-
1.发明申请公开(公告)号：US20130217113A1
公开(公告)日：2013-08-22
申请号：US13809762
申请日：2011-07-12
申请人： Vijay Srinivasan , William Craig Bauer , Gregory F. Smith , Ryan A. Sturmer , Zhishan Hua , Allen E. Eckhardt
发明人： Vijay Srinivasan , William Craig Bauer , Gregory F. Smith , Ryan A. Sturmer , Zhishan Hua , Allen E. Eckhardt
IPC分类号： C12M1/42
CPC分类号： C12M1/42 , B01L3/502792 , B01L2200/0647 , B01L2300/0672 , B01L2400/0427 , B01L2400/0439 , B01L2400/088 , C12M47/06 , C12N1/066 , C12N13/00
摘要： The invention relates to a droplet actuator for conducting droplet operations. The actuator includes a bottom substrate and a top substrate separated from the bottom substrate to form a gap. An arrangement of droplet operations electrodes may be located on a surface of the bottom substrate and/or top substrate. Optionally, a sample reservoir may hold a quantity of a sample fluid containing cells. A disruption device which can take various forms is used to lyse the cells in the sample or in a sample droplet to thereby conduct operations on samples having lysed cells therein.
摘要翻译： 本发明涉及一种用于进行液滴操作的液滴致动器。 致动器包括底部基板和与底部基板分离以形成间隙的顶部基板。 液滴操作电极的布置可以位于底部基板和/或顶部基板的表面上。 任选地，样品储存器可以容纳一定量的含有细胞的样品流体。 可以采用各种形式的破坏装置来裂解样品或样品液滴中的细胞，从而对其中具有裂解细胞的样品进行操作。
-
公开(公告)号：US09248450B2
公开(公告)日：2016-02-02
申请号：US13638324
申请日：2011-03-30
申请人： William Craig Bauer
发明人： William Craig Bauer
CPC分类号： G01N27/44734 , B01F13/0071 , B01F13/0076 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L3/502784 , B01L7/525 , B01L7/54 , B01L2200/027 , B01L2200/06 , B01L2200/0668 , B01L2200/10 , B01L2200/16 , B01L2300/0887 , B01L2300/12 , B01L2300/18 , B01L2300/1805 , B01L2300/1827 , B01L2400/0427 , B01L2400/043 , B01L2400/0677 , B01L2400/0683 , G01N27/44791
摘要： The invention relates to a droplet actuator device and methods for integrated sample preparation and analysis of a biological sample. A droplet actuator device is provided for conducting droplet operations. The droplet actuator device may include a bottom substrate and a top substrate separated from each other to form a gap therebetween; an arrangement of droplet operations electrodes arranged on one or both of the bottom and/or top substrates for conducting droplet operations thereon; a reagent storage layer comprising one or more compartments bound to the top substrate; and one or more openings arranged to provide a fluidic path from the one or more compartments into the gap, upon breach of a breachable seal separating the one or more compartments and openings.
摘要翻译： 本发明涉及液滴致动器装置以及用于生物样品的综合样品制备和分析的方法。 提供液滴致动器装置用于进行液滴操作。 液滴致动器装置可以包括彼此分离的底部基板和顶部基板，以在它们之间形成间隙; 布置在底部和/或顶部衬底中的一个或两个上的液滴操作电极的布置，用于在其上进行液滴操作; 试剂储存层，包含一个或多个结合到顶部基底的隔室; 以及一个或多个开口，其布置成在违反分离所述一个或多个隔室和开口的可破裂密封件时提供从所述一个或多个隔室进入所述间隙的流体路径。
-
公开(公告)号：US09446404B2
公开(公告)日：2016-09-20
申请号：US14234855
申请日：2012-07-25
CPC分类号： B01L3/502715 , B01L3/502792 , B01L2200/025 , B01L2200/04 , B01L2300/0816 , B01L2300/089 , B01L2400/0427 , B01L2400/043 , B23P11/02 , Y10T29/49945
摘要： Droplet actuator apparatus and system are provided. An apparatus comprises: a microfluidics system having an insertion slot for insertion of a droplet actuator; a bottom plate against which the droplet actuator would slide when inserting the droplet actuator into the insertion slot; and means for forcing a substrate in the droplet actuator parallel to the bottom plate, wherein warpage in the substrate is corrected.
摘要翻译： 提供液滴致动器装置和系统。 一种装置包括：具有用于插入液滴致动器的插入口的微流体系统; 当将液滴致动器插入插槽时液滴致动器将滑动的底板; 以及用于强制平行于底板的液滴致动器中的基板的装置，其中校正基板中的翘曲。
-
公开(公告)号：US20130217103A1
公开(公告)日：2013-08-22
申请号：US13638324
申请日：2011-03-30
申请人： William Craig Bauer
发明人： William Craig Bauer
IPC分类号： B01L7/00
CPC分类号： G01N27/44734 , B01F13/0071 , B01F13/0076 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L3/502784 , B01L7/525 , B01L7/54 , B01L2200/027 , B01L2200/06 , B01L2200/0668 , B01L2200/10 , B01L2200/16 , B01L2300/0887 , B01L2300/12 , B01L2300/18 , B01L2300/1805 , B01L2300/1827 , B01L2400/0427 , B01L2400/043 , B01L2400/0677 , B01L2400/0683 , G01N27/44791
摘要： The invention relates to a droplet actuator device and methods for integrated sample preparation and analysis of a biological sample. A droplet actuator device is provided for conducting droplet operations. The droplet actuator device may include a bottom substrate and a top substrate separated from each other to form a gap therebetween; an arrangement of droplet operations electrodes arranged on one or both of the bottom and/or top substrates for conducting droplet operations thereon; a reagent storage layer comprising one or more compartments bound to the top substrate; and one or more openings arranged to provide a fluidic path from the one or more compartments into the gap, upon breach of a breachable seal separating the one or more compartments and openings.
摘要翻译： 本发明涉及一种液滴致动器装置和用于生物样品的综合样品制备和分析的方法。 提供液滴致动器装置用于进行液滴操作。 液滴致动器装置可以包括彼此分离的底部基板和顶部基板，以在它们之间形成间隙; 布置在底部和/或顶部衬底中的一个或两个上的液滴操作电极的布置，用于在其上进行液滴操作; 试剂储存层，包含一个或多个结合到顶部基底的隔室; 以及一个或多个开口，其布置成在违反分离所述一个或多个隔室和开口的可破裂密封件时提供从所述一个或多个隔室进入所述间隙的流体路径。
-
-
-
搜索结果
4 条记录 (耗时 0.017 秒)
