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公开(公告)号：US20150158929A1
公开(公告)日：2015-06-11
申请号：US14379192
申请日：2012-07-11
申请人： Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , Sheng Ding , Joshua Silverman , Chia-wei Wang , Benjamin Spink , Willem P. Stemmer , Nathan Geething , John Kulman , Tongyao Liu , Garabet G. Toby , Haiyan Jiang , Robert Peters , Deping Wang , Baisong Mei
发明人： Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , Sheng Ding , Joshua Silverman , Chia-wei Wang , Benjamin Spink , Willem P. Stemmer , Nathan Geething , John Kulman , Tongyao Liu , Garabet G. Toby , Haiyan Jiang , Robert Peters , Deping Wang , Baisong Mei
IPC分类号： C07K14/755
摘要： The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor VIII-related diseases, disorders, and conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的因子VIII凝血因子的组合物，编码组合物的分离的核酸和含有它们的载体和宿主细胞，以及制备和使用这些组合物治疗因子VIII相关的方法 疾病，病症和状况。
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公开(公告)号：US08957021B2
公开(公告)日：2015-02-17
申请号：US12796650
申请日：2010-06-08
申请人： Volker Schellenberger , Joshua Silverman , Willem P. Stemmer , Chia-wei Wang , Nathan Geething , Jeffrey L. Cleland
发明人： Volker Schellenberger , Joshua Silverman , Willem P. Stemmer , Chia-wei Wang , Nathan Geething , Jeffrey L. Cleland
IPC分类号： A61K38/00 , C07K19/00 , A61P3/10 , C07K14/605 , C07K14/575
CPC分类号： C07K14/605 , A23V2200/328 , A61K38/00 , C07K14/575 , C07K14/57563 , C07K2319/00 , C07K2319/31 , C07K2319/50 , C12N15/70 , C12P21/02 , Y10S514/866
摘要： The present invention relates to compositions comprising glucose regulating peptides linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of glucose regulating peptide-related diseases, disorders, and conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的葡萄糖调节肽的组合物，编码组合物的分离的核酸和含有该组合物的载体和宿主细胞，以及制备和使用该组合物治疗葡萄糖调节肽相关的方法 疾病，病症和状况。
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公开(公告)号：US20130039884A1
公开(公告)日：2013-02-14
申请号：US13469902
申请日：2012-05-11
申请人： Oren Bogin , Willem P. Stemmer , Volker Schellenberger , Yong Yin , Chia-wei Wang , Nathan C. Geething
发明人： Oren Bogin , Willem P. Stemmer , Volker Schellenberger , Yong Yin , Chia-wei Wang , Nathan C. Geething
IPC分类号： A61K39/395
CPC分类号： C07K16/30 , A61K38/00 , C07K14/00 , C07K14/535 , C07K14/56 , C07K14/61 , C07K16/2863 , C07K16/32 , C07K16/40 , C07K2317/22 , C07K2317/55 , C07K2317/569 , C07K2317/622 , C07K2317/626 , C07K2319/00 , C07K2319/33
摘要： The present invention relates to biologically active polypeptides linked to one or more accessory polypeptides. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous entities, as well as host cells comprising the vectors. The subject compositions have a variety of utilities including a range of pharmaceutical applications.
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4.发明申请BIOLOGICALLY ACTIVE PROTEINS HAVING INCREASED IN VIVO AND/OR IN VITRO STABILITY 审中-公开生物活性蛋白在体内和/或体内稳定性增加公开(公告)号：US20120230947A1
公开(公告)日：2012-09-13
申请号：US13439738
申请日：2012-04-04
申请人： VOLKER SCHELLENBERGER , WILLEM P. STEMMER , CHIA-WEI WANG , MICHAEL D. SCHOLLE , MIKHAIL POPKOV , NATHANIEL C. GORDON , ANDREAS CRAMERI
发明人： VOLKER SCHELLENBERGER , WILLEM P. STEMMER , CHIA-WEI WANG , MICHAEL D. SCHOLLE , MIKHAIL POPKOV , NATHANIEL C. GORDON , ANDREAS CRAMERI
IPC分类号： A61K38/16 , C12N9/00 , A61K39/395 , A61K38/19 , A61K38/18 , A61K38/43 , A61K38/22 , A61K38/21 , A61K38/37 , A61K38/20 , C12N15/62 , C12N15/63 , C12P21/00 , C12N5/10 , C12N1/21 , C12N1/19 , A61P5/00 , A61P37/06 , A61P35/00 , A61P7/06 , A61P9/00 , A61P31/00 , A61P29/00 , A61P7/02 , A61P9/10 , A61P3/10 , A61P13/12 , C07K19/00
CPC分类号： C07K14/56 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/001 , C07K14/415 , C07K14/47 , C07K14/53 , C07K14/535 , C07K14/61 , C07K2319/31 , C07K2319/35 , C12N15/1044 , G01N33/6845
摘要： The present invention provides unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related proteinaceous entities, as well as genetic packages displaying these entities. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous entities, as well as host cells comprising the vectors. The subject compositions have a variety of utilities including a range of pharmaceutical applications.
