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公开(公告)号：US09822178B2
公开(公告)日：2017-11-21
申请号：US15158178
申请日：2016-05-18
Applicant: AMGEN INC.
Inventor： Cen Xu , Agnes Eva Hamburger
CPC classification number: C07K16/28 , C07K16/2869 , C07K2317/21 , C07K2317/24 , C07K2317/41 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: Antibodies and antigen-binding fragments thereof that bind to human PAC1 are provided. Nucleic acids encoding the antibodies and antigen-binding fragments thereof, vectors, and cells encoding the same are also provided. The antibodies and antigen-binding fragments thereof can inhibit binding of PAC1 to PACAP, and are useful in a number of PAC1 related disorders, including the treatment and/or prevention of headache disorders, including migraine.
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公开(公告)号：US10822408B2
公开(公告)日：2020-11-03
申请号：US16063152
申请日：2016-12-15
Applicant: AMGEN INC.
Inventor： Agnes E. Hamburger , Cen Xu , Hong Sun , Yuan D. Shih , Dohan Weeraratne
Abstract: The present invention relates to monoclonal antibodies that specifically bind to human pituitary adenylate cyclase activating polypeptide (PACAP) and pharmaceutical compositions comprising such antibodies. Methods of treating or preventing headache conditions, such as migraine and cluster headache, using the monoclonal antibodies are also described.
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公开(公告)号：US10793631B2
公开(公告)日：2020-10-06
申请号：US16572271
申请日：2019-09-16
Applicant: AMGEN INC.
Inventor： Cen Xu , Agnes Eva Hamburger
Abstract: Antibodies and antigen-binding fragments thereof that bind to human PAC1 are provided. Nucleic acids encoding the antibodies and antigen-binding fragments thereof, vectors, and cells encoding the same are also provided. The antibodies and antigen-binding fragments thereof can inhibit binding of PAC1 to PACAP, and are useful in a number of PAC1 related disorders, including the treatment and/or prevention of headache disorders, including migraine and cluster headache.
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公开(公告)号：US12122841B2
公开(公告)日：2024-10-22
申请号：US17111442
申请日：2020-12-03
Applicant: AMGEN INC.
Inventor： Thomas C. Boone , David W. Brankow , Colin V. Gegg, Jr. , Shaw-Fen Sylvia Hu , Chadwick T. King , Hsieng Sen Lu , Licheng Shi , Cen Xu
CPC classification number: C07K16/2869 , A61K39/39533 , A61K39/395 , A61K2039/505 , C07K2317/21 , C07K2317/32 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C12N5/10 , C12N15/00 , C12N15/63
Abstract: Antigen binding proteins that bind to human CGRP receptor (CGRP R) are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of CGRP R to CGRP, and are useful in a number of CGRP R related disorders, including the treatment and/or prevention of migraine headaches.
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公开(公告)号：US09862771B2
公开(公告)日：2018-01-09
申请号：US14752493
申请日：2015-06-26
Applicant: AMGEN INC.
Inventor： Thomas C. Boone , David W. Brankow , Colin V. Gegg, Jr. , Shaw-Fen Sylvia Hu , Chadwick T. King , Hsieng Sen Lu , Licheng Shi , Cen Xu
IPC: A61K39/395 , C07K16/28 , A61K39/00
CPC classification number: C07K16/2869 , A61K39/395 , A61K39/39533 , A61K2039/505 , C07K2317/21 , C07K2317/32 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
Abstract: Antigen binding proteins that bind to human CGRP receptor (CGRP R) are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of CGRP R to CGRP, and are useful in a number of CGRP R related disorders, including the treatment and/or prevention of migraine headaches.
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Patent Agency Ranking
公开(公告)号：US12134652B2
公开(公告)日：2024-11-05
申请号：US17111453
申请日：2020-12-03
Applicant: AMGEN INC.
Inventor： Thomas C. Boone , David W. Brankow , Colin V. Gegg, Jr. , Shaw-Fen Sylvia Hu , Chadwick T. King , Hsieng Sen Lu , Licheng Shi , Cen Xu
Abstract: Antigen binding proteins that bind to human CGRP receptor (CGRP R) are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of CGRP R to CGRP, and are useful in a number of CGRP R related disorders, including the treatment and/or prevention of migraine headaches.
