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    Mnk KINASE HOMOLOGOUS PROTEINS INVOLVED IN THE REGULATION OF ENERGY HOMEOSTASIS AND ORGANELLE METABOLISM
    1.
    发明申请
    Mnk KINASE HOMOLOGOUS PROTEINS INVOLVED IN THE REGULATION OF ENERGY HOMEOSTASIS AND ORGANELLE METABOLISM 有权
    Mnk激活能源家畜和有机物代谢调控中涉及的同种异体蛋白

    公开(公告)号：US20120045452A1

    公开(公告)日：2012-02-23

    申请号：US13245188

    申请日：2011-09-26

    申请人： Arnd Steuernagel ,  Karsten Eulenberg ,  Günter Brönner ,  Thomas Ciossek ,  Bettina Rudolph ,  Dorothea Rudolph ,  Funmi Belgore ,  Stefan Jäkel ,  Christoph Meyer

    发明人： Arnd Steuernagel ,  Karsten Eulenberg ,  Günter Brönner ,  Thomas Ciossek ,  Bettina Rudolph ,  Dorothea Rudolph ,  Funmi Belgore ,  Stefan Jäkel ,  Christoph Meyer

    IPC分类号： A61K31/7088 ,  A61P1/18 ,  G01N33/573 ,  C12Q1/48 ,  C12Q1/68 ,  A61K39/395 ,  A61P3/10

    CPC分类号： C12N9/1205 ,  A61K38/45 ,  Y10S514/909

    摘要： This invention relates to the use of nucleic acid sequences of the MAP kinase-interacting kinase (Mnk) gene family and amino acid sequences encoded thereby, and to using these sequences or effectors of Mnk nucleic acids or polypeptides, particularly Mnk kinase inhibitors and activators, in the diagnosis and treatment of diseases and disorders related to body-weight regulation and thermogenesis. One aspect of the disclosure encompasses methods of identifying an animal or human having an elevated probability of having or developing a pancreatic malfunction, the method comprising: (a) obtaining a biological sample from an animal or human subject; and (b) determining from the biological sample whether the subject has a genetic variant of an Mnk2 and/or Mnk1 gene or a homolog thereof, or an expression product of said Mnk2 and/or Mnk1 gene or homolog thereof, wherein said genetic variant is associated with an elevated probability of having or developing a pancreatic malfunction.

    摘要翻译： 本发明涉及MAP激酶相互作用激酶（Mnk）基因家族的核酸序列及其编码的氨基酸序列的用途，以及使用Mnk核酸或多肽，特别是Mnk激酶抑制剂和激活剂的这些序列或效应物， 在与体重调节和产热相关的疾病和病症的诊断和治疗中。 本公开的一个方面包括识别具有升高的胰腺功能障碍或发展中的可能性的动物或人的方法，所述方法包括：（a）从动物或人类受试者获得生物样品; 和（b）从生物样品中确定受试者是否具有Mnk2和/或Mnk1基因的遗传变体或其同源物，或所述Mnk2和/或Mnk1基因的表达产物或其同源物，其中所述遗传变异体为 与胰腺功能障碍的发生概率相关。

    Mnk kinase homologous proteins involved in the regulation of energy homeostasis and organelle metabolism
    2.
    发明授权
    Mnk kinase homologous proteins involved in the regulation of energy homeostasis and organelle metabolism 有权
    参与调节能量稳态和细胞器代谢的Mnk激酶同源蛋白

    公开(公告)号：US08828934B2

    公开(公告)日：2014-09-09

    申请号：US13245188

    申请日：2011-09-26

    申请人： Arnd Steuernagel ,  Karsten Eulenberg ,  Guenter Broenner ,  Thomas Ciossek ,  Bettina Rudolph ,  Dorothea Rudolph ,  Funmi Belgore ,  Stefan Jaekel ,  Christoph Meyer

    发明人： Arnd Steuernagel ,  Karsten Eulenberg ,  Guenter Broenner ,  Thomas Ciossek ,  Bettina Rudolph ,  Dorothea Rudolph ,  Funmi Belgore ,  Stefan Jaekel ,  Christoph Meyer

    IPC分类号： A61K38/45 ,  C12N9/12 ,  A61K38/00

    CPC分类号： C12N9/1205 ,  A61K38/45 ,  Y10S514/909

    摘要： This invention relates to the use of nucleic acid sequences of the MAP kinase-interacting kinase (Mnk) gene family and amino acid sequences encoded thereby, and to using these sequences or effectors of Mnk nucleic acids or polypeptides, particularly Mnk kinase inhibitors and activators, in the diagnosis and treatment of diseases and disorders related to body-weight regulation and thermogenesis. One aspect of the disclosure encompasses methods of identifying an animal or human having an elevated probability of having or developing a pancreatic malfunction, the method comprising: (a) obtaining a biological sample from an animal or human subject; and (b) determining from the biological sample whether the subject has a genetic variant of an Mnk2 and/or Mnk1 gene or a homolog thereof, or an expression product of said Mnk2 and/or Mnk1 gene or homolog thereof, wherein said genetic variant is associated with an elevated probability of having or developing a pancreatic malfunction.

