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公开(公告)号：US20160137711A1
公开(公告)日：2016-05-19
申请号：US14343111
申请日：2012-09-12
申请人： Volker Schellenberger , Joshua Silverman , Willem P. Stemmer , Chia-Wei Wang , Nathan Geething , Benjamin Spink
发明人： Volker Schellenberger , Joshua Silverman , Willem P. Stemmer , Chia-Wei Wang , Nathan Geething , Benjamin Spink
IPC分类号： C07K14/605
CPC分类号： C07K14/605 , A61K38/00 , C07K2319/31
摘要： The present invention relates to compositions comprising GLP-2 protein or variants thereof linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in the treatment of GLP-2-related conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的GLP-2蛋白或其变体的组合物，编码组合物的分离的核酸和含有该组合物的载体和宿主细胞，以及制备和使用该组合物治疗 GLP-2相关条件。
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2.发明授权Growth hormone polypeptides fused to extended recombinant polypeptides and methods of making and using same 有权与扩展的重组多肽融合的生长激素多肽及其制备和使用方法公开(公告)号：US08680050B2
公开(公告)日：2014-03-25
申请号：US12848984
申请日：2010-08-02
申请人： Volker Schellenberger , Joshua Silverman , Willem P. Stemmer , Chia-Wei Wang , Nathan Geething , Jeffrey L. Cleland
发明人： Volker Schellenberger , Joshua Silverman , Willem P. Stemmer , Chia-Wei Wang , Nathan Geething , Jeffrey L. Cleland
CPC分类号： C07K14/001 , C07K14/61 , C07K2319/00 , C07K2319/31 , C07K2319/75
摘要： The present invention relates to compositions comprising growth hormone linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in administration to animals.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的生长激素，编码组合物的分离的核酸和载体的组合物和含有其的宿主细胞的组合物，以及在给予动物时制备和使用这些组合物的方法。
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公开(公告)号：US20110172146A1
公开(公告)日：2011-07-14
申请号：US12848984
申请日：2010-08-02
CPC分类号： C07K14/001 , C07K14/61 , C07K2319/00 , C07K2319/31 , C07K2319/75
摘要： The present invention relates to compositions comprising growth hormone linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in administration to animals.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的生长激素，编码组合物的分离的核酸和载体的组合物和含有其的宿主细胞的组合物，以及在给予动物时制备和使用这些组合物的方法。
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4.发明申请公开(公告)号：US20110288005A1
公开(公告)日：2011-11-24
申请号：US13078499
申请日：2011-04-01
CPC分类号： C12P21/02 , A61K38/00 , C07K14/00 , C07K14/70521 , C07K14/7155 , C07K14/8125 , C07K16/18 , C07K16/241 , C07K16/244 , C07K16/2809 , C07K16/2863 , C07K16/2878 , C07K16/32 , C07K16/40 , C07K2317/31 , C07K2317/569 , C07K2317/622 , C07K2317/92 , C07K2317/94 , C07K2319/31 , C07K2319/70 , C07K2319/74 , C12N15/625
摘要： The present invention relates to compositions comprising alpha 1-antitrypsin linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in the treatment of alpha 1-antitrypsin-related diseases, disorders, and conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的α1-抗胰蛋白酶的组合物，编码组合物的分离的核酸和含有该组合物的载体和宿主细胞，以及制备和使用这些组合物治疗α1- 抗胰蛋白酶相关疾病，病症和病症。
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5.发明授权公开(公告)号：US08557961B2
公开(公告)日：2013-10-15
申请号：US13078499
申请日：2011-04-01
CPC分类号： C12P21/02 , A61K38/00 , C07K14/00 , C07K14/70521 , C07K14/7155 , C07K14/8125 , C07K16/18 , C07K16/241 , C07K16/244 , C07K16/2809 , C07K16/2863 , C07K16/2878 , C07K16/32 , C07K16/40 , C07K2317/31 , C07K2317/569 , C07K2317/622 , C07K2317/92 , C07K2317/94 , C07K2319/31 , C07K2319/70 , C07K2319/74 , C12N15/625
摘要： The present invention relates to compositions comprising alpha 1-antitrypsin linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in the treatment of alpha 1-antitrypsin-related diseases, disorders, and conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的α1-抗胰蛋白酶的组合物，编码组合物的分离的核酸和含有该组合物的载体和宿主细胞，以及制备和使用这些组合物治疗α1- 抗胰蛋白酶相关疾病，病症和病症。
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公开(公告)号：US20120178691A1
公开(公告)日：2012-07-12
申请号：US13423031
申请日：2012-03-16
申请人： Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , Joshua Silverman , Chia-Wei Wang , Benjamin Spink , Nathan Geething
发明人： Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , Joshua Silverman , Chia-Wei Wang , Benjamin Spink , Nathan Geething
IPC分类号： A61K38/37 , C12N15/62 , C12N15/63 , A61P7/04 , C12N1/19 , C12N1/15 , C12N1/21 , C07K19/00 , C12N5/10
CPC分类号： C07K14/755 , A61K38/00 , C07K14/001 , C07K2319/00 , C07K2319/21 , C07K2319/31 , C07K2319/41 , C07K2319/50 , C07K2319/95
摘要： The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor VIII-related diseases, disorders, and conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的因子VIII凝血因子的组合物，编码组合物的分离的核酸和含有它们的载体和宿主细胞，以及制备和使用这些组合物治疗因子VIII相关的方法 疾病，病症和状况。
