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公开(公告)号：US06617315B1
公开(公告)日：2003-09-09
申请号：US09712739
申请日：2000-11-14
Applicant: Stanley Dawes Chamberlain , George Walter Koszalka , Jeffrey H. Tidwell , Nanine Agneta Vandraanen
Inventor： Stanley Dawes Chamberlain , George Walter Koszalka , Jeffrey H. Tidwell , Nanine Agneta Vandraanen
IPC: C07H1702
CPC classification number: C07H19/052
Abstract: The present invention relates to benzimidazole derivatives and their use in medical therapy particularly for the treatment or prophylaxis of restenosis.
Abstract translation: 本发明涉及苯并咪唑衍生物及其在药物治疗中的用途，特别是用于治疗或预防再狭窄。
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公开(公告)号：US06204249B1
公开(公告)日：2001-03-20
申请号：US09101103
申请日：1998-07-13
Applicant: Stanley Dawes Chamberlain , George Walter Koszalka , Jeffrey H. Tidwell , Nanine Agneta Vandraanen
Inventor： Stanley Dawes Chamberlain , George Walter Koszalka , Jeffrey H. Tidwell , Nanine Agneta Vandraanen
IPC: C07H1702
CPC classification number: C07H19/052
Abstract: The present invention relates to benzimidazole derivatives and their use in medical therapy particularly for the treatment or prophylaxis of virus infections such as those caused by herpes viruses. The invention also relates to the preparation of the benzimidazole derivatives and pharmaceutical formulations containing them.
Abstract translation: 本发明涉及苯并咪唑衍生物及其在药物治疗中的用途，特别是用于治疗或预防诸如由疱疹病毒引起的病毒感染的病毒感染。 本发明还涉及苯并咪唑衍生物的制备和含有它们的药物制剂。
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公开(公告)号：US06455507B1
公开(公告)日：2002-09-24
申请号：US09424934
申请日：2000-03-17
Applicant: John Charles Drach , Leroy B. Townsend , Frank Leslie Boyd, Jr. , Stanley Dawes Chamberlain , Susan Mary Daluge , David Norman Deaton , Marc W. Andersen , George Andrew Freeman
Inventor： John Charles Drach , Leroy B. Townsend , Frank Leslie Boyd, Jr. , Stanley Dawes Chamberlain , Susan Mary Daluge , David Norman Deaton , Marc W. Andersen , George Andrew Freeman
IPC: A61K3170
CPC classification number: C07D235/24 , C07D235/30 , C07D405/04 , C07H19/052
Abstract: Benzimidazole derivatives useful for treating or preventing viral infections such as those caused by herpes viruses or in the treatment of restenosis following surgical techniques. Methods of preparing these benzimidazole derivatives and pharmaceutical compositions containing them are described.
Abstract translation: 用于治疗或预防病毒感染的苯并咪唑衍生物，例如由疱疹病毒引起的那些或在手术技术后治疗再狭窄。 描述制备这些苯并咪唑衍生物的方法和含有它们的药物组合物。
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![2-[2-{phenylamino}-1H-pyrrolo[2,3-D]pyrimidin-4-yl)amino] benzamide derivatives as IGF-1R inhibitors for the treatment of cancer](/abs-image/US/2011/07/19/US07981903B2/abs.jpg.150x150.jpg)
4.发明授权2-[2-{phenylamino}-1H-pyrrolo[2,3-D]pyrimidin-4-yl)amino] benzamide derivatives as IGF-1R inhibitors for the treatment of cancer 有权2- [2- {苯基氨基} -1H-吡咯并[2,3-D]嘧啶-4-基）氨基]苯甲酰胺衍生物作为治疗癌症的IGF-1R抑制剂公开(公告)号：US07981903B2
公开(公告)日：2011-07-19
申请号：US12671960
申请日：2008-08-06
Applicant: Stanley Dawes Chamberlain , Felix Deanda, Jr. , Roseanne Gerding , Masaichi Hasegawa , Kevin Kuntz , Huangshu Lei , Yasushi Miyazaki , Naohiko Nishigaki , Samarjit Patnaik , Aniko Redman , John Brad Shotwell , Kirk Stevens , Joseph Wilson , Bin Yang
Inventor： Stanley Dawes Chamberlain , Felix Deanda, Jr. , Roseanne Gerding , Masaichi Hasegawa , Kevin Kuntz , Huangshu Lei , Yasushi Miyazaki , Naohiko Nishigaki , Samarjit Patnaik , Aniko Redman , John Brad Shotwell , Kirk Stevens , Joseph Wilson , Bin Yang
IPC: A01N43/90 , A61K31/519 , C07D487/00
CPC classification number: C07D487/04 , C07D487/14
Abstract: Novel pyrrolopyrimidines as shown in formula (I): and pharmaceutically acceptable derivatives thereof. The compounds are useful in the inhibition of IGF-1R.
