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1.发明授权公开(公告)号：US09447404B2
公开(公告)日：2016-09-20
申请号：US14560263
申请日：2014-12-04
Applicant: BASF SE
Inventor： Michael Breuer , Bernhard Hauer , Dieter Jendrossek , Gabrielle Siedenburg , Juergen Pleiss , Demet Sirim , Silvia Fadenrecht
CPC classification number: C12N9/88 , C12N9/90 , C12P5/007 , C12P7/02 , C12P7/22 , C12Y406/01 , C12Y504/99017 , Y02P20/52
Abstract: The present invention relates to novel mutants with cyclase activity and use thereof in a method for biocatalytic cyclization of terpenes, such as in particular for the production of isopulegol by cyclization of citronellal; a method for the preparation of menthol and methods for the biocatalytic conversion of further compounds with structural motifs similar to terpene.
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公开(公告)号：US20150147800A1
公开(公告)日：2015-05-28
申请号：US14584289
申请日：2014-12-29
Applicant: BASF SE
Inventor： Bernhard Hauer , Nina Schneider , Krzysztof Okrasa , Jason Micklefield , David Leys , Colin Levy
IPC: C12N9/88
CPC classification number: C12N9/88 , C07K14/235 , C07K2299/00 , C12N9/90 , C12P7/40 , C12P7/42 , C12Q1/00 , C12Y401/01075 , C12Y401/01076 , G01N2333/235 , G01N2500/00
Abstract: The present invention relates to a method for the enzymatic decarboxylation of malonic acid (propanedioic acid) derivatives catalyzed by enzymes structurally and/or functionally related to arylmalonate decarboxylase (AMDase) as isolated from microorganisms of the genus Bordetella. The present invention also relates to novel enzymes with a decarboxylase activity, useful for performing the claimed method, mutants thereof, corresponding coding sequences and expression systems, methods of preparing said novel enzymes, and screening methods for obtaining further suitable enzymes also having said decarboxylase activity.
Abstract translation: 本发明涉及由结构和/或与芳基丙二酸酯脱羧酶（AMDase）功能相关的酶催化的由在博德特氏菌属微生物分离的酶催化的丙二酸（丙二酸）衍生物的酶脱羧的方法。 本发明还涉及具有脱羧酶活性的新型酶，可用于实施要求保护的方法，其突变体，相应的编码序列和表达系统，制备所述新型酶的方法，以及筛选获得还具有所述脱羧酶活性的合适酶的筛选方法 。
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公开(公告)号：US20190201721A1
公开(公告)日：2019-07-04
申请号：US15771236
申请日：2016-10-25
Applicant: BASF SE
Inventor： Nina Schneider , Thomas Subkowski , Stefan Jenewein , Marvin Karos , Claus Bollschweiler , Volker Wendel , Thorsten Henkes , Sandra Facey , Bernhard Hauer
Abstract: Provided herein are oral care compositions comprising HABP, which are useful in methods of repairing or inhibiting dental erosion, promoting dental remineralization, and/or enhancing the anti-cavity effects of fluoride.
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4.发明授权Method for the enzyme-catalysed hydrolysis of polyacrylic acid esters, and esterases used therefor 有权聚丙烯酸酯的酶催化水解方法和用于其的酯酶的方法公开(公告)号：US09587257B2
公开(公告)日：2017-03-07
申请号：US15013299
申请日：2016-02-02
Applicant: BASF SE
Inventor： Bernhard Hauer , Hans Wolfgang Höffken , Cecilia Kvarnström Branneby , Helmut Schwab , Sabine Feichtenhofer , Marlene Buchebner , Brigitte Pohn
CPC classification number: C12P7/62 , C08F8/12 , C12N9/16 , C12N9/18 , C12Y301/01001 , C08F120/18
Abstract: The invention relates to a method for the enzyme-catalysed hydrolysis of polyacrylic acid esters. According to the method, at least one polyacrylic acid ester is provided and incubated with at least one enzyme selected from enzymes (EC 3.1) acting on ester bindings, until the ester groups contained in the polyacrylic acid ester are partially or fully hydrolytically split, and optionally the modified polymer obtained thereby is isolated. The invention also relates to the enzymes used and mutants thereof, nucleic acids coding for the enzymes, vectors comprising the nucleic acids, micro-organisms comprising the vectors, and the use of the enzymes, the vectors or the micro-organisms for carrying out a method for the enzyme-catalysed hydrolysis of polyacrylic acid esters. The present application also relates to polymer reaction products that can be obtained by the method, and methods for producing esterases.
