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    SWALLOWABLE DRUG DELIVERY DEVICES
    1.
    发明公开
    SWALLOWABLE DRUG DELIVERY DEVICES 审中-公开

    公开(公告)号：US20230302264A1

    公开(公告)日：2023-09-28

    申请号：US18022245

    申请日：2021-09-02

    Applicant: AMGEN INC.

    Inventor： Mehran Mojarrad ,  Scott R. Gibson ,  Scott Castanon ,  Robert Eisele ,  Dylann Ceriani

    IPC: A61M31/00 ,  A61M37/00

    CPC classification number: A61M31/002 ,  A61M37/0015

    Abstract: A swallowable drug delivery device includes a capsule and a tissue attachment member. The capsule may contain a drug and may be sized to pass through at least a portion of the gastrointestinal tract of a patient. The tissue attachment member may be coupled to the capsule. In an initial state, the tissue attachment member may allow the capsule to pass through the at least a portion of the gastrointestinal tract of the patient. In an activated state, the tissue attachment member is configured to at least selectively attach the capsule to a wall of the gastrointestinal tract of the patient. The tissue attachment member may be configured to change from the initial state to the activated state in response to an in vivo condition associated with a predetermined location in the gastrointestinal tract of the patient.

    HYDRAULIC-PNEUMATIC PRESSURIZED CHAMBER DRUG DELIVERY SYSTEM
    3.
    发明申请
    HYDRAULIC-PNEUMATIC PRESSURIZED CHAMBER DRUG DELIVERY SYSTEM 审中-公开

    公开(公告)号：US20200164155A1

    公开(公告)日：2020-05-28

    申请号：US16630329

    申请日：2018-08-07

    Applicant: AMGEN INC.

    Inventor： Mehran Mojarrad ,  John K. Floffman ,  Paul Daniel Faucher ,  Matthew Pacheco ,  Ed Maher

    IPC: A61M5/315 ,  A61M5/32 ,  A61M5/34 ,  A61M5/19

    Abstract: A wearable drug delivery device includes a housing, a needle assembly at least partially disposed in the housing, and a drive assembly at least partially disposed in the housing and coupled to the needle assembly. The needle assembly includes a needle or cannula and a sterile barrier disposed proximal to the needle or cannula in a first configuration where the sterile barrier is intact. The drive assembly includes a container that contains a medicament to be administered, a first plunger disposed in the container, and a drive mechanism that forces the first plunger to urge the medicament through the container. Upon engaging the drive mechanism, the needle or cannula and the sterile barrier move relative to each other from the first configuration to a second configuration where the needle or cannula breaks the sterile barrier, thereby allowing the medicament to be administered via the needle or cannula.

    DRUG PRODUCT CONTAINER AND DRUG DELIVERY SYSTEM
    6.
    发明申请
    DRUG PRODUCT CONTAINER AND DRUG DELIVERY SYSTEM 有权

    公开(公告)号：US20220401643A1

    公开(公告)日：2022-12-22

    申请号：US17763692

    申请日：2020-10-14

    Applicant: AMGEN INC.

    Inventor： Scott R. Gibson ,  Paul D. Faucher ,  Mehran Mojarrad

    IPC: A61M5/148

    Abstract: A drug delivery device includes a drug product container, a pressurized vessel, and an urging member. The drug product container can have at least one flexible wall and defining a cavity configured to contain a drug product. The pressurized vessel can contain a gas under pressure. And the urging member is in working connection with the pressurized vessel such that, upon at least partial release of the gas under pressure, the urging member moves from a first portion of the drug product container to a second portion, thereby ejecting at least a portion of the drug product from the drug product container.

    PRESSURE RELIEF VALVE FOR DRUG DELIVERY DEVICE
    7.
    发明申请
    PRESSURE RELIEF VALVE FOR DRUG DELIVERY DEVICE 有权

    公开(公告)号：US20220288305A1

    公开(公告)日：2022-09-15

    申请号：US17626667

    申请日：2020-07-16

    Applicant: AMGEN INC.

    Inventor： Mehran Mojarrad ,  Ali Nekouzadeh ,  Scott R. Gibson ,  Sheldon Moberg ,  Paul Daniel Faucher

    IPC: A61M5/145 ,  A61M5/142

    Abstract: A drug delivery device includes a housing releasably coupled with a patient, a pressure chamber disposed in the housing and including a vent, a container at least partially disposed in the pressure chamber for storing a drug connectable in fluid communication with a fluid conduit, an activation mechanism, and a relief mechanism. The activation mechanism releases a pressurized drive fluid into the pressure chamber for expelling the drug from the container into the fluid conduit. The relief mechanism is operably coupled to the fluid conduit and is adapted to open the vent to release the drive fluid from the pressure chamber in response to a predetermined condition.

    Needle insertion-retraction system having dual torsion spring system
    8.
    发明授权
    Needle insertion-retraction system having dual torsion spring system 有权

    公开(公告)号：US11305056B2

    公开(公告)日：2022-04-19

    申请号：US16620016

    申请日：2018-07-14

    Applicant: AMGEN INC.

    Inventor： Mehran Mojarrad ,  Scott Robert Gibson ,  Adam Livingston

    IPC: A61M5/142 ,  A61M5/145

    Abstract: An insertion/retraction mechanism for a drug delivery device is disclosed. The insertion/retraction mechanism includes a retraction hub, an insertion hub, an insertion/retraction mechanism housing, and a dual torsion spring system. The retraction hub includes a first primary rotational stop and a second primary rotational stop extending radially inwardly from an inside surface. The insertion hub is disposed inside the retraction hub and comprises a first complementary rotational stop and a second complementary rotational stop extending radially outwardly from an outside surface. The dual torsion spring system causes the first primary rotational stop and the second primary rotational stop to selectively engage the first complementary rotational stop and the secondary rotational stop, respectively, and further causes the retraction hub to rotate relative to the insertion/retraction mechanism housing as the insertion/retraction mechanism moves between an initial position, an inserted position, and a retracted position.

    NEEDLE INSERTION-RETRACTION SYSTEM HAVING DUAL TORSION SPRING SYSTEM
    9.
    发明申请
    NEEDLE INSERTION-RETRACTION SYSTEM HAVING DUAL TORSION SPRING SYSTEM 审中-公开

    公开(公告)号：US20200230313A1

    公开(公告)日：2020-07-23

    申请号：US16620016

    申请日：2018-07-03

    Applicant: AMGEN INC.

    Inventor： Mehran Mojarrad ,  Scott Robert Gibson ,  Adam Livingston

    IPC: A61M5/142

    Abstract: An insertion/retraction mechanism for a drug delivery device is disclosed. The insertion/retraction mechanism includes a retraction hub, an insertion hub, an insertion/retraction mechanism housing, and a dual torsion spring system. The retraction hub includes a first primary rotational stop and a second primary rotational stop extending radially inwardly from an inside surface. The insertion hub is disposed inside the retraction hub and comprises a first complementary rotational stop and a second complementary rotational stop extending radially outwardly from an outside surface. The dual torsion spring system causes the first primary rotational stop and the second primary rotational stop to selectively engage the first complementary rotational stop and the secondary rotational stop, respectively, and further causes the retraction hub to rotate relative to the insertion/retraction mechanism housing as the insertion/retraction mechanism moves between an initial position, an inserted position, and a retracted position.

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