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公开(公告)号：US20090318749A1
公开(公告)日：2009-12-24
申请号：US12484822
申请日：2009-06-15
CPC分类号： A61N1/056 , A61B5/02028 , A61B5/0215 , A61B5/026 , A61F2/95 , A61N1/3625 , A61N1/3627 , A61N1/36514 , A61N1/36564 , A61N1/36571
摘要： A system delivers multiple enhanced therapies to limit myocardial damage post-revascularization. The system includes a catheter that incorporates features for delivering cardiac protection pacing therapy (CPPT) and intermittent ischemia therapy. In one embodiment, a method for delivering cardiac protection therapies to a heart is provided. One or more catheters are provided having a balloon, at least one pacing electrode and at least one hemodynamic sensor. Cardiac protection pacing therapy (CPPT) and intermittent ischemia therapy are concurrently delivered using the one or more catheters. The pacing and ischemia are adapted to protect the heart from ischemic and reperfusion injuries. The delivery of the CPPT and the intermittent ischemia are controlled using a closed-loop system monitoring a signal sensed by the at least one hemodynamic sensor.
摘要翻译： 系统提供多种增强疗法以限制血运重建后的心肌损伤。 该系统包括导管，其包括用于递送心脏保护起搏治疗（CPPT）和间歇性缺血治疗的特征。 在一个实施方案中，提供了将心脏保护治疗递送至心脏的方法。 提供一个或多个导管，其具有球囊，至少一个起搏电极和至少一个血流动力学传感器。 使用一个或多个导管同时输送心脏保护起搏治疗（CPPT）和间歇性缺血治疗。 起搏和缺血适应于保护心脏免于缺血和再灌注损伤。 CPPT的传送和间歇性缺血通过监视由至少一个血流动力学传感器感测到的信号的闭环系统来控制。
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2.发明授权Method and apparatus for safe and efficient delivery of cardiac stress augmentation pacing 有权安全高效地递送心脏应激增加起搏的方法和装置公开(公告)号：US08958873B2
公开(公告)日：2015-02-17
申请号：US12770351
申请日：2010-04-29
CPC分类号： A61N1/3627 , A61N1/37
摘要： A cardiac pacing system controls the progression of a cardiac disorder such as heart failure by delivering cardiac stress augmentation pacing to create or augment regional stress in the heart according to a delivery schedule programmed for a patient. Various events associated with the patient's conditions, activities, and other treatments may render the cardiac stress augmentation pacing risky or ineffective. The system detects such events before and during each cardiac stress augmentation pacing session and modifies the delivery schedule in response to the detection of each event to ensure patient safety and therapy efficiency.
摘要翻译： 心脏起搏系统通过递送心脏应力增加起搏来控制心脏疾病例如心力衰竭的进展，以根据为患者编程的递送计划创建或增加心脏中的区域应力。 与患者病情，活动和其他治疗相关的各种事件可能使心脏应激增加起搏风险或无效。 该系统在每个心脏应激增强起搏会话之前和期间检测这些事件，并根据每个事件的检测来修改递送计划，以确保患者的安全性和治疗效率。
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3.发明申请METHOD AND APPARATUS FOR SAFE AND EFFICIENT DELIVERY OF CARDIAC STRESS AUGMENTATION PACING 有权安全有效地提供CARDIAC应力补充剂的方法和装置公开(公告)号：US20100305648A1
公开(公告)日：2010-12-02
申请号：US12770351
申请日：2010-04-29
CPC分类号： A61N1/3627 , A61N1/37
摘要： A cardiac pacing system controls the progression of a cardiac disorder such as heart failure by delivering cardiac stress augmentation pacing to create or augment regional stress in the heart according to a delivery schedule programmed for a patient. Various events associated with the patient's conditions, activities, and other treatments may render the cardiac stress augmentation pacing risky or ineffective. The system detects such events before and during each cardiac stress augmentation pacing session and modifies the delivery schedule in response to the detection of each event to ensure patient safety and therapy efficiency.
