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    Modulation of miRNA Activity
    3.
    发明申请
    Modulation of miRNA Activity 审中-公开
    调节miRNA活性

    公开(公告)号：US20120184457A1

    公开(公告)日：2012-07-19

    申请号：US13389159

    申请日：2010-08-06

    Applicant: Eric Miska ,  Nicolas Lehrbach ,  Javier Armisen-Garrido ,  Shankar Balasubramanian

    Inventor： Eric Miska ,  Nicolas Lehrbach ,  Javier Armisen-Garrido ,  Shankar Balasubramanian

    IPC: G01N33/53 ,  C12Q1/68 ,  C40B30/04

    CPC classification number: C12Q1/485 ,  G01N33/573 ,  G01N2333/9125 ,  G01N2500/02

    Abstract: Provided is a method of identifying a compound which modulates miRNA activity comprising (i) determining the ability of a test compound to alter the polyuridylation activity of a ZCCHC polypeptide wherein a test compound which alters the polyuridylation activity is useful in modulating miRNA activity; or (ii) determining the ability of a test compound to alter the binding of a ZCCHC polypeptide to a LIN28 polypeptide, wherein a test compound which alters said binding may be useful in modulating miRNA activity; or (iii) determining the ability of a test compound to bind to a ZCCHC polypeptide, wherein a test compound which binds to the ZCCHC polypeptide may be useful in modulating miRNA activity.

    Abstract translation: 提供了鉴定调节miRNA活性的化合物的方法，其包括（i）测定测试化合物改变ZCCHC多肽的多聚尿苷酸化活性的能力，其中改变多聚尿苷酸化活性的测试化合物可用于调节miRNA活性; 或（ii）测定测试化合物改变ZCCHC多肽与LIN28多肽的结合的能力，其中改变所述结合的测试化合物可用于调节miRNA活性; 或（iii）测定测试化合物结合ZCCHC多肽的能力，其中与ZCCHC多肽结合的测试化合物可用于调节miRNA活性。

    FABRIC WITH FIBRE CHANNEL FABRIC SNAPSHOT SERVICE
    6.
    发明申请
    FABRIC WITH FIBRE CHANNEL FABRIC SNAPSHOT SERVICE 失效
    织物与纤维通道织物快速服务

    公开(公告)号：US20060248299A1

    公开(公告)日：2006-11-02

    申请号：US11457757

    申请日：2006-07-14

    Applicant: BALAKUMAR KAUSHIK ,  SHANKAR BALASUBRAMANIAN ,  RICHARD HAMMONS

    Inventor： BALAKUMAR KAUSHIK ,  SHANKAR BALASUBRAMANIAN ,  RICHARD HAMMONS

    IPC: G06F12/16

    CPC classification number: G06F11/1464 ,  G06F11/1466 ,  G06F2201/84 ,  H04L49/357 ,  H04L67/1097 ,  Y10S707/99953 ,  Y10S707/99955

    Abstract: The snapshot capability moving into the SAN fabric and being provided as a snapshot service. A well-known address is utilized to receive snapshot commands. Each switch in the fabric connected to a host contains a front end or service interface to receive the snapshot command. Each switch of the fabric connected to a storage device used in the snapshot process contains a write interceptor module which cooperates with hardware in the switch to capture any write operations which would occur to the snapshot data area. The write interceptor then holds these particular write operations until the original blocks are transferred to a snapshot or separate area so that the original read data is maintained. Should a read operation occur to the snapshot device and the original data from requested location has been relocated, a snapshot server captures these commands and redirects the read operation to occur from the snapshot area. If, however, the read operation is directed to the original drive, the read is provided from the original data areas, even if the data had been replaced. The snapshot server determines the existence of particular snapshot devices, allocates their storage locations, provides this information to both the service interfaces and the write interceptors and handles read and write operations to the snapshot device.

    Abstract translation: 快照功能进入SAN架构，并作为快照服务提供。 利用着名的地址接收快照命令。 连接到主机的每个交换机都包含一个前端或服务接口来接收快照命令。 连接到快照过程中使用的存储设备的结构的每个交换机都包含一个写入拦截器模块，该模块与交换机中的硬件配合，以捕获快照数据区域将发生的任何写入操作。 写拦截器然后保存这些特定的写入操作，直到原始块被传送到快照或分离区域，以便保持原始读取数据。 如果快照设备发生读取操作，并且重新定位了来自请求位置的原始数据，则快照服务器捕获这些命令并重定向从快照区域发生的读取操作。 但是，如果读取操作指向原始驱动器，则即使已更换数据，也会从原始数据区域提供读取。 快照服务器确定特定快照设备的存在，分配其存储位置，将此信息提供给服务接口和写截取器，并处理对快照设备的读写操作。

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