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14 条记录 (耗时 0.024 秒)

    Method and system for desorption atmospheric pressure chemical ionization
    1.
    发明申请
    Method and system for desorption atmospheric pressure chemical ionization 有权
    解吸大气压化学电离方法与系统

    公开(公告)号：US20070187589A1

    公开(公告)日：2007-08-16

    申请号：US11653569

    申请日：2007-01-16

    申请人： Robert Cooks ,  Bogdan Gologan ,  Zoltan Takats ,  Justin Wiseman ,  Ismael Cotte-Rodriguez

    发明人： Robert Cooks ,  Bogdan Gologan ,  Zoltan Takats ,  Justin Wiseman ,  Ismael Cotte-Rodriguez

    IPC分类号： H01J49/00

    CPC分类号： H01J49/14

    摘要： A desorption atmospheric pressure chemical ionization (DAPCI) system delivers a primary ion beam composed of an inert, high velocity gas and solvent ions to a surface to effect desorption and ionization of both volatile and non-volatile species present on surfaces. A electrode having a tapered tip is connected to a high voltage power supply. The tapered tip projects outward from a capillary carrying a high-speed flow of gas. A vapor of a solvent is mixed into the annular gas flow surrounding the needle. The gaseous solvent vapor is ionized in close proximity to the tapered tip by virtue of the high voltage applied to the electrode. The high-speed flow of gas and solvent vapor ions extending outward from the capillary is directed toward a substrate on which an analyte of interest may have been deposited. The solvent vapor ions can blanket the surface of the analyte causing a static charge build up that facilitates ion desorption and additionally can provide positive ion adducts of the analyte freed from the substrate surface that can be directed toward an atmospheric intake of a mass spectrometer or other instrument capable of studying the analyte.

    摘要翻译： 解吸大气压化学电离（DAPCI）系统将由惰性高速气体和溶剂离子组成的初级离子束传送到表面，以实现表面上存在的挥发性和非挥发性物质的解吸和离子化。 具有锥形尖端的电极连接到高压电源。 锥形尖端从携带高速气体流的毛细管向外突出。 将溶剂的蒸气混合到围绕针的环形气流中。 通过施加到电极的高电压，气态溶剂蒸气被离子化，紧邻锥形尖端。 从毛细管向外延伸的气体和溶剂蒸汽离子的高速流动被引导到其上可能沉积感兴趣的分析物的基底。 溶剂蒸汽离子可以覆盖分析物的表面，导致静电荷积聚，促进离子解吸，并且另外可以提供从衬底表面释放的分析物的阳离子加合物，其可以被引导到大气摄入的质谱仪或其它 能够研究分析物的仪器。

    Method and system for desorption electrospray ionization
    2.
    发明申请
    Method and system for desorption electrospray ionization 有权
    解吸电喷雾离子化的方法和系统

    公开(公告)号：US20050230635A1

    公开(公告)日：2005-10-20

    申请号：US11090455

    申请日：2005-03-25

    申请人： Zoltan Takats ,  Bogdan Gologan ,  Justin Wiseman ,  Robert Cooks

    发明人： Zoltan Takats ,  Bogdan Gologan ,  Justin Wiseman ,  Robert Cooks

    IPC分类号： H01J27/00 ,  H01J49/04

    CPC分类号： H01J49/142 ,  H01J49/0004 ,  H01J49/0404

    摘要： A new method and system for desorption ionization is described and applied to the ionization of various compounds, including peptides and proteins present on metal, polymer, and mineral surfaces. Desorption electrospray ionization (DESI) is carried out by directing charged droplets and/or ions of a liquid onto the surface to be analyzed. The impact of the charged particles on the surface produces gaseous ions of material originally present on the surface. The resulting mass spectra are similar to normal ESI mass spectra in that they show mainly singly or multiply charged molecular ions of the analytes. The DESI phenomenon was observed both in the case of conductive and insulator surfaces and for compounds ranging from nonpolar small molecules such as lycopene, the alkaloid coniceine, and small drugs, through polar compounds such as peptides and proteins. Changes in the solution that is sprayed can be used to selectively ionize particular compounds, including those in biological matrices. In vivo analysis is demonstrated.

