公开(公告)号：US08700139B2

公开(公告)日：2014-04-15

申请号：US13380933

申请日：2009-06-26

申请人： Andreas Blomqvist

发明人： Andreas Blomqvist

IPC分类号： A61B5/04

CPC分类号： A61B5/0452 ,  A61B5/0006 ,  A61B5/002 ,  A61B5/0031 ,  A61B5/0422 ,  A61B5/686 ,  A61B5/7242 ,  A61B5/7275 ,  A61B2505/07 ,  A61N1/362 ,  G06F19/00

摘要： A late potential detecting system has an implantable medical device connected to at least one cardiac lead having implantable electrodes positioned at different sites of a ventricle myocardium. A sampling unit of the implantable medical device records electrogram samples for the different implantable electrodes to get different sample sets. The electrogram samples of the sample sets are time synchronized and magnitude potential representations of the potential data of the electrogram samples are determined. The magnitude potential representations of the time synchronized electrogram samples are then co-processed and used for determining a parameter that is indicative of any late potentials of the monitored ventricle.

摘要翻译： 晚期电位检测系统具有连接到至少一个具有位于心室心肌不同部位的可植入电极的心脏引线的可植入医疗装置。 可植入医疗装置的采样单元记录不同可植入电极的电描记图样品以获得不同的样品组。 样本集的电描记图样本是时间同步的，并且确定电描记图样本的潜在数据的幅度电位表示。 然后对时间同步电描记图样本的幅度电位表示进行协处理，并用于确定指示所监测的心室的任何后期电位的参数。

公开(公告)号：US08679026B2

公开(公告)日：2014-03-25

申请号：US12679711

申请日：2007-11-08

申请人： Andreas Blomqvist

发明人： Andreas Blomqvist

IPC分类号： A61B5/0215 ,  A61B5/021

CPC分类号： A61B5/053 ,  A61B5/02028 ,  A61B5/0215 ,  A61B5/0538 ,  A61N1/36521 ,  A61N1/36564 ,  G06F19/00

摘要： In a medical device and method to monitor pulmonary artery pressure of a patient, a first parameter related to the right ventricular straight volume of the patient's is detected, and a second parameter related to the right ventricular ejection rate of the patient's heart, or related to the workload of the patient's heart, is also determined. A pulmonary pressure index is determined by combining the first and second parameters, with variations of the pulmonary pressure index indicating variations in the pulmonary artery pressure. Pulmonary artery hypertension can be monitored with such a device and method.

摘要翻译： 在用于监测患者的肺动脉压力的医疗装置和方法中，检测与患者的右心室直线容积相关的第一参数，以及与患者心脏的右心室射血率相关的第二参数， 病人心脏的工作量也是确定的。 通过组合第一和第二参数来确定肺压力指数，肺动脉压指数的变化指示肺动脉压力的变化。 可以用这种装置和方法监测肺动脉高血压。

公开(公告)号：US08386041B2

公开(公告)日：2013-02-26

申请号：US12307970

申请日：2006-06-21

申请人： Andreas Blomqvist ,  Johan Svahn

发明人： Andreas Blomqvist ,  Johan Svahn

IPC分类号： A61N1/365 ,  A61B5/05

CPC分类号： A61N1/36521 ,  A61B5/0031 ,  A61B5/02028 ,  A61B5/053

摘要： In implantable medical devices such a pacemaker or cardioverter/defibrillators (ICDs) and systems including such a device and an external programmer a measure of a hemodynamic parameter such as the cardiac output, the stroke volume, or the contractility of a patient is used to trend heart failure or in an AV/VV optimization scheme. The implantable medical device is adapted to measure the cardiac impedance and the cardiac impedance data is used to determine impedance morphology curves, which, in turn, are used to compute a measure of the hemodynamic parameter.

摘要翻译： 在诸如起搏器或心脏复律器/除颤器（ICD）和包括这种装置和外部程序员的系统的可植入医疗装置中，使用诸如心输出量，行程体积或患者的收缩性的血液动力学参数的度量趋势 心力衰竭或AV / VV优化方案。 可植入医疗装置适于测量心脏阻抗，并且心脏阻抗数据用于确定阻抗形态曲线，其又用于计算血液动力学参数的度量。

公开(公告)号：US20120059272A1

公开(公告)日：2012-03-08

申请号：US13319776

申请日：2009-05-13

申请人： Andreas Blomqvist

发明人： Andreas Blomqvist

IPC分类号： A61B5/0452 ,  A61B5/053

CPC分类号： A61B5/1102 ,  A61B5/053 ,  A61B5/0538 ,  A61B5/6869 ,  A61N1/3627 ,  A61N1/36521 ,  A61N1/3684

摘要： In an implantable medical device, such as a bi-ventricular pacemaker and a method for detecting and monitoring mechanical dyssynchronicity of the heart, a dyssynchronicity measure indicating a degree of mechanical dyssynchronicity of a heart of a patient is calculated. A first intracardiac impedance set is measured using electrodes placed such that the first intracardiac impedance set substantially reflects a mechanical activity of the left side of the heart and a second intracardiac impedance set is measure using electrodes placed such that the second intracardiac impedance set substantially reflects a mechanical activity of the right side of the heart. The measure of a dyssynchronicity is calculated based on a resulting parameter set from a comparison between at least a subset of the first and the second impedance sets, respectively, the subsets containing information of the mechanical systole, wherein a reduced dyssynchronicity measure corresponds to an improved synchronicity between the right side and the left side of the heart.

