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公开(公告)号：US08492342B2
公开(公告)日：2013-07-23
申请号：US12664956
申请日：2008-06-19
CPC分类号： C07K14/585 , A61K39/00 , A61K39/0011 , A61K2039/53
摘要： The present invention is related to Preprocalcitonin antigen T epitopes, presented by the Major Histocompatibility Complex I (MHC I). These peptides can be used in cancer immunotherapy.
摘要翻译： 本发明涉及由主要组织相容性复合体I（MHC I）呈递的降血糖原素抗原T表位。 这些肽可用于癌症免疫治疗。
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公开(公告)号：US20110112282A1
公开(公告)日：2011-05-12
申请号：US12736526
申请日：2009-04-15
申请人： Ute Roehrig , Loay Awad , Olivier Michelin , Benoit Van Den Eynde , Luc Pilotte , Vincent Stroobant , Pierre Larrieu
发明人： Ute Roehrig , Loay Awad , Olivier Michelin , Benoit Van Den Eynde , Luc Pilotte , Vincent Stroobant , Pierre Larrieu
IPC分类号： C07H7/04 , C07D209/48 , C07C211/58 , C07C211/63 , C07D215/38 , C07C237/20 , C07D207/16
CPC分类号： A61K31/136 , A61K31/05 , A61K31/085 , A61K31/12 , A61K31/167 , A61K31/4045 , A61K31/4192 , A61K31/428 , A61K31/4439 , A61K31/47 , C07C35/36 , C07C35/38 , C07C39/367 , C07C43/23 , C07C49/786 , C07C49/83 , C07C215/86 , C07C217/90 , C07C237/04 , C07C251/22 , C07C2602/10 , C07C2603/18 , C07D207/16 , C07D209/14 , C07D209/48 , C07D209/88 , C07D215/26 , C07D215/38 , C07D215/40 , C07D249/06 , C07D277/36 , C07D277/40 , C07D277/72 , C07D277/74 , C07D401/04
摘要： Compounds of formula (I), and pharmaceutically acceptable salts thereof, in which each compound is adapted to occupy the binding site of human IDO, which comprises a large hydrophobic pocket A and a second, proximal hydrophobic pocket B, the compound comprising at least one of the following elements: (i) a large hydrophobic fragment to substantially fill pocket A in the binding site of human IDO; (ii) an atom that can coordinate to the heme iron of human IDO, (iii) a positively charged group that can form a salt-bridge with the heme 7-propionate of the human IDO; (iv) a negatively charged group that can form a salt-bridge with Arg231 of the human IDO; (v) a hydrophobic group that can form van der Waals interactions with pocket B; and (vi) one or more substituents that can hydrogen bond to Ser167 and to Gly262, and as IDO inhibitors and their therapeutic use, eg in the treatment of cancer.
摘要翻译： 其中每种化合物适于占据人IDO的结合位点的式（I）化合物及其药学上可接受的盐，其包含大的疏水性口袋A和第二近端疏水口袋B，所述化合物包含至少一种 的以下元素：（i）大的疏水性片段，以基本上填充人IDO的结合位点中的口袋A; （ii）可以配合人类IDO的血红素铁的原子，（iii）可以与人类IDO的7-丙酸血红素形成盐桥的带正电荷的基团; （iv）可以与人类IDO的Arg231形成盐桥的带负电荷的基团; （v）可与袋B形成范德华相互作用的疏水基团; 和（vi）可以与Ser167和Gly262氢键合的一个或多个取代基，以及作为IDO抑制剂及其治疗用途，例如用于治疗癌症。
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公开(公告)号：US06407063B1
公开(公告)日：2002-06-18
申请号：US09165863
申请日：1998-10-02
申请人： Rosalie Luiten , Marie-Therese Duffour , Nathalie Demotte , Pierre van der Bruggan , Guy Cornelius , Vincent Stroobant , Christophe Lurquin , Thierry Boon-Falleur
发明人： Rosalie Luiten , Marie-Therese Duffour , Nathalie Demotte , Pierre van der Bruggan , Guy Cornelius , Vincent Stroobant , Christophe Lurquin , Thierry Boon-Falleur
IPC分类号： A61K3808
CPC分类号： C07K14/4748
摘要： The present invention relates to isolation of cytotoxic T lymphocyte (CTL) clones. In particular, the present invention relates to isolated CTL clones that are specific for MAGE-1 and MAGE-4, respectively. The CTL clones of the present invention have been isolated by successive steps of stimulation and testing of lymphocytes with antigen presenting cells which present antigens derived from different expression systems, e.g., from recombinant Yersinia, recombinant Salmonella, or recombinant viruses. The present invention further relates to the MAGE-1 and MAGE-4 antigenic peptides as well as the peptide/HLA complexes which are recognized by the isolated CTL clones.