Abstract translation: 式（I）所示的新型吡咯并嘧啶及其药学上可接受的衍生物。 该化合物可用于抑制IGF-1R。
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公开(公告)号：US07491731B2
公开(公告)日：2009-02-17
申请号：US11430342
申请日：2006-05-09
Applicant: Holly Kathleen Emerson , David Lee Musso , Stanley Dawes Chamberlain , Gregory Edward Peckham
Inventor： Holly Kathleen Emerson , David Lee Musso , Stanley Dawes Chamberlain , Gregory Edward Peckham
IPC: C07D239/49 , A61K31/505
CPC classification number: C12N9/12 , C07K14/7153 , C07K2299/00 , G06F19/16
Abstract: A crystal structure of the cfms kinase domain, co-crystal structure with a bound small molecule, as well as methods of using the same in the discovery of cfms inhibitors and in the treatment of diseases mediated by inappropriate cfms activity.
Abstract translation: 具有结合的小分子的cfms激酶结构域，共晶体结构的晶体结构，以及在发现cfms抑制剂以及治疗由不适当cfms活性介导的疾病的治疗方法。
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Patent Agency Ranking6.发明授权Antiviral benzimidazole nucleoside analogues and a method for their preparation 失效抗病毒苯并咪唑核苷类似物及其制备方法
公开(公告)号：US6077832A
公开(公告)日：2000-06-20
申请号：US765758
申请日：1997-01-06
Applicant: Stanley Dawes Chamberlain , Susan Mary Daluge , George Walter Koszalka
Inventor： Stanley Dawes Chamberlain , Susan Mary Daluge , George Walter Koszalka
IPC: C07H19/04 , A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/7056 , A61P31/12 , A61P31/22 , C07D235/30 , C07H19/052
CPC classification number: C07D235/30 , C07H19/052
Abstract: The present invention relates to benzimidazole derivatives and their use in medical therapy particularly for the treatment or prophylaxis of virus infections such as those caused by herpes viruses. The invention also relates to the preparation of the benzimidazole derivatives and pharmaceutical formulations containing them.
Abstract translation: PCT No.PCT / GB95 / 01597 Sec。 371日期1997年1月6日 102（e）日期1997年1月6日PCT提交1995年7月6日PCT公布。 出版物WO96 / 01833 日期1996年1月25日本发明涉及苯并咪唑衍生物及其在药物治疗中的用途，特别是用于治疗或预防由疱疹病毒引起的病毒感染。 本发明还涉及苯并咪唑衍生物的制备和含有它们的药物制剂。
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![2-[2--1H-Pyrrolo[2,3-D]Pyrimidin-4-YL)Amino] Benzamide Derivatives As IGF-1R Inhibitors For The Treatment Of Cancer](/abs-image/US/2010/08/12/US20100204196A1/abs.jpg.150x150.jpg)
7.发明申请2-[2--1H-Pyrrolo[2,3-D]Pyrimidin-4-YL)Amino] Benzamide Derivatives As IGF-1R Inhibitors For The Treatment Of Cancer 有权2- [2- [1H-吡咯并[2,3-D]嘧啶-4-基）氨基]苯甲酰胺衍生物作为IGF-1R抑制剂治疗癌症公开(公告)号：US20100204196A1
公开(公告)日：2010-08-12
申请号：US12671960
申请日：2008-08-06
Applicant: Stanley Dawes Chamberlain , Felix Deanda, JR. , Roseanne Gerding , Masaichi Hasegawa , Kevin Kuntz , Huangshu Lei , Yasushi Miyazaki , Naohiko Nishigaki , Samarjit Patnaik , Aniko Redman , John Brad Shotwell , Kirk Stevens , Joseph Wilson , Bin Yang
Inventor： Stanley Dawes Chamberlain , Felix Deanda, JR. , Roseanne Gerding , Masaichi Hasegawa , Kevin Kuntz , Huangshu Lei , Yasushi Miyazaki , Naohiko Nishigaki , Samarjit Patnaik , Aniko Redman , John Brad Shotwell , Kirk Stevens , Joseph Wilson , Bin Yang
IPC: A61K31/397 , C07D487/04 , A61K31/519 , A61K31/496 , A61K31/5377 , A61K31/551 , A61P35/00
CPC classification number: C07D487/04 , C07D487/14
Abstract: Novel pyrrolopyrimidines as shown in formula (I): and pharmaceutically acceptable derivatives thereof. The compounds are useful in the inhibition of IGF-1R.
