公开(公告)号：US08620851B2

公开(公告)日：2013-12-31

申请号：US12952314

申请日：2010-11-23

申请人： Jeremy Brown ,  Jason Allen Sabin ,  Nathaniel Brent Kranendonk ,  Kal A. Larsen ,  Lloyd Leon Burch ,  Michael Fairbanks ,  Michael Jorgensen ,  Thomas Larry Biggs

发明人： Jeremy Brown ,  Jason Allen Sabin ,  Nathaniel Brent Kranendonk ,  Kal A. Larsen ,  Lloyd Leon Burch ,  Michael Fairbanks ,  Michael Jorgensen ,  Thomas Larry Biggs

IPC分类号： G06N5/02 ,  G06N7/02

CPC分类号： G06N7/02 ,  G06N5/048 ,  G06Q10/0633

摘要： The system and method for determining fuzzy cause and effect relationships in an intelligent workload management system described herein may combine potential causes and effects captured from various different sources associated with an information technology infrastructure with substantially instantaneous feedback mechanisms and other knowledge sources. As such, fuzzy correlation logic may then be applied to the combined information to determine potential cause and effect relationships and thereby diagnose problems and otherwise manage interactions that occur in the infrastructure. For example, information describing potential causes and potential effects associated with an operational state of the infrastructure may be captured and combined, and any patterns among the information that describes the multiple potential causes and effects may then be identified. As such, fuzzy logic may the be applied to any such patterns to determine possible relationships among the potential causes and the potential effects associated with the infrastructure operational state.

摘要翻译： 用于确定本文描述的智能工作负载管理系统中的模糊因果关系的系统和方法可以将从与信息技术基础设施相关联的各种不同来源捕获的潜在原因和效果与基本上即时的反馈机制和其他知识源组合。 因此，然后可以将模糊相关逻辑应用于组合信息以确定潜在的因果关系，从而诊断问题并以其他方式管理基础设施中发生的交互。 例如，可以捕获和组合描述与基础设施的操作状态相关联的潜在原因和潜在效果的信息，并且然后可以识别描述多个潜在原因和效果的信息中的任何模式。 因此，模糊逻辑可以应用于任何这样的模式，以确定潜在原因与与基础设施操作状态相关联的潜在效应之间的可能关系。

公开(公告)号：US08468455B2

公开(公告)日：2013-06-18

申请号：US12711833

申请日：2010-02-24

申请人： Michael Jorgensen ,  Michael Fairbanks ,  Jason Allen Sabin ,  Nathaniel Brent Kranendonk ,  Kal A. Larsen

发明人： Michael Jorgensen ,  Michael Fairbanks ,  Jason Allen Sabin ,  Nathaniel Brent Kranendonk ,  Kal A. Larsen

IPC分类号： G06F3/14

CPC分类号： G06F9/455 ,  G06F9/452 ,  G06F9/54 ,  G06F2209/549 ,  H04L12/4641 ,  H04L63/08 ,  H04L63/20 ,  H04L67/141 ,  H04L67/34 ,  H04W12/06 ,  H04W12/08

摘要： The system and method described herein may identify one or more virtual desktop extensions available in a cloud computing environment and launch virtual machine instances to host the available virtual desktop extensions in the cloud. For example, a virtual desktop extension manager may receive a virtual desktop extension request from a client desktop and determine whether authentication credentials for the client desktop indicate that the client desktop has access to the requested virtual desktop extension. In response to authenticating the client desktop, the virtual desktop extension manager may then launch a virtual machine instance to host the virtual desktop extension in the cloud and provide the client desktop with information for locally controlling the virtual desktop extension remotely hosted in the cloud.

摘要翻译： 本文描述的系统和方法可以标识云计算环境中可用的一个或多个虚拟桌面扩展，并启动虚拟机实例来托管云中的可用虚拟桌面扩展。 例如，虚拟桌面扩展管理器可以从客户端桌面接收虚拟桌面扩展请求，并确定客户端桌面的验证凭证是否指示客户端桌面可以访问请求的虚拟桌面扩展。 响应于验证客户端桌面，虚拟桌面扩展管理器可以启动虚拟机实例来托管云中的虚拟桌面扩展，并为客户端桌面提供用于本地控制云中远程托管的虚拟桌面扩展的信息。