    摘要翻译： 本发明涉及MAP激酶相互作用激酶（Mnk）基因家族的核酸序列及其编码的氨基酸序列的用途，以及使用Mnk核酸或多肽，特别是Mnk激酶抑制剂和激活剂的这些序列或效应物， 在与体重调节和产热相关的疾病和病症的诊断和治疗中。 本公开的一个方面包括识别具有升高的胰腺功能障碍或发展中的可能性的动物或人的方法，所述方法包括：（a）从动物或人类受试者获得生物样品; 和（b）从生物样品中确定受试者是否具有Mnk2和/或Mnk1基因的遗传变体或其同源物，或所述Mnk2和/或Mnk1基因的表达产物或其同源物，其中所述遗传变异体为 与胰腺功能障碍的发生概率相关。

    Mnk kinase homologous proteins involved in the regulation of energy homeostasis and organelle metabolism
    4.
    发明授权
    Mnk kinase homologous proteins involved in the regulation of energy homeostasis and organelle metabolism 失效
    参与调节能量稳态和细胞器代谢的Mnk激酶同源蛋白

    公开(公告)号：US08076098B2

    公开(公告)日：2011-12-13

    申请号：US12174301

    申请日：2008-07-16

    申请人： Arnd Steuernagel ,  Karsten Eulenberg ,  Guenter Broenner ,  Thomas Ciossek ,  Bettina Rudolph ,  Dorothea Rudolph ,  Funmi Belgore ,  Stefan Jaekel ,  Christoph Meyer

    发明人： Arnd Steuernagel ,  Karsten Eulenberg ,  Guenter Broenner ,  Thomas Ciossek ,  Bettina Rudolph ,  Dorothea Rudolph ,  Funmi Belgore ,  Stefan Jaekel ,  Christoph Meyer

    IPC分类号： C12Q1/48

    CPC分类号： C12N9/1205 ,  A61K38/45 ,  Y10S514/909

    摘要： The present invention discloses Mnk homologous proteins regulating the energy homeostasis, the metabolism of triglycerides, and/or is contributing to membrane stability and/or function of organelles, and polynucleotides, which identify and encode the proteins disclosed in this invention. The invention also relates to the use of these sequences in the diagnosis, study, prevention, and treatment of diseases and disorders related to body-weight regulation and thermogenesis, for example, but not limited to, metabolic diseases such as obesity, as well as related disorders such as eating disorder, cachexia, diabetes mellitus, hypertension, coronary heart disease, hypercholesterolemia, dyslipidemia, osteoarthritis, gallstones, and sleep apnea, and disorders related to ROS defence, such as diabetes mellitus, neurodegenerative disorders, and cancer, e.g. cancers of the reproductive organs, and others.

    摘要翻译： 本发明公开了调节能量稳态的Mnk同源蛋白质，甘油三酸酯的代谢和/或有助于细胞器的膜稳定性和/或功能，以及鉴定和编码本发明公开的蛋白质的多核苷酸。 本发明还涉及这些序列用于诊断，研究，预防和治疗与体重调节和产热有关的疾病和病症的用途，例如但不限于代谢性疾病如肥胖症，以及 相关疾病如进食障碍，恶病质，糖尿病，高血压，冠心病，高胆固醇血症，血脂异常，骨关节炎，胆结石和睡眠呼吸暂停，以及与ROS防御相关的疾病，如糖尿病，神经变性疾病和癌症，例如 生殖器官的癌症等。

    Mnk kinase homologous proteins involved in the regulation of energy homeostasis and organelle metabolism
    5.
    发明授权
    Mnk kinase homologous proteins involved in the regulation of energy homeostasis and organelle metabolism 有权
    参与调节能量稳态和细胞器代谢的Mnk激酶同源蛋白

    公开(公告)号：US08957020B2

    公开(公告)日：2015-02-17

    申请号：US13245113

    申请日：2011-09-26

    申请人： Arnd Steuernagel ,  Karsten Eulenberg ,  Guenter Broenner ,  Thomas Ciossek ,  Bettina Rudolph ,  Dorothea Rudolph ,  Funmi Belgore ,  Stefan Jaekel ,  Christoph Meyer

    发明人： Arnd Steuernagel ,  Karsten Eulenberg ,  Guenter Broenner ,  Thomas Ciossek ,  Bettina Rudolph ,  Dorothea Rudolph ,  Funmi Belgore ,  Stefan Jaekel ,  Christoph Meyer

