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1.发明申请公开(公告)号：US20180037581A1
公开(公告)日：2018-02-08
申请号：US15785608
申请日：2017-10-17
Applicant: Bristol-Myers Squibb Company
Inventor： Ivar M. MCDONALD , Naidu S. CHOWDARI , Walter Lewis JOHNSON , Yong ZHANG , Robert M. BORZILLERI , Sanjeev GANGWAR
IPC: C07D471/04 , C07D487/04 , C07D519/00 , A61K47/68 , C07K5/062
CPC classification number: C07D471/04 , A61K47/6803 , A61K47/6851 , A61K47/6889 , C07D487/04 , C07D519/00 , C07K5/06052
Abstract: Benzodiazepine dimers having a structure represented by wherein X comprises a heteroaromatic moiety and is as further defined in the application; R1 is and the other variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
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公开(公告)号：US20230242569A1
公开(公告)日：2023-08-03
申请号：US18167772
申请日：2023-02-10
Inventor： Michael Anthony SCHMIDT , Bin ZHENG , Kyle KNOUSE , Justine deGRUYTER , Martin D. EASTGATE , Phil BARAN , William R. EWING , Richard E. OLSON , Ivar M. MCDONALD
IPC: C07H21/00
CPC classification number: C07H21/00
Abstract: The present invention relates to novel phosphorous (V) (P(V)) reagents, methods for preparing thereof, and methods for preparing organophosphorous (V) compounds by using the novel reagents.
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公开(公告)号：US20180110873A1
公开(公告)日：2018-04-26
申请号：US15789027
申请日：2017-10-20
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Ivar M. MCDONALD , Prasanna SIVAPRAKASAM , Christiana I. IWUAGWU , Kevin M. Peese , Heng CHENG , Naidu S. CHOWDARI , Sanjeev GANGWAR
IPC: A61K47/68 , C07F7/08 , C07K5/062 , C07D471/04 , C07D519/00
CPC classification number: A61K47/6803 , C07D471/04 , C07D519/00 , C07F7/0814 , C07K5/06026
Abstract: A compound capable of inhibiting cell proliferation, having a structure according to formula (I) wherein the variables in formula (I) are as defined in the specification. Such compounds are useful as anti-cancer agents, especially in antibody-drug conjugates.
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公开(公告)号：US20210378652A1
公开(公告)日：2021-12-09
申请号：US17303890
申请日：2021-06-09
Inventor： Richard E. OLSON , Brian R. ANDERSON , Peter HAGEDORN , Marianne Lerbech JENSEN , Ivar M. MCDONALD , Stephen E. MERCER
Abstract: The present disclosure relates to antisense oligonucleotides, which target CAMK2D mRNA in a cell, leading to reduced expression of CAMK2D protein. Reduction of CAMK2D protein expression is beneficial for the treatment of certain medical disorders, e.g., cardiovascular-related diseases or disorders.
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公开(公告)号：US20170233436A1
公开(公告)日：2017-08-17
申请号：US15587715
申请日：2017-05-05
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Yong ZHANG , Ivar M. MCDONALD , Naidu S. CHOWDARI , Tram N. HUYNH , Robert M. BORZILLERI , Sanjeev GANGWAR
IPC: C07K5/062
CPC classification number: C07K5/06052 , A61K47/6843 , A61K47/6849 , C07D487/04 , C07D519/00 , C07K16/18 , C07K16/28 , C07K16/30 , C07K2317/76
Abstract: Benzodiazepine dimers having a structure represented by wherein R1 is wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
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Patent Agency Ranking
6.发明申请公开(公告)号：US20170233392A1
公开(公告)日：2017-08-17
申请号：US15587679
申请日：2017-05-05
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Ivar M. MCDONALD , Naidu S. Chowdari , Walter Lewis Johnson , Yong Zhang , Robert M. Borzilleri , Sanjeev Gangwar
IPC: C07D471/04
CPC classification number: C07D471/04 , A61K47/6803 , A61K47/6851 , A61K47/6889 , C07D487/04 , C07D519/00 , C07K5/06052
Abstract: Benzodiazepine dimers having a structure represented by wherein X comprises a heteroaromatic moiety and is as further defined in the application; R1 is and the other variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
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公开(公告)号：US20230089255A1
公开(公告)日：2023-03-23
申请号：US17786442
申请日：2020-12-18
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Susan WEE , Joseph L. BENC , Xinyu WANG , Upender VELAPARTHI , Louis S. CHUPAK , Chatan P. DARNE , Min DING , Robert G. GENTLES , Yazhong HUANG , Scott W. MARTIN , Ivar M. MCDONALD , Richard E. OLSON , Xiaofan ZHENG , John S. TOKARSKI , Bireshwar DASGUPTA , Manjunatha Narayana Rao KAMBLE , Raju MANNOORI , Haslbur RAHAMAN , Prasada Rao JALAGAM , Saumya ROY , Gopikishan TONUKUNURU , Sivasudar VELAIAH , Jayakumar Sankara WARRIER , Kotha Rathnakar REDDY , Thiruvenkadam RAJA , Denise GRUNENFELDER , Michael WICHROSKI
IPC: A61K31/519 , A61K31/496 , A61K39/395 , A61P35/00
Abstract: Provided are inhibitors of diacylglycerol kinases (DGK) and methods for treating diseases that would benefit from the stimulation of the immune system, such as cancer and infections diseases, comprising administering a DGK inhibitor in combination with an antagonist of the PD 1/PD-L 1 axis and/or an antagonist of CTLA4.
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公开(公告)号：US20180079781A1
公开(公告)日：2018-03-22
申请号：US15785675
申请日：2017-10-17
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Yong ZHANG , Ivar M. MCDONALD , Naidu S. CHOWDARI , Tram N. HUYNH , Robert M. BORZILLERI , Sanjeev GANGWAR
IPC: C07K5/062
CPC classification number: C07K5/06052 , A61K47/6843 , A61K47/6849 , C07D487/04 , C07D519/00 , C07K16/18 , C07K16/28 , C07K16/30 , C07K2317/76
Abstract: Benzodiazepine dimers having a structure represented by wherein R1 is wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
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公开(公告)号：US20170137425A1
公开(公告)日：2017-05-18
申请号：US15317546
申请日：2015-06-05
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Ivar M. MCDONALD , F. Christopher ZUSI , Richard E. OLSON
IPC: C07D471/18
CPC classification number: C07D471/18
Abstract: The disclosure provides compounds of formula I including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic 7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.
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10.发明申请公开(公告)号：US20170073357A1
公开(公告)日：2017-03-16
申请号：US15351843
申请日：2016-11-15
Applicant: Bristol-Myers Squibb Company
Inventor： Yong ZHANG , Ivar M. MCDONALD , Naidu S. CHOWDARI , Tram N. HUYNH , Robert M. BORZILLERI , Sanjeev GANGWAR
IPC: C07D519/00
CPC classification number: C07K5/06052 , A61K47/6843 , A61K47/6849 , C07D487/04 , C07D519/00 , C07K16/18 , C07K16/28 , C07K16/30 , C07K2317/76
Abstract: Benzodiazepine dimers having a structure represented by wherein R1 is wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
Abstract translation: 其中式（I），（Ia）和（Ib）中的变量如本申请中所定义。 这种二聚体可用作抗癌剂，特别是当用于抗体 - 药物偶联物（ADC）时。
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