摘要翻译： 心脏起搏系统通过递送心脏应力增加起搏来控制心脏疾病例如心力衰竭的进展，以根据为患者编程的递送计划创建或增加心脏中的区域应力。 与患者病情，活动和其他治疗相关的各种事件可能使心脏应激增加起搏风险或无效。 该系统在每个心脏应激增强起搏会话之前和期间检测这些事件，并根据每个事件的检测来修改递送计划，以确保患者的安全性和治疗效率。
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公开(公告)号：US20100076279A1
公开(公告)日：2010-03-25
申请号：US12565233
申请日：2009-09-23
CPC分类号： A61N1/3627 , A61B5/0031 , A61B5/01 , A61B5/036 , A61B5/053 , A61B5/1076 , A61B5/415 , A61B5/416 , A61B5/418 , A61B5/4205 , A61B5/4878 , A61B5/7275 , A61B8/488 , A61N1/36521
摘要： An apparatus comprises an implantable sensor and a detection circuit. The implantable sensor provides a physiologic sensor signal and is to be positioned at a lymph node of a subject. The detection circuit detects a change in a physiologic parameter of the lymph node that exceeds a threshold change, and deems that the change in the physiologic parameter indicates a change in inflammation of an organ associated with the lymph node.
摘要翻译： 一种装置包括可植入传感器和检测电路。 植入式传感器提供生理传感器信号并且被定位在受试者的淋巴结处。 检测电路检测超过阈值变化的淋巴结生理参数的变化，认为生理参数的变化表示与淋巴结相关的器官的炎症变化。
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公开(公告)号：US20100256700A1
公开(公告)日：2010-10-07
申请号：US12755041
申请日：2010-04-06
CPC分类号： A61N1/36521 , A61N1/3627 , A61N1/365 , A61N1/3702
摘要： A method and device are described for delivering cardiac therapy in which an implantable device for delivering such cardiac therapy is additionally configured to detect the presence of inflammation. Upon detection of inflammation, the device may be configured to modify its delivery of therapy in various ways and/or to communicate the information to an external agent for other types of interventions.
摘要翻译： 描述了用于递送心脏疗法的方法和装置，其中用于递送这种心脏治疗的可植入装置另外配置为检测炎症的存在。 在检测到炎症时，该装置可以被配置为以各种方式修改其治疗递送和/或将信息传达给外部代理以用于其他类型的干预。
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公开(公告)号：US09186512B2
公开(公告)日：2015-11-17
申请号：US12565233
申请日：2009-09-23
CPC分类号： A61N1/3627 , A61B5/0031 , A61B5/01 , A61B5/036 , A61B5/053 , A61B5/1076 , A61B5/415 , A61B5/416 , A61B5/418 , A61B5/4205 , A61B5/4878 , A61B5/7275 , A61B8/488 , A61N1/36521
摘要： An apparatus comprises an implantable sensor and a detection circuit. The implantable sensor provides a physiologic sensor signal and is to be positioned at a lymph node of a subject. The detection circuit detects a change in a physiologic parameter of the lymph node that exceeds a threshold change, and deems that the change in the physiologic parameter indicates a change in inflammation of an organ associated with the lymph node.
摘要翻译： 一种装置包括可植入传感器和检测电路。 植入式传感器提供生理传感器信号并且被定位在受试者的淋巴结处。 检测电路检测超过阈值变化的淋巴结生理参数的变化，认为生理参数的变化表示与淋巴结相关的器官的炎症变化。
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公开(公告)号：US20090299420A1
公开(公告)日：2009-12-03
申请号：US12474448
申请日：2009-05-29
CPC分类号： A61N1/06 , A61B18/02 , A61B2017/22002 , A61B2018/0022 , A61B2018/0212 , A61B2018/0243 , A61F2/958 , A61N1/362
摘要： A method and apparatus are described for delivering myocardial pacing and cryotherapy in conjunction with a coronary revascularization procedure using one catheter/stent system. In one embodiment, a balloon-stent delivery platform incorporates pacing electrode(s) on or near the distal tip for myocardial pacing.
