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    Process for producing an organic compound
    1.
    发明授权
    Process for producing an organic compound 有权

    公开(公告)号：US11279955B2

    公开(公告)日：2022-03-22

    申请号：US16614772

    申请日：2018-05-18

    Applicant: BASF SE

    Inventor： Hartwig Schroeder ,  Stefan Haefner ,  Oskar Zelder ,  Christoph Wittmann ,  Anna Christine Schroer ,  Birgit Hoff ,  Nico Boehmer

    IPC: C12N1/20 ,  C12P7/18 ,  C12P7/46

    Abstract: Described herein is a process of producing an organic compound, the process including: I) cultivating a genetically modified microorganism in a culture medium including sucrose as an assimilable carbon source to allow the genetically modified microorganism to produce the organic compound, and II) recovering the organic compound from the fermentation broth obtained in process step I) The genetically modified microorganism includes A) at least one genetic modification that leads to an increased activity of the enzyme encoded by the rbsK-gene, compared to the original microorganism that has not been genetically modified, and the original microorganism belongs to the family Pasteurellaceae. Also described herein are a genetically modified microorganism and the use thereof for the fermentative production of an organic compound from sucrose as an assimilable carbon source.

    PROCESSES AND RECOMBINANT MICROORGANISMS FOR THE PRODUCTION OF FINE CHEMICALS
    2.
    发明申请
    PROCESSES AND RECOMBINANT MICROORGANISMS FOR THE PRODUCTION OF FINE CHEMICALS 有权
    用于生产精细化学品的方法和重组微生物

    公开(公告)号：US20140356916A1

    公开(公告)日：2014-12-04

    申请号：US14365660

    申请日：2012-12-14

    Applicant: BASF SE

    Inventor： Christoph Wittmann ,  Stefanie Kind ,  Judith Becker

    IPC: C12P13/08 ,  C12P13/00

    CPC classification number: C12P13/08 ,  C12N9/93 ,  C12P13/001 ,  C12Y602/01004 ,  C12Y602/01005 ,  Y02P20/52

    Abstract: Recombinant microorganisms with deregulated succinyl-CoA synthetase activity, as well as the uses for producing lysine, β-lysine, cadaverine or N-acetylcadaverine thereby are provided. Recombinant polypeptides comprising an amino acid sequence being at least 80% identical to SEQ ID NO: 51 or 53 are also provided. The method of producing fine chemicals using said recombinant microorganisms, in particular the method of producing lysine, or derivatives thereof, such as β-lysine, cadaverine or N-acetylcadaverine is further provided.

    Abstract translation: 提供了具有失控的琥珀酰-CoA合成酶活性的重组微生物，以及用于产生赖氨酸，赖氨酸，尸胺或N-乙酰胆碱酯酶的用途。 还提供了包含与SEQ ID NO：51或53至少80％相同的氨基酸序列的重组多肽。 进一步提供使用所述重组微生物生产精细化学品的方法，特别是生产赖氨酸的方法或其衍生物，例如β-赖氨酸，尸胺或N-乙酰基尸胺。

    PROCESS FOR PRODUCING AN ORGANIC COMPOUND
    6.
    发明申请
    PROCESS FOR PRODUCING AN ORGANIC COMPOUND 审中-公开

    公开(公告)号：US20200181653A1

    公开(公告)日：2020-06-11

    申请号：US16614772

    申请日：2018-05-18

    Applicant: BASF SE

    Inventor： Hartwig Schroeder ,  Stefan Haefner ,  Oskar Zelder ,  Christoph Wittmann ,  Anna Christine Schroer ,  Birgit Hoff ,  Nico Boehmer

    IPC: C12P7/18 ,  C12N1/20

    Abstract: Described herein is a process of producing an organic compound, the process including: I) cultivating a genetically modified microorganism in a culture medium including sucrose as an assimilable carbon source to allow the genetically modified microorganism to produce the organic compound, and II) recovering the organic compound from the fermentation broth obtained in process step I) The genetically modified microorganism includes A) at least one genetic modification that leads to an increased activity of the enzyme encoded by the rbsK-gene, compared to the original microorganism that has not been genetically modified, and the original microorganism belongs to the family Pasteurellaceae. Also described herein are a genetically modified microorganism and the use thereof for the fermentative production of an organic compound from sucrose as an assimilable carbon source.

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