摘要翻译： 本发明提供非结构化重组聚合物（URP）和含有一种或多种URP的蛋白质。 本发明还提供微蛋白，毒素和其它相关的蛋白质实体，以及显示这些实体的遗传包。 本发明还提供重组多肽，包括编码受试蛋白质实体的载体，以及包含载体的宿主细胞。 主题组合物具有各种实用性，包括一系列药物应用。
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5.发明申请BIFUNCTIONAL POLYPEPTIDE COMPOSITIONS AND METHODS FOR TREATMENT OF METABOLIC AND CARDIOVASCULAR DISEASES 审中-公开双功能多肽组合物和治疗代谢性和心脏血管疾病的方法公开(公告)号：US20110312881A1
公开(公告)日：2011-12-22
申请号：US12975054
申请日：2010-12-21
IPC分类号： A61K38/16 , C12N1/19 , C12N1/21 , C12N1/15 , C12N15/63 , C07H21/04 , A61P5/50 , A61P3/10 , A61P9/00 , A61P25/28 , C07K14/00 , C12N5/10 , A61P3/04
CPC分类号： C07K19/00 , C07K2319/00
摘要： The present invention relates to compositions comprising combinations of biologically active proteins linked to extended recombinant polymer, methods of production of the compositions and their use in treatment of metabolic and cardiovascular diseases, disorders and conditions.
摘要翻译： 本发明涉及包含与延伸的重组聚合物连接的生物活性蛋白质的组合的组合物，组合物的生产方法及其在治疗代谢和心血管疾病，病症和病症中的用途。
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6.发明授权公开(公告)号：US07846445B2
公开(公告)日：2010-12-07
申请号：US11715296
申请日：2007-03-06
申请人： Volker Schellenberger , Willem P. Stemmer , Chia-wei Wang , Michael D. Scholle , Mikhail Popkov , Nathaniel C. Gordon , Andreas Crameri
发明人： Volker Schellenberger , Willem P. Stemmer , Chia-wei Wang , Michael D. Scholle , Mikhail Popkov , Nathaniel C. Gordon , Andreas Crameri
CPC分类号： C07K14/415 , A61K38/00 , C07K14/001 , C07K14/475 , C07K2319/21 , C07K2319/43 , C12N15/1044 , C12N2795/14011 , G01N33/68 , G01N33/6845
摘要： The present invention provides methods of using unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related proteinaceous entities, as well as genetic packages displaying these entities, and the uses thereof. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous entities, as well as host cells comprising the vectors. The subject compositions have a variety of utilities including a range of pharmaceutical applications.
摘要翻译： 本发明提供了使用非结构化重组聚合物（URP）和含有一种或多种URP的蛋白质的方法。 本发明还提供微蛋白，毒素和其它相关的蛋白质实体，以及显示这些实体的遗传包装及其用途。 本发明还提供重组多肽，包括编码受试蛋白质实体的载体，以及包含载体的宿主细胞。 主题组合物具有各种实用性，包括一系列药物应用。
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公开(公告)号：US20110172146A1
公开(公告)日：2011-07-14
申请号：US12848984
申请日：2010-08-02
CPC分类号： C07K14/001 , C07K14/61 , C07K2319/00 , C07K2319/31 , C07K2319/75
摘要： The present invention relates to compositions comprising growth hormone linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in administration to animals.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的生长激素，编码组合物的分离的核酸和载体的组合物和含有其的宿主细胞的组合物，以及在给予动物时制备和使用这些组合物的方法。
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公开(公告)号：US20110171687A1
公开(公告)日：2011-07-14
申请号：US12939120
申请日：2010-11-03
申请人： Volker Schellenberger , Willem P. Stemmer , Chia-wei Wang , Michael D. Scholle , Mikhail Popkov , Nathaniel C. Gordon , Andreas Crameri
发明人： Volker Schellenberger , Willem P. Stemmer , Chia-wei Wang , Michael D. Scholle , Mikhail Popkov , Nathaniel C. Gordon , Andreas Crameri
CPC分类号： C07K14/56 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/001 , C07K14/415 , C07K14/47 , C07K14/53 , C07K14/535 , C07K14/61 , C07K2319/31 , C07K2319/35 , C12N15/1044 , G01N33/6845
摘要： The present invention provides unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related proteinaceous entities, as well as genetic packages displaying these entities. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous entities, as well as host cells comprising the vectors. The subject compositions have a variety of utilities including a range of pharmaceutical applications.