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公开(公告)号：US20130017997A1
公开(公告)日：2013-01-17
申请号：US13365166
申请日：2012-02-02
申请人： Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , John Kulman , Tongyao Liu , Garabet G. Toby , Haiyan Jiang , Robert Peters , Deping Wang , Baisong Mei , Joshua Silverman , Chia-Wei Wang , Benjamin Spink , Nathan Geething
发明人： Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , John Kulman , Tongyao Liu , Garabet G. Toby , Haiyan Jiang , Robert Peters , Deping Wang , Baisong Mei , Joshua Silverman , Chia-Wei Wang , Benjamin Spink , Nathan Geething
CPC分类号： C07K14/755 , A61K38/00 , C07K14/001 , C07K2319/00 , C07K2319/21 , C07K2319/31 , C07K2319/41 , C07K2319/50 , C07K2319/95
摘要： The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor VIII-related diseases, disorders, and conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的因子VIII凝血因子的组合物，编码组合物的分离的核酸和含有它们的载体和宿主细胞，以及制备和使用这些组合物治疗因子VIII相关的方法 疾病，病症和状况。
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公开(公告)号：US08492530B2
公开(公告)日：2013-07-23
申请号：US12939120
申请日：2010-11-03
申请人： Volker Schellenberger , Willem P. Stemmer , Chia-Wei Wang , Michael D. Scholle , Mikhail Popkov , Nathaniel C. Gordon , Andreas Crameri
发明人： Volker Schellenberger , Willem P. Stemmer , Chia-Wei Wang , Michael D. Scholle , Mikhail Popkov , Nathaniel C. Gordon , Andreas Crameri
CPC分类号： C07K14/56 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/001 , C07K14/415 , C07K14/47 , C07K14/53 , C07K14/535 , C07K14/61 , C07K2319/31 , C07K2319/35 , C12N15/1044 , G01N33/6845
摘要： The present invention provides unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related proteinaceous entities, as well as genetic packages displaying these entities. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous entities, as well as host cells comprising the vectors. The subject compositions have a variety of utilities including a range of pharmaceutical applications.
摘要翻译： 本发明提供非结构化重组聚合物（URP）和含有一种或多种URP的蛋白质。 本发明还提供微蛋白，毒素和其它相关的蛋白质实体，以及显示这些实体的遗传包。 本发明还提供重组多肽，包括编码受试蛋白质实体的载体，以及包含载体的宿主细胞。 主题组合物具有各种实用性，包括一系列药物应用。
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9.发明申请METHODS FOR PRODUCTION OF UNSTRUCTURED RECOMBINANT POLYMERS AND USES THEREOF 审中-公开生产未经改造的重组聚合物的方法及其用途公开(公告)号：US20110151433A1
公开(公告)日：2011-06-23
申请号：US12939129
申请日：2010-11-03
申请人： Volker Schellenberger , Willem P. Stemmer , Chia-Wei Wang , Michael D. Scholle , Mikhail Popkov , Nathaniel C. Gordon , Andreas Crameri
发明人： Volker Schellenberger , Willem P. Stemmer , Chia-Wei Wang , Michael D. Scholle , Mikhail Popkov , Nathaniel C. Gordon , Andreas Crameri
CPC分类号： C07K14/415 , A61K38/00 , C07K14/001 , C07K14/475 , C07K2319/21 , C07K2319/43 , C12N15/1044 , C12N2795/14011 , G01N33/68 , G01N33/6845
摘要： The present invention provides unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related proteinaceous entities, as well as genetic packages displaying these entities. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous entities, as well as host cells comprising the vectors. The subject compositions have a variety of utilities including a range of pharmaceutical applications.
摘要翻译： 本发明提供非结构化重组聚合物（URP）和含有一种或多种URP的蛋白质。 本发明还提供微蛋白，毒素和其它相关的蛋白质实体，以及显示这些实体的遗传包。 本发明还提供重组多肽，包括编码受试蛋白质实体的载体，以及包含载体的宿主细胞。 主题组合物具有各种实用性，包括一系列药物应用。
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公开(公告)号：US09666895B2
公开(公告)日：2017-05-30
申请号：US13086825
申请日：2011-04-14
申请人： Chia-Wei Wang , Fabio Albano , Ann Marie Sastry
发明人： Chia-Wei Wang , Fabio Albano , Ann Marie Sastry
IPC分类号： H01M10/052 , H01M10/04 , H01M10/058 , H01M4/131 , H01M4/139 , H01M4/1395 , H01M4/134 , H01M4/1391 , H01M4/02
CPC分类号： H01M10/052 , H01M4/131 , H01M4/134 , H01M4/139 , H01M4/1391 , H01M4/1395 , H01M10/04 , H01M10/058 , H01M2004/021 , Y02T10/7011
摘要： A method for manufacturing an electrochemical cell. The method includes generating spatial information including an anode geometry, a cathode geometry, a separator geometry, and one or more current collector geometries. The method also includes storing the spatial information including the anode geometry, the cathode geometry, the separator geometry, and the one or more current collector geometries into a database structure. In a specific embodiment, the method includes selecting one or more material properties from a plurality of materials and using the one or more material properties with the spatial information in a simulation program. The method includes outputting one or more performance parameters from the simulation program.
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