated with each modulation coefficient; and calculating isobar curves of p-value as a function of the mean level of expression of each of such genes under the reference condition; calculating and associating a median modulation coefficient on the isobar curve of each p-value observed; this method applies in particular to the processing of results of experiments carried out on DNA chips.

    摘要翻译： 通过差异分析获得的转录组实验处理结果的校正方法包括以下步骤：获得参考条件下基因表达水平的结果，并计算各基因的平均表达水平; 在治疗条件下获得这些基因表达水平的结果，并计算每个这样的基因的平均表达水平; 计算每个这样的基因的表达水平的调节系数; 计算与每个调制系数相关联的p值; 并计算p值的等压曲线作为参考条件下每个这样的基因的平均表达水平的函数; 计算和关联每个p值的等压曲线上的中值调制系数; 该方法特别适用于对DNA芯片进行的实验结果的处理。