摘要翻译： 本发明提供非结构化重组聚合物（URP）和含有一种或多种URP的蛋白质。 本发明还提供微蛋白，毒素和其它相关的蛋白质实体，以及显示这些实体的遗传包。 本发明还提供重组多肽，包括编码受试蛋白质实体的载体，以及包含载体的宿主细胞。 主题组合物具有各种实用性，包括一系列药物应用。
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公开(公告)号：US20100323956A1
公开(公告)日：2010-12-23
申请号：US12796650
申请日：2010-06-08
IPC分类号： A61K38/26 , C07K19/00 , C07K14/605 , A61K38/16 , C12P21/02 , C07H21/00 , C12N15/63 , C12N1/00 , A61P3/10 , A61P3/08 , A61P11/00 , A61P13/12 , A61P19/02 , A61P19/10 , A61P25/00 , A61P25/28 , A61P9/04 , A61P1/16 , A61P1/00 , A61P13/00 , A61P9/00 , A61P43/00
CPC分类号： C07K14/605 , A23V2200/328 , A61K38/00 , C07K14/575 , C07K14/57563 , C07K2319/00 , C07K2319/31 , C07K2319/50 , C12N15/70 , C12P21/02 , Y10S514/866
摘要： The present invention relates to compositions comprising glucose regulating peptides linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of glucose regulating peptide-related diseases, disorders, and conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的葡萄糖调节肽的组合物，编码组合物的分离的核酸和含有该组合物的载体和宿主细胞，以及制备和使用该组合物治疗葡萄糖调节肽相关的方法 疾病，病症和状况。
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10.发明申请COMPOSITIONS AND METHODS FOR IMPROVING PRODUCTION OF RECOMBINANT POLYPEPTIDES 审中-公开用于改善重组多糖生产的组合物和方法公开(公告)号：US20100260706A1
公开(公告)日：2010-10-14
申请号：US12646566
申请日：2009-12-23
申请人： Oren Bogin , Willem P. Stemmer , Volker Schellenberger , Yong Yin , Chia-wei Wang , Nathan C. Geething
发明人： Oren Bogin , Willem P. Stemmer , Volker Schellenberger , Yong Yin , Chia-wei Wang , Nathan C. Geething
IPC分类号： A61K39/395 , C07K14/00 , C07K14/575 , C07K16/00 , C12N9/00 , C07K14/54 , C07K14/56 , C07K14/565 , C07K14/57 , C07K14/505 , C07K14/745 , A61K38/22 , A61K38/16 , A61K38/36 , A61P3/10 , A61P9/10 , A61P7/02 , A61P31/00 , A61P7/06 , A61K38/43 , A61P35/00 , A61K38/20 , A61K38/21 , A61P13/12 , A61P29/00 , A61K38/18 , C07H21/04 , C12N15/63 , C12N5/10 , C12P21/00
CPC分类号： C07K16/30 , A61K38/00 , C07K14/00 , C07K14/535 , C07K14/56 , C07K14/61 , C07K16/2863 , C07K16/32 , C07K16/40 , C07K2317/22 , C07K2317/55 , C07K2317/569 , C07K2317/622 , C07K2317/626 , C07K2319/00 , C07K2319/33
摘要： The present invention relates to biologically active polypeptides linked to one or more accessory polypeptides. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous entities, as well as host cells comprising the vectors. The subject compositions have a variety of utilities including a range of pharmaceutical applications.
摘要翻译： 本发明涉及与一种或多种辅助多肽连接的生物活性多肽。 本发明还提供重组多肽，包括编码受试蛋白质实体的载体，以及包含载体的宿主细胞。 主题组合物具有各种实用性，包括一系列药物应用。
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