公开(公告)号：US20230405154A1

公开(公告)日：2023-12-21

申请号：US18253586

申请日：2021-11-19

Applicant: NH THERAGUIX ,  UNIVERSITE CLAUDE BERNARD LYON 1 ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -

Inventor： Olivier TILLEMENT ,  François LUX ,  Fabien ROSSETTI ,  Paul ROCCHI ,  Tristan DOUSSINEAU

IPC: A61K49/18 ,  A61K51/12

CPC classification number: A61K49/1881 ,  A61K51/1244 ,  B82Y5/00

Abstract: The present disclosure relates to nanoparticles and the uses thereof in medicine, in particular for the treatment of tumours.

公开(公告)号：US20220249711A1

公开(公告)日：2022-08-11

申请号：US17597903

申请日：2020-07-28

Applicant: CENTRE HOSPITALIER UNIVERSITAIRE DE GRENOBLE ,  UNIVERSITE GRENOBLE ALPES ,  NH THERAGUIX

Inventor： Olivier TILLEMENT ,  François LUX ,  Sandrine DUFORT ,  Camille VERRY ,  Géraldine LEDUC

IPC: A61K51/06 ,  A61K9/00 ,  A61K51/12 ,  A61K49/12 ,  A61K49/18 ,  A61P35/00

Abstract: The disclosure relates to methods for treating tumors. In particular, the disclosure relates to a method of treating a tumor by ionizing radiations in a subject in need thereof, said method comprising the steps of: (i) injecting a first therapeutically effective amount of high-Z element containing nanoparticles as radiosensitizing agents in said subject in need thereof within a period between 2 and 7 days prior to the first irradiation of the tumor, (ii) injecting a second therapeutically effective amount of the same or different high-Z element containing nanoparticles within a period between 1 hour to 12 hours prior to the first irradiation of the tumor, and, (iii) irradiating the tumor of said subject with a therapeutically efficient dose of radiations; wherein said high-Z element containing nanoparticles are nanoparticles containing an element with an atomic Z number higher than 40 and said nanoparticles have a mean hydrodynamic diameter below 10 nm.

公开(公告)号：US11857604B2

公开(公告)日：2024-01-02

申请号：US16755866

申请日：2018-10-12

Applicant: NH THERAGUIX ,  Universite Claude Bernard Lyon 1 ,  Centre National de La Recherche Scientifique—CNRS—

Inventor： Olivier Tillement ,  François Lux ,  Fabien Rossetti ,  Vu-Long Tran ,  Clélia Mathieu ,  Myleva Dahan

IPC: A61K38/31 ,  A61K47/69 ,  A61P35/00 ,  A61K33/243 ,  A61K9/14 ,  A61K31/704 ,  A61K49/00 ,  A61K49/12 ,  A61K49/18 ,  B82Y5/00 ,  A61K33/244 ,  A61K9/00

CPC classification number: A61K38/31 ,  A61K9/146 ,  A61K31/704 ,  A61K33/243 ,  A61K33/244 ,  A61K47/6929 ,  A61K49/0002 ,  A61K49/128 ,  A61K49/1881 ,  A61P35/00 ,  B82Y5/00 ,  A61K9/0019

Abstract: The present invention relates to the field of nanovectors for the delivery of active substances in the body, in particular for the treatment of tumours. In particular, the use of these nanovectors makes it possible to improve the pharmacokinetics of the active substances with a more selective delivery, for example in the tumour tissues.