Abstract translation: 式（I）所示的新型吡咯并嘧啶及其药学上可接受的衍生物。 该化合物可用于抑制IGF-1R。
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公开(公告)号：US06307043B1
公开(公告)日：2001-10-23
申请号：US09489098
申请日：2000-01-21
Applicant: Stanley Dawes Chamberlain , Jeffrey H. Tidwell
Inventor： Stanley Dawes Chamberlain , Jeffrey H. Tidwell
IPC: C07H1904
CPC classification number: C07D235/30 , C07H19/052
Abstract: The present invention relates to benzimidazole derivatives and their use in medical therapy particularly for the treatment or prophylaxis of virus infections such as those caused by herpes viruses. The invention also relates to the preparation of the benzimidazole derivatives and pharmaceutical formulations containing them.
Abstract translation: 本发明涉及苯并咪唑衍生物及其在药物治疗中的用途，特别是用于治疗或预防诸如由疱疹病毒引起的病毒感染的病毒感染。 本发明还涉及苯并咪唑衍生物的制备和含有它们的药物制剂。
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公开(公告)号：US07338959B2
公开(公告)日：2008-03-04
申请号：US10506447
申请日：2003-02-28
Applicant: Stanley Dawes Chamberlain , Mui Cheung , Holly Kathleen Emerson , Neil W. Johnson , Kristen Elizabeth Nailor , Douglas McCord Sammond , Marcus Semones
Inventor： Stanley Dawes Chamberlain , Mui Cheung , Holly Kathleen Emerson , Neil W. Johnson , Kristen Elizabeth Nailor , Douglas McCord Sammond , Marcus Semones
IPC: C07D239/48 , C07D403/12 , C07D403/14 , A61K31/506 , A61K31/4184 , A61P35/00
CPC classification number: C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
Abstract: Benzimidazole derivatives, which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such benzimidazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
Abstract translation: 本文描述了可用作TIE-2和/或VEGFR-2抑制剂的苯并咪唑衍生物。 所述的发明还包括制备这种苯并咪唑衍生物的方法以及使用它们在治疗过度增殖性疾病中的方法。
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10.发明授权
公开(公告)号：US5998605A
公开(公告)日：1999-12-07
申请号：US216719
申请日：1998-12-18
Applicant: Stanley Dawes Chamberlain , Susan Mary Daluge , George Walter Koszalka
Inventor： Stanley Dawes Chamberlain , Susan Mary Daluge , George Walter Koszalka
IPC: C07H19/04 , A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/7056 , A61P31/12 , A61P31/22 , C07D235/30 , C07H19/052
CPC classification number: C07D235/30 , C07H19/052
Abstract: The present invention relates to benzimidazole derivatives and their use in medical therapy particularly for the treatment or prophylaxis of virus infections such as those caused by herpes viruses. The invention also relates to the preparation of the benzimidazole derivatives and pharmaceutical formulations containing them.
Abstract translation: 本发明涉及苯并咪唑衍生物及其在药物治疗中的用途，特别是用于治疗或预防诸如由疱疹病毒引起的病毒感染的病毒感染。 本发明还涉及苯并咪唑衍生物的制备和含有它们的药物制剂。
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