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公开(公告)号：US06428970B2
公开(公告)日：2002-08-06
申请号：US09747142
申请日：2000-12-22
IPC分类号： G01N3353
CPC分类号： C07K14/521 , A61K38/00 , A61K48/00 , C07K2319/00 , C12Q1/703
摘要： The invention relates to therapeutic compositions and methods for treating and preventing infection by an immunodeficiency virus, particularly HIV infection, using chemokine proteins, nucleic acids and/or derivatives or analogs thereof.
摘要翻译： 本发明涉及使用趋化因子蛋白，核酸和/或其衍生物或类似物治疗和预防免疫缺陷病毒感染，特别是HIV感染的治疗组合物和方法。
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2.发明授权Macrophage derived chemokine (MDC) as an anti-viral agent for the treatment and prevention of lentivirus infection 失效巨噬细胞来源的趋化因子（MDC）作为用于治疗和预防慢病毒感染的抗病毒剂公开(公告)号：US06548631B1
公开(公告)日：2003-04-15
申请号：US08931764
申请日：1997-09-16
IPC分类号： C07K700
CPC分类号： C07K14/523 , A61K38/00 , A61K48/00
摘要： The present invention relates to therapeutic compositions of macrophage derived chemokine (MDC) and methods for treating and preventing infection by a lentivirus, particularly an immunodeficiency virus, particularly HIV, using MDC proteins, nucleic acids and/or derivatives or analogues thereof. The present invention further relates to methods for detection and prognosis of lenivirus infection, particularly HIV infection using MDC as a prognostic indicator. The present invention further provides MDC proteins, nucleic acids encoding such proteins, that have amino-terminal sequences that differ from other MDC isolates. Recombinant host cells and methods of production are also provided.
摘要翻译： 本发明涉及巨噬细胞来源的趋化因子（MDC）的治疗组合物以及使用MDC蛋白质，核酸和/或其衍生物或类似物治疗和预防慢病毒，特别是免疫缺陷病毒，特别是HIV的感染的方法。 本发明还涉及使用MDC作为预后指标的禽流感病毒感染特别是HIV感染的检测和预后的方法。 本发明还提供了MDC蛋白质，编码这种蛋白质的核酸，其具有不同于其他MDC分离物的氨基末端序列。 还提供了重组宿主细胞和生产方法。
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3.发明授权Directional induction of immune response by co-administration of antigens with chemokines 失效通过与趋化因子共同给予抗原来定向诱导免疫应答公开(公告)号：US07708983B2
公开(公告)日：2010-05-04
申请号：US11458555
申请日：2006-07-19
CPC分类号： A61K39/00 , A61K39/12 , A61K39/21 , A61K39/39 , A61K2039/53 , A61K2039/55522 , C07K14/005 , C12N2740/16122 , C12N2740/16134
摘要： The present invention relates to compositions and methods of using same to direct an immune response thereby enhancing the efficacy of an antigen containing vaccine by combining a chemokine in conjunction with the vaccine, wherein the choice of the chemokine directs the immune response in either the Th1 or Th2 direction.
摘要翻译： 本发明涉及使用其组合物和方法来引导免疫应答从而通过将趋化因子与疫苗组合而增强抗原含有疫苗的功效，其中趋化因子的选择将免疫应答指导在Th1或 Th2方向。
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4.发明申请Directional induction of immune response by co-administration of antigens with chemokines 失效通过与趋化因子共同给予抗原来定向诱导免疫应答公开(公告)号：US20080112976A1
公开(公告)日：2008-05-15
申请号：US11458555
申请日：2006-07-19
CPC分类号： A61K39/00 , A61K39/12 , A61K39/21 , A61K39/39 , A61K2039/53 , A61K2039/55522 , C07K14/005 , C12N2740/16122 , C12N2740/16134
摘要： The present invention relates to compositions and methods of using same to direct an immune response thereby enhancing the efficacy of an antigen containing vaccine by combining a chemokine in conjunction with the vaccine, wherein the choice of the chemokine directs the immune response in either the Th1 or Th2 direction.
