公开(公告)号：US20220378657A1

公开(公告)日：2022-12-01

申请号：US17770320

申请日：2020-10-22

Applicant: AMGEN INC.

Inventor： Scott R. Gibson ,  Olivia Li ,  Nicholas J. Clark ,  Adam B. McCullough

IPC: A61J1/20 ,  A61J1/14

Abstract: A device for connecting tubes for a drug delivery system includes a connecting portion having a first tube channel, a second tube channel, a connecting heating element, and a carriage assembly. The first tube channel is adapted to receive a first tube, and the second tube channel is adapted to receive a second tube. The connecting heating element is positioned adjacent to and/or intersecting the first and second tube channels and is adapted to selectively heat at least a portion of the first and second tube. The carriage assembly moves the heated first and second tubes into end-to-end contact with each other to couple the first and second tubes together.

公开(公告)号：US20230330323A1

公开(公告)日：2023-10-19

申请号：US18027192

申请日：2021-09-03

Applicant: AMGEN INC.

Inventor： Alan Dominguez ,  Nicholas J. Clark

IPC: A61M5/00

CPC classification number: A61M5/002 ,  A61M5/001 ,  A61M2209/06 ,  A61M2205/3606

Abstract: An apparatus for storing a medicament delivery device, the apparatus comprising: a container defining a storage cavity having an opening, the storage cavity configured to receive a syringe pre-filled with medicament; an absorbent disposed in the cavity, the absorbent at least partially hydrated with a liquid solution; and a seal member at least selectively connected with the cavity to form a seal that is at least substantially gas impermeable.

公开(公告)号：US20220387710A1

公开(公告)日：2022-12-08

申请号：US17770341

申请日：2020-10-22

Applicant: AMGEN INC.

Inventor： Shawn Malloy ,  Nicholas J. Clark ,  Hillary Doucette ,  Zaheer Darrell Abdool

IPC: A61M5/168 ,  A61M5/172

Abstract: A drug delivery system for delivering a drug product is provided that includes a drug product container containing a drug product, a fluid path adapted to receive the drug product from the drug product container, and a drug delivery device positioned along and/or adjacent to the fluid path. The drug delivery device may include a housing, a fluid displacement assembly at least partially supported by and/or surrounded by the housing, and a drive component at least partially supported by and/or surrounded by the housing. The drive component may drive the medicament through the fluid displacement assembly. Further, the drug delivery device includes a controller workingly coupled with the drive component for controlling the drug delivery device. The controller may operate in a normal operation mode and a reserve mode.

公开(公告)号：US20200254173A1

公开(公告)日：2020-08-13

申请号：US16787077

申请日：2020-02-11

Applicant: AMGEN INC.

Inventor： Adam B. McCullough ,  Sarah M. Korman ,  Nicholas J. Clark ,  Rafi Muhammad Sufi

IPC: A61M5/168 ,  A61B46/10 ,  A61M5/14 ,  A61M5/142 ,  A61M5/178 ,  A61M39/10

Abstract: A take-home drug delivery system includes a kit container defining an inner volume, a drug delivery container preparation assembly at least partially disposed within the inner volume of the kit container, and a sterile drape at least partially disposed within the inner volume of the kit container. The drug delivery container preparation assembly includes at least a drug delivery container, a drug vial containing a drug to be administered, a tubing set, and a drug delivery container mounting apparatus. The sterile drape includes a placement legend illustrated thereon.

公开(公告)号：US20220387700A1

公开(公告)日：2022-12-08

申请号：US17770326

申请日：2020-10-14

Applicant: AMGEN INC.

Inventor： Scott R. Gibson ,  Xiaotong Li ,  Nicholas J. Clark ,  Carsten Bech ,  Daniel Rojecki ,  Joshua Jay Dudman ,  Jakob Pedersen ,  Jennifer L. Sawicky ,  Laura Watson

IPC: A61M5/00 ,  A61J1/10 ,  A61J1/20 ,  A61M5/14

Abstract: A drug delivery system includes a packaging housing a first component including at least one of a drug product, a diluent, a saline solution, or an IV stabilizing solution (“IVSS”) and a second component comprising at least one of the drug product, the diluent, the saline solution, and the IVSS, the first component being different than the second component. The first component is disposed in a first container in a storage state and the first container is positioned in a first compartment of the packaging housing. The second component is disposed in a second container in a storage state and the second container is positioned in a second compartment of the packaging housing. At least one of the first compartment and the second compartment may include an individual seal and wherein each of the individual seals and the first and second compartments are sterilized.

公开(公告)号：US20220362104A1

公开(公告)日：2022-11-17

申请号：US17770355

申请日：2020-10-23

Applicant: AMGEN INC. ,  AMGEN RESEARCH MUNICH GMBH

Inventor： Cornelius Pompe ,  Nicholas J. Clark ,  Wei Qi ,  Arnold J. McAuley ,  MIchael Schneider ,  Chia-Jung Wu ,  Twinkle R. Christian ,  Heather N. Franey ,  Bharadwaj Jagannathan ,  Jeffrey Abel ,  Franz Dietzel

IPC: A61J1/14 ,  A61M5/14 ,  G01N33/15

Abstract: An approach for determining material compatibility for components of a drug delivery system is provided that includes using surface zeta-potential analytical method to evaluate surface interactions between a desired molecule and at least one material present within a given IV-bag system.

公开(公告)号：US20220087901A1

公开(公告)日：2022-03-24

申请号：US17425412

申请日：2020-02-12

Applicant: AMGEN INC.

Inventor： Nicholas J. Clark ,  Chia-Jung Wu ,  Mingda Eu ,  Artemio A. Alanis ,  Jennifer Lyn Sawicky ,  Monica Goss ,  Jennifer Stevenson ,  Heather N. Franey ,  Deirdre Piedmonte ,  Stephen Robert Brych

IPC: A61J1/20 ,  A61M39/00

Abstract: An approach for preparing a drug delivery device includes providing a prefilled delivery container and transferring a drug product contained in a drug container to the prefilled delivery container. The prefilled delivery container includes a container body containing a predetermined quantity of saline solution and a predetermined quantity of IV stabilizing solution (“IVSS”). The drug product is transferred to the prefilled delivery container via a delivery container adapter.

公开(公告)号：US20200253823A1

公开(公告)日：2020-08-13

申请号：US16782306

申请日：2020-02-05

Applicant: AMGEN INC.

Inventor： Chia-Jung Wu ,  Nicholas J. Clark ,  Ronak Maheshwari ,  Heather N. Franey

IPC: A61J1/10 ,  A61J1/14 ,  A61J1/16

Abstract: A drug delivery system includes a delivery container, a first drug insertion port, at least one additional drug insertion port, and an IV connection port. The delivery container includes upper, lower, first side, and second side portions, and further includes a tapered region extending between the first side portion and the second side portion. The first drug insertion port is positioned at the lower portion of the delivery container and has a first coupling mechanism. The at least one additional drug insertion port is also positioned at the lower portion of the delivery container, but includes a second coupling mechanism that is different than the first coupling mechanism. The IV connection port is positioned at the lower portion of the delivery container adjacent to a lower portion of the tapered region.