    摘要翻译： 一种解吸电离的新方法和系统被描述和应用于各种化合物的电离，包括存在于金属，聚合物和矿物表面上的肽和蛋白质。 通过将液体的带电液滴和/或离子引导到要分析的表面上来进行解吸电喷雾离子化（DESI）。 带电粒子对表面的影响产生了最初存在于表面上的材料的气态离子。 所得质谱与正常的ESI质谱相似，因为它们主要表现出分析物的单一或多重带电分子离子。 在导电性和绝缘体表面以及通过极性化合物如肽和蛋白质从非极性小分子（如番茄红素，生物碱美西汀和小药物）的化合物观察到DESI现象。 喷雾溶液中的变化可用于选择性地电离特定化合物，包括生物基质中的化合物。 证明体内分析。

    System and method for landing of ions on a gas/liquid interface
    3.
    发明申请
    System and method for landing of ions on a gas/liquid interface 审中-公开
    离子在气/液界面上着陆的系统和方法

    公开(公告)号：US20060079002A1

    公开(公告)日：2006-04-13

    申请号：US11228946

    申请日：2005-09-16

    申请人： Bogdan Gologan ,  Zoltan Takats ,  Zheng Ouyang ,  Robert Cooks

    发明人： Bogdan Gologan ,  Zoltan Takats ,  Zheng Ouyang ,  Robert Cooks

    IPC分类号： G01N1/00

    CPC分类号： B82Y30/00 ,  H01J49/04 ,  Y10T436/25

    摘要： A system for collecting gaseous ions from a mixture of molecules includes an ionizer, a separator, and a surface that is positioned in cooperative relationship with the separator. The ionizer converts at least a portion of the molecules into gas phase ions and the separator separates the ions. The ions land in a layer of liquid phase material on the surface.

    摘要翻译： 用于从分子混合物中收集气态离子的系统包括离子发生器，分离器和与分离器配合关系的表面。 离子发生器将至少一部分分子转化为气相离子，分离器分离离子。 离子落在表层的液相材料层中。

    Parallel sample handling for high-throughput mass spectrometric analysis
    4.
    发明申请
    Parallel sample handling for high-throughput mass spectrometric analysis 审中-公开
    用于高通量质谱分析的并行样品处理

    公开(公告)号：US20070023631A1

    公开(公告)日：2007-02-01

    申请号：US11092104

    申请日：2005-03-29

    申请人： Zoltan Takats ,  Robert Cooks

    发明人： Zoltan Takats ,  Robert Cooks

    IPC分类号： H01J49/00

    CPC分类号： H01J49/0018 ,  H01J49/165

    摘要： A system to handle a set of samples for mass spectrometric analysis includes a set of elements that couples to a sample plate containing the set of samples. Each element is integrated with a respective mass analyzer, and includes an ionizer to ionize the respective sample. The set of samples are collected and then ionized simultaneously, and the ionized samples are transferred simultaneously to the respective mass analyzers.

    摘要翻译： 用于处理用于质谱分析的一组样品的系统包括耦合到包含该组样品的样品板的一组元件。 每个元件与相应的质量分析器集成，并且包括离子化器以电离相应的样品。 收集样品集合，然后同时电离，并将离子化样品同时转移到相应的质量分析器。

    Electrosonic spray ionization method and device for the atmospheric ionization of molecules
    5.
    发明申请
    Electrosonic spray ionization method and device for the atmospheric ionization of molecules 有权
    电喷雾电离法和分子大气电离装置

