BENZOXABOROLE COMPOUNDS AND USES THEREOF
    8.
    发明申请
    BENZOXABOROLE COMPOUNDS AND USES THEREOF 审中-公开
    苯并噻唑化合物及其用途

    公开(公告)号:US20150080342A1

    公开(公告)日:2015-03-19

    申请号:US14394427

    申请日:2013-03-15

    IPC分类号: A61K31/69 A61K31/198

    摘要: Norvaline and/or other amino acids that are capable of being acylated onto tRNALeu by LeuRS, in combination with substituted benzoxaboroles, such as a compound having a structure according to formula III: and methods for decreasing the frequency of resistance and/or reducing the rate of resistance and/or suppressing the emergence of resistance that develops in bacteria exposed to a substituted benzoxaborole or salt thereof by administering a combination of a substituted benzoxaborole such as a compound of formula III or salt thereof and an amino acid or a salt thereof.

    摘要翻译: 能够通过LeuRS酰化成tRNALeu的诺瓦宁和/或其它氨基酸与取代的苯并恶唑组合,例如具有根据式III的结构的化合物,以及降低抗性频率和/或降低速率的方法 的抗性和/或抑制暴露于取代的苯并恶唑或其盐的细菌中产生的抗性的出现,其通过给予取代的苯并恶灵如结构式III的化合物或其盐与氨基酸或其盐的组合。