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    System and method for preparative mass spectrometry
    1.
    发明申请
    System and method for preparative mass spectrometry 有权
    制备质谱的系统和方法

    公开(公告)号：US20060071665A1

    公开(公告)日：2006-04-06

    申请号：US11228826

    申请日：2005-09-16

    Applicant: Thomas Blake ,  Zheng Ouyang ,  Robert Cooks

    Inventor： Thomas Blake ,  Zheng Ouyang ,  Robert Cooks

    IPC: G01N27/62

    CPC classification number: H01J49/02 ,  B82Y30/00 ,  H01J49/04 ,  Y10T436/25 ,  Y10T436/25375 ,  Y10T436/25875

    Abstract: A preparative mass spectrometer system includes an ionizer which converts the mixture into gas phase ions of the molecules in the mixture, and a separator which separates the ions according to their mass to charge ratio or mobility. The separator is a linear ion trap mass analyzer that accumulates the ions based on their mass to charge ratio. A surface is in cooperative relationship with the separator so that the separated molecules are soft landed onto the surface at different locations such that the collected molecules can be stored or further processed/analyzed.

    Abstract translation: 制备型质谱仪系统包括将混合物转化为混合物中分子的气相离子的离子发生器，以及根据其质荷比或迁移率分离离子的分离器。 分离器是一种线性离子阱质量分析仪，其基于其质荷比积聚离子。 表面与分离器具有协同关系，使得分离的分子在不同位置软着陆到表面上，使得收集的分子可以被储存或进一步加工/分析。

    Method and system for desorption electrospray ionization
    4.
    发明申请
    Method and system for desorption electrospray ionization 有权
    解吸电喷雾离子化的方法和系统

    公开(公告)号：US20050230635A1

    公开(公告)日：2005-10-20

    申请号：US11090455

    申请日：2005-03-25

    Applicant: Zoltan Takats ,  Bogdan Gologan ,  Justin Wiseman ,  Robert Cooks

    Inventor： Zoltan Takats ,  Bogdan Gologan ,  Justin Wiseman ,  Robert Cooks

    IPC: H01J27/00 ,  H01J49/04

    CPC classification number: H01J49/142 ,  H01J49/0004 ,  H01J49/0404

    Abstract: A new method and system for desorption ionization is described and applied to the ionization of various compounds, including peptides and proteins present on metal, polymer, and mineral surfaces. Desorption electrospray ionization (DESI) is carried out by directing charged droplets and/or ions of a liquid onto the surface to be analyzed. The impact of the charged particles on the surface produces gaseous ions of material originally present on the surface. The resulting mass spectra are similar to normal ESI mass spectra in that they show mainly singly or multiply charged molecular ions of the analytes. The DESI phenomenon was observed both in the case of conductive and insulator surfaces and for compounds ranging from nonpolar small molecules such as lycopene, the alkaloid coniceine, and small drugs, through polar compounds such as peptides and proteins. Changes in the solution that is sprayed can be used to selectively ionize particular compounds, including those in biological matrices. In vivo analysis is demonstrated.

    Abstract translation: 一种解吸电离的新方法和系统被描述和应用于各种化合物的电离，包括存在于金属，聚合物和矿物表面上的肽和蛋白质。 通过将液体的带电液滴和/或离子引导到要分析的表面上来进行解吸电喷雾离子化（DESI）。 带电粒子对表面的影响产生了最初存在于表面上的材料的气态离子。 所得质谱与正常的ESI质谱相似，因为它们主要表现出分析物的单一或多重带电分子离子。 在导电性和绝缘体表面以及通过极性化合物如肽和蛋白质从非极性小分子（如番茄红素，生物碱美西汀和小药物）的化合物观察到DESI现象。 喷雾溶液中的变化可用于选择性地电离特定化合物，包括生物基质中的化合物。 证明体内分析。

    Method and system for desorption atmospheric pressure chemical ionization
    8.
    发明申请
    Method and system for desorption atmospheric pressure chemical ionization 有权
    解吸大气压化学电离方法与系统

    公开(公告)号：US20070187589A1

    公开(公告)日：2007-08-16

    申请号：US11653569

    申请日：2007-01-16

    Applicant: Robert Cooks ,  Bogdan Gologan ,  Zoltan Takats ,  Justin Wiseman ,  Ismael Cotte-Rodriguez

    Inventor： Robert Cooks ,  Bogdan Gologan ,  Zoltan Takats ,  Justin Wiseman ,  Ismael Cotte-Rodriguez

    IPC: H01J49/00

    CPC classification number: H01J49/14

    Abstract: A desorption atmospheric pressure chemical ionization (DAPCI) system delivers a primary ion beam composed of an inert, high velocity gas and solvent ions to a surface to effect desorption and ionization of both volatile and non-volatile species present on surfaces. A electrode having a tapered tip is connected to a high voltage power supply. The tapered tip projects outward from a capillary carrying a high-speed flow of gas. A vapor of a solvent is mixed into the annular gas flow surrounding the needle. The gaseous solvent vapor is ionized in close proximity to the tapered tip by virtue of the high voltage applied to the electrode. The high-speed flow of gas and solvent vapor ions extending outward from the capillary is directed toward a substrate on which an analyte of interest may have been deposited. The solvent vapor ions can blanket the surface of the analyte causing a static charge build up that facilitates ion desorption and additionally can provide positive ion adducts of the analyte freed from the substrate surface that can be directed toward an atmospheric intake of a mass spectrometer or other instrument capable of studying the analyte.

    Abstract translation: 解吸大气压化学电离（DAPCI）系统将由惰性高速气体和溶剂离子组成的初级离子束传送到表面，以实现表面上存在的挥发性和非挥发性物质的解吸和离子化。 具有锥形尖端的电极连接到高压电源。 锥形尖端从携带高速气体流的毛细管向外突出。 将溶剂的蒸气混合到围绕针的环形气流中。 通过施加到电极的高电压，气态溶剂蒸气被离子化，紧邻锥形尖端。 从毛细管向外延伸的气体和溶剂蒸汽离子的高速流动被引导到其上可能沉积感兴趣的分析物的基底。 溶剂蒸汽离子可以覆盖分析物的表面，导致静电荷积聚，促进离子解吸，并且另外可以提供从衬底表面释放的分析物的阳离子加合物，其可以被引导到大气摄入的质谱仪或其它 能够研究分析物的仪器。

    Parallel sample handling for high-throughput mass spectrometric analysis
    9.
    发明申请
    Parallel sample handling for high-throughput mass spectrometric analysis 审中-公开
    用于高通量质谱分析的并行样品处理

    公开(公告)号：US20070023631A1

    公开(公告)日：2007-02-01

    申请号：US11092104

    申请日：2005-03-29

    Applicant: Zoltan Takats ,  Robert Cooks

    Inventor： Zoltan Takats ,  Robert Cooks

    IPC: H01J49/00

    CPC classification number: H01J49/0018 ,  H01J49/165

    Abstract: A system to handle a set of samples for mass spectrometric analysis includes a set of elements that couples to a sample plate containing the set of samples. Each element is integrated with a respective mass analyzer, and includes an ionizer to ionize the respective sample. The set of samples are collected and then ionized simultaneously, and the ionized samples are transferred simultaneously to the respective mass analyzers.

    Abstract translation: 用于处理用于质谱分析的一组样品的系统包括耦合到包含该组样品的样品板的一组元件。 每个元件与相应的质量分析器集成，并且包括离子化器以电离相应的样品。 收集样品集合，然后同时电离，并将离子化样品同时转移到相应的质量分析器。

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