摘要翻译： 本发明涉及使用其组合物和方法来引导免疫应答从而通过将趋化因子与疫苗组合而增强抗原含有疫苗的功效，其中趋化因子的选择将免疫应答指导在Th1或 Th2方向。
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5.发明授权Chemokines that inhibit immunodeficiency virus infection and methods based thereon 失效抑制免疫缺陷病毒感染的趋化因子及其基础的方法公开(公告)号：US06214540B1
公开(公告)日：2001-04-10
申请号：US08826133
申请日：1997-03-26
IPC分类号： C12Q170
CPC分类号： C07K14/521 , A61K38/00 , A61K48/00 , C07K2319/00 , C12Q1/703
摘要： The present invention relates to therapeutic compositions and methods for treating and preventing infection by an immunodeficiency virus, particularly HIV infection, using chemokine proteins, nucleic acids and/or derivatives or analogues thereof.
摘要翻译： 本发明涉及使用趋化因子蛋白，核酸和/或其衍生物或类似物治疗和预防免疫缺陷病毒感染，特别是HIV感染的治疗组合物和方法。
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6.发明授权Biologically active polypeptides derived from a novel early stage pregnancy factor designated maternin (MA) 有权衍生自命名为雌激素（MA）的新型早期妊娠因子的生物活性多肽公开(公告)号：US07994278B1
公开(公告)日：2011-08-09
申请号：US09632831
申请日：2000-08-04
CPC分类号： C07K16/26 , A61K38/00 , A61K48/00 , C07K14/59 , C07K2319/00
摘要： The invention relates to therapeutic polypeptides isolated from beta-human chorionic gonadotropin (β-hCG) found in human early pregnancy urine, now synthetically produced and designated Maternin. The therapeutic polypeptides and their functional equivalents are useful in treating and/or preventing various medical conditions. Examples of therapeutic effects of the therapeutic polypeptides include anti-HIV, anti-cancer, anti-wasting, prohematopoietic (e.g., anemias, radiation-mediated bone marrow damage, and trauma-mediated blood loss), and anti-angiogenic effects. The invention also provides pharmaceutical compositions comprising the therapeutic polypeptides, as well as methods for using the therapeutic polypeptides, functional equivalents and/or pharmaceutical compositions in the treatment and/or prevention of such medical conditions.
摘要翻译： 本发明涉及从人类早孕尿中发现的β-人绒毛膜促性腺激素（＆bgr--hCG）分离的治疗性多肽，现在合成产生并命名为Maternin。 治疗性多肽及其功能等同物可用于治疗和/或预防各种医疗状况。 治疗性多肽的治疗效果的实例包括抗HIV，抗癌，抗浪费，造血（例如，贫血，辐射介导的骨髓损伤和创伤介导的失血）和抗血管生成作用。 本发明还提供了包含治疗性多肽的药物组合物，以及使用治疗性多肽，功能等同物和/或药物组合物治疗和/或预防这些医学病症的方法。
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7.发明授权Methods for the propagation, isolation, identification, and preparation of human immunodeficiency virus type 1 (HIV-1) 失效人类免疫缺陷病毒1型（HIV-1）的繁殖，分离，鉴定和制备方法公开(公告)号：US06627395B1
公开(公告)日：2003-09-30
申请号：US08466256
申请日：1995-06-06
申请人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Francoise Brun-Vezinet , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Therese Nugeyre , Francoise Rey , Claudine Axler-Blin , Solange Chamaret , Robert C. Gallo , Mikulas Popovic , Mangalasseril G. Sarngadharan
发明人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Francoise Brun-Vezinet , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Therese Nugeyre , Francoise Rey , Claudine Axler-Blin , Solange Chamaret , Robert C. Gallo , Mikulas Popovic , Mangalasseril G. Sarngadharan
IPC分类号： C12Q170
CPC分类号： C07K16/1045 , C07K14/005 , C12N7/00 , C12N2740/16051 , C12N2740/16222 , G01N2333/16
摘要： The identification, separation, purification, and propagation of the HIV-1 virus is provided. Moreover, the preparation of antigens from HIV-1 is further provided. The identification of HIV-1 involves the purification of a virus sample from lymphocytes and contacting the sample with antibodies, which bind to HIV-1 viruses, is provided. The propagation of HIV-1 virus involves infecting uninfected T lymphocytes with the virus. Moreover, the preparation of antigens from HIV-1 involves the separation of protein components of a purified HIV-1 virus under denaturing conditions.