Abstract translation: 本发明涉及聚丙烯酸酯的酶催化水解方法。 根据该方法，提供至少一种聚丙烯酸酯，并与至少一种选自作用于酯结合的酶（EC 3.1）的酶进行温育，直到聚丙烯酸酯中所含的酯基部分或完全水解分裂为止，以及 由此分离获得的改性聚合物。 本发明还涉及使用的酶及其突变体，编码酶的核酸，包含核酸的载体，包含载体的微生物，以及使用酶，载体或微生物进行酶 聚丙烯酸酯酶催化水解的方法。 本申请还涉及可以通过该方法获得的聚合物反应产物和生产酯酶的方法。
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公开(公告)号：US08932837B2
公开(公告)日：2015-01-13
申请号：US13942184
申请日：2013-07-15
Applicant: BASF SE
Inventor： Bernhard Hauer , Thomas Friedrich , Rainer Stürmer , Nina Schneider , Susanne Sabrowski , Wolf-Rüdiger Krahnert
CPC classification number: C12P13/001 , C12N9/80 , C12P13/04 , C12P41/007
Abstract: Process for producing optically active 3-aminocarboxylic acid ester compounds of general Formula I, and the ammonium salts thereof, in which R1 stands for alkyl, alkoxyalkyl, alkenyl, cycloalkyl, heterocycloalkyl, aryl, or hetaryl, and R2 stands for alkyl, cycloalkyl or aryl, in which an enantiomeric mixture of a simply N-acylated 3-aminocarboxylic acid ester of general formula (I.b), in which R1 and R2 have the meanings given above and R3 stands for hydrogen, alkyl, cycloalkyl or aryl, is submitted to an enantioselective deacylation by adding a polypeptide according to claim 1.
Abstract translation: 制备通式I的光学活性3-氨基羧酸酯化合物及其铵盐的方法，其中R1代表烷基，烷氧基烷基，烯基，环烷基，杂环烷基，芳基或杂芳基，R2代表烷基，环烷基或 芳基，其中通式（Ib）的简单N-酰化3-氨基羧酸酯的对映体混合物，其中R 1和R 2具有上面给出的含义，R 3代表氢，烷基，环烷基或芳基，被提交到 根据权利要求1的通过加入多肽的对映选择性脱酰作用。
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Patent Agency Ranking
6.发明申请Process for the Bioconversion of C3-C13 Alkanes to C3-C13 Primary Alcohols 审中-公开将C3-C13烷烃生物转化为C3-C13伯醇的方法公开(公告)号：US20160201093A1
公开(公告)日：2016-07-14
申请号：US14908293
申请日：2014-07-21
Applicant: BASF SE
Inventor： Michael Breuer , Boris Breitscheidel , Hans-Günter Wagner , Detlef Kratz , Bernhard Hauer , Daniel Scheps , Bernd Nebel
CPC classification number: C12P7/16 , C12P7/04 , C12Y114/15003 , C12Y118/01001 , Y02E50/10
Abstract: A process for preparing linear or branched primary alcohols with 3 to 13 carbon atoms from linear or branched alkanes with 3 to 13 carbon atoms by incubating a host organism having a functional P153 enzyme under elevated pressure in the presence of oxygen.
Abstract translation: 通过在氧气存在下在升高的压力下孵育具有功能性P153酶的宿主生物体，从具有3至13个碳原子的直链或支链烷烃制备具有3至13个碳原子的直链或支链伯醇的方法。
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7.发明申请公开(公告)号：US20160168602A1
公开(公告)日：2016-06-16
申请号：US15013299
申请日：2016-02-02
Applicant: BASF SE
Inventor： Bernhard Hauer , Hans Wolfgang Höffken , Cecilia Kvarnström Branneby , Helmut Schwab , Sabine Feichtenhofer , Marlene Buchebner , Brigitte Pohn
CPC classification number: C12P7/62 , C08F8/12 , C12N9/16 , C12N9/18 , C12Y301/01001 , C08F120/18
Abstract: The invention relates to a method for the enzyme-catalysed hydrolysis of polyacrylic acid esters. According to the method, at least one polyacrylic acid ester is provided and incubated with at least one enzyme selected from enzymes (EC 3.1) acting on ester bindings, until the ester groups contained in the polyacrylic acid ester are partially or fully hydrolytically split, and optionally the modified polymer obtained thereby is isolated. The invention also relates to the enzymes used and mutants thereof, nucleic acids coding for the enzymes, vectors comprising the nucleic acids, micro-organisms comprising the vectors, and the use of the enzymes, the vectors or the micro-organisms for carrying out a method for the enzyme-catalysed hydrolysis of polyacrylic acid esters. The present application also relates to polymer reaction products that can be obtained by the method, and methods for producing esterases.
