公开(公告)号：US09341568B2

公开(公告)日：2016-05-17

申请号：US14434319

申请日：2013-10-08

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Qing Liu ,  Jack Sheng Kee ,  Mi Kyoung Park

IPC: G01N21/41 ,  G01N21/55 ,  G02B6/10

CPC classification number: G01N21/41 ,  G01N21/45 ,  G01N21/55 ,  G01N21/648 ,  G01N21/7703 ,  G01N21/774 ,  G01N2021/458 ,  G01N2021/7776 ,  G02B6/10

Abstract: A refractive index sensor is provided for analyzing an analyte, the sensor including: a strip waveguide for receiving an input light signal therein and transmitting the light signal, subject to manipulation as it propagates through the strip waveguide, to a detector for analysis with respect to the analyte; and a slot waveguide for sensing the analyte disposed thereon and for receiving a sensing signal, corresponding to said manipulation of the light signal, from the strip waveguide, wherein a grating is formed on a surface of the strip waveguide to enable coupling of the sensing signal from the strip waveguide to the slot waveguide, and the sensor is configured with enhanced sensitivity based on a sensitivity difference between the slot waveguide and the strip waveguide, and/or a group index difference between the slot waveguide and the strip waveguide.

Abstract translation: 提供折射率传感器用于分析分析物，所述传感器包括：带状波导，用于在其中接收输入光信号，并将光信号传送到经由带状波导传播的操作时，传输到相对于 分析物; 以及用于感测设置在其上的分析物并且用于从条形波导接收对应于所述光信号的所述操纵的感测信号的槽波导，其中在所述带状波导的表面上形成光栅以使得能够耦合所述感测信号 从带状波导到槽波导，并且传感器被配置为基于槽波导和带状波导之间的灵敏度差异增强的灵敏度和/或槽波导与带状波导之间的组折射率差。

公开(公告)号：US10463304B2

公开(公告)日：2019-11-05

申请号：US14897578

申请日：2014-06-12

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH ,  SINGAPORE HEALTH SERVICES PTE. LTD.

Inventor： Wai Pan Chan ,  Margarita Sofia Narducci ,  Yuan Gao ,  Julius Ming Lin Tsai ,  Ruiqi Lim ,  Ming-Yuan Cheng ,  Abdur Rub Abdur Rahman ,  Mi Kyoung Park ,  Minkyu Je ,  Jai Prashanth Rao

IPC: A61B5/00 ,  A61B5/01 ,  A61B5/03 ,  A61B5/145 ,  A61B5/1486

Abstract: There is provided a monolithically integrated multimodal sensor device for intracranial neuromonitoring, the sensor device including: a single substrate; a temperature sensor formed on a first portion of the single substrate for detecting temperature; a pressure sensor formed on a second portion of the single substrate for detecting intracranial pressure; and an oxygen sensor formed on a third portion of the single substrate for detecting oxygen concentration. In particular, sensing portions of the temperature sensor, the oxygen sensor and the pressure sensor, respectively, are formed at different layers of the sensor device. There is also provided an integrated multimodal sensor system incorporating the sensor device and the associated methods of fabrication.

公开(公告)号：US09856520B2

公开(公告)日：2018-01-02

申请号：US14652099

申请日：2013-12-13

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Yong Shin ,  Mi Kyoung Park

IPC: C12M1/34 ,  C12Q1/68 ,  C12N15/10

CPC classification number: C12Q1/6827 ,  C12N15/1006 ,  C12Q1/6806 ,  C12Q1/6825 ,  C12Q1/686 ,  C12Q2525/197 ,  C12Q2565/628 ,  C12Q2565/629 ,  C12Q2565/518 ,  C12Q2565/632

Abstract: Methods and system for the isolation and/or analysis of nucleic acids on a solid phase device comprising (i) incubating a nucleic acid sample with Dimethyl adipimidate (DMA) on said solid phase under conditions that allow formation of a complex of the nucleic acid with the DMA; contacting the complex of (i) with said surface; and isolating and/or analyzing the nucleic acid of the complex.