摘要翻译： 本发明涉及细胞毒性T淋巴细胞（CTL）克隆的分离。 特别地，本发明涉及分别对MAGE-1和MAGE-4特异的分离的CTL克隆。 本发明的CTL克隆已经通过连续的步骤来刺激和测试淋巴细胞来分离，所述抗原呈递细胞提供来自不同表达系统的抗原，例如来自重组耶尔森氏菌，重组沙门氏菌或重组病毒。 本发明还涉及由分离的CTL克隆识别的MAGE-1和MAGE-4抗原肽以及肽/ HLA复合物。
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公开(公告)号：US07351409B2
公开(公告)日：2008-04-01
申请号：US10753158
申请日：2004-01-07
申请人： Pascal Chaux , Rosalie Luiten , Nathalie Demotte , Marie-Therese Duffour , Christophe Lurquin , Catie Traversari , Vincent Stroobant , Guy R. Cornelis , Thierry Boon-Falleur , Pierre van der Bruggen , Erwin Schultz , Guy Warnier
发明人： Pascal Chaux , Rosalie Luiten , Nathalie Demotte , Marie-Therese Duffour , Christophe Lurquin , Catie Traversari , Vincent Stroobant , Guy R. Cornelis , Thierry Boon-Falleur , Pierre van der Bruggen , Erwin Schultz , Guy Warnier
CPC分类号： C07K14/4748
摘要： The present invention relates to isolation of cytotoxic T lymphocyte (CTL) clones. In particular, the present invention relates to isolated CTL clones that are specific for proteins of the MAGE family. The CTL clones of the present invention have been isolated by successive steps of stimulation and testing of lymphocytes with antigen presenting cells which present antigens derived from different expression systems, e.g., from recombinant Yersinia, recombinant Salmonella, or recombinant viruses. The present invention further relates to antigenic peptides as well as the peptide/HLA complexes which are recognized by the isolated CTL clones.
摘要翻译： 本发明涉及细胞毒性T淋巴细胞（CTL）克隆的分离。 特别地，本发明涉及对MAGE家族的蛋白质特异的分离的CTL克隆。 本发明的CTL克隆已经通过连续的步骤来刺激和测试淋巴细胞来分离，所述抗原呈递细胞提供来自不同表达系统的抗原，例如来自重组耶尔森氏菌，重组沙门氏菌或重组病毒。 本发明还涉及被分离的CTL克隆识别的抗原肽以及肽/ HLA复合物。
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公开(公告)号：US06291430B1
公开(公告)日：2001-09-18
申请号：US09166448
申请日：1998-10-05
申请人： Pascal Chaux , Vincent Stroobant , Thierry Boon-Falleur , Pierre van der Bruggen , Kris Thielemans , Jurgen Kurthals
发明人： Pascal Chaux , Vincent Stroobant , Thierry Boon-Falleur , Pierre van der Bruggen , Kris Thielemans , Jurgen Kurthals
IPC分类号： A61K3804
CPC分类号： C07K14/4748 , A61K39/00 , C07K2319/00
摘要： The invention describes HLA class II binding peptides encoded by the MAGE-3 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the MAGE-3 gene.
摘要翻译： 本发明描述了由MAGE-3肿瘤相关基因编码的HLA II类结合肽，以及编码这样的肽和与之有关的抗体的核酸。 肽刺激CD4 + T淋巴细胞的活性和增殖。 还提供了用于诊断和治疗以MAGE-3基因表达为特征的病症的方法和产品。
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公开(公告)号：US20100184700A1
公开(公告)日：2010-07-22
申请号：US12664956
申请日：2008-06-19
IPC分类号： A61K38/08 , C07K7/06 , C07H21/04 , C12N5/0784 , A61P35/00
CPC分类号： C07K14/585 , A61K39/00 , A61K39/0011 , A61K2039/53
摘要： The present invention is related to Preprocalcitonin antigen T epitopes, presented by the Major Histocompatibility Complex I (MHC I). These peptides can be used in cancer immunotherapy.