摘要翻译： 在诸如双心室起搏器的可植入医疗装置和用于检测和监测心脏的机械不同步性的方法中，计算指示患者心脏的机械不同步程度的不同步性测量。 使用放置使得第一心内阻抗设定基本上反映心脏左侧的机械活动的电极来测量第一心内阻抗集，并且使用放置的第二心内阻抗设定的电极来测量第二心内阻抗集， 心脏右侧的机械活动。 基于从第一和第二阻抗组的至少一个子集之间的比较的结果参数集计算包含机械收缩信息的子集，其中减少的不同步度测量对应于改进的 心脏右侧和左侧的同步性。

公开(公告)号：US20100268102A1

公开(公告)日：2010-10-21

申请号：US12808041

申请日：2007-12-19

申请人： Andreas Blomqvist ,  Nils Holmstöm ,  Sven-Erik Hedberg ,  Malin Öhlander

发明人： Andreas Blomqvist ,  Nils Holmstöm ,  Sven-Erik Hedberg ,  Malin Öhlander

IPC分类号： A61B5/0472

CPC分类号： A61N1/36521 ,  A61B5/0456 ,  A61B5/053 ,  A61B5/0538 ,  A61N1/3622 ,  A61N1/3684

摘要： In an implantable heart monitoring device and a monitoring method, an impedance is measured across at least part of an atrium, such that variation of the impedance is related to the volume change of the atrium. Values are stored at different occasions that indicate the rate of change of the measured impedance. The stored values are determined such that, when the device is used in a living being, the variation of the stored values will be related to the variation of the speed with which the atrium is filled with blood during the atrial diastole.

摘要翻译： 在可植入心脏监测装置和监测方法中，跨越心房的至少一部分测量阻抗，使得阻抗的变化与心房的体积变化相关。 值存储在指示测量阻抗的变化率的不同场合。 确定所存储的值，使得当在生物体中使用该装置时，存储值的变化将与在心房舒张期期间心房充满血液的速度的变化相关。

公开(公告)号：US20100168812A1

公开(公告)日：2010-07-01

申请号：US12663304

申请日：2007-06-27

申请人： Andreas Blomqvist ,  Michael Broomé

发明人： Andreas Blomqvist ,  Michael Broomé

IPC分类号： A61N1/365 ,  A61B5/00

CPC分类号： A61N1/3702 ,  A61B5/02405 ,  A61B5/053 ,  A61B5/076 ,  A61B5/4812 ,  A61B5/7275 ,  A61N1/36521 ,  A61N1/36585 ,  A61N1/37282 ,  G16H50/20 ,  G16H50/70

摘要： In a method and a device for trending and prediction of monitored conditions or diseases, an REM sleep detector is provided to allow data collected during REM sleep to be separated from other data so stable and uniform conditions for data collection are achieved. The REM sleep detector can advantageously be provided inside an implantable medical device.

摘要翻译： 在用于趋势和预测监测的病症或疾病的方法和装置中，提供REM睡眠检测器以允许在REM睡眠期间收集的数据与其他数据分离，从而实现用于数据收集的稳定和均匀的条件。 REM睡眠检测器可以有利地设置在可植入医疗装置的内部。

公开(公告)号：US20100099994A1

公开(公告)日：2010-04-22

申请号：US12528160

申请日：2007-02-28

申请人： Nils Holmström ,  Andreas Blomqvist ,  Berit Larsson ,  Karin Järverud ,  Sven-Erik Hedberg

发明人： Nils Holmström ,  Andreas Blomqvist ,  Berit Larsson ,  Karin Järverud ,  Sven-Erik Hedberg

IPC分类号： A61B5/02

CPC分类号： A61B5/1107 ,  A61B5/0051 ,  A61B5/4519 ,  A61B5/6869 ,  A61N1/36578

摘要： An implantable heart analyzing device has a housing and a control circuit located within said housing. The control circuit generates an output signal adapted to actuate an activator, which is able to make a wall of the heart deflect or vibrate. The control circuit also communicates with a sensor, which can be identical with the activator, with which the movement of the heart wall can be sensed. The control circuit executes a procedure that involves the generation of an output signal and sensing a corresponding sensor signal, and to be able to derive information concerning the tension of the heart wall. An implantable heart analyzing includes the aforementioned heart analyzing device, as well as the activator and the sensor. The heart analyzing device and the system implement a method that results in generation of the aforementioned information concerning the tension of the heart wall.

