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    BIDIRECTIONAL FLOW REACTION SYSTEM FOR SOLID PHASE SYNTHESIS
    3.
    发明申请
    BIDIRECTIONAL FLOW REACTION SYSTEM FOR SOLID PHASE SYNTHESIS 有权

    公开(公告)号：US20210402364A1

    公开(公告)日：2021-12-30

    申请号：US17359021

    申请日：2021-06-25

    Applicant: Biolytic Lab Performance, Inc.

    Inventor： Thomas J. Demmitt ,  Laurent Jaquinod

    IPC: B01J19/24 ,  B01J19/00 ,  C07H21/00 ,  C07H1/00

    Abstract: Flow control mechanisms control the direction and flow rate of synthesis reagent through one or more synthesis reaction vessels for automated solid phase synthesis. Selectable, known, and reproducible positive or negative pressure differentials (−5 to +10 psi) accomplish controlled, bidirectional (forward and reverse) flow of synthesis reagents through synthesis media contained within the reaction vessels. Venturi-based vacuum apparatus, valves, electronic pressure regulators and compound digital pressure gauge, can be added to automated solid phase synthesis instruments to provide, control, and monitor known, selectable, reproducible negative and positive pressures to one or both valve sealable and un-sealable ends (inlets and outlets) of the reaction vessel as needed to generate and reverse said pressure differentials between the opposite ends of said synthesis reaction vessels, yielding controlled forward and backward flows of synthesis reagents through the synthesis media.

    Tubing support system
    4.
    发明授权
    Tubing support system 有权

    公开(公告)号：US11473699B2

    公开(公告)日：2022-10-18

    申请号：US17360022

    申请日：2021-06-28

    Applicant: Biolytic Lab Performance, Inc.

    Inventor： Thomas J. Demmitt

    IPC: F16L3/223 ,  F16B7/18 ,  B01J19/24

    Abstract: A mechanism for securing tubes in a fixed position is described wherein a body to which a tube is to be fixed has at least one smooth bore hole extending therethrough. A tube has an inner diameter accommodating fluid flow and an outer diameter passing through the smooth bore hole in slip fit relation with the smooth bore of the hole. A threaded hole with helical grooves is parallel to the smooth bore hole and located such that its grooves intersect the diameter of the smooth bore hole. A set screw made of a tougher material than the tube has threads that will seat in the threaded hole in a manner such that advancing the set screw scratches the outer diameter of the tube to a depth wherein the set screw retains the tube in place without deformation of the inner diameter of the tube whereby fluid flow in the tube is not affected by advancement of the set screw while the tube is retained in place by the set screw. The invention can connect tubes in all sorts of patterns with many center-to-center tube distances.

    System for controlling and optimizing reactions in solid phase synthesis of small molecules
    5.
    发明授权
    System for controlling and optimizing reactions in solid phase synthesis of small molecules 有权
    控制和优化小分子固相合成反应的系统

    公开(公告)号：US09069358B2

    公开(公告)日：2015-06-30

    申请号：US13925642

    申请日：2013-06-24

    Applicant: Biolytic Lab Performance, Inc.

    Inventor： Thomas J. Demmitt

    IPC: G01N35/10 ,  G05D7/06 ,  G05D16/00 ,  G01N35/00 ,  B01J3/04 ,  C07K1/00

    CPC classification number: G05D7/0605 ,  B01J3/042 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00308 ,  B01J2219/00326 ,  B01J2219/0036 ,  B01J2219/00389 ,  B01J2219/00418 ,  C07K1/00 ,  G01N35/00 ,  G01N35/10 ,  G05D16/00 ,  Y10T137/0318

    Abstract: A instrument for performing synthesis of small molecules such as Oligos and Peptides when using solid phase synthesis techniques to synthesize small molecules. The system and methods include a mechanism for controlling the pressure differential across the reaction vessels that contain the solid support used in solid phase synthesis. Reaction vessels are held in a holder that provides a sealable chamber at the outlet ends of the reaction vessels. The rotor containing the reaction vessels is placed within a sealable chamber. The sealable chamber is fitted with a means for engaging the rotor and draining the reaction vessels to waste. The sealable chamber is also fitted with a means for engaging the rotor to drain the reaction vessels at a slower, variable rate.

    Abstract translation: 当使用固相合成技术合成小分子时，用于进行小分子如Oligos和Peptide的合成的仪器。 该系统和方法包括用于控制包含固相合成中使用的固体支持物的跨反应容器的压力差的机理。 反应容器保持在保持器中，该保持器在反应容器的出口端提供可密封的室。 将包含反应容器的转子放置在可密封的室内。 可密封的腔室装配有用于接合转子并将反应器排放到废物的装置。 可密封腔室还配备有用于接合转子的装置，以较慢的可变速率排放反应容器。

    Bidirectional flow reaction system for solid phase synthesis
    6.
    发明授权
    Bidirectional flow reaction system for solid phase synthesis 有权

    公开(公告)号：US11666882B2

    公开(公告)日：2023-06-06

    申请号：US17359021

    申请日：2021-06-25

    Applicant: Biolytic Lab Performance, Inc.

