公开(公告)号：US09399215B2

公开(公告)日：2016-07-26

申请号：US13863231

申请日：2013-04-15

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Thomas H. Cauley, III ,  Luc Bousse ,  Jonathan Petersen ,  Kevin D. Ness ,  Steven Romine

IPC: B01L3/00 ,  G01N1/00 ,  B32B38/00

CPC classification number: B01L3/502715 ,  B01L3/502707 ,  B01L3/502746 ,  B01L3/502784 ,  B01L2200/027 ,  B01L2200/0673 ,  B01L2300/161 ,  B01L2400/0406 ,  B01L2400/086 ,  B01L2400/088 ,  B32B38/0012 ,  G01N1/00 ,  Y10T156/10 ,  Y10T156/1002

Abstract: Sample holding system, including methods and apparatus, including a holder defining a well having a wicking promoter that encourages flow of a sample to the bottom of the well. Methods of making and using the holder are also disclosed.

Abstract translation: 样品保持系统，包括方法和装置，包括限定具有促进样品流到井的底部的芯吸促进剂的阱的保持器。 还公开了制造和使用保持器的方法。

公开(公告)号：US11542541B2

公开(公告)日：2023-01-03

申请号：US17105333

申请日：2020-11-25

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Arkadiusz Bibillo ,  Pranav Patel ,  Christopher Reggiardo ,  Jonathan Petersen

IPC: C12Q1/68 ,  C12Q1/6806 ,  C12N15/10 ,  C12Q1/6853 ,  C12Q1/6874

Abstract: Methods, systems, and devices for sampling/isolating material from cells. An exemplary system may comprise a chip including an electrode array of sampling electrodes arranged along a surface of the chip. A cell-receiving area may be located adjacent the surface of the chip. The system also may comprise a tag array of tags supported by the chip and aligned with the electrode array. Each tag of the tag array may include an identifier that is unique to the tag within the tag array. Each tag may be configured to bind nucleic acids, or a capturing agent distinct from the tag may be aligned with each sampling electrode of the electrode array to capture a protein or other analyte of interest. The system further may comprise a control circuit configured to apply an individually controllable voltage to each sampling electrode of the electrode array and measure an electrical property of the sampling electrode.

公开(公告)号：US09896717B2

公开(公告)日：2018-02-20

申请号：US14272370

申请日：2014-05-07

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Shawn Hodges ,  Nick Heredia ,  Jonathan Petersen

IPC: G01N33/53 ,  C12Q1/68

CPC classification number: C12Q1/6804 ,  C12Q2537/159 ,  C12Q2561/101 ,  C12Q2563/143 ,  C12Q2563/149

Abstract: The present invention provides methods of detecting an antigen in a sample comprising contacting the sample with affinity agents to form an antigen-affinity agent-label complex, separating the antigen-affinity agent-label complex from uncomplexed components, partitioning label from the separated sample into multiple partitions, and detecting the presence of the label in one or more partitions. Compositions and kits for detecting an antigen in a sample are also provided.

公开(公告)号：US20230366005A1

公开(公告)日：2023-11-16

申请号：US18149143

申请日：2023-01-02

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Arkadiusz BIBILLO ,  Pranav PATEL ,  Christopher REGGIARDO ,  Jonathan Petersen

IPC: C12Q1/6806 ,  C12N15/10 ,  C12Q1/6853 ,  C12Q1/6874

CPC classification number: C12Q1/6806 ,  C12N15/1003 ,  C12Q1/6853 ,  C12Q1/6874

Abstract: Methods, systems, and devices for sampling/isolating material from cells. An exemplary system may comprise a chip including an electrode array of sampling electrodes arranged along a surface of the chip. A cell-receiving area may be located adjacent the surface of the chip. The system also may comprise a tag array of tags supported by the chip and aligned with the electrode array. Each tag of the tag array may include an identifier that is unique to the tag within the tag array. Each tag may be configured to bind nucleic acids, or a capturing agent distinct from the tag may be aligned with each sampling electrode of the electrode array to capture a protein or other analyte of interest. The system further may comprise a control circuit configured to apply an individually controllable voltage to each sampling electrode of the electrode array and measure an electrical property of the sampling electrode.

公开(公告)号：US20140336068A1

公开(公告)日：2014-11-13

申请号：US14272370

申请日：2014-05-07

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Shawn Hodges ,  Nick Heredia ,  Jonathan Petersen

IPC: C12Q1/68

CPC classification number: C12Q1/6804 ,  C12Q2537/159 ,  C12Q2561/101 ,  C12Q2563/143 ,  C12Q2563/149

Abstract: The present invention provides methods of detecting an antigen in a sample comprising contacting the sample with affinity agents to form an antigen-affinity agent-label complex, separating the antigen-affinity agent-label complex from uncomplexed components, partitioning label from the separated sample into multiple partitions, and detecting the presence of the label in one or more partitions. Compositions and kits for detecting an antigen in a sample are also provided.

Abstract translation: 本发明提供检测样品中的抗原的方法，包括使样品与亲和试剂接触以形成抗原亲和试剂 - 标记复合物，将抗原亲和试剂 - 标记复合物与未络合的组分分离，将标记从分离的样品分离成 多个分区，并且检测标签在一个或多个分区中的存在。 还提供了用于检测样品中的抗原的组合物和试剂盒。