公开(公告)号：US20060105987A1

公开(公告)日：2006-05-18

申请号：US10518427

申请日：2003-06-16

申请人： Andrew Miller ,  Michael Jorgensen ,  Rolf Berge ,  Jon Skorve

发明人： Andrew Miller ,  Michael Jorgensen ,  Rolf Berge ,  Jon Skorve

IPC分类号： A61K31/739 ,  A61K31/225

CPC分类号： C07C329/06 ,  A61K9/1272 ,  C07C323/52 ,  C07F9/10

摘要： The present invention provides a lipid compound comprising at least one non-polar moiety and a polar moiety, wherein each or at least one non-polar moiety is of the formula X—Y-Z-, wherein X is a hydrocarbyl chain, Y is selected from at least one of S, Se, SO2, SO, and O, and Z is an optional hydrocarbyl group, wherein the polar moiety is of the formula —[C(O)]mPHG, wherein PHG is a polar head group, and wherein m is the number of non-polar moieties.

摘要翻译： 本发明提供了包含至少一个非极性部分和极性部分的脂质化合物，其中每个或至少一个非极性部分具有式XYZ-，其中X是烃基链，Y至少选自 S，Se，SO 2，SO和O之一，Z是任选的烃基，其中极性部分具有式 - [C（O）] m - PHG，其中PHG是极性头基，并且其中m是非极性部分的数目。

公开(公告)号：US20050287202A1

公开(公告)日：2005-12-29

申请号：US11159938

申请日：2005-06-23

申请人： Andrew Miller ,  Michael Keller ,  Michael Jorgensen ,  Eric Perouzel

发明人： Andrew Miller ,  Michael Keller ,  Michael Jorgensen ,  Eric Perouzel

IPC分类号： A61K9/127 ,  A61K47/48 ,  A61K48/00

CPC分类号： A61K47/644

摘要： The present invention provides a process for preparing a modified lipid of the formula comprising reacting (I) a compound of the formula; and (ii) a compound of the formula wherein component (ii) is formulated as a liposome; wherein B is a lipid; wherein A is a moiety of interest (MOI) and is a hydrocarbyl group; wherein X is an optional linker group; wherein R1 is H or a hydrocarbyl group; and wherein R2 is a lone pair, H or a hydrocarbyl group. The moiety of interest A may be selected from a carbohydrate moiety, a polymer, a peptide, a glycoprotein, a small biomolecule (such as a folic acid derivative) and a bioconjugate linker.

摘要翻译： 本发明提供制备下式的改性脂质的方法，包括使（I）式（I）化合物与 和（ii）下式的化合物其中组分（ii）被配制为脂质体; 其中B是脂质; 其中A是感兴趣部分（MOI）并且是烃基; 其中X是任选的连接基团; 其中R 1是H或烃基; 并且其中R 2是孤对的，H或烃基。 感兴趣的部分A可以选自碳水化合物部分，聚合物，肽，糖蛋白，小生物分子（如叶酸衍生物）和生物缀合物接头。

公开(公告)号：US20120130936A1

公开(公告)日：2012-05-24

申请号：US12952314

申请日：2010-11-23

申请人： Jeremy Brown ,  Jason Allen Sabin ,  Nathaniel Brent Kranendonk ,  Kal A. Larsen ,  Lloyd Leon Burch ,  Michael Fairbanks ,  Michael Jorgensen ,  Thomas Larry Biggs

发明人： Jeremy Brown ,  Jason Allen Sabin ,  Nathaniel Brent Kranendonk ,  Kal A. Larsen ,  Lloyd Leon Burch ,  Michael Fairbanks ,  Michael Jorgensen ,  Thomas Larry Biggs

IPC分类号： G06N5/02 ,  G06N7/02

CPC分类号： G06N7/02 ,  G06N5/048 ,  G06Q10/0633

摘要： The system and method for determining fuzzy cause and effect relationships in an intelligent workload management system described herein may combine potential causes and effects captured from various different sources associated with an information technology infrastructure with substantially instantaneous feedback mechanisms and other knowledge sources. As such, fuzzy correlation logic may then be applied to the combined information to determine potential cause and effect relationships and thereby diagnose problems and otherwise manage interactions that occur in the infrastructure. For example, information describing potential causes and potential effects associated with an operational state of the infrastructure may be captured and combined, and any patterns among the information that describes the multiple potential causes and effects may then be identified. As such, fuzzy logic may the be applied to any such patterns to determine possible relationships among the potential causes and the potential effects associated with the infrastructure operational state.

