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公开(公告)号：US11713304B2
公开(公告)日：2023-08-01
申请号：US17407951
申请日：2021-08-20
申请人： BAYER AKTIENGESELLSCHAFT , BAYER PHARMA AKTIENGESELLSCHAFT , THE BROAD INSTITUTE, INC. , PRESIDENT AND FELLOWS OF HARVARD COLLEGE , THE GENERAL HOSPITAL CORPORATION
发明人： Stefan Nikolaus Gradl , Duy Nguyen , Knut Eis , Judith Günther , Timo Stellfeld , Andreas Janzer , Sven Christian , Thomas Müller , Sherif El Sheikh , David B. Sykes , Steven James Ferrara , Michael Kröber , Claudia Merz , Michael Niehues , Martina Schäfer , Katja Zimmermann , Carl Friedrich Nising
IPC分类号： A61P35/00 , C07D401/12 , C07D249/12 , C07D403/12 , C07D405/12 , C07D413/12 , A61K45/06
CPC分类号： C07D401/12 , A61P35/00 , C07D249/12 , C07D403/12 , C07D405/12 , C07D413/12 , A61K45/06
摘要： The present invention provides triazolone compounds of general formula (I):
in which R1, R2, R3, R4, and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and prophylaxis of diseases, in particular hyperproliferative disorders, as a sole agent or in combination with other active ingredients.-
公开(公告)号：US10968216B2
公开(公告)日：2021-04-06
申请号：US16345178
申请日：2017-10-25
申请人： BAYER AKTIENGESELLSCHAFT , BAYER PHARMA AKTIENGESELLSCHAFT , THE BROAD INSTITUTE, INC. , PRESIDENT AND FELLOWS OF HARVARD COLLEGE , THE GENERAL HOSPITAL CORPORATION
发明人： Stefan Nikolaus Gradl , Duy Nguyen , Knut Eis , Judith Günther , Timo Stellfeld , Andreas Janzer , Sven Christian , Thomas Mueller , Sherif El Sheikh , Han Jie Zhou , Changjia Zhao , David B. Sykes , Steven James Ferrara , Kery Liu , Simon Anthony Herbert , Claudia Merz , Michael Niehues , Carl Friedrich Nising , Martina Schäfer , Katja Zimmermann , Jörg Knäblein , Kai Thede , Thomas Faupel
IPC分类号： C07D471/04 , A61P35/00 , C07D487/04 , C07D498/04 , C07D513/04 , C07D519/00 , C12N1/20 , C12P17/18
摘要： The present invention provides triazolone compounds of general formula (I): in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US11787797B2
公开(公告)日：2023-10-17
申请号：US17161615
申请日：2021-01-28
申请人： BAYER AKTIENGESELLSCHAFT , BAYER PHARMA AKTIENGESELLSCHAFT , THE BROAD INSTITUTE, INC. , PRESIDENT AND FELLOWS OF HARVARD COLLEGE , THE GENERAL HOSPITAL CORPORATION
发明人： Stefan Nikolaus Gradl , Duy Nguyen , Knut Eis , Judith Günther , Timo Stellfeld , Andreas Janzer , Sven Christian , Thomas Mueller , Sherif El Sheikh , Han Jie Zhou , Changjia Zhao , David B. Sykes , Steven James Ferrara , Kery Liu , Simon Anthony Herbert , Claudia Merz , Michael Niehues , Carl Friedrich Nising , Martina Schäfer , Katja Zimmermann , Jörg Knäblein , Kai Thede , Thomas Faupel
IPC分类号： C07D471/04 , A61P35/00 , C07D487/04 , C07D498/04 , C07D513/04 , C07D519/00 , C12N1/20 , C12P17/18
CPC分类号： C07D471/04 , A61P35/00 , C07D487/04 , C07D498/04 , C07D513/04 , C07D519/00 , C12N1/20 , C12P17/18 , C12P17/182 , C12P17/188
摘要： The present invention provides triazolone compounds of general formula (I):
in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.-
公开(公告)号：US11130745B2
公开(公告)日：2021-09-28
申请号：US16996721
申请日：2020-08-18
申请人： BAYER AKTIENGESELLSCHAFT , BAYER PHARMA AKTIENGELLSCHAFT , THE BROAD INSTITUTE, INC. , PRESIDENT AND FELLOWS OF HARVARD COLLEGE , THE GENERAL HOSPITAL CORPORATION
发明人： Stefan Nikolaus Gradl , Duy Nguyen , Knut Eis , Judith Günther , Timo Stellfeld , Andreas Janzer , Sven Christian , Thomas Müller , Sherif El Sheikh , David B. Sykes , Steven James Ferrara , Michael Kröber , Claudia Merz , Michael Niehues , Martina Schäfer , Katja Zimmermann , Carl Friedrich Nising
IPC分类号： A61P35/00 , A61K45/06 , C07D401/12 , C07D249/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要： The present invention provides triazolone compounds of general formula (I): in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US10815215B2
公开(公告)日：2020-10-27
申请号：US16345168
申请日：2017-10-25
申请人： BAYER AKTIENGESELLSCHAFT , BAYER PHARMA AKTIENGELLSCHAFT , THE BROAD INSTITUTE, INC. , PRESIDENT AND FELLOWS OF HARVARD COLLEGE , THE GENERAL HOSPITAL CORPORATION
发明人： Stefan Nikolaus Gradl , Duy Nguyen , Knut Eis , Judith Günther , Timo Stellfeld , Andreas Janzer , Sven Christian , Thomas Müller , Sherif El Sheikh , Han Jie Zhou , Changjia Zhao , David B. Sykes , Steven James Ferrara , Kery Liu , Michael Kröber , Claudia Merz , Michael Niehues , Martina Schäfer , Katja Zimmermann , Carl Friedrich Nising
