公开(公告)号：US20210340518A1

公开(公告)日：2021-11-04

申请号：US17286328

申请日：2019-10-09

Applicant: BASF SE

Inventor： Diego Ghislieri ,  Tobias Joachim Zimmermann ,  Stefan Seemayer ,  Michael Breuer ,  Doreen Schactschabel

IPC: C12N9/78 ,  C12P7/40

Abstract: Described herein are methods for the production of ammonium acrylate or salts thereof from acrylonitrile using nitrilase as a catalyst.

公开(公告)号：US11136611B2

公开(公告)日：2021-10-05

申请号：US16487978

申请日：2018-02-23

Applicant: BASF SE

Inventor： Wolfgang Siegel ,  Melanie Weingarten ,  Michael Breuer ,  Mathias Schelwies

IPC: C12P41/00 ,  C12P7/40 ,  C12P17/04

Abstract: The invention provides an improved method of isolating the 3-(E)-isomer of an unsaturated carboxylic acid from a mixture of corresponding (E/Z)isomers. More particularly, the present invention relates to an improved method for the biocatalytic preparation of (3E,7E)-homofarnesylic acid; as well as a novel biocatalytic method for the improved preparation of homofarnesol, in particular of (3E,7E)-homofarnesol and homofarnesol preparations having an increased content of (3E,7E)-homofarnesol. The present invention also relates to methods of preparing(−)-ambroxby applying (3E,7E)-homofarnesylic acid or (3E,7E)-homofarnesol as obtained according to the invention as starting material.

公开(公告)号：US10179923B2

公开(公告)日：2019-01-15

申请号：US15514706

申请日：2015-09-28

Applicant: BASF SE

Inventor： Michael Breuer ,  Ralf Pelzer

IPC: C12P7/00 ,  C12P5/00 ,  C12N9/90 ,  C12N9/88 ,  C12N15/61 ,  C12P17/06 ,  C07D311/92

Abstract: The present invention relates to a novel process for cyclizing geranyllinalool using the squalene-hopene cyclase from Zymomonas mobilis (Zm-SHC) or a cyclase with at least 80% sequence identity to the Zm-SHC, and cyclization products obtained in this process.

公开(公告)号：US09796992B2

公开(公告)日：2017-10-24

申请号：US14084030

申请日：2013-11-19

Applicant: BASF SE

Inventor： Oskar Zelder ,  Birgit Hoff ,  Hartwig Schröder ,  Andrea Molt ,  Holger Hartmann ,  Klaus Ditrich ,  Michael Breuer ,  Rüdiger Reingruber ,  Jakob Weber

IPC: C12N1/21 ,  C12P17/04 ,  C12N15/52 ,  C12P7/50

CPC classification number: C12P17/04 ,  C12N15/52 ,  C12P7/50

Abstract: The invention pertains to the field of production of natural products and, in particular, in the field of production of cornexistin and hydroxycornexistin. It provides polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising such polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using such polynucleotides and polypeptides encoded therein, as well as vectors and recombinant microorganisms comprising such polynucleotides and polypeptides.

公开(公告)号：US20150275248A1

公开(公告)日：2015-10-01

申请号：US14441215

申请日：2013-11-13

Applicant: BASF SE

Inventor： Oskar Zelder ,  Birgit Hoff ,  Hartwig Schroeder ,  Andrea Molt ,  Holger Hartmann ,  Klaus Ditrich ,  Michael Breuer ,  Rüdiger Reingrubber ,  Jakob Weber

IPC: C12P17/04 ,  C12N15/80

CPC classification number: C12P17/04 ,  A01N37/42 ,  A01N37/46 ,  A01N63/04 ,  C07D307/93 ,  C07K14/37 ,  C12N15/52 ,  C12N15/67 ,  C12N15/80

Abstract: The invention pertains to the field of production of natural products and, in particular, in the field of production of cornexistin and hydroxycornexistin. It provides polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising such polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using such polynucleotides and polpeptides encoded therein, as well as vectors and recombinant microorganisms comprising such polynucleotides and polypeptides.

Abstract translation: 本发明涉及天然产物的生产领域，尤其涉及在玉米corn霉素和羟基角质素的生产领域。 它提供了编码涉及Cornexistin和羟基角质素的生物合成的多肽的多核苷酸以及包含这种多核苷酸的载体和重组微生物。 还提供了生产天然产物的方法，特别是使用这样的多核苷酸和其中编码的多肽以及包含这种多核苷酸和多肽的载体和重组微生物来生产玉米corn霉素和羟基角质柔比星的方法。

公开(公告)号：US20150211036A1

公开(公告)日：2015-07-30

申请号：US14421872

申请日：2013-08-13

Applicant: BASF SE ,  Evolva SA

Inventor： Michael Naesby ,  Christophe Folly ,  Curt Aimé Friis Nielsen ,  Anaelle Hatsch ,  Markus Schwab ,  Oskar Zelder ,  Stefan Haefner ,  Hartwig Schroeder ,  Birgit Hoff ,  Andrea Molt ,  Klaus Ditrich ,  Michael Breuer ,  Holger Hartmann ,  Karsten Koerber

IPC: C12P17/12 ,  C12N9/02 ,  C07D209/90 ,  C12P17/10 ,  C07K16/40 ,  C07D487/06 ,  C12N9/10 ,  C12N9/90

CPC classification number: C12P17/12 ,  C07D209/90 ,  C07D487/06 ,  C07K16/40 ,  C12N9/0004 ,  C12N9/001 ,  C12N9/1007 ,  C12N9/1085 ,  C12N9/90 ,  C12N15/52 ,  C12P17/10 ,  C12P17/182 ,  C12Y205/01

Abstract: Microorganisms and processes for the recombinant manufacture of clavine-type alkaloids such as cycloclavine, festuclavine, agroclavine, chanoclavine and chanoclavine aldehyde, as well as polypeptides, polynucleotides and vectors comprising such polynucleotides which can be applied in a method for the manufacture of clavine-type alkaloids are provided.

