Hydroxymethyl ether hydroisoindoline tachykinin receptor antagonists
    10.
    发明授权
    Hydroxymethyl ether hydroisoindoline tachykinin receptor antagonists 有权
    羟甲醚加氢异吲哚啉速效肽受体拮抗剂

    公开(公告)号:US08124633B2

    公开(公告)日:2012-02-28

    申请号:US12593168

    申请日:2008-04-07

    IPC分类号: A61K31/422 C07D209/02

    CPC分类号: C07D209/44 C07D413/04

    摘要: The present invention is directed to certain hydroxymethyl ether hydroisoindoline compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, LUTS, depression, and anxiety.

    摘要翻译: 本发明涉及某些可用作神经激肽-1(NK-1)受体拮抗剂,速激肽抑制剂,特别是物质P的羟甲基醚异二氢吲哚化合物。本发明还涉及包含这些化合物作为活性成分的药物制剂 以及化合物及其制剂在治疗某些疾病(包括呕吐,尿失禁,LUTS,抑郁和焦虑)中的用途。