公开(公告)号：US20230390394A1

公开(公告)日：2023-12-07

申请号：US18100953

申请日：2023-01-24

Applicant: The Brigham and Women's Hospital, Inc. ,  UNIVERSITÉ CLAUDE BERNARD LYON 1 ,  NH THERAGUIX ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

Inventor： Ross Berbeco ,  Eloise Thomas ,  Francois Lux ,  Olivier Tillement ,  Alexandre Detappe ,  Geraldine Le Duc

IPC: A61K41/00 ,  A61P35/00 ,  A61K9/00 ,  A61K9/51 ,  A61K49/04 ,  A61K49/10 ,  A61K49/18 ,  A61N5/10

CPC classification number: A61K41/0038 ,  A61P35/00 ,  A61K9/0019 ,  A61K9/0043 ,  A61K9/5115 ,  A61K9/5146 ,  A61K49/049 ,  A61K49/108 ,  A61K49/1824 ,  A61N5/10 ,  A61N2005/1098

Abstract: Provided herein are nanoparticle compositions (e.g., nanoparticle compositions comprising high atomic number ions) that are useful for imaging diseases in a subject as well as radiosensitizing a disease in a subject (e.g., radiosensitizing a cancer in the subject). Methods of imaging a subject, methods of treating cancer, and processes of preparing the nanoparticle compositions are also provided.

公开(公告)号：US20230218781A1

公开(公告)日：2023-07-13

申请号：US17753893

申请日：2020-09-18

Applicant: NH THERAGUIX ,  INSTITUT GUSTAVE ROUSSY ,  INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  UNIVERSITE PARIS-SACLAY

Inventor： Awatef ALLOUCH ,  Eric DEUTSCH ,  Jean-Luc PERFETTINI ,  François LUX ,  Olivier TILLEMENT

IPC: A61K49/18 ,  A61K45/06

CPC classification number: A61K49/1881 ,  A61K45/06

Abstract: The present disclosure relates to the field of nanomedicine, in particular for treating cancers. The present disclosure more specifically provides new methods of treating undesirable M2-polarized macrophages and/or inducing M1 macrophage polarization in a subject in need thereof, comprising administering to said subject a therapeutically effective amount of nanoparticles containing metallic elements.

公开(公告)号：US20220288206A1

公开(公告)日：2022-09-15

申请号：US17635116

申请日：2020-08-13

Applicant: NATIONAL RESEARCH NUCLEAR UNIVERSITY MEPHI ,  NH THERAGUIX

Inventor： Victor TIMOSHENKO ,  Alexander KHARIN ,  Volodymyn LYSENKO ,  Simon CHAMPAGNE ,  François LUX ,  Paul ROCCHI ,  Olivier TILLEMENT

IPC: A61K41/00 ,  A61K47/69 ,  A61K33/24 ,  A61K47/54 ,  A61P35/00

Abstract: The present disclosure relates to a method for treating tumours. In particular, the invention relates to a new therapeutic use of nanoparticles as a sensitiser agent to radiofrequency radiation. More particularly, the invention relates to the use of nanoparticles in combination with radiofrequency radiations for the treatment of tumours, the radiofrequencies inducing hyperthermia of said tumour comprising the nanoparticles in the patient.

公开(公告)号：US20230346971A1

公开(公告)日：2023-11-02

申请号：US18253694

申请日：2021-11-19

Applicant: NH THERAGUIX ,  UNIVERSITE CLAUDE BERNARD LYON 1 ,  MEXBRAIN ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS - ,  INSERM (Institut National de la Santé et de la Recherche Médicale) ,  HOSPICES CIVILS DE LYON ,  INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT

Inventor： Olivier TILLEMENT ,  François LUX ,  Delphine VERNOS ,  Claire RODRIGUEZ-LAFRASSE ,  Thomas BRICHART ,  Marco NATUZZI ,  Alain GELOEN ,  Simon CHAMPAGNE ,  Matteo MARTINI ,  Paul ROCCHI

IPC: A61K47/69 ,  A61K9/08 ,  A61P35/00 ,  A61N5/10

CPC classification number: A61K47/6935 ,  A61K9/08 ,  A61P35/00 ,  A61N5/10 ,  A61N2005/1098

Abstract: The present disclosure relates to nanoparticles and the uses thereof in medicine, in particular for the treatment of tumours.

公开(公告)号：US20230330229A1

公开(公告)日：2023-10-19

申请号：US17998708

申请日：2021-05-11

Applicant: UNIVERSITE CLAUDE BERNARD LYON 1 ,  NH THERAGUIX ,  CENTRE GEORGES FRANCOIS LECLERC ,  The Brigham and Women's Hospital, Inc.

