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1.发明授权Chroman-derived anti-androgens for treatment of androgen-mediated disorders 失效用于治疗雄激素介导的疾病的色甘酸衍生的抗雄激素公开(公告)号：US07709525B2
公开(公告)日：2010-05-04
申请号：US10789835
申请日：2004-02-27
申请人： Todd A. Thompson , George Wilding
发明人： Todd A. Thompson , George Wilding
IPC分类号： A61K31/353
CPC分类号： C07D311/72 , A61K31/353
摘要： Methods for the prevention and/or alleviation of androgen-mediated disorders treatable by administering a chroman-derived anti-androgen compound are provided by the present invention. The invention further provides pharmaceutical and nutraceutical compositions containing chroman-derived anti-androgen compounds useful in the prevention and/or alleviation of androgen-mediated disorders, particularly prostate cancer.
摘要翻译： 通过本发明提供了通过施用苯并二氢吡喃衍生的抗雄激素化合物可治疗的雄激素介导的疾病的预防和/或缓解方法。 本发明进一步提供了含有色氨酸衍生的抗雄激素化合物的药物和营养组合物，其用于预防和/或减轻雄激素介导的病症，特别是前列腺癌。
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2.发明申请Chroman-Derived Anti-Androgens For Treatment of Androgen-Mediated Disorders 审中-公开用于治疗雄激素介导性疾病的色甘酸衍生的抗雄激素公开(公告)号：US20100056619A1
公开(公告)日：2010-03-04
申请号：US12581501
申请日：2009-10-19
申请人： Todd A. Thompson , George Wilding
发明人： Todd A. Thompson , George Wilding
IPC分类号： A61K31/352 , C12N5/02
CPC分类号： C07D311/72 , A61K31/353
摘要： Methods for the prevention and/or alleviation of androgen-mediated disorders by administering a chroman-derived anti-androgen compound are provided by the present invention. The invention further provides pharmaceutical and nutraceutical compositions containing chroman-derived anti-androgen compounds useful in the prevention and/or alleviation of androgen-mediated disorders, particularly prostate cancer.
摘要翻译： 通过本发明提供通过施用苯并二氢吡喃衍生的抗雄激素化合物来预防和/或缓解雄激素介导的病症的方法。 本发明进一步提供了含有色氨酸衍生的抗雄激素化合物的药物和营养组合物，其用于预防和/或减轻雄激素介导的病症，特别是前列腺癌。
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3.发明申请Systems and methods for applying ultrasound energy to increase tissue perfusion and/or vasodilation without substantial deep heating of tissue 审中-公开用于施加超声能量以增加组织灌注和/或血管舒张的系统和方法而没有对组织的大量深度加热公开(公告)号：US20080208084A1
公开(公告)日：2008-08-28
申请号：US12082627
申请日：2008-04-11
IPC分类号： A61N7/00
CPC分类号： A61N7/00 , A61B90/50 , A61B2017/00725 , A61B2017/00734 , A61B2018/00023 , H04N1/387 , H04N1/58
摘要： Systems and methods apply ultrasound energy to achieve vasodilation and/or to increase tissue perfusion without causing substantial deep tissue heating.
摘要翻译： 系统和方法应用超声波能量以实现血管舒张和/或增加组织灌注而不引起显着的深层组织加热。
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公开(公告)号：US20080132568A1
公开(公告)日：2008-06-05
申请号：US11937351
申请日：2007-11-08
IPC分类号： A61K31/277 , A61K31/185 , A61K31/13 , A61K31/135 , A61K31/165 , A61K31/12 , A61K31/095
CPC分类号： A61K31/095 , A61K31/12 , A61K31/13 , A61K31/135 , A61K31/165 , A61K31/185 , A61K31/277
摘要： Compounds having anti-androgenic activities are disclosed. Further disclosed are methods of using the compounds to prevent or treat androgen-dependent diseases or to provide nutraceutical benefits. Pharmaceutical and nutraceutical compositions containing the anti-androgenic compounds are also disclosed.
摘要翻译： 公开了具有抗雄激素活性的化合物。 进一步公开的是使用该化合物来预防或治疗雄激素依赖性疾病或提供营养保健益处的方法。 还公开了含有抗雄激素化合物的药物和营养组合物。
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公开(公告)号：US07229423B2
公开(公告)日：2007-06-12
申请号：US10359040
申请日：2003-02-05
IPC分类号： A61H1/00
CPC分类号： A61H23/0236 , A61H2205/08 , A61N7/00
摘要： Systems and methods apply audible acoustic energy to cause vasodilation and/or to increase tissue perfusion.
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6.发明申请公开(公告)号：US20120277301A1
公开(公告)日：2012-11-01
申请号：US13542432
申请日：2012-07-05
申请人： Todd A. Thompson , George Wilding
发明人： Todd A. Thompson , George Wilding
IPC分类号： A61K31/353 , C12N5/02 , A61P35/00
CPC分类号： C07D311/72 , A61K31/353
摘要： Methods for the prevention and/or alleviation of androgen-mediated disorders treatable by administering a chroman-derived anti-androgen compound are provided by the present invention. The invention further provides pharmaceutical and nutraceutical compositions containing chroman-derived anti-androgen compounds useful in the prevention and/or alleviation of androgen-mediated disorders, particularly prostate cancer.