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公开(公告)号：US11891435B2
公开(公告)日：2024-02-06
申请号：US17558032
申请日：2021-12-21
Applicant: AMGEN INC.
Inventor： Neeraj Jagdish Agrawal , Kevin Graham , Agnes Eva Hamburger , Christopher Mohr , Derek E. Piper , Kenneth William Walker , Zhulun Wang , Cen Xu
IPC: C07K16/00 , A61K39/395 , A61K39/00 , A61K49/00 , A61K49/16 , C12P21/08 , G01N33/53 , C07K16/18 , C07K16/28 , A61P25/06 , A61K38/22 , A61K47/68 , A61K38/17 , A61K51/10 , C07K14/575 , C07K16/26 , C07K14/72 , C07K14/47 , G01N33/74 , G01N33/68
CPC classification number: C07K16/18 , A61K38/2278 , A61P25/06 , C07K16/2869 , A61K38/1796 , A61K38/22 , A61K47/6843 , A61K47/6849 , A61K51/10 , A61K2039/505 , A61K2039/545 , A61K2300/00 , C07K14/47 , C07K14/575 , C07K14/57563 , C07K14/72 , C07K16/00 , C07K16/26 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/522 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/70 , C07K2317/72 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C12N2501/30 , G01N33/6854 , G01N33/6896 , G01N33/74 , G01N2333/575 , G01N2333/5757 , Y02A50/30
Abstract: The present invention relates to neutralizing antibodies of the human pituitary adenylate cyclase activating polypeptide type I receptor (PAC1) and pharmaceutical compositions comprising such antibodies. Methods of treating or preventing headache conditions, such as migraine and cluster headache, using the neutralizing antibodies are also described.
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公开(公告)号：US11780914B2
公开(公告)日：2023-10-10
申请号：US17031674
申请日：2020-09-24
Applicant: AMGEN INC.
Inventor： Agnes E. Hamburger , Cen Xu , Hong Sun , Yuan D. Shih , Dohan Weeraratne
CPC classification number: C07K16/26 , A61P25/06 , C07K16/4283 , A61K9/0019 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76
Abstract: The present invention relates to monoclonal antibodies that specifically bind to human pituitary adenylate cyclase activating polypeptide (PACAP) and pharmaceutical compositions comprising such antibodies. Methods of treating or preventing headache conditions, such as migraine and cluster headache, using the monoclonal antibodies are also described.
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公开(公告)号：US10053507B2
公开(公告)日：2018-08-21
申请号：US15592115
申请日：2017-05-10
Applicant: AMGEN INC.
Inventor： Cen Xu , Agnes Eva Hamburger
CPC classification number: C07K16/28 , A61P25/06 , C07K16/2869 , C07K2317/21 , C07K2317/24 , C07K2317/41 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: Antibodies and antigen-binding fragments thereof that bind to human PAC1 are provided. Nucleic acids encoding the antibodies and antigen-binding fragments thereof, vectors, and cells encoding the same are also provided. The antibodies and antigen-binding fragments thereof can inhibit binding of PAC1 to PACAP, and are useful in a number of PAC1 related disorders, including the treatment and/or prevention of headache disorders, including migraine and cluster headache.
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公开(公告)号：US09676851B2
公开(公告)日：2017-06-13
申请号：US14775995
申请日：2014-03-14
Applicant: AMGEN INC.
Inventor： Cen Xu , Agnes Eva Hamburger
CPC classification number: C07K16/28 , C07K16/2869 , C07K2317/21 , C07K2317/24 , C07K2317/41 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: Antibodies and antigen-binding fragments thereof that bind to human PAC1 are provided. Nucleic acids encoding the antibodies and antigen-binding fragments thereof, vectors, and cells encoding the same are also provided. The antibodies and antigen-binding fragments thereof can inhibit binding of PAC1 to PACAP, and are useful in a number of PAC1 related disorders, including the treatment and/or prevention of headache disorders, including migraine and cluster headache.
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