摘要翻译： 描述了一种用于使用一个导管/支架系统与冠状动脉血运重建术一起递送心肌起搏和冷冻治疗的方法和装置。 在一个实施例中，球囊支架递送平台包括用于心肌起搏的远侧末端上或附近的起搏电极。
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公开(公告)号：US08600499B2
公开(公告)日：2013-12-03
申请号：US11566896
申请日：2006-12-05
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61F2/82 , A61N1/3688
摘要： A method and device for treating myocardial ischemia in which an implantable pulse generator delivers electrical stimulation to electrodes disposed near a coronary artery. The stimulation parameters may be adjusted to produce vasodilation and/or vasoconstriction of the artery. The device may be configured to operate in a vasodilation and/or vasoconstriction mode in accordance with specified entry and exit conditions.
摘要翻译： 一种用于治疗心肌缺血的方法和装置，其中植入式脉冲发生器将电刺激递送到设置在冠状动脉附近的电极。 可以调节刺激参数以产生动脉的血管舒张和/或血管收缩。 该装置可以被配置为根据指定的入口和出口条件在血管舒张和/或血管收缩模式中操作。
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9.发明授权Automatic adaptation of A-V delay and HR for heart failure using beat to beat measures 有权自动适应心律失常的A-V延迟和人力资源公开(公告)号：US08463380B2
公开(公告)日：2013-06-11
申请号：US13357259
申请日：2012-01-24
申请人： Donald Hopper , Yinghong Yu , Allan C. Shuros , Shantha Arcot-Krishnamurthy , Gerrard M. Carlson , Jeffrey E. Stahmann
发明人： Donald Hopper , Yinghong Yu , Allan C. Shuros , Shantha Arcot-Krishnamurthy , Gerrard M. Carlson , Jeffrey E. Stahmann
IPC分类号： A61N1/362
CPC分类号： A61N1/36585 , A61N1/368 , A61N1/3682 , A61N1/3684
摘要： Methods and systems to modulate timing intervals for pacing therapy are described. For each cardiac cycle, one or both of an atrioventricular (A-V) timing interval and an atrial (A-A) timing interval are modulated to oppose beat-to-beat ventricular (V-V) timing variability. Pacing therapy is delivered using the modulated timing intervals.
摘要翻译： 描述了调节起搏治疗时间间隔的方法和系统。 对于每个心动周期，房室（A-V）定时间隔和心房（A-A）定时间隔中的一个或两个被调制以抵抗搏动到心室（V-V）的时间变异性。 使用调制的定时间隔来提供起搏治疗。
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10.发明授权公开(公告)号：US08131363B2
公开(公告)日：2012-03-06
申请号：US11860957
申请日：2007-09-25
CPC分类号： A61N1/3627
摘要： A device and method for delivering electrical stimulation to the heart in order to improve cardiac function in heart failure patients. The stimulation is delivered as high-output pacing in which the stimulation is excitatory and also of sufficient energy to augment myocardial contractility. In order to provide a consistent hemodynamic response, the high-output pacing is optimized by delivering it using different parameter sets, evaluating the hemodynamic response thereto as reflected by one or more measured physiological variables, and selecting the parameter set with the best hemodynamic response.
摘要翻译： 用于向心脏递送电刺激以改善心力衰竭患者的心脏功能的装置和方法。 刺激作为高产出起搏，其中刺激是兴奋性的，并且具有足够的能量以增加心肌收缩力。 为了提供一致的血流动力学响应，通过使用不同的参数组递送高输出起搏，通过一个或多个测量的生理变量反映的血液动力学响应进行评估，并且选择具有最佳血液动力学响应的参数集来优化高输出起搏。
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