摘要翻译： 提供HIV-1病毒的鉴定，分离，纯化和扩增。 此外，还提供了来自HIV-1的抗原的制备。 HIV-1的鉴定涉及从淋巴细胞中纯化病毒样品并使样品与结合HIV-1病毒的抗体接触。 HIV-1病毒的传播涉及用病毒感染未感染的T淋巴细胞。 此外，HIV-1抗原的制备涉及在变性条件下分离纯化的HIV-1病毒的蛋白质组分。
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公开(公告)号：US06290963B1
公开(公告)日：2001-09-18
申请号：US07314664
申请日：1989-02-23
申请人： Peter J. Fischinger , Flossie Wong-Stall , Robert C. Gallo , Thomas J. Matthews , Dani P. Bolognesi , Gerard W. Robey , Kai Krohn , Annamarie Ranki
发明人： Peter J. Fischinger , Flossie Wong-Stall , Robert C. Gallo , Thomas J. Matthews , Dani P. Bolognesi , Gerard W. Robey , Kai Krohn , Annamarie Ranki
IPC分类号： A61K3921
CPC分类号： C07K14/005 , A61K2039/5156 , A61K2039/57 , C12N2740/16122
摘要： Native and recombinant peptides which elicit anti-HIV immune response are provided.
摘要翻译： 提供引起抗HIV免疫应答的天然和重组肽
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公开(公告)号：US6018027A
公开(公告)日：2000-01-25
申请号：US854
申请日：1997-12-30
申请人： Syed Zaki Salahuddin , Dharam V Ablashi , Steven F. Josephs , Carl W. Saxinger , Flossie Wong-Staal , Robert C. Gallo
发明人： Syed Zaki Salahuddin , Dharam V Ablashi , Steven F. Josephs , Carl W. Saxinger , Flossie Wong-Staal , Robert C. Gallo
IPC分类号： C07K14/03 , C12N7/00 , C12N7/02 , C12Q1/70 , G01N33/569
CPC分类号： C07K14/005 , C12N7/00 , C12Q1/701 , C12Q1/702 , C12Q1/703 , C12Q1/705 , G01N33/56983 , C12N2710/16521 , C12N2710/16522 , C12N2710/16551 , C12N2710/16622
摘要： A new human B lymphotropic virus, also designated human herpesvirus-6, has been isolated. DNA, molecular clones, antigenic viral proteins and antibodies having specificity to the new virus have been prepared. Various utilities of the new virus and products derived therefrom have been described.
摘要翻译： 已经分离出新的人B淋巴细胞病毒，也被称为人疱疹病毒-6。 已经制备了DNA，分子克隆，抗原性病毒蛋白和对新病毒具有特异性的抗体。 已描述了新病毒及其衍生产品的各种用途。
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10.发明授权Method of promoting hematopoiesis using derivatives of human chorionic gonadotropin 失效使用人绒毛膜促性腺激素衍生物促进造血的方法
公开(公告)号：US5968513A
公开(公告)日：1999-10-19
申请号：US709924
申请日：1996-09-09
CPC分类号： A61K38/24 , A61K48/00 , Y10S514/885
摘要： The present invention relates to methods of treating or preventing diseases or disorders associated with hematopoietic deficiency by administration of human chorionic gonadotropin, .beta.-human chorionic gonadotropin or a peptide containing a sequence of a portion of .beta.-human chorionic gonadotropin. The invention also relates to methods of treating or preventing diseases or disorders associated with hematopoietic deficiency by administration of hematopoietic cells, the numbers of which have been increased by contacting the cells with human chorionic gonadotropin, .beta.-human chorionic gonadotropin or a peptide containing a sequence of a portion of .beta.-human chorionic gonadotropin. The invention also provides assays for the utility of particular human chorionic gonadotropin preparations in the treatment or prevention of hematopoietic deficiencies or in the increasing of hematopoietic cell numbers in vitro. Pharmaceutical compositions and methods of administration of are also provided.
摘要翻译： 本发明涉及通过施用人绒毛膜促性腺激素，β-人绒毛膜促性腺激素或含有一部分β-人绒毛膜促性腺激素序列的肽来治疗或预防与造血缺陷相关的疾病或病症的方法。 本发明还涉及通过给予造血细胞来治疗或预防与造血缺陷相关的疾病或病症的方法，所述造血细胞的数量通过使细胞与人绒毛膜促性腺激素接触而增加，β-人绒毛膜促性腺激素或含有序列的肽 的一部分β-人绒毛膜促性腺激素。 本发明还提供特异性人绒毛膜促性腺激素制剂用于治疗或预防造血缺陷或增加体外造血细胞数量的测定。 还提供了药物组合物和给药方法。
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