    Inventor： Thomas J. Demmitt ,  Laurent Jaquinod

    IPC: B01J19/00 ,  B01J19/24

    CPC classification number: B01J19/0046 ,  B01J19/246 ,  B01J2219/00162 ,  B01J2219/00164 ,  B01J2219/00166

    Abstract: Flow control mechanisms control the direction and flow rate of synthesis reagent through one or more synthesis reaction vessels for automated solid phase synthesis. Selectable, known, and reproducible positive or negative pressure differentials (−5 to +10 psi) accomplish controlled, bidirectional (forward and reverse) flow of synthesis reagents through synthesis media contained within the reaction vessels. Venturi-based vacuum apparatus, valves, electronic pressure regulators and compound digital pressure gauge, can be added to automated solid phase synthesis instruments to provide, control, and monitor known, selectable, reproducible negative and positive pressures to one or both valve sealable and un-sealable ends (inlets and outlets) of the reaction vessel as needed to generate and reverse said pressure differentials between the opposite ends of said synthesis reaction vessels, yielding controlled forward and backward flows of synthesis reagents through the synthesis media.

    TUBING SUPPORT SYSTEM
    7.
    发明申请
    TUBING SUPPORT SYSTEM 有权

    公开(公告)号：US20210404578A1

    公开(公告)日：2021-12-30

    申请号：US17360022

    申请日：2021-06-28

    Applicant: Biolytic Lab Performance, Inc.

    Inventor： Thomas J. Demmitt

    IPC: F16L3/223 ,  F16B7/18

    Abstract: A mechanism for securing tubes in a fixed position is described wherein a body to which a tube is to be fixed has at least one smooth bore hole extending therethrough. A tube has an inner diameter accommodating fluid flow and an outer diameter passing through the smooth bore hole in slip fit relation with the smooth bore of the hole. A threaded hole with helical grooves is parallel to the smooth bore hole and located such that its grooves intersect the diameter of the smooth bore hole. A set screw made of a tougher material than the tube has threads that will seat in the threaded hole in a manner such that advancing the set screw scratches the outer diameter of the tube to a depth wherein the set screw retains the tube in place without deformation of the inner diameter of the tube whereby fluid flow in the tube is not affected by advancement of the set screw while the tube is retained in place by the set screw. The invention can connect tubes in all sorts of patterns with many center-to-center tube distances.

    SYSTEM FOR CONTROLLING AND OPTIMIZING REACTIONS IN SOLID PHASE SYNTHESIS OF SMALL MOLECULES
    8.
    发明申请
    SYSTEM FOR CONTROLLING AND OPTIMIZING REACTIONS IN SOLID PHASE SYNTHESIS OF SMALL MOLECULES 有权
    用于控制和优化小分子固相合成反应的系统

    公开(公告)号：US20140377134A1

    公开(公告)日：2014-12-25

    申请号：US13925642

    申请日：2013-06-24

    Applicant: Biolytic Lab Performance, Inc.

    Inventor： Thomas J. Demmitt

    IPC: G05D7/06 ,  G05D16/00

    CPC classification number: G05D7/0605 ,  B01J3/042 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00308 ,  B01J2219/00326 ,  B01J2219/0036 ,  B01J2219/00389 ,  B01J2219/00418 ,  C07K1/00 ,  G01N35/00 ,  G01N35/10 ,  G05D16/00 ,  Y10T137/0318

    Abstract: A instrument for performing synthesis of small molecules such as Oligos and Peptides when using solid phase synthesis techniques to synthesize small molecules. The system and methods include a mechanism for controlling the pressure differential across the reaction vessels that contain the solid support used in solid phase synthesis. Reaction vessels are held in a holder that provides a sealable chamber at the outlet ends of the reaction vessels. The rotor containing the reaction vessels is placed within a sealable chamber. The sealable chamber is fitted with a means for engaging the rotor and draining the reaction vessels to waste. The sealable chamber is also fitted with a means for engaging the rotor to drain the reaction vessels at a slower, variable rate.

    Abstract translation: 当使用固相合成技术合成小分子时，用于进行小分子如Oligos和Peptide的合成的仪器。 该系统和方法包括用于控制包含固相合成中使用的固体支持物的跨反应容器的压力差的机理。 反应容器保持在保持器中，该保持器在反应容器的出口端提供可密封的室。 将包含反应容器的转子放置在可密封的室内。 可密封的腔室装配有用于接合转子并将反应器排放到废物的装置。 可密封腔室还配备有用于接合转子的装置，以较慢的可变速率排放反应容器。

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