Inventor： François LUX ,  Olivier TILLEMENT ,  Géraldine LE DUC ,  Aurélien MEYZAUD ,  Magali ROUFFIAC ,  Céline MIRJOLET ,  Daniel CAGNEY ,  Ross BERBECO ,  Needa Virani

IPC: A61K41/00 ,  A61K49/18 ,  A61P35/04 ,  A61N5/10

CPC classification number: A61K41/0038 ,  A61K49/1881 ,  A61P35/04 ,  A61N5/1049 ,  A61N5/1067 ,  A61N2005/1055 ,  A61N2005/1098

Abstract: The disclosure relates to methods for treating tumors. In particular, the disclosure relates to a method of treating a tumor by magnetic resonance image-guided radiation therapy in a subject in need thereof, said method comprising the steps of:



(i) administering an efficient amount of high-Z element containing nanoparticles having, contrast enhancement for magnetic resonance imaging and/or radiosensitizing properties for radiation therapy, in a subject in need thereof, and,
(ii) exposing said subject to magnetic resonance image-guided radiation therapy by means of a Magnetic Resonance Imaging Guided Linear Accelerator (MR-Linac),

wherein said high-Z element containing nanoparticles are nanoparticles containing an element with an atomic Z number higher than 40, preferably higher than 50, and said nanoparticles have a mean hydrodynamic diameter below 20 nm, for example between 1 and 10 nm, preferably between 2 and 8 nm.

公开(公告)号：US11512003B2

公开(公告)日：2022-11-29

申请号：US16620413

申请日：2018-06-08

Applicant: NH THERAGUIX ,  Universite Claude Bernard Lyon 1 ,  Centre National de La Recherche Scientifique—CNRS

Inventor： François Lux ,  Olivier Tillement ,  Fabien Rossetti ,  Vivek Thakare ,  Vu Long Tran

IPC: C01B33/18 ,  A61K49/08 ,  A61N5/10 ,  A61K49/18 ,  A61K49/10 ,  B82Y30/00 ,  B82Y40/00

Abstract: The invention relates to a method for synthesizing ultrasmall silica nanoparticles, useful in particular for diagnostics and/or therapy. More specifically, a method for synthesizing silica nanoparticles, said method comprising the mixing of at least one silane which is negatively charged at physiological pH with at least one silane which is neutral at physiological pH, and/or at least one silane which is positively charged at physiological pH, wherein: —the molar ratio A of neutral silane(s) to negatively charged silane(s) is defined as follows: 0≤A≤6, —the molar ratio B of positively charged silane(s) to negatively charged silane(s) is defined as follows: 0≤B≤5, —the molar ratio C of neutral and positively charged silanes to negatively charged silane(s) is defined as follows: 0

公开(公告)号：US20210078867A1

公开(公告)日：2021-03-18

申请号：US16620413

申请日：2018-06-08

Applicant: NH THERAGUIX ,  Universite Claude Bernard Lyon 1 ,  Centre National de La Recherche Scientifique - CNRS -

Inventor： François LUX ,  Olivier TILLEMENT ,  Fabien ROSSETI ,  Vivek THAKARE ,  Vu Long TRAN

IPC: C01B33/18 ,  A61N5/10 ,  A61K49/08

Abstract: The invention relates to a method for synthesizing ultrasmall silica nanoparticles, useful in particular for diagnostics and/or therapy. More specifically, a method for synthesizing silica nanoparticles, said method comprising the mixing of at least one silane which is negatively charged at physiological pH with at least one silane which is neutral at physiological pH, and/or at least one silane which is positively charged at physiological pH, wherein: —the molar ratio A of neutral silane(s) to negatively charged silane(s) is defined as follows: 0≤A≤6, —the molar ratio B of positively charged silane(s) to negatively charged silane(s) is defined as follows: 0≤B≤5, —the molar ratio C of neutral and positively charged silanes to negatively charged silane(s) is defined as follows: 0