    公开(公告)号：US20050029442A1

    公开(公告)日：2005-02-10

    申请号：US10888869

    申请日：2004-07-09

    申请人： Zoltan Takats ,  Robert Cooks

    发明人： Zoltan Takats ,  Robert Cooks

    IPC分类号： B05B5/03 ,  H01J49/04 ,  H01J49/16 ,  H01J49/00 ,  B01D59/44

    CPC分类号： H01J49/167 ,  B05B5/03

    摘要： There is described a device and method for generating gaseous ions of a sample material such as molecules in solution at atmospheric pressure. The device includes a conduit for receiving a solution containing the material to be ionized and form a stream. A jet of gas at supersonic velocity is directed at the stream and interacts therewith. Droplets are formed and by the adiabatic expansion of the gas and vigorous evaporation of the solution gaseous ions are generated. In the method a stream of the sample solution is delivered from a conduit with an electric potential. A gas jet at supersonic velocity interacts with the delivered solution and through the action of adiabatic expansion of the gas and evaporation of the solution gaseous ions are formed.

    摘要翻译： 描述了用于产生样品材料的气体离子的装置和方法，例如在大气压下溶液中的分子。 该装置包括用于接收含有待离子化材料并形成流的溶液的导管。 超声速度的气体射流指向流并与其相互作用。 形成液滴，并且通过气体的绝热膨胀和溶液的剧烈蒸发产生气态离子。 在该方法中，样品溶液的流从具有电位的导管输送。 超音速的气体射流与输送的溶液相互作用，并且通过气体的绝热膨胀的作用和溶液的蒸发形成气态离子。

    System and method for preparative mass spectrometry
    6.
    发明申请
    System and method for preparative mass spectrometry 有权
    制备质谱的系统和方法

    公开(公告)号：US20060071665A1

    公开(公告)日：2006-04-06

    申请号：US11228826

    申请日：2005-09-16

    申请人： Thomas Blake ,  Zheng Ouyang ,  Robert Cooks

    发明人： Thomas Blake ,  Zheng Ouyang ,  Robert Cooks

    IPC分类号： G01N27/62

    CPC分类号： H01J49/02 ,  B82Y30/00 ,  H01J49/04 ,  Y10T436/25 ,  Y10T436/25375 ,  Y10T436/25875

    摘要： A preparative mass spectrometer system includes an ionizer which converts the mixture into gas phase ions of the molecules in the mixture, and a separator which separates the ions according to their mass to charge ratio or mobility. The separator is a linear ion trap mass analyzer that accumulates the ions based on their mass to charge ratio. A surface is in cooperative relationship with the separator so that the separated molecules are soft landed onto the surface at different locations such that the collected molecules can be stored or further processed/analyzed.

    摘要翻译： 制备型质谱仪系统包括将混合物转化为混合物中分子的气相离子的离子发生器，以及根据其质荷比或迁移率分离离子的分离器。 分离器是一种线性离子阱质量分析仪，其基于其质荷比积聚离子。 表面与分离器具有协同关系，使得分离的分子在不同位置软着陆到表面上，使得收集的分子可以被储存或进一步加工/分析。

    Multiplexed mass spectrometer
    8.
    发明申请
    Multiplexed mass spectrometer 失效
    复用质谱仪

    公开(公告)号：US20060097157A1

    公开(公告)日：2006-05-11

    申请号：US11092106

    申请日：2005-03-29

    申请人： Zheng Ouyang ,  Robert Cooks

    发明人： Zheng Ouyang ,  Robert Cooks

    IPC分类号： B01D59/44

    CPC分类号： H01J49/009 ,  H01J49/4205

    摘要： A multiplexed mass spectrometer system includes an array of mass analyzers and a data acquisition system. Each mass analyzer is associated with one or more data channels, and the data acquisition system selectively reduces the number of data channels through combinations of particular channels to define data acquisition modes for the molecular characterization of the samples. The selective reduction in channels can be achieved, for example by software manipulation of the acquired data or by combining the detected signals.

    摘要翻译： 复用质谱仪系统包括质量分析器阵列和数据采集系统。 每个质量分析器与一个或多个数据通道相关联，并且数据采集系统通过特定通道的组合选择性地减少数据通道的数量，以定义样品的分子表征的数据采集模式。 可以例如通过对获取的数据的软件操纵或通过组合检测到的信号来实现信道的选择性减少。