摘要翻译： 用于确定本文描述的智能工作负载管理系统中的模糊因果关系的系统和方法可以将从与信息技术基础设施相关联的各种不同来源捕获的潜在原因和效果与基本上即时的反馈机制和其他知识源组合。 因此，然后可以将模糊相关逻辑应用于组合信息以确定潜在的因果关系，从而诊断问题并以其他方式管理基础设施中发生的交互。 例如，可以捕获和组合描述与基础设施的操作状态相关联的潜在原因和潜在效果的信息，并且然后可以识别描述多个潜在原因和效果的信息中的任何模式。 因此，模糊逻辑可以应用于任何这样的模式，以确定潜在原因与与基础设施操作状态相关联的潜在效应之间的可能关系。

公开(公告)号：US20110126197A1

公开(公告)日：2011-05-26

申请号：US12645114

申请日：2009-12-22

申请人： Kal A. Larsen ,  Stephen R. Carter ,  Michael Jorgensen ,  Nathaniel Brent Kranendonk

发明人： Kal A. Larsen ,  Stephen R. Carter ,  Michael Jorgensen ,  Nathaniel Brent Kranendonk

IPC分类号： G06F9/455 ,  G06F15/173 ,  G06F9/445

CPC分类号： H04L63/08 ,  G06F9/455 ,  G06F9/45533 ,  G06F21/31 ,  G06Q10/06 ,  G06Q10/06313 ,  G06Q10/10 ,  H04L9/3213 ,  H04L63/0807 ,  H04L63/0815 ,  H04L63/14

摘要： The system and method for controlling cloud and virtualized data centers described herein may include a computing environment having a model-driven, service-oriented architecture for creating collaborative threads to manage workloads, and further to creating cloud images having embedded management agents and identity services for validating the cloud images prior to deployment into the cloud and virtualized data centers and controlling, monitoring, and auditing activity associated with the cloud images following deployment into the cloud and virtualized data centers.

摘要翻译： 本文描述的用于控制云和虚拟化数据中心的系统和方法可以包括具有模型驱动的面向服务的架构以用于创建协调线程以管理工作负载的计算环境，并且还可以创建具有嵌入式管理代理和身份服务的云图像 在部署到云端和虚拟化数据中心之前，将云映像进行验证，并将其与云映像相关联的控制，监视和审核活动进行云计算和虚拟化数据中心的部署。

公开(公告)号：US20100297023A1

公开(公告)日：2010-11-25

申请号：US12520261

申请日：2007-12-21

申请人： Andrew David Miller ,  Patrick Arbuthnot ,  Michael Jorgensen ,  Michael Keller ,  Nazila Kamaly ,  Abderrahim Aissaoui ,  Maya Thanou

发明人： Andrew David Miller ,  Patrick Arbuthnot ,  Michael Jorgensen ,  Michael Keller ,  Nazila Kamaly ,  Abderrahim Aissaoui ,  Maya Thanou

IPC分类号： A61K47/18 ,  C07C237/22 ,  A61K31/713 ,  A61K48/00 ,  A61K49/10 ,  C12N5/02

CPC分类号： C07C237/22 ,  A01K2267/0337 ,  A61K9/1272 ,  A61K47/34 ,  A61K47/543 ,  A61K47/6907 ,  A61K47/6911 ,  A61K48/0025 ,  C12N15/111 ,  C12N15/88 ,  C12N2310/14 ,  C12N2320/32 ,  C12N2730/10111 ,  Y10T428/2984

摘要： The present invention provides a lipid of the formula (I) R3R4N—[Y]q—(CpH2p)—X-Linker-NR1R2 (I) wherein R3 and R4 are independently selected from H and hydrocarbyl groups; q is an integer selected from 1 to 10; Y represents a group (CnH2n)NR5, wherein (i) when q is 1, n is 2, or (ii) when q is greater than 1, each Y may be the same or different and each n is an integer independently selected from 1 to 10, with the proviso that for at least one unit Y, n is 2, and (iii) each R5 is independently selected from H and hydrocarbyl groups; p is an integer selected from 1 to 10; X is an optional group selected from —NR7—, —C(═O)—NR8—, —NR9—C(═O)—, —C(═O)—, —O—, and NR10—C(=0)0-, wherein each R7, R8, R9 and R10 is independently selected from H and hydrocarbyl groups, Linker is an optional group selected from amino acid residues, peptide residues and groups of the formula —(OCH2CH2)1-10, —NR6-(CvH2v)—C(═O)—, wherein R6 is H or a hydrocarbyl group and v is an integer selected from 1 to 11, and —C(=0)-(CH2)0-10—CH2—C(=0)-; R1 is selected from acyclic groups having from 4 to 30 carbon atoms; and R2 is selected from H and acyclic groups having from 4 to 30 carbon atoms. Said lipids can be used in a delivery vehicle (e.g. micelle or liposome) for the delivery of one or more (therapeutic or diagnostic) agents.

