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公开(公告)号：US11725047B2
公开(公告)日：2023-08-15
申请号：US16824034
申请日：2020-03-19
发明人： Lorena Lerner , Sandra Abbott , Ailin Bai , Ting Chen , Maria Isabel Chiu , Qing Liu , Laura Poling , Nianjun Tao , Solly Weiler , Zhigang Weng , William M. Winston, Jr. , Jeno Gyuris
IPC分类号： C07K16/22 , A61K39/395 , A61K39/00 , C12N15/10 , C12N15/63 , C12N5/10 , A61P3/02 , A61K45/06
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61P3/02 , A61K2039/505 , C07K2317/24 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C12N5/10 , C12N15/10 , C12N15/63
摘要： Monoclonal antibodies that bind and inhibit the activity of human GDF15 are disclosed. The antibodies can be used to treat body weight loss, including cachexia, associated with the over-expression of human GDF15.
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公开(公告)号：US10745476B2
公开(公告)日：2020-08-18
申请号：US15864710
申请日：2018-01-08
发明人： Heidi Okamura , Sandra Abbott , Alisa C. Bell , Kelly Kreuter , Ronan O'Hagan , Samantha Perino , Hamid Tissire , William M. Winston, Jr. , Jeno Gyuris
IPC分类号： C07K16/18 , C07K16/28 , A61K39/395 , C12N15/09 , C12N15/63 , C12N5/10 , C12N5/12 , C12N5/16 , A61K39/00
摘要： Monoclonal antibodies that bind and inhibit activation of human Notch3 are disclosed. The antibodies can be used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation of Notch3.
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公开(公告)号：US09725505B2
公开(公告)日：2017-08-08
申请号：US14863870
申请日：2015-09-24
发明人： Lorena Lerner , Sandra Abbott , Ailin Bai , Ting Chen , Maria I. Chiu , Qing Liu , Laura Poling , Nianjun Tao , Solly Weiler , Zhigang Weng , William M. Winston, Jr. , Jeno Gyuris
IPC分类号： A61K39/395 , C07K16/22 , A61K45/06 , A61K39/00
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/24 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： Monoclonal antibodies that bind and inhibit the activity of human GDF15 are disclosed. The antibodies can be used to treat body weight loss, including cachexia, associated with the over-expression of human GDF15.
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公开(公告)号：US08829164B2
公开(公告)日：2014-09-09
申请号：US14070070
申请日：2013-11-01
发明人： Kerry Whalen , Steve Bottega , Andrea Boudrow , Lyne Breault , Ting Chen , James Gifford , May Han , Jinwei Jiang , Lorena Lerner , Qing Liu , Kristan Meetze , Sylvie Vincent , Solly Weiler , William M. Winston, Jr. , Jeno Gyuris
IPC分类号： C07K16/30
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/2896 , C07K2317/24 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要： Monoclonal antibodies that bind and inhibit activation of human RON (Recepteur d'Origine Nantais) are disclosed. The antibodies can be used to treat certain forms of cancer that are associated with activation of RON.
摘要翻译： 公开了结合并抑制人RON（Recepteur d'Origine Nantais）活化的单克隆抗体。 抗体可用于治疗与RON活化相关的特定形式的癌症。
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公开(公告)号：US11142573B2
公开(公告)日：2021-10-12
申请号：US16097489
申请日：2017-04-28
IPC分类号： A61K39/395 , C07K16/28 , C07K16/30 , C12N5/10 , C12N5/12 , C12N15/63 , A61P35/00 , C07K14/71 , A61K39/00
摘要： Monoclonal antibodies that bind and inhibit activation of human Notch3 are disclosed. The antibodies can be used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation and/or overexpression of Notch3.
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公开(公告)号：US20190144537A1
公开(公告)日：2019-05-16
申请号：US16097489
申请日：2017-04-28
摘要： Monoclonal antibodies that bind and inhibit activation of human Notch3 are disclosed. The antibodies can be used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation and/or overexpression of Notch3.
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公开(公告)号：US09879083B2
公开(公告)日：2018-01-30
申请号：US14653684
申请日：2013-12-19
发明人： Heidi Okamura , Sandra Abbott , Alisa C. Bell , Kelly Kreuter , Ronan O'Hagan , Samantha Perino , Hamid Tissire , William M. Winston, Jr. , Jeno Gyuris
IPC分类号： C07K16/18 , C07K16/28 , A61K39/395 , C12N15/09 , C12N15/63 , C12N5/10 , C12N5/12 , C12N5/16 , C07K14/705 , C07K14/71 , A61K39/00
CPC分类号： C07K16/28 , A61K39/3955 , A61K2039/505 , C07K16/2863 , C07K2317/14 , C07K2317/24 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N5/10 , C12N5/12 , C12N5/16 , C12N15/09 , C12N15/63
摘要： Monoclonal antibodies that bind and inhibit activation of human Notch3 are disclosed. The antibodies can be used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation of Notch3.
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公开(公告)号：US09598498B2
公开(公告)日：2017-03-21
申请号：US14987374
申请日：2016-01-04
发明人： Sylvie Vincent , William M. Winston, Jr. , Fang Wang , Solly Weiler , Kristan Meetze , Lyne Breault , Steve Bottega , Ting Chen , Michael DePrima , Christina Fleet , Steven Tyler , Jin-Kyeung Woo , Jeno Gyuris
IPC分类号： A61K39/395 , C07K16/32 , C07K16/30 , A61K39/00
CPC分类号： C07K16/32 , A61K39/39558 , A61K2039/505 , C07K16/30 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Monoclonal antibodies that bind and inhibit activation of epidermal growth factor receptor related member ErbB3/HER3 are disclosed. The antibodies can be used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation of ErbB3/HER3.
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公开(公告)号：US09175076B2
公开(公告)日：2015-11-03
申请号：US14137415
申请日：2013-12-20
发明人： Lorena Lerner , Sandra Abbott , Ailin Bai , Ting Chen , Maria Isabel Chiu , Qing Liu , Laura Poling , Nianjun Tao , Solly Weiler , Zhigang Weng , William M. Winston, Jr. , Jeno Gyuris
IPC分类号： C07K16/00 , C07K16/18 , C07K16/22 , C12N1/21 , C12N5/10 , C12N5/12 , C12N15/09 , C12N15/13 , C12N15/63 , C12N15/64 , A61K39/00
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/24 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： Monoclonal antibodies that bind and inhibit the activity of human GDF15 are disclosed. The antibodies can be used to treat body weight loss, including cachexia, associated with the over-expression of human GDF15.
摘要翻译： 公开了结合和抑制人GDF15活性的单克隆抗体。 抗体可用于治疗体重减轻，包括与人类GDF15过度表达相关的恶病质。
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10.发明授权公开(公告)号：US09096664B2
公开(公告)日：2015-08-04
申请号：US14044278
申请日：2013-10-02
发明人： William M. Winston, Jr. , S. Kirk Wright , May Han , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris , Arnold Horwitz
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
摘要翻译： 本发明提供结合并中和肝细胞生长因子（HGF），特别是人HGF的活性的结合蛋白家族。 结合蛋白可用作诊断和/或治疗剂。 关于它们的治疗活性，结合蛋白可用于治疗某些HGF应答性病症，例如某些HGF反应性肿瘤。
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