摘要翻译： 可植入心脏分析装置具有壳体和位于所述壳体内的控制电路。 控制电路产生适于致动激活器的输出信号，其能够使心脏的壁发生偏转或振动。 控制电路还与传感器通信，传感器可以与激活器相同，通过该传感器可以感测心脏壁的移动。 控制电路执行涉及生成输出信号并感测相应的传感器信号的过程，并且能够得出关于心壁的张力的信息。 可植入心脏分析包括上述心脏分析装置，以及活化剂和传感器。 心脏分析装置和系统实施导致产生上述关于心脏壁张力的信息的方法。

公开(公告)号：US20100041970A1

公开(公告)日：2010-02-18

申请号：US12532186

申请日：2007-11-27

申请人： Sven-Erik Hedberg ,  Andreas Blomqvist ,  Karin Järverud ,  Karin Ljungström ,  Leif Lindkvist ,  Urban Lönn ,  Nils Holmström

发明人： Sven-Erik Hedberg ,  Andreas Blomqvist ,  Karin Järverud ,  Karin Ljungström ,  Leif Lindkvist ,  Urban Lönn ,  Nils Holmström

IPC分类号： A61B5/1459

CPC分类号： A61N1/3702 ,  A61B5/14542 ,  A61B5/1459 ,  A61N1/056 ,  A61N1/36557

摘要： An implantable medical device has an oxygen sensor adapted to measure the level of oxygen in oxygenized blood, and to generate an oxygen measurement signal in dependence of the level of oxygen. The oxygen sensor is adapted to perform measurements inside the heart, of blood entering the left atrium of a patient's heart. The obtained oxygen measurement signal is compared to a predetermined threshold level and an indication signal is generated in dependence of the comparison. The, indication signal is indicative of the lung functionality of the patient.

摘要翻译： 可植入医疗装置具有适于测量氧合血液中的氧气水平的氧传感器，并且根据氧气水平产生氧测量信号。 氧传感器适于在心脏内进行血液进入患者心脏左心房的血液。 将获得的氧测量信号与预定阈值电平进行比较，并根据比较产生指示信号。 该指示信号表示患者的肺功能。

公开(公告)号：US09026207B2

公开(公告)日：2015-05-05

申请号：US12810406

申请日：2008-01-28

申请人： Andreas Blomqvist

发明人： Andreas Blomqvist

IPC分类号： A61N1/365 ,  A61B5/02 ,  A61B5/0205 ,  A61B5/0452 ,  A61B5/053 ,  A61B5/08 ,  A61B5/00 ,  A61N1/362

CPC分类号： A61N1/36521 ,  A61B5/0031 ,  A61B5/02028 ,  A61B5/0205 ,  A61B5/0452 ,  A61B5/053 ,  A61B5/0809 ,  A61B5/4818 ,  A61B5/7239 ,  A61N1/3622

摘要： In a device and a method for providing correlated measures for predicting potential occurrence of atrial fibrillation, an impedance of the patient is measured to obtain impedance information; cardiogenic data is determined from the information; respiratory data is determined from the information; at least one hemodynamic measure is calculated from the cardiogenic data and at least one apnea measure is calculated from the respiratory data; the hemodynamic and apnea measures are correlated such that the correlated measures can be utilized for predicting potential occurrence of atrial fibrillation.

摘要翻译： 在用于提供用于预测心房颤动的潜在发生的相关措施的装置和方法中，测量患者的阻抗以获得阻抗信息; 从信息确定心源生成数据; 从信息中确定呼吸数据; 从心源性数据计算出至少一种血液动力学测量，并根据呼吸数据计算至少一种呼吸暂停测量; 血流动力学和呼吸暂停测量是相关的，以便相关度量可用于预测房颤的潜在发生。

公开(公告)号：US08812109B2

公开(公告)日：2014-08-19

申请号：US13593334

申请日：2012-08-23

申请人： Andreas Blomqvist ,  Kjell Noren

发明人： Andreas Blomqvist ,  Kjell Noren

IPC分类号： A61N1/00

CPC分类号： A61N1/00 ,  A61N1/3627 ,  A61N1/36514 ,  A61N1/36564 ,  A61N1/3682 ,  A61N1/3684

摘要： In an implantable medical device and a method for stimulating a heart of a patient, at least one left atrial pressure (LAP) signal over a cardiac cycle is obtained. The A-wave is identified using the LAP signal and a maximum positive rate of change of the A-wave of the LAP signal is determined. The maximum positive rate of change of the A-wave corresponds to the rate which the pressure in the atrium raises as the atria contraction forces more blood into the ventricle during the very last stage of diastole. Further, AV and/or VV delay is adjusted in response to the maximum positive rate of change of the A-wave, wherein a reduction of the maximum positive rate of change of the A-wave indicates an AV and/or VV delay providing an enhanced hemodynamic performance.

摘要翻译： 在可植入医疗装置和刺激患者心脏的方法中，获得心动周期上的至少一个左心房压力（LAP）信号。 使用LAP信号识别A波，并确定LAP信号的A波的最大正比率。 A波的最大阳性变化率对应于心房收缩期间压力升高的速率，因为心房收缩在舒张期的最后阶段迫使更多的血液进入心室。 此外，AV和/或VV延迟响应于A波的最大正的变化速率而被调整，其中A波的最大正的变化率的减小表示AV和/或VV延迟提供 增强血液动力学性能。