摘要翻译： 本发明提供式（I）R3R4N- [Y] q-（CpH2p）-X-连接子-NR1R2（I）的脂质，其中R3和R4独立地选自H和烃基; q是选自1至10的整数; Y表示基团（C n H 2n）NR 5，其中（i）当q为1时，n为2，或（ii）当q大于1时，每个Y可以相同或不同，并且每个n是独立地选自 1至10，条件是对于至少一个单元Y，n为2，和（iii）每个R 5独立地选自H和烃基; p是选自1至10的整数; X是选自-NR 7 - ， - C（= O）-NR 8 - ， - NR 9 -C（= O） - ， - C（= O） - ， - O-和NR 10 -C（= O ）0-，其中每个R 7，R 8，R 9和R 10独立地选自H和烃基，连接子是选自氨基酸残基，肽残基和式 - （OCH 2 CH 2）1-10，-NR 6 - （CvH2v）-C（= O） - ，其中R6是H或烃基，v是选自1至11的整数，和-C（= O） - （CH 2）0-10-CH 2 -C = 0） - ; R1选自具有4至30个碳原子的无环基团; 并且R 2选自H和具有4至30个碳原子的无环基。 所述脂质可用于递送载体（例如胶束或脂质体）中以递送一种或多种（治疗或诊断）试剂。

公开(公告)号：US20100056048A1

公开(公告)日：2010-03-04

申请号：US12202930

申请日：2008-09-02

申请人： Michael Jorgensen ,  Curt Andersson

发明人： Michael Jorgensen ,  Curt Andersson

IPC分类号： H04B7/00 ,  H02J7/00

CPC分类号： H04B1/034 ,  H04B1/3883

摘要： Ultra low frequency transmissions can be used to penetrate obstructions to areas where other operation of other communication devices may be limited, such as in a mine, tunnel, or other underground location. A portable device that includes a supercapacitor, a transmitter, and an antenna can be used to communicate using ultra low frequency transmissions. In one aspect, a communication device comprises a supercapacitor; a transmitter powered by the supercapacitor; and an antenna connected to the transmitter for sending messages. In another aspect, a method for communicating comprises the steps of receiving a message to be transmitted, powering a transmitter from a charged supercapacitor, and transmitting the message via an antenna.

摘要翻译： 可以使用超低频传输来穿透其他通信设备的其它操作可能受到限制的区域的障碍物，例如在矿井，隧道或其他地下位置。 可以使用包括超级电容器，发射器和天线的便携式设备来使用超低频传输。 一方面，通信装置包括超级电容器; 由超级电容器供电的发射器; 和连接到发射机的天线用于发送消息。 在另一方面，一种用于通信的方法包括以下步骤：接收要发送的消息，从充电的超级电容器向发射机供电，以及经由天线发送所述消息。

公开(公告)号：US20110209064A1

公开(公告)日：2011-08-25

申请号：US12711833

申请日：2010-02-24

申请人： Michael Jorgensen ,  Michael Fairbanks ,  Jason Allen Sabin ,  Nathaniel Brent Kranendonk ,  Kal A. Larsen

发明人： Michael Jorgensen ,  Michael Fairbanks ,  Jason Allen Sabin ,  Nathaniel Brent Kranendonk ,  Kal A. Larsen

IPC分类号： G06F9/455 ,  H04L9/32 ,  G06F21/00 ,  G06F15/16 ,  G06F3/01

CPC分类号： G06F9/455 ,  G06F9/452 ,  G06F9/54 ,  G06F2209/549 ,  H04L12/4641 ,  H04L63/08 ,  H04L63/20 ,  H04L67/141 ,  H04L67/34 ,  H04W12/06 ,  H04W12/08

摘要： The system and method described herein may identify one or more virtual desktop extensions available in a cloud computing environment and launch virtual machine instances to host the available virtual desktop extensions in the cloud. For example, a virtual desktop extension manager may receive a virtual desktop extension request from a client desktop and determine whether authentication credentials for the client desktop indicate that the client desktop has access to the requested virtual desktop extension. In response to authenticating the client desktop, the virtual desktop extension manager may then launch a virtual machine instance to host the virtual desktop extension in the cloud and provide the client desktop with information for locally controlling the virtual desktop extension remotely hosted in the cloud.