摘要翻译： 本发明涉及由主要组织相容性复合体I（MHC I）呈递的降血糖原素抗原T表位。 这些肽可用于癌症免疫治疗。
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公开(公告)号：US06531451B1
公开(公告)日：2003-03-11
申请号：US09289350
申请日：1999-04-09
申请人： Pascal Chaux , Rosalie Luiten , Nathalie Demotte , Marie-Therese Duffour , Christophe Lurquin , Catia Traversari , Vincent Stroobant , Guy Cornelis , Thiery Boon-Falleur , Pierre van der Bruggen
发明人： Pascal Chaux , Rosalie Luiten , Nathalie Demotte , Marie-Therese Duffour , Christophe Lurquin , Catia Traversari , Vincent Stroobant , Guy Cornelis , Thiery Boon-Falleur , Pierre van der Bruggen
IPC分类号： A61K3800
CPC分类号： C07K14/4748
摘要： The present invention relates to isolation of cytotoxic T lymphocyte (CTL) clones. In particular, the present invention relates to isolated CTL clones that are specific for MAGE-1 and MAGE-4, respectively. The CTL clones of the present invention have been isolated by successive steps of stimulation and testing of lymphocytes with antigen presenting cells which present antigens derived from different expression systems, e.g., from recombinant Yersinia, recombinant Salmonella, or recombinant viruses. The present invention further relates to the MAGE-1 and MAGE-4 antigenic peptides as well as the peptide/HLA complexes which are recognized by the isolated CTL clones.
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公开(公告)号：US07311914B2
公开(公告)日：2007-12-25
申请号：US10218095
申请日：2002-08-13
IPC分类号： A61K39/00
CPC分类号： G01N33/57484 , G01N33/57407 , G01N33/6893
摘要： The invention provides antigenic peptides derived from MAGE polypeptides and presented by HLA-B37 molecules. Methods for diagnosis and treatment which involve the polypeptides also are provided.
摘要翻译： 本发明提供了衍生自MAGE多肽并由HLA-B37分子呈递的抗原肽。 还提供了涉及多肽的诊断和治疗方法。
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公开(公告)号：US07252825B2
公开(公告)日：2007-08-07
申请号：US10170832
申请日：2002-06-12
申请人： Pascal Chaux , Vincent Stroobant , Thierry Boon-Falleur , Pierre van der Bruggen , Kris Thielemans , Jurgen Kurthals
发明人： Pascal Chaux , Vincent Stroobant , Thierry Boon-Falleur , Pierre van der Bruggen , Kris Thielemans , Jurgen Kurthals
IPC分类号： A61K39/00
CPC分类号： C07K14/4748 , A61K39/00 , C07K2319/00
摘要： The invention describes HLA class II binding peptides encoded by the MAGE-3 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the MAGE-3 gene.
摘要翻译： 本发明描述了由MAGE-3肿瘤相关基因编码的HLA II类结合肽，以及编码这样的肽和与之有关的抗体的核酸。 肽刺激CD4 + T淋巴细胞的活性和增殖。 还提供了用于诊断和治疗以MAGE-3基因表达为特征的病症的方法和产品。
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公开(公告)号：US06716809B1
公开(公告)日：2004-04-06
申请号：US09396315
申请日：1999-09-15
申请人： Erwin Schultz , Pascal Chaux , Jacques van Snick , Bernard Lethe , Thierry Boon-Fallaur , Pierre van der Bruggan , Vincent Stroobant , Kris Thielemans , Jurgen Corthals , Carlo Heirman
发明人： Erwin Schultz , Pascal Chaux , Jacques van Snick , Bernard Lethe , Thierry Boon-Fallaur , Pierre van der Bruggan , Vincent Stroobant , Kris Thielemans , Jurgen Corthals , Carlo Heirman
IPC分类号： A61K3803
CPC分类号： C07K14/4748 , A61K39/00 , C07K2319/00
摘要： The invention describes HLA class II binding peptides encoded by the MAGE-A3 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the MAGE-A3 gene.
摘要翻译： 本发明描述了由MAGE-A3肿瘤相关基因编码的HLA II类结合肽，以及编码这样的肽和与之有关的抗体的核酸。 肽刺激CD4 + T淋巴细胞的活性和增殖。 还提供了用于诊断和治疗以MAGE-A3基因表达为特征的病症的方法和产品。
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