摘要翻译： 通过本发明提供了通过施用苯并二氢吡喃衍生的抗雄激素化合物可治疗的雄激素介导的疾病的预防和/或缓解方法。 本发明进一步提供了含有色氨酸衍生的抗雄激素化合物的药物和营养组合物，其用于预防和/或减轻雄激素介导的病症，特别是前列腺癌。
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7.发明授权Systems and methods for delivering ultrasound energy at an output power level that remains essentially constant despite variations in transducer impedance 有权用于在输出功率水平下输送超声波能量的系统和方法，尽管传感器阻抗有变化，但仍保持基本恒定公开(公告)号：US07335169B2
公开(公告)日：2008-02-26
申请号：US10202446
申请日：2002-07-24
CPC分类号： A61N7/00 , A61B90/50 , A61B2017/00725 , A61B2017/00734 , A61B2018/00023 , A61N2007/0073
摘要： Systems and methods deliver ultrasound energy to an ultrasound transducer having an impedance subject to variations. The systems and methods electrically couple an ultrasound generator to the ultrasound transducer to deliver ultrasound energy. The systems and methods deliver ultrasound energy to the ultrasound transducer at a set output frequency and at an output power level that remains essentially constant, despite variations in the impedance, based upon preprogrammed rules.
摘要翻译： 系统和方法将超声能量传递给具有变化的阻抗的超声换能器。 该系统和方法将超声发生器电耦合到超声换能器以输送超声能量。 系统和方法以设定的输出频率和输出功率电平向超声波换能器提供超声波能量，尽管阻抗的变化基本上保持基本上恒定，但是基于预编程规则。
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公开(公告)号：US5618291A
公开(公告)日：1997-04-08
申请号：US459790
申请日：1995-06-02
申请人： Todd A. Thompson , Tim Kovac
发明人： Todd A. Thompson , Tim Kovac
IPC分类号： A61B17/122 , A61B17/128 , A61B17/28 , A61B17/04
CPC分类号： A61B17/1285 , A61B17/122 , A61B17/128 , A61B2017/2929 , A61B2017/2948
摘要： A gas-sealed instrument for use in laparoscopic procedures in a gas-insufflated body cavity. The instrument comprises a static portion, a moving portion, and a sealing means for preventing gas from escaping from the body cavity through the static portion. The static portion includes a handle, and an elongate outer tube having a bore, a proximal portion attached to the handle, and a distal portion adapted for inserting into the body cavity. The moving portion includes an operating lever pivotally mounted in the handle, and an elongate operating rod mounted in the bore of the elongate outer tube, and sliding axially relative thereto in response to the operating lever.The sealing means includes a cylinder in the handle and a piston slidably mounted in the cylinder. The cylinder is in gas-tight communication with the bore of the outer tube, and the piston interconnects the operating lever and the operating rod.
摘要翻译： 一种气体密封仪器，用于气体吹入体腔内的腹腔镜手术。 仪器包括静止部分，移动部分和用于防止气体通过静态部分从体腔逸出的密封装置。 静止部分包括手柄和细长的外管，其具有孔，附接到手柄的近端部分和适于插入体腔的远侧部分。 移动部分包括可旋转地安装在手柄中的操作杆和安装在细长外管的孔中的细长操作杆，并且响应于操作杆而相对于其滑动。 密封装置包括手柄中的气缸和可滑动地安装在气缸中的活塞。 气缸与外管的孔气密封连通，活塞将操作杆和操作杆相互连接。
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公开(公告)号：US07863324B2
公开(公告)日：2011-01-04
申请号：US12129338
申请日：2008-05-29
申请人： Todd A. Thompson , George Wilding
发明人： Todd A. Thompson , George Wilding
IPC分类号： A61K31/353
CPC分类号： C07D311/72 , A61K31/353
摘要： The present invention provides methods for inhibiting the growth of androgen-independent prostate cancer tumor cells in a human comprising administering to the human. The invention further provides pharmaceutical and nutraceutical compositions containing chroman-derived compounds useful in the alleviation of cancer.
摘要翻译： 本发明提供了抑制人中雄激素依赖性前列腺癌肿瘤细胞生长的方法，包括向人施用。 本发明进一步提供含有色素衍生化合物的药物和营养组合物，其可用于缓解癌症。
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10.发明申请Systems and methods for applying audible acoustic energy to increase tissue perfusion and/or vasodilation 审中-公开应用声音能量以增加组织灌注和/或血管舒张的系统和方法公开(公告)号：US20100049100A1
公开(公告)日：2010-02-25
申请号：US12589740
申请日：2009-10-28
IPC分类号： A61N7/00
CPC分类号： A61H23/0236 , A61H2205/08 , A61N7/00
摘要： Systems and methods apply audible acoustic energy to cause vasodilation and/or to increase tissue perfusion.
摘要翻译： 系统和方法应用声音能量引起血管舒张和/或增加组织灌注。
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