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公开(公告)号：US10064802B2
公开(公告)日：2018-09-04
申请号：US14917431
申请日：2014-09-10
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Yizhong Wang , Joel D. Oxman , Paul R. Klaiber , Jie J. Liu , Joanne A. Fitch , Tiffany T. Ton , Reinhold Hecht
Abstract: An oral composition and a method of delivering an oral composition to a dental structure are described. The oral composition can include a solvent; an acidic copolymer having acidic acrylate monomeric units, acidic methacrylate monomeric units, or a combination thereof; a neutral copolymer having neutral acrylate monomeric units, neutral methacrylate monomeric units, or a combination thereof; and optionally an active agent. The acidic and neutral copolymers can be dissolved in the oral composition and the oral composition can form a film on a surface when contacted with an aqueous solution.
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2.发明申请METHOD OF MAKING AGGLOMERATED MICROBIOLOGICAL MEDIA AND COMPOSITIONS THEREOF 审中-公开制备聚集微生物培养基的方法及其组合物公开(公告)号：US20150225691A1
公开(公告)日：2015-08-13
申请号：US14419483
申请日：2013-07-22
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Jie J. Liu , Wensheng Xia
IPC: C12N1/20
CPC classification number: C12N1/20
Abstract: A method of making a flowable, agglomerated nutrient medium is provided. The method comprises forming a nutrient medium composition by placing a powdered nutrient into a fluidized bed-type agglomeration chamber, flowing a fluidizing gas through the chamber, and contacting in the agglomeration chamber the powdered nutrient with an aerosol spray of an agglomeration liquid; and collecting the composition from the chamber. The nutrient component facilitates the growth of a microorganism. The composition formed by the method comprises a population of agglomerated nutrient medium particles and, optionally, nonagglomerated powdered nutrient. The population comprises at least about 30 weight percent agglomerated nutrient particles having an effective particle diameter of about 250-400 microns. Compositions, thin film culture devices, and kits comprising the flowable, dried agglomerated nutrient medium are also provided.
Abstract translation: 提供了制备可流动的附聚营养培养基的方法。 所述方法包括通过将粉状营养物放入流化床型附聚室中形成营养培养基组合物，使流化气体流过所述室，并使所述粉末状营养物与附聚液体的气溶胶喷雾接触; 并从室收集组合物。 营养成分促进微生物的生长。 通过该方法形成的组合物包含聚集的营养培养基颗粒群和任选的非团聚的粉状营养物质。 群体包含至少约30重量％的有效粒径为约250-400微米的附聚营养颗粒。 还提供了组合物，薄膜培养装置和包含可流动，干燥的附聚营养培养基的试剂盒。
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公开(公告)号：US12102499B2
公开(公告)日：2024-10-01
申请号：US17247244
申请日：2019-06-04
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Randilynn B. Christensen , Kenton D. Budd , Afshin Falsafi , Mahmut Aksit , Jana Ninkovic , Jie J. Liu , Mark B. Agre , Masayuki Nakamura , Jason W. Bjork , Bradley D. Craig , Richard P. Rusin , Paul J. Homnick , Joel D. Oxman , Yizhong Wang , Paul R. Klaiber , Bill H. Dodge
Abstract: A method of applying a two-part dental sealant is described comprising providing a syringe device (1) comprising a cartridge (10) including first and second chamber. The first chamber contains a first part of a dental sealant comprising a (meth)acrylate resin and an oxidizing curing agent. The second chamber contains a second part of a dental sealant comprising a (meth)acrylate resin and a reducing curing agent that reacts with the oxidizing curing agent of the first chamber. The first and/or second part of the dental sealant further comprise a single component or multiple components that neutralize acid and promote remineralization. The syringe device comprises a dispensing nozzle (17) comprising a static mixer and an outlet at one end of the cartridge and a plunger (20) at the opposing end of the cartridge. Also described is a kit for storing and applying the dental sealant is described.
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公开(公告)号：US11318005B2
公开(公告)日：2022-05-03
申请号：US17270879
申请日：2019-08-27
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Yizhong Wang , Jie J. Liu , Richard P. Rusin , Melinda B. Gustafson , Ingo Haeberlein , Carola A. Carrera Vidal
Abstract: An aqueous oral care solution, a kit that includes such solution, a method of making such solution, a method of using such solution (e.g., a method of providing fluoride to a patient's tooth surface), and a tooth surface having a coating derived from the aqueous oral care solution, wherein the oral care solution includes: silver cations; thiocyanatc anions provided by a thiocyanatc source comprising Ca(SCN)2; fluoride anions; and water; wherein the molar ratio of silver to thiocyanatc ions is up to 0.40:1, and water is up to 57 wt-%, based on the total weight of the solution.
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公开(公告)号：US20210228315A1
公开(公告)日：2021-07-29
申请号：US15734357
申请日：2019-06-05
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Randilynn B. Christensen , Kenton D. Budd , Afshin Falsafi , Mahmut Aksit , Jana Ninkovic , Jie J. Liu , Mark B. Agre , Masayuki Nakamura , Jason W. Bjork , Bradley D. Craig , Richard P. Rusin , Paul J. Homnick , Joel D. Oxman , Yizhong Wang , Paul R. Klaiber
IPC: A61C5/64 , A61C5/68 , A61K6/818 , A61K6/853 , A61K6/876 , A61K6/851 , A61K6/17 , A61K6/62 , A61K6/61 , A61K6/71 , A61K6/887
Abstract: A hardenable (e.g. dental) compositions is described comprising an encapsulated material. The encapsulated material comprises a basic core material and an inorganic shell material having certain viscosity criteria. Also described are dispensing devices and kits are described comprising a hardenable (e.g. dental) composition comprising a liquid material and an encapsulated material wherein the encapsulated material comprises a basic core material and an inorganic shell material comprising a metal oxide surrounding the core. The dispensing devices and kits can facilitate the methods of applying the hardenable composition. The hardenable or hardened (e.g. cured) composition can provide various technical effects such as a delayed release of a basic core material, a delayed increase in basicity, promoting remineralization of a tooth or bone structure, and increasing the average alkaline phosphatase (ALP) activity of pulp cells. In some embodiments, the composition is a dental (e.g. sealant) composition to a tooth structure.
