公开(公告)号：US20230134622A1

公开(公告)日：2023-05-04

申请号：US17247244

申请日：2019-06-04

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Randilynn B. Christensen ,  Kenton D. Budd ,  Afshin Falsafi ,  Mahmut Aksit ,  Jana Ninkovic ,  Jie J. Liu ,  Mark B. Agre ,  Masayuki Nakamura ,  Jason W. Bjork ,  Bradley D. Craig ,  Richard P. Rusin ,  Paul J. Homnick ,  Joel D. Oxman ,  Yizhong Wang ,  Paul R. Klaiber ,  Bill H. Dodge

IPC: A61C5/64 ,  A61K6/887 ,  A61K6/79 ,  A61K6/61 ,  A61K6/62

Abstract: A method of applying a two-part dental sealant is described comprising providing a syringe device (1) comprising a cartridge (10) including first and second chamber. The first chamber contains a first part of a dental sealant comprising a (meth)acrylate resin and an oxidizing curing agent. The second chamber contains a second part of a dental sealant comprising a (meth)acrylate resin and a reducing curing agent that reacts with the oxidizing curing agent of the first chamber. The first and/or second part of the dental sealant further comprise a single component or multiple components that neutralize acid and promote remineralization. The syringe device comprises a dispensing nozzle (17) comprising a static mixer and an outlet at one end of the cartridge and a plunger (20) at the opposing end of the cartridge. Also described is a kit for storing and applying the dental sealant is described.

公开(公告)号：US20220033345A1

公开(公告)日：2022-02-03

申请号：US17280021

申请日：2019-10-01

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Ahmed S. Abuelyaman ,  Babu N. Gaddam ,  Afshin Falsafi ,  Tianyu Wu ,  Yizhong Wang ,  Randilynn B. Christensen ,  William H. Moser

IPC: C07C229/42 ,  C08F220/20 ,  C08F222/10

Abstract: Provided is an addition-fragmentation agent of the formula (I) where Ramine comprises a tertiary amine group; R2 linking group of valence a+2; Z is an ethylenically unsaturated polymerizable group; and subscript a is 0 or 1.

公开(公告)号：US20230256131A1

公开(公告)日：2023-08-17

申请号：US18012614

申请日：2021-06-10

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Bryan A. Baker ,  Randilynn B. Christensen

IPC: A61L15/18 ,  A61L15/32 ,  A61L15/42

CPC classification number: A61L15/18 ,  A61L15/325 ,  A61L15/42

Abstract: An article and a method of making the article. The article can include a conformable matrix comprising a mixture of collagen and bioactive glass; wherein the article is a conformable wound dressing. The method includes dissolving collagen in an acid solution; adding bioactive glass to the acid solution; mixing collagen and bioactive glass to increase or decrease the pH of the solution; and forming a mixture of collagen and bioactive glass.

公开(公告)号：US20190388355A1

公开(公告)日：2019-12-26

申请号：US16465346

申请日：2017-11-30

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Randilynn B. Christensen ,  Kenton D. Budd ,  Afshin Falsafi ,  Mahmut Aksit ,  Jana Ninkovic ,  Jie Liu ,  Mark B. Agre ,  Masayuki Nakamura ,  Jason W. Bjork ,  Bill H. Dodge

IPC: A61K9/50 ,  A61K6/00 ,  A61K6/02 ,  A61K6/06

Abstract: A (e.g. hardenable dental) composition is described comprising (e.g. a first part comprising) an encapsulated material wherein the encapsulated material comprises a basic core material and an inorganic shell material comprising a metal oxide surrounding the core; and (e.g. a second part comprising) water or an acidic component. Also described is an encapsulated material (e.g. suitable for use in a biological carrier material) comprising a basic core material and an inorganic shell material comprising a metal oxide surrounding the core.

