Chroman-derived anti-androgens for treatment of androgen-mediated disorders
    1.
    发明授权
    Chroman-derived anti-androgens for treatment of androgen-mediated disorders 失效
    用于治疗雄激素介导的疾病的色甘酸衍生的抗雄激素

    公开(公告)号:US07709525B2

    公开(公告)日:2010-05-04

    申请号:US10789835

    申请日:2004-02-27

    IPC分类号: A61K31/353

    CPC分类号: C07D311/72 A61K31/353

    摘要: Methods for the prevention and/or alleviation of androgen-mediated disorders treatable by administering a chroman-derived anti-androgen compound are provided by the present invention. The invention further provides pharmaceutical and nutraceutical compositions containing chroman-derived anti-androgen compounds useful in the prevention and/or alleviation of androgen-mediated disorders, particularly prostate cancer.

    摘要翻译: 通过本发明提供了通过施用苯并二氢吡喃衍生的抗雄激素化合物可治疗的雄激素介导的疾病的预防和/或缓解方法。 本发明进一步提供了含有色氨酸衍生的抗雄激素化合物的药物和营养组合物,其用于预防和/或减轻雄激素介导的病症,特别是前列腺癌。

    Chroman-Derived Anti-Androgens For Treatment of Androgen-Mediated Disorders
    2.
    发明申请
    Chroman-Derived Anti-Androgens For Treatment of Androgen-Mediated Disorders 审中-公开
    用于治疗雄激素介导性疾病的色甘酸衍生的抗雄激素

    公开(公告)号:US20100056619A1

    公开(公告)日:2010-03-04

    申请号:US12581501

    申请日:2009-10-19

    IPC分类号: A61K31/352 C12N5/02

    CPC分类号: C07D311/72 A61K31/353

    摘要: Methods for the prevention and/or alleviation of androgen-mediated disorders by administering a chroman-derived anti-androgen compound are provided by the present invention. The invention further provides pharmaceutical and nutraceutical compositions containing chroman-derived anti-androgen compounds useful in the prevention and/or alleviation of androgen-mediated disorders, particularly prostate cancer.

    摘要翻译: 通过本发明提供通过施用苯并二氢吡喃衍生的抗雄激素化合物来预防和/或缓解雄激素介导的病症的方法。 本发明进一步提供了含有色氨酸衍生的抗雄激素化合物的药物和营养组合物,其用于预防和/或减轻雄激素介导的病症,特别是前列腺癌。

    CHROMAN-DERIVED ANTI-ANDROGENS FOR TREATMENT OF ANDROGEN MEDIATED DISORDERS
    6.
    发明申请
    CHROMAN-DERIVED ANTI-ANDROGENS FOR TREATMENT OF ANDROGEN MEDIATED DISORDERS 失效
    用于治疗恶性肿瘤的染色体用抗精神病药

    公开(公告)号:US20120277301A1

    公开(公告)日:2012-11-01

    申请号:US13542432

    申请日:2012-07-05

    IPC分类号: A61K31/353 C12N5/02 A61P35/00

    CPC分类号: C07D311/72 A61K31/353

    摘要: Methods for the prevention and/or alleviation of androgen-mediated disorders treatable by administering a chroman-derived anti-androgen compound are provided by the present invention. The invention further provides pharmaceutical and nutraceutical compositions containing chroman-derived anti-androgen compounds useful in the prevention and/or alleviation of androgen-mediated disorders, particularly prostate cancer.

    摘要翻译: 通过本发明提供了通过施用苯并二氢吡喃衍生的抗雄激素化合物可治疗的雄激素介导的疾病的预防和/或缓解方法。 本发明进一步提供了含有色氨酸衍生的抗雄激素化合物的药物和营养组合物,其用于预防和/或减轻雄激素介导的病症,特别是前列腺癌。

    Gas-sealed instruments for use in laparoscopic surgery
    8.
    发明授权
    Gas-sealed instruments for use in laparoscopic surgery 失效
    用于腹腔镜手术的气密仪器

    公开(公告)号:US5618291A

    公开(公告)日:1997-04-08

    申请号:US459790

    申请日:1995-06-02

    摘要: A gas-sealed instrument for use in laparoscopic procedures in a gas-insufflated body cavity. The instrument comprises a static portion, a moving portion, and a sealing means for preventing gas from escaping from the body cavity through the static portion. The static portion includes a handle, and an elongate outer tube having a bore, a proximal portion attached to the handle, and a distal portion adapted for inserting into the body cavity. The moving portion includes an operating lever pivotally mounted in the handle, and an elongate operating rod mounted in the bore of the elongate outer tube, and sliding axially relative thereto in response to the operating lever.The sealing means includes a cylinder in the handle and a piston slidably mounted in the cylinder. The cylinder is in gas-tight communication with the bore of the outer tube, and the piston interconnects the operating lever and the operating rod.

    摘要翻译: 一种气体密封仪器,用于气体吹入体腔内的腹腔镜手术。 仪器包括静止部分,移动部分和用于防止气体通过静态部分从体腔逸出的密封装置。 静止部分包括手柄和细长的外管,其具有孔,附接到手柄的近端部分和适于插入体腔的远侧部分。 移动部分包括可旋转地安装在手柄中的操作杆和安装在细长外管的孔中的细长操作杆,并且响应于操作杆而相对于其滑动。 密封装置包括手柄中的气缸和可滑动地安装在气缸中的活塞。 气缸与外管的孔气密封连通,活塞将操作杆和操作杆相互连接。

    Chroman-derived compounds for the treatment of cancer
    9.
    发明授权
    Chroman-derived compounds for the treatment of cancer 有权
    用于治疗癌症的色甘酸衍生化合物

    公开(公告)号:US07863324B2

    公开(公告)日:2011-01-04

    申请号:US12129338

    申请日:2008-05-29

    IPC分类号: A61K31/353

    CPC分类号: C07D311/72 A61K31/353

    摘要: The present invention provides methods for inhibiting the growth of androgen-independent prostate cancer tumor cells in a human comprising administering to the human. The invention further provides pharmaceutical and nutraceutical compositions containing chroman-derived compounds useful in the alleviation of cancer.

    摘要翻译: 本发明提供了抑制人中雄激素依赖性前列腺癌肿瘤细胞生长的方法,包括向人施用。 本发明进一步提供含有色素衍生化合物的药物和营养组合物,其可用于缓解癌症。