Abstract translation: 本发明涉及聚丙烯酸酯的酶催化水解方法。 根据该方法，提供至少一种聚丙烯酸酯，并与至少一种选自作用于酯结合的酶（EC 3.1）的酶进行温育，直到聚丙烯酸酯中所含的酯基部分或完全水解分裂为止，以及 由此分离获得的改性聚合物。 本发明还涉及使用的酶及其突变体，编码酶的核酸，包含核酸的载体，包含载体的微生物，以及使用酶，载体或微生物进行酶 聚丙烯酸酯酶催化水解的方法。 本申请还涉及可以通过该方法获得的聚合物反应产物和生产酯酶的方法。
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8.发明申请METHOD FOR THE BIOCATALYTIC CYCLIZATION OF TERPENES AND CYCLASE MUTANTS EMPLOYABLE THEREIN 有权用于生物化学循环的方法和可用于其的环状基因突变体公开(公告)号：US20150104851A1
公开(公告)日：2015-04-16
申请号：US14560263
申请日：2014-12-04
Applicant: BASF SE
Inventor： Michael Breuer , Bernhard Hauer , Dieter Jendrossek , Gabrielle Siedenburg , Juergen Pleiss , Demet Sirim , Silvia Racolta
IPC: C12N9/90
CPC classification number: C12N9/88 , C12N9/90 , C12P5/007 , C12P7/02 , C12P7/22 , C12Y406/01 , C12Y504/99017 , Y02P20/52
Abstract: The present invention relates to novel mutants with cyclase activity and use thereof in a method for biocatalytic cyclization of terpenes, such as in particular for the production of isopulegol by cyclization of citronellal; a method for the preparation of menthol and methods for the biocatalytic conversion of further compounds with structural motifs similar to terpene.
Abstract translation: 本发明涉及具有环化酶活性的新颖突变体及其在萜烯生物催化环化方法中的应用，特别是通过香茅醛环化生产异胡胆糖; 用于制备薄荷醇的方法和用于生物催化转化具有类似于萜烯的结构基序的其它化合物的方法。
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公开(公告)号：US20130337512A1
公开(公告)日：2013-12-19
申请号：US13942184
申请日：2013-07-15
Applicant: BASF SE
Inventor： Bernhard Hauer , Thomas Friedrich , Rainer Stürmer , Nina Schneider , Susanne Krauser , Wolf-Rüdiger Krahnert
IPC: C12P13/00
CPC classification number: C12P13/001 , C12N9/80 , C12P13/04 , C12P41/007
Abstract: Process for producing optically active 3-aminocarboxylic acid ester compounds of general Formula I, and the ammonium salts thereof, in which R1 stands for alkyl, alkoxyalkyl, alkenyl, cycloalkyl, heterocycloalkyl, aryl, or hetaryl, and R2 stands for alkyl, cycloalkyl or aryl, in which an enantiomeric mixture of a simply N-acylated 3-aminocarboxylic acid ester of general formula (I.b), in which R1 and R2 have the meanings given above and R3 stands for hydrogen, alkyl, cycloalkyl or aryl, is submitted to an enantioselective deacylation by adding a polypeptide according to claim 1.
Abstract translation: 制备通式I的光学活性3-氨基羧酸酯化合物及其铵盐的方法，其中R1代表烷基，烷氧基烷基，烯基，环烷基，杂环烷基，芳基或杂芳基，R2代表烷基，环烷基或 芳基，其中通式（Ib）的简单N-酰化3-氨基羧酸酯的对映体混合物，其中R 1和R 2具有上面给出的含义，R 3代表氢，烷基，环烷基或芳基，被提交到 根据权利要求1的通过加入多肽的对映选择性脱酰作用。
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10.发明授权公开(公告)号：US10717973B2
公开(公告)日：2020-07-21
申请号：US16212287
申请日：2018-12-06
Applicant: BASF SE
Inventor： Michael Breuer , Bernhard Hauer , Dieter Jendrossek , Gabriele Siedenburg , Juergen Pleiss , Demet Sirim , Silvia Fadenrecht
Abstract: The present invention relates to novel mutants with cyclase activity and use thereof in a method for biocatalytic cyclization of terpenes, such as in particular for the production of isopulegol by cyclization of citronellal; a method for the preparation of menthol and methods for the biocatalytic conversion of further compounds with structural motifs similar to terpene.
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