公开(公告)号：US20240216228A1

公开(公告)日：2024-07-04

申请号：US18556736

申请日：2022-03-20

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Kai U. Claussen ,  Johannes M. Leykauff ,  Gioacchino Raia ,  Reinhold Hecht ,  Randilynn B. Christensen

IPC: A61K6/30 ,  A61K6/802 ,  A61K6/889

CPC classification number: A61K6/30 ,  A61K6/802 ,  A61K6/889

Abstract: The invention relates to a dental composition comprising polymerizable components, an initiator suitable for curing the polymerizable components, a Ca-ions releasing component having a Ca-ions releasing capability of 400 to 700 mg/l (ppm) if 2.5 g Ca-ions releasing component is steered in 50 ml de-ionized water having a pH of 2 for 24 hours; a F-ions releasing component having a F-ions releasing capability of 1,500 to 3,500 mg/l (ppm) if 2.5 g F-ions releasing component is steered in 50 ml de-ionized water having a pH of 7 for 24 hours. The invention also relates to a kit of parts comprising such a dental composition according and the following items alone or in combination: dental adhesive, dental milling block, prefabricated dental crown. The dental composition is suitable for use in a process of remineralizing a defect tooth in the mouth of a mammal, the process comprising the step of fixing a dental restoration to the surface of the defect tooth with the dental composition.

公开(公告)号：US12102499B2

公开(公告)日：2024-10-01

申请号：US17247244

申请日：2019-06-04

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Randilynn B. Christensen ,  Kenton D. Budd ,  Afshin Falsafi ,  Mahmut Aksit ,  Jana Ninkovic ,  Jie J. Liu ,  Mark B. Agre ,  Masayuki Nakamura ,  Jason W. Bjork ,  Bradley D. Craig ,  Richard P. Rusin ,  Paul J. Homnick ,  Joel D. Oxman ,  Yizhong Wang ,  Paul R. Klaiber ,  Bill H. Dodge

IPC: A61C5/64 ,  A61K6/61 ,  A61K6/62 ,  A61K6/79 ,  A61K6/887

CPC classification number: A61C5/64 ,  A61K6/61 ,  A61K6/62 ,  A61K6/79 ,  A61K6/887

Abstract: A method of applying a two-part dental sealant is described comprising providing a syringe device (1) comprising a cartridge (10) including first and second chamber. The first chamber contains a first part of a dental sealant comprising a (meth)acrylate resin and an oxidizing curing agent. The second chamber contains a second part of a dental sealant comprising a (meth)acrylate resin and a reducing curing agent that reacts with the oxidizing curing agent of the first chamber. The first and/or second part of the dental sealant further comprise a single component or multiple components that neutralize acid and promote remineralization. The syringe device comprises a dispensing nozzle (17) comprising a static mixer and an outlet at one end of the cartridge and a plunger (20) at the opposing end of the cartridge. Also described is a kit for storing and applying the dental sealant is described.

公开(公告)号：US20210228315A1

公开(公告)日：2021-07-29

申请号：US15734357

申请日：2019-06-05

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Randilynn B. Christensen ,  Kenton D. Budd ,  Afshin Falsafi ,  Mahmut Aksit ,  Jana Ninkovic ,  Jie J. Liu ,  Mark B. Agre ,  Masayuki Nakamura ,  Jason W. Bjork ,  Bradley D. Craig ,  Richard P. Rusin ,  Paul J. Homnick ,  Joel D. Oxman ,  Yizhong Wang ,  Paul R. Klaiber

IPC: A61C5/64 ,  A61C5/68 ,  A61K6/818 ,  A61K6/853 ,  A61K6/876 ,  A61K6/851 ,  A61K6/17 ,  A61K6/62 ,  A61K6/61 ,  A61K6/71 ,  A61K6/887

Abstract: A hardenable (e.g. dental) compositions is described comprising an encapsulated material. The encapsulated material comprises a basic core material and an inorganic shell material having certain viscosity criteria. Also described are dispensing devices and kits are described comprising a hardenable (e.g. dental) composition comprising a liquid material and an encapsulated material wherein the encapsulated material comprises a basic core material and an inorganic shell material comprising a metal oxide surrounding the core. The dispensing devices and kits can facilitate the methods of applying the hardenable composition. The hardenable or hardened (e.g. cured) composition can provide various technical effects such as a delayed release of a basic core material, a delayed increase in basicity, promoting remineralization of a tooth or bone structure, and increasing the average alkaline phosphatase (ALP) activity of pulp cells. In some embodiments, the composition is a dental (e.g. sealant) composition to a tooth structure.