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Patent Agency Ranking
公开(公告)号：US20210177563A1
公开(公告)日：2021-06-17
申请号：US17270879
申请日：2019-08-27
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Yizhong Wang , Jie J. Liu , Richard P. Rusin , Melinda B. Gustafson , Ingo Haeberlein , Carola A. Carrera Vidal
Abstract: An aqueous oral care solution, a kit that includes such solution, a method of making such solution, a method of using such solution (e.g., a method of providing fluoride to a patient's tooth surface), and a tooth surface having a coating derived from the aqueous oral care solution, wherein the oral care solution includes: silver cations; thiocyanatc anions provided by a thiocyanatc source comprising Ca(SCN)2; fluoride anions; and water; wherein the molar ratio of silver to thiocyanatc ions is up to 0.40:1, and water is up to 57 wt-%, based on the total weight of the solution.
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公开(公告)号：US10378041B2
公开(公告)日：2019-08-13
申请号：US15002696
申请日：2016-01-21
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Wensheng Xia , Patrick A. Mach , Joseph M. Beaurline , Jason W. Bjork , Jie J. Liu
Abstract: A latent effervescent body comprising a selective agent is disclosed. A method of using the latent effervescent body in a method to selectively enrich a target microorganism is also disclosed. The method comprises providing a sample, a culture medium, and the latent effervescent body. The method further comprises contacting the sample, the culture medium, and the latent effervescent body under conditions to facilitate growth of the target microorganism. The method further comprises releasing the selective agent from the latent effervescent body. Optionally, the method includes detecting a microorganism.
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公开(公告)号：US20150191692A1
公开(公告)日：2015-07-09
申请号：US14415744
申请日：2013-07-22
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Jie J. Liu , Wensheng Xia
CPC classification number: C12N1/20 , C12N1/14 , C12N1/16 , C12N2500/46 , C12N2500/60
Abstract: A method of making a flowable, dried agglomerated nutrient medium is provided. The method comprises introducing a nutrient component comprising a powdered nutrient, and an agglomeration liquid, into an agglomerator comprising a flow-through-type agglomeration chamber, wet-massing the nutrient component with the agglomeration liquid in the agglomeration chamber for a predetermined period of time to form agglomerated nutrient medium particles, and exposing the agglomerated nutrient medium particles to drying conditions for a period of time to form the dried, agglomerated nutrient medium. The nutrient component facilitates the growth of a microorganism. Compositions, articles, and kits comprising the flowable, dried agglomerated nutrient medium are also provided.
Abstract translation: 提供了制备可流动的，干燥的附聚营养培养基的方法。 该方法包括将包含粉末状营养物和附聚液的营养成分引入包含流通型附聚室的附聚器中，将附聚液中的营养成分与附聚室湿式预定一段时间 以形成附聚的营养培养基颗粒，并将附聚的营养培养基颗粒暴露于干燥条件下一段时间以形成干燥的聚集的营养培养基。 营养成分促进微生物的生长。 还提供了包含可流动，干燥的附聚营养培养基的组合物，制品和试剂盒。
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公开(公告)号：US20230166000A1
公开(公告)日：2023-06-01
申请号：US17782439
申请日：2020-12-04
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Minguha Dai , Jie J. Liu , Joseph C. Spagnola , Stephen A. O. Olson , Ta-Hua Yu , Junkang J. Liu , Lei Zhang
CPC classification number: A61L15/44 , A61L15/28 , A61L2300/104 , A61L2300/406
Abstract: An article. The article includes a substrate, wherein the substrate having two opposing major surfaces; and particles coated with a metal oxide on the substrate: particles coated with a metal on the substrate; wherein the coated particles are randomly distributed on or in the substrate; and wherein at least some of coated particles are discrete particles.
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公开(公告)号：US20230134622A1
公开(公告)日：2023-05-04
申请号：US17247244
申请日：2019-06-04
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Randilynn B. Christensen , Kenton D. Budd , Afshin Falsafi , Mahmut Aksit , Jana Ninkovic , Jie J. Liu , Mark B. Agre , Masayuki Nakamura , Jason W. Bjork , Bradley D. Craig , Richard P. Rusin , Paul J. Homnick , Joel D. Oxman , Yizhong Wang , Paul R. Klaiber , Bill H. Dodge
Abstract: A method of applying a two-part dental sealant is described comprising providing a syringe device (1) comprising a cartridge (10) including first and second chamber. The first chamber contains a first part of a dental sealant comprising a (meth)acrylate resin and an oxidizing curing agent. The second chamber contains a second part of a dental sealant comprising a (meth)acrylate resin and a reducing curing agent that reacts with the oxidizing curing agent of the first chamber. The first and/or second part of the dental sealant further comprise a single component or multiple components that neutralize acid and promote remineralization. The syringe device comprises a dispensing nozzle (17) comprising a static mixer and an outlet at one end of the cartridge and a plunger (20) at the opposing end of the cartridge. Also described is a kit for storing and applying the dental sealant is described.
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