IPC分类号： C07D401/12 , A61P35/00 , C07D249/12 , C07D403/12 , C07D405/12 , C07D413/12 , A61K45/06
摘要： The present invention provides triazolone compounds of general formula (I): in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US11524944B2
公开(公告)日：2022-12-13
申请号：US16765780
申请日：2018-11-16
发明人： Julien Lefranc , Norbert Schmees , Ulrike Röhn , Ludwig Zorn , Judith Günther , Ilona Gutcher , Lars Röse , Benjamin Bader , Detlef Stöckigt , Michael Platten
IPC分类号： C07D239/28 , A61P35/04 , C07D405/12 , A61K45/06
摘要： The present invention covers 2-phenylpyrimidine-4-carboxamide compounds of general formula (I): (I) 5 in which X, Y, Z, R1, R2, R4, R5 and R6 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with 10 dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US11304946B2
公开(公告)日：2022-04-19
申请号：US16765778
申请日：2018-11-16
发明人： Julien Lefranc , Norbert Schmees , Ulrike Röhn , Ludwig Zorn , Judith Günther , Ilona Gutcher , Lars Röse , Benjamin Bader , Detlef Stöckigt , Michael Platten
IPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , A61K31/506
摘要： The present invention covers 2-hetarylpyrimidine-4-carboxamide compounds of general formula (I): in which X, Y, Z, R1, R2 and R4 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US12006304B2
公开(公告)日：2024-06-11
申请号：US17869674
申请日：2022-07-20
发明人： Ulrich Bothe , Holger Siebeneicher , Nicole Schmidt , Reinhard Nubbemeyer , Ulf Bömer , Judith Günther , Holger Steuber , Martin Lange , Christian Stegmann , Andreas Sutter , Alexandra Rausch , Christian Friedrich , Peter Hauff
IPC分类号： C07D401/12 , A61K31/4439 , A61P19/02 , C07D405/14 , C07F7/18
CPC分类号： C07D401/12 , A61K31/4439 , A61P19/02 , C07D405/14 , C07F7/1804
摘要： The present application relates to novel substituted indazoles, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of endometriosis and endometriosis-associated pain and other endometriosis-associated symptoms such as dysmenorrhoea, dyspareunia, dysuria and dyschezia, of lymphoma, rheumatoid arthritis, spondyloarthritis (especially psoriatic spondyloarthritis and Bekhterev's disease), lupus erythematosus, multiple sclerosis, macular degeneration, COPD, gout, fatty liver disorders, insulin resistance, neoplastic disorders and psoriasis.
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公开(公告)号：US12006303B2
公开(公告)日：2024-06-11
申请号：US17869673
申请日：2022-07-20
发明人： Ulrich Bothe , Holger Siebeneicher , Nicole Schmidt , Reinhard Nubbemeyer , Ulf Bömer , Judith Günther , Holger Steuber , Martin Lange , Christian Stegmann , Andreas Sutter , Alexandra Rausch , Christian Friedrich , Peter Hauff
IPC分类号： C07D401/12 , A61K31/4439 , A61P19/02 , C07D405/14 , C07F7/18
CPC分类号： C07D401/12 , A61K31/4439 , A61P19/02 , C07D405/14 , C07F7/1804
摘要： The present application relates to novel substituted indazoles, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of endometriosis and endometriosis-associated pain and other endometriosis-associated symptoms such as dysmenorrhoea, dyspareunia, dysuria and dyschezia, of lymphoma, rheumatoid arthritis, spondyloarthritis (especially psoriatic spondyloarthritis and Bekhterev's disease), lupus erythematosus, multiple sclerosis, macular degeneration, COPD, gout, fatty liver disorders, insulin resistance, neoplastic disorders and psoriasis.
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公开(公告)号：US10793545B2
公开(公告)日：2020-10-06
申请号：US16377025
申请日：2019-04-05
发明人： Ulrich Bothe , Holger Siebeneicher , Nicole Schmidt , Reinhard Nubbemeyer , Ulf Bömer , Judith Günther , Holger Steuber , Martin Lange , Christian Stegmann , Andreas Sutter , Alexandra Rausch , Christian Friedrich , Peter Hauff
IPC分类号： C07D401/12 , A61K31/4439 , A61P19/02 , C07F7/18 , C07D405/14
摘要： The present application relates to novel substituted indazoles, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of endometriosis and endometriosis-associated pain and other endometriosis-associated symptoms such as dysmenorrhoea, dyspareunia, dysuria and dyschezia, of lymphoma, rheumatoid arthritis, spondyloarthritis (especially psoriatic spondyloarthritis and Bekhterev's disease), lupus erythematosus, multiple sclerosis, macular degeneration, COPD, gout, fatty liver disorders, insulin resistance, neoplastic disorders and psoriasis.
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