摘要翻译： 本文描述的系统和方法可以标识云计算环境中可用的一个或多个虚拟桌面扩展，并启动虚拟机实例来托管云中的可用虚拟桌面扩展。 例如，虚拟桌面扩展管理器可以从客户端桌面接收虚拟桌面扩展请求，并确定客户端桌面的验证凭证是否指示客户端桌面可以访问请求的虚拟桌面扩展。 响应于验证客户端桌面，虚拟桌面扩展管理器可以启动虚拟机实例来托管云中的虚拟桌面扩展，并为客户端桌面提供用于本地控制云中远程托管的虚拟桌面扩展的信息。

公开(公告)号：US20110208372A1

公开(公告)日：2011-08-25

申请号：US13121968

申请日：2009-09-30

申请人： Erik Hansen ,  Dennis Roy Andersen ,  Anders Hyldgard ,  Anders Michael Jorgensen

发明人： Erik Hansen ,  Dennis Roy Andersen ,  Anders Hyldgard ,  Anders Michael Jorgensen

IPC分类号： G06F1/28

CPC分类号： G05F1/67 ,  H02J1/102 ,  H02S50/10

摘要： The present invention relates to a power generation system PGS comprising—a system intermediate output SIO, —a central controller CC, and—at least two DC/DC converters DD1, DD2, DDn each comprising—a power input PI1, PI2, PIn for connecting to an output of one or more solar cells SC1, SC2, SCn, —a control input CI1, CI2, CIn, and—a power output PO1, PO2, POn, wherein said power outputs PO1, PO2, POn of said at least two DC/DC converters DD1, DD2, DDn are coupled in series to establish an accumulated system output voltage or in parallel to establish an accumulated system output current, or a combination thereof, at said system intermediate output ISO, and wherein said central controller CC is arranged to be able to selectively set, via said control inputs CI1, CI2, CIn, an output state of each of at least two of said DC/DC converters DD1, DD2, DDn. The present invention further relates to a method of operating a power generation system PGS comprising a plurality of DC/DC converters DD1, DD2, DDn each connected to at least one solar cell SC1, SC2, SCn and having their power outputs PO1, PO2, POn coupled in series or in parallel to provide an accumulated system output voltage or an accumulated system output current, respectively, at a system intermediate output SIO, characterised in that a central controller CC selectively sets an output state of each of at least two of said DC/DC converters DD1, DD2, DDn.

摘要翻译： 发电系统PGS技术领域本发明涉及一种发电系统PGS，其包括：系统中间输出SIO，中央控制器CC，以及至少两个DC / DC转换器DD1，DD2，DDn，每个DC / DC转换器DD1，DD2，DDn包括：功率输入PI1，PI2，PIn， 连接到一个或多个太阳能电池单元SC1，SC2，SCn的输出， - 控制输入C11，CI2，CIn，以及 - 功率输出PO1，PO2，POn，其中所述功率输出至少所述功率输出PO1，PO2，POn 两个DC / DC转换器DD1，DD2，DDn串联耦合以建立累积的系统输出电压或并联以在所述系统中间输出ISO处建立累积的系统输出电流或其组合，并且其中所述中央控制器CC 被配置为能够经由所述控制输入C11，CI2，CIn选择性地设置所述DC / DC转换器DD1，DD2，DDn中的至少两个的输出状态。 本发明还涉及一种操作包括多个DC / DC转换器DD1，DD2，DDn的发电系统PGS的方法，每个DC / DC转换器DD1，DD2，DDn分别与至少一个太阳能电池SC1，SC2，SCn连接并具有其功率输出PO1，PO2， POn分别串联或并联耦合以在系统中间输出SIO分别提供累积的系统输出电压或累积的系统输出电流，其特征在于，中央控制器CC选择性地设置所述至少两个的输出状态 DC / DC转换器DD1，DD2，DDn。