    IPC分类号： C12N9/12 ,  A61K38/45 ,  A61K38/00

    CPC分类号： C12N9/1205 ,  A61K38/45 ,  Y10S514/909

    摘要： This invention relates to the use of nucleic acid sequences of the MAP kinase-interacting kinase (Mnk) gene family and amino acid sequences encoded thereby, and to using these sequences or effectors of Mnk nucleic acids or polypeptides, particularly Mnk kinase inhibitors and activators, in the diagnosis and treatment of diseases and disorders related to body-weight regulation and thermogenesis. One aspect of the disclosure encompasses methods of identifying an animal or human having an elevated probability of having or developing obesity, the method comprising: (a) obtaining a biological sample from an animal or human subject; and (b) determining from the biological sample whether the animal or human subject has a genetic variant of an Mnk2 and/or Mnk1 gene or a homolog thereof, or an expression product of said Mnk2 and/or Mnk1 gene or homolog thereof, wherein said genetic variant is associated with an elevated probability of having or developing obesity.

    摘要翻译： 本发明涉及MAP激酶相互作用激酶（Mnk）基因家族的核酸序列及其编码的氨基酸序列的用途，以及使用Mnk核酸或多肽，特别是Mnk激酶抑制剂和激活剂的这些序列或效应物， 在与体重调节和产热相关的疾病和病症的诊断和治疗中。 本公开的一个方面包括鉴定具有升高的发生或发展肥胖的概率的动物或人的方法，所述方法包括：（a）从动物或人类受试者获得生物样品; 和（b）从生物样品中确定动物或人类受试者是否具有Mnk2和/或Mnk1基因或其同源物的遗传变体，或所述Mnk2和/或Mnk1基因的表达产物或其同源物，其中所述 遗传变异与增加或发展肥胖的可能性相关。

    Mnk KINASE HOMOLOGOUS PROTEINS INVOLVED IN THE REGULATION OF ENERGY HOMEOSTASIS AND ORGANELLE METABOLISM
    7.
    发明申请
    Mnk KINASE HOMOLOGOUS PROTEINS INVOLVED IN THE REGULATION OF ENERGY HOMEOSTASIS AND ORGANELLE METABOLISM 失效
    Mnk激活能源家畜和有机物代谢调控中涉及的同种异体蛋白

    公开(公告)号：US20090170095A1

    公开(公告)日：2009-07-02

    申请号：US12174301

    申请日：2008-07-16

    申请人： Arnd Steuernagel ,  Karsten Eulenberg ,  Gunter Broenner ,  Thomas Clossek ,  Bettina Rudoplh ,  Dorothea Rudolph ,  Funmi Belgore ,  Stefan Jakel ,  Christoph Meyer

    发明人： Arnd Steuernagel ,  Karsten Eulenberg ,  Gunter Broenner ,  Thomas Clossek ,  Bettina Rudoplh ,  Dorothea Rudolph ,  Funmi Belgore ,  Stefan Jakel ,  Christoph Meyer

    IPC分类号： C12Q1/68 ,  G01N33/53 ,  C12Q1/48

    CPC分类号： C12N9/1205 ,  A61K38/45 ,  Y10S514/909

    摘要： The present invention discloses Mnk homologous proteins regulating the energy homeostasis, the metabolism of triglycerides, and/or is contributing to membrane stability and/or function of organelles, and polynucleotides, which identify and encode the proteins disclosed in this invention. The invention also relates to the use of these sequences in the diagnosis, study, prevention, and treatment of diseases and disorders related to body-weight regulation and thermogenesis, for example, but not limited to, metabolic diseases such as obesity, as well as related disorders such as eating disorder, cachexia, diabetes mellitus, hypertension, coronary heart disease, hypercholesterolemia, dyslipidemia, osteoarthritis, gallstones, and sleep apnea, and disorders related to ROS defence, such as diabetes mellitus, neurodegenerative disorders, and cancer, e.g. cancers of the reproductive organs, and others.

    摘要翻译： 本发明公开了调节能量稳态的Mnk同源蛋白质，甘油三酸酯的代谢和/或有助于细胞器的膜稳定性和/或功能，以及鉴定和编码本发明公开的蛋白质的多核苷酸。 本发明还涉及这些序列用于诊断，研究，预防和治疗与体重调节和产热有关的疾病和病症的用途，例如但不限于代谢性疾病如肥胖症，以及 相关疾病如进食障碍，恶病质，糖尿病，高血压，冠心病，高胆固醇血症，血脂异常，骨关节炎，胆结石和睡眠呼吸暂停，以及与ROS防御相关的疾病，如糖尿病，神经变性疾病和癌症，例如 生殖器官的癌症等。