Abstract translation: 用于重组生产角鲨烯型生物碱如环圈子，festuclavine，agroclavine，chanoclavine和chanoclavine醛的微生物和方法，以及多肽，多核苷酸和包含这样的多核苷酸的载体，其可以用于制造棒状的方法 提供生物碱。

公开(公告)号：US09828617B2

公开(公告)日：2017-11-28

申请号：US14421872

申请日：2013-08-13

Applicant: BASF SE ,  Evolva SA

Inventor： Michael Naesby ,  Christophe Folly ,  Curt Aimé Friis Nielsen ,  Anaelle Hatsch ,  Markus Schwab ,  Oskar Zelder ,  Stefan Haefner ,  Hartwig Schroeder ,  Birgit Hoff ,  Andrea Molt ,  Klaus Ditrich ,  Michael Breuer ,  Holger Hartmann ,  Karsten Koerber

IPC: C12N15/53 ,  C12P17/12 ,  C12N9/02 ,  C12N9/90 ,  C12N15/52 ,  C12P17/10 ,  C12P17/18 ,  C07D209/90 ,  C07D487/06 ,  C07K16/40 ,  C12N9/10

CPC classification number: C12P17/12 ,  C07D209/90 ,  C07D487/06 ,  C07K16/40 ,  C12N9/0004 ,  C12N9/001 ,  C12N9/1007 ,  C12N9/1085 ,  C12N9/90 ,  C12N15/52 ,  C12P17/10 ,  C12P17/182 ,  C12Y205/01

Abstract: Microorganisms and processes for the recombinant manufacture of clavine-type alkaloids such as cycloclavine, festuclavine, agroclavine, chanoclavine and chanoclavine aldehyde, as well as polypeptides, polynucleotides and vectors comprising such polynucleotides which can be applied in a method for the manufacture of clavine-type alkaloids are provided.

公开(公告)号：US20170145451A1

公开(公告)日：2017-05-25

申请号：US15323515

申请日：2015-07-02

Applicant: BASF SE

Inventor： Kai-Uwe Baldenius ,  Michael Breuer ,  Klaus Ditrich ,  Vaidotas Navickas ,  Francesco Mutti ,  Tanja Knaus ,  Nicholas Turner

IPC: C12P13/00 ,  C12N9/04 ,  C12N9/06

CPC classification number: C12P13/001 ,  C12N9/0006 ,  C12N9/0016 ,  C12N9/0018 ,  C12Y101/01001 ,  C12Y104/01009 ,  C12Y104/0102

Abstract: The present invention relates to a novel biocatalytic method for the production of primary and secondary amines, comprising coupled enzymatic oxidation and reduction processes simultaneously regenerating the required cofactor; making use of two enzymes—i.e. an alcohol dehydrogenase and an amine dehydrogenase—operating simultaneously in a one pot process (i.e. biocatalytic cascade). Furthermore, the overall process is redox neutral, since the hydride generated from the first oxidative step is internally recycled in the second reductive step. The invention also relates to recombinant expression systems and microorganisms procuring the required enzyme activities; and bioreactors for performing such methods.

公开(公告)号：US09447404B2

公开(公告)日：2016-09-20

申请号：US14560263

申请日：2014-12-04

Applicant: BASF SE

Inventor： Michael Breuer ,  Bernhard Hauer ,  Dieter Jendrossek ,  Gabrielle Siedenburg ,  Juergen Pleiss ,  Demet Sirim ,  Silvia Fadenrecht

IPC: C12N9/10 ,  C12N1/19 ,  C12P5/02 ,  C12N9/90 ,  C12N9/88 ,  C12P7/02 ,  C12P5/00

CPC classification number: C12N9/88 ,  C12N9/90 ,  C12P5/007 ,  C12P7/02 ,  C12P7/22 ,  C12Y406/01 ,  C12Y504/99017 ,  Y02P20/52

Abstract: The present invention relates to novel mutants with cyclase activity and use thereof in a method for biocatalytic cyclization of terpenes, such as in particular for the production of isopulegol by cyclization of citronellal; a method for the preparation of menthol and methods for the biocatalytic conversion of further compounds with structural motifs similar to terpene.

公开(公告)号：US20250049037A1

公开(公告)日：2025-02-13

申请号：US18717747

申请日：2022-12-12

Applicant: BASF SE

Inventor： Klaus Ditrich ,  Michael Breuer ,  Moritz Stefan Pott ,  Gunther Zimmermann

IPC: A01N57/20 ,  A01N57/24 ,  A01P13/02 ,  C07F9/32

Abstract: The present invention relates to compounds of formula (I) and compositions comprising the same. The invention also relates to the use of compounds of formula (I), or of compositions comprising the same, or of compounds of formula (II), for controlling unwanted vegetation. Further, the invention relates to methods of applying compounds of formula (I), or compositions comprising the same, or compounds of formula (II) on plants, their seed and/or their habitat. Finally, the invention relates to a method of manufacturing a compound of formula (III) via a compound of formula (I).