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    Methods of generating novel peptides
    2.
    发明授权
    Methods of generating novel peptides 失效
    产生新肽的方法

    公开(公告)号：US6031071A

    公开(公告)日：2000-02-29

    申请号：US590897

    申请日：1996-01-24

    申请人： Rosemonde Mandeville ,  Mikhail Popkov

    发明人： Rosemonde Mandeville ,  Mikhail Popkov

    IPC分类号： A61K38/00 ,  C07K7/06 ,  C07K7/08 ,  C12N15/10 ,  C40B40/02 ,  A61K38/04 ,  C12N15/00

    CPC分类号： C40B40/02 ,  C07K7/06 ,  C07K7/08 ,  C12N15/1037 ,  A61K38/00

    摘要： The present invention describes peptides capable of specifically binding to preselected micromolecules or to their natural receptor. The preselected molecules include but are not limited to drugs, vitamins, neuromediators and steroid hormones. Methods of using the phage display libraries to identify peptide compositions in preselected binding interactions are also disclosed. The retrieved peptides mimicking a natural receptor binding site to preselected molecules are used as is or as ligands to re-screen the same or different libraries to find and/or derive new receptor ligands, or are used to elicit the production of antibodies capable of binding to the natural receptor. The two categories of effector molecules (peptides or antibodies) may find diagnostic, therapeutic or prophylactic uses. The peptides directly derived from the phage display libraries may be used as drug detectors or antidotes. The others may be used to identify, target, activate or neutralize the receptor for the preselected micromolecules, the receptor being known or unknown.

    摘要翻译： 本发明描述能够特异性结合预选的小分子或其天然受体的肽。 预选的分子包括但不限于药物，维生素，神经调节剂和类固醇激素。 还公开了使用噬菌体展示文库来鉴定预选结合相互作用中的肽组合物的方法。 模仿天然受体结合位点到预选分子的检索的肽直接使用或作为配体重新筛选相同或不同的文库以发现和/或衍生新的受体配体，或用于引发能够结合的抗体的产生 到天然受体。 两类效应分子（肽或抗体）可能会发现诊断，治疗或预防用途。 直接衍生自噬菌体展示文库的肽可以用作药物检测器或解毒剂。 其他可用于鉴定，靶向，激活或中和预选小分子的受体，该受体是已知或未知的。