公开(公告)号：US20150087057A1

公开(公告)日：2015-03-26

申请号：US14395811

申请日：2013-04-22

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Daniele Zink ,  Ming Ni ,  Karthikeyan Narayanan ,  Karthikeyan Kandasamy ,  Andrew C.A. Wan ,  Jackie Y. Ying

IPC: C12N5/074 ,  C12N5/0775 ,  C12N5/0735

CPC classification number: C12N5/0696 ,  C12N5/0068 ,  C12N5/0075 ,  C12N5/0606 ,  C12N5/0663 ,  C12N2500/90 ,  C12N2501/815 ,  C12N2531/00 ,  C12N2533/00 ,  C12N2533/20 ,  C12N2533/30 ,  C12N2533/50 ,  C12N2533/70 ,  C12N2533/78

Abstract: There is provided a method for culturing a stem cell in vitro. The method comprises providing a substrate surface coated with a coating comprising a molecule having a catechol moiety or a polymer thereof; and growing a stem cell on said coated substrate surface in a growth medium.

Abstract translation: 提供了体外培养干细胞的方法。 该方法包括提供涂覆有包含具有儿茶酚部分或其聚合物的分子的涂层的基底表面; 以及在生长培养基中在所述涂覆的基底表面上生长干细胞。

公开(公告)号：US20140349933A1

公开(公告)日：2014-11-27

申请号：US14356116

申请日：2012-11-05

Applicant: Agency for Science, Technology and Research

Inventor： Charlotte Hauser ,  Yihua Loo ,  Andrew C.A. Wan ,  Michael Reithofer

IPC: A61K47/36 ,  A61K38/18 ,  C12N5/00 ,  A61K31/7088 ,  A61K47/48 ,  A61K47/18 ,  C12N15/113

CPC classification number: A61K47/36 ,  A61K31/7088 ,  A61K35/28 ,  A61K35/51 ,  A61K35/545 ,  A61K38/06 ,  A61K38/07 ,  A61K38/08 ,  A61K38/18 ,  A61K38/1825 ,  A61K38/19 ,  A61K47/183 ,  A61L26/0052 ,  A61L26/0066 ,  A61L26/008 ,  A61L26/0095 ,  A61L27/26 ,  A61L27/3834 ,  A61L27/48 ,  A61L27/52 ,  A61L27/54 ,  C08L5/00 ,  C08L5/04 ,  C08L5/08 ,  C08L5/10 ,  C08L5/16 ,  C08L71/02 ,  C08L89/00 ,  C12N5/0068 ,  C12N15/113 ,  C12N2310/11 ,  C12N2320/32 ,  C12N2533/30 ,  C12N2533/50 ,  C12N2533/72

Abstract: The present invention relates to composite hydrogels comprising at least one non-peptidic polymer and at least one peptide having the general formula: Z—(X)m—(Y)n—Z′p, wherein Z is an N-terminal protecting group; X is, at each occurrence, independently selected from an aliphatic amino acid, an aliphatic amino acid derivative and a glycine; Y is, at each occurrence, independently selected from a polar amino acid and a polar amino acid derivative; Z′ is a C-terminal protecting group; m is an integer selected from 2 to 6; n is selected from 1 or 2; and p is selected from 0 or 1. The present invention further relates to methods of producing the composite hydrogels, to uses of the composite hydrogels for the delivery of drugs and other bioactive agents/moieties, as an implant or injectable agent that facilitates tissue regeneration, and as a topical agent for wound healing. The present invention further relates to devices and pharmaceutical or cosmetic compositions comprising the composite hydrogels and to medical uses of the composite hydrogels.

Abstract translation: 本发明涉及包含至少一种非肽聚合物和至少一种具有以下通式的肽的复合水凝胶：Z-（X）m-（Y）n-Z'p，其中Z是N-末端保护基 ; X在每次出现时独立地选自脂族氨基酸，脂族氨基酸衍生物和甘氨酸; Y在每次出现时独立地选自极性氨基酸和极性氨基酸衍生物; Z'是C端保护基; m是选自2至6的整数; n选自1或2; 本发明还涉及生产复合水凝胶的方法，使用复合水凝胶来递送药物和其它生物活性剂/部分，作为促进组织再生的植入物或可注射剂 ，以及作为伤口愈合的局部剂。 本发明还涉及包含复合水凝胶的装置和药物或化妆品组合物以及复合水凝胶的医疗用途。