公开(公告)号：US20150104851A1

公开(公告)日：2015-04-16

申请号：US14560263

申请日：2014-12-04

申请人： BASF SE

发明人： Michael Breuer ,  Bernhard Hauer ,  Dieter Jendrossek ,  Gabrielle Siedenburg ,  Juergen Pleiss ,  Demet Sirim ,  Silvia Racolta

IPC分类号： C12N9/90

CPC分类号： C12N9/88 ,  C12N9/90 ,  C12P5/007 ,  C12P7/02 ,  C12P7/22 ,  C12Y406/01 ,  C12Y504/99017 ,  Y02P20/52

摘要： The present invention relates to novel mutants with cyclase activity and use thereof in a method for biocatalytic cyclization of terpenes, such as in particular for the production of isopulegol by cyclization of citronellal; a method for the preparation of menthol and methods for the biocatalytic conversion of further compounds with structural motifs similar to terpene.

摘要翻译： 本发明涉及具有环化酶活性的新颖突变体及其在萜烯生物催化环化方法中的应用，特别是通过香茅醛环化生产异胡胆糖; 用于制备薄荷醇的方法和用于生物催化转化具有类似于萜烯的结构基序的其它化合物的方法。

公开(公告)号：US09447404B2

公开(公告)日：2016-09-20

申请号：US14560263

申请日：2014-12-04

申请人： BASF SE

发明人： Michael Breuer ,  Bernhard Hauer ,  Dieter Jendrossek ,  Gabrielle Siedenburg ,  Juergen Pleiss ,  Demet Sirim ,  Silvia Fadenrecht

IPC分类号： C12N9/10 ,  C12N1/19 ,  C12P5/02 ,  C12N9/90 ,  C12N9/88 ,  C12P7/02 ,  C12P5/00

CPC分类号： C12N9/88 ,  C12N9/90 ,  C12P5/007 ,  C12P7/02 ,  C12P7/22 ,  C12Y406/01 ,  C12Y504/99017 ,  Y02P20/52

摘要： The present invention relates to novel mutants with cyclase activity and use thereof in a method for biocatalytic cyclization of terpenes, such as in particular for the production of isopulegol by cyclization of citronellal; a method for the preparation of menthol and methods for the biocatalytic conversion of further compounds with structural motifs similar to terpene.

公开(公告)号：US10717973B2

公开(公告)日：2020-07-21

申请号：US16212287

申请日：2018-12-06

申请人： BASF SE

发明人： Michael Breuer ,  Bernhard Hauer ,  Dieter Jendrossek ,  Gabriele Siedenburg ,  Juergen Pleiss ,  Demet Sirim ,  Silvia Fadenrecht

IPC分类号： C12P7/22 ,  C12P7/02 ,  C12N9/88 ,  C12N9/90 ,  C12P5/00

摘要： The present invention relates to novel mutants with cyclase activity and use thereof in a method for biocatalytic cyclization of terpenes, such as in particular for the production of isopulegol by cyclization of citronellal; a method for the preparation of menthol and methods for the biocatalytic conversion of further compounds with structural motifs similar to terpene.

公开(公告)号：US10190112B2

公开(公告)日：2019-01-29

申请号：US15234529

申请日：2016-08-11

申请人： BASF SE

发明人： Michael Breuer ,  Bernhard Hauer ,  Dieter Jendrossek ,  Gabriele Siedenburg ,  Juergen Pleiss ,  Demet Sirim ,  Silvia Fadenrecht

IPC分类号： C12N9/88 ,  C12N9/10 ,  C12N15/00 ,  C12P7/02 ,  C12P5/00 ,  C12N9/90 ,  C12P7/22

摘要： The present invention relates to novel mutants with cyclase activity and use thereof in a method for biocatalytic cyclization of terpenes, such as in particular for the production of isopulegol by cyclization of citronellal; a method for the preparation of menthol and methods for the biocatalytic conversion of further compounds with structural motifs similar to terpene.

公开(公告)号：US20160340666A1

公开(公告)日：2016-11-24

申请号：US15234529

申请日：2016-08-11

申请人： BASF SE

发明人： Michael Breuer ,  Bernhard Hauer ,  Dieter Jendrossek ,  Gabrielle Siedenburg ,  Juergen Pleiss ,  Demet Sirim ,  Silivia Fadenrecht

IPC分类号： C12N9/88 ,  C12P7/22 ,  C12P5/00

CPC分类号： C12N9/88 ,  C12N9/90 ,  C12P5/007 ,  C12P7/02 ,  C12P7/22 ,  C12Y406/01 ,  C12Y504/99017 ,  Y02P20/52

摘要： The present invention relates to novel mutants with cyclase activity and use thereof in a method for biocatalytic cyclization of terpenes, such as in particular for the production of isopulegol by cyclization of citronellal; a method for the preparation of menthol and methods for the biocatalytic conversion of further compounds with structural motifs similar to terpene.