公开(公告)号：US20150268160A1

公开(公告)日：2015-09-24

申请号：US14434319

申请日：2013-10-08

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Qing Liu ,  Jack Sheng Kee ,  Mi Kyoung Park

IPC: G01N21/41

CPC classification number: G01N21/41 ,  G01N21/45 ,  G01N21/55 ,  G01N21/648 ,  G01N21/7703 ,  G01N21/774 ,  G01N2021/458 ,  G01N2021/7776 ,  G02B6/10

Abstract: A refractive index sensor is provided for analysing an analyte, the sensor including: a strip waveguide for receiving an input light signal therein and transmitting the light signal, subject to manipulation as it propagates through the strip waveguide, to a detector for analysis with respect to the analyte; and a slot waveguide for sensing the analyte disposed thereon and for receiving a sensing signal, corresponding to said manipulation of the light signal, from the strip waveguide, wherein a grating is formed on a surface of the strip waveguide to enable coupling of the sensing signal from the strip waveguide to the slot waveguide, and the sensor is configured with enhanced sensitivity based on a sensitivity difference between the slot waveguide and the strip waveguide, and/or a group index difference between the slot waveguide and the strip waveguide

Abstract translation: 提供折射率传感器用于分析分析物，所述传感器包括：带状波导，用于在其中接收输入光信号，并将光信号传送到经由带状波导传播的操作时，传输到相对于 分析物; 以及用于感测设置在其上的分析物并且用于从条形波导接收对应于所述光信号的所述操纵的感测信号的槽波导，其中在所述带状波导的表面上形成光栅以使得能够耦合所述感测信号 从带状波导到槽波导，并且传感器被配置为基于槽波导和带状波导之间的灵敏度差异增强的灵敏度，和/或槽波导与条形波导之间的组折射率差

公开(公告)号：US20180073061A1

公开(公告)日：2018-03-15

申请号：US15817107

申请日：2017-11-17

Applicant: Agency for Science, Technology and Research

Inventor： Yong Shin ,  Mi Kyoung Park

IPC: C12Q1/68 ,  C12N15/10

Abstract: Methods and system for the isolation and/or analysis of nucleic acids on a solid phase device comprising (i) incubating a nucleic acid sample with Dimethyl adipimidate (DMA) on said solid phase under conditions that allow formation of a complex of the nucleic acid with the DMA; contacting the complex of (i) with said surface; and isolating and/or analyzing the nucleic acid of the complex.

公开(公告)号：US20150268195A1

公开(公告)日：2015-09-24

申请号：US14664606

申请日：2015-03-20

Applicant: Agency for Science, Technology and Research

Inventor： Patthara Kongsuphol ,  Sunil Kumar Arya ,  Qing Liu ,  Mi Kyoung Park

IPC: G01N27/447

CPC classification number: G01N27/44791 ,  G01N27/44713 ,  G01N27/44739

Abstract: According to various embodiments, there is provided a sensor device including a separation reservoir configured to contain a plurality of target molecules; a first electric field generator configured to provide a first electric field across the separation reservoir, the first electric field having a first direction; a second electric field generator configured to provide a second electric field across the separation reservoir, the second electric field having a second direction, wherein the second direction is at least substantially perpendicular to the first direction; and a plurality of sensing elements arranged on a side of the separation reservoir, wherein each sensing element of the plurality of sensing elements is configured to detect target molecules within a vicinity of the respective sensing element.

Abstract translation: 根据各种实施例，提供了一种传感器装置，其包括分配储存器，该分离储存器配置成容纳多个目标分子; 第一电场发生器，被配置为跨越所述分离容器提供第一电场，所述第一电场具有第一方向; 第二电场发生器，其被配置为跨越所述分离储存器提供第二电场，所述第二电场具有第二方向，其中所述第二方向至少基本上垂直于所述第一方向; 以及布置在所述分离储存器侧面的多个感测元件，其中所述多个感测元件中的每个感测元件被配置为检测所述相应感测元件附近的目标分子。