    Handling of data transfers in a network with a ring topology
    8.
    发明授权
    Handling of data transfers in a network with a ring topology 有权

    公开(公告)号：US09716652B2

    公开(公告)日：2017-07-25

    申请号：US14381309

    申请日：2012-03-05

    申请人： Dirk Kampmann ,  Christoph Meyer ,  Andreas Witzel

    发明人： Dirk Kampmann ,  Christoph Meyer ,  Andreas Witzel

    IPC分类号： H04L12/741 ,  H04L12/42 ,  H04L12/46 ,  H04L12/715

    CPC分类号： H04L45/74 ,  H04L12/42 ,  H04L12/462 ,  H04L45/64

    摘要： A method for handling, by a ring node of a network having a ring topology, a data transfer of data packets through the network via which the data packets are transmitted to their destination node, wherein each ring node has two neighboring ring nodes. The method includes detecting data packets of an incoming data transfer received from a non ring node to be transmitted through the network to their destination node. Furthermore, a ring direction is added to the data packets of the incoming data transfer, the indication indicating in which direction the data packets of the incoming data transfer are passed through the network having the ring topology. The data packets of the incoming data transfer are forwarded to one of the two neighboring ring nodes based on the added indication.

    Service assurance using network measurement triggers
    9.
    发明授权
    Service assurance using network measurement triggers 有权
    使用网络测量触发器的服务保证

    公开(公告)号：US09032068B2

    公开(公告)日：2015-05-12

    申请号：US13289854

    申请日：2011-11-04

    申请人： Samita Chakrabarti ,  Tomas Thyni ,  Christoph Meyer ,  Robert C. Frazier ,  Scott Andrew Mansfield

    发明人： Samita Chakrabarti ,  Tomas Thyni ,  Christoph Meyer ,  Robert C. Frazier ,  Scott Andrew Mansfield

    IPC分类号： G01R31/08 ,  G06F11/00 ,  G06F15/173 ,  H04L12/801 ,  H04L12/721 ,  H04L12/841

    CPC分类号： H04L47/12 ,  H04L45/70 ,  H04L47/283

    摘要： A method performed in a network element for reacting to communication performance measurements that fall outside of communication performance thresholds. The network element generates a communication performance measurement between a first endpoint and a second endpoint, wherein each endpoint is a point of communication in the network and at least the first endpoint resides on the network element. The network element retrieves a communication performance threshold and determines whether the communication performance measurement falls outside of the communication performance threshold. The network element generates a trigger associated with the communication performance measurement and the communication performance threshold when it is determined that the communication performance measurement falls outside of the communication performance threshold. The network element retrieves a registered handler associated with the generated trigger to indicate that the registered handler requires execution in response to the generated trigger and executes the registered handler.

    摘要翻译： 在网络元件中执行的用于响应于超出通信性能阈值的通信性能测量的方法。 网络元件在第一端点和第二端点之间生成通信性能测量，其中每个端点是网络中的通信点，并且至少第一端点驻留在网络元件上。 网络元件检索通信性能阈值，并确定通信性能测量是否超出通信性能阈值。 当确定通信性能测量值超出通信性能阈值时，网元产生与通信性能测量和通信性能阈值相关联的触发。 网络元素检索与生成的触发器相关联的注册处理程序，以指示所注册的处理程序响应于所生成的触发器而需要执行并执行注册的处理程序。

    Series motor
    10.
    发明授权
    Series motor 有权
    系列电机

    公开(公告)号：US06353297B1

    公开(公告)日：2002-03-05

    申请号：US09470391

    申请日：1999-12-22

    申请人： Christoph Meyer

    发明人： Christoph Meyer

    IPC分类号： H02P300

    CPC分类号： H02P3/06 ,  H02P3/10

    摘要： A series motor with commutator is disclosed which is especially suited as universal motor for a braked power tool. The series motor comprises a switch for switching between a motor mode and a braking mode, wherein, in motor mode, at least one field winding is connected in series with an armature winding in a motor circuit, which is connected to an a.c. power source, and wherein, in braking mode, the at least one field winding and the armature winding form together a closed braking circuit disconnected from the power source. The secondary winding of a mains-operated transformer is connected within the braking circuit. This arrangement guarantees improved safety of the braking action.

    摘要翻译： 公开了一种具有换向器的串联电动机，其特别适用于制动动力工具的通用电动机。 串联电动机包括用于在电动机模式和制动模式之间切换的开关，其中，在电动机模式中，至少一个励磁绕组与电动机电路中的电枢绕组串联连接，电动机电路连接到直流电。 电源，并且其中，在制动模式中，所述至少一个励磁绕组和所述电枢绕组形成与所述电源断开的闭合制动电路。 电动变压器的次级绕组连接在制动电路内。 这种布置保证提高制动动作的安全性。