公开(公告)号：US20210206776A1

公开(公告)日：2021-07-08

申请号：US17057225

申请日：2019-05-17

Applicant: Constellation Pharmaceuticals, Inc.

Inventor： Alexandre Côté ,  Avinash Khanna ,  Ludivine Moine

IPC: C07D491/056 ,  A61P35/00

Abstract: Provided are novel compounds of Formula (I): Formula (I); and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with methyl modifying enzymes. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with methyl modifying enzymes.

公开(公告)号：US20190322651A1

公开(公告)日：2019-10-24

申请号：US16387851

申请日：2019-04-18

Applicant: Constellation Pharmaceuticals, Inc.

Inventor： Alexandre Côté ,  Victor S. Gehling ,  Avinash Khanna ,  Ludivine Moine ,  Jacob I. Stuckey

IPC: C07D405/14 ,  C07D405/12 ,  A61P35/00

Abstract: Provided are novel compounds of Formula (I): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with methyl modifying enzymes. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with methyl modifying enzymes.

公开(公告)号：US09763922B2

公开(公告)日：2017-09-19

申请号：US14952821

申请日：2015-11-25

Applicant: Genentech, Inc. ,  Constellation Pharmaceuticals, Inc.

Inventor： Marc Adler ,  Brian K. Albrecht ,  Sarah Bronner ,  Kevin X. Chen ,  Alexandre Côté ,  Terry Crawford ,  Patrick Cyr ,  Jackson Egen ,  Steven Kauder ,  Kwong Wah Lai ,  Jiangpeng Liao ,  Steven Magnuson ,  Jeremy Murray ,  Richard Pastor ,  F. Anthony Romero ,  Alexander M. Taylor ,  Vickie Hsiao-Wei Tsui ,  Fei Wang ,  Bing-Yan Zhu

IPC: A61K31/437 ,  A61K31/4375 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/498 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/5415 ,  A61K31/55 ,  C07D471/04 ,  C07D519/00 ,  A61K45/06

CPC classification number: A61K31/437 ,  A61K31/4375 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/498 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/5415 ,  A61K31/55 ,  A61K45/06 ,  C07D471/04 ,  C07D519/00

Abstract: The present invention relates to compounds of formula (I) or formula (II): and to salts thereof, wherein R1-R4 of formula (I) and R1-R3 of formula (II) have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) of formula (II) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.

公开(公告)号：US09522920B2

公开(公告)日：2016-12-20

申请号：US14313148

申请日：2014-06-24

Applicant: Constellation Pharmaceuticals, Inc.

Inventor： Brian K. Albrecht ,  James Edmund Audia ,  Alexandre Côté ,  Victor S. Gehling ,  Jean-Christophe Harmange ,  Michael Charles Hewitt ,  Yves Leblanc ,  Christopher G. Nasveschuk ,  Alexander M. Taylor ,  Rishi G. Vaswani

IPC: A61K31/55 ,  C07D498/04 ,  C07D498/14 ,  C07D498/20 ,  C07D498/22 ,  C07K14/47 ,  A61K31/424

CPC classification number: C07D498/04 ,  A61K31/424 ,  A61K31/55 ,  C07D498/14 ,  C07D498/20 ,  C07D498/22 ,  C07K14/4702

Abstract: The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.

公开(公告)号：US20240116905A1

公开(公告)日：2024-04-11

申请号：US18140730

申请日：2023-04-28

Applicant: Constellation Pharmaceuticals, Inc.

Inventor： Alexandre Côté ,  Victor S. Gehling ,  Avinash Khanna ,  Ludivine Moine ,  Jacob I. Stuckey

IPC: C07D405/14 ,  A61P35/00 ,  C07D405/12

CPC classification number: C07D405/14 ,  A61P35/00 ,  C07D405/12

Abstract: Provided are novel compounds of Formula (I):




and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with methyl modifying enzymes. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with methyl modifying enzymes.

公开(公告)号：US11919912B2

公开(公告)日：2024-03-05

申请号：US17057225

申请日：2019-05-17

Applicant: Constellation Pharmaceuticals, Inc.

Inventor： Alexandre Côté ,  Avinash Khanna ,  Ludivine Moine

IPC: C07D491/056 ,  A61K31/435 ,  A61P35/00

CPC classification number: C07D491/056 ,  A61P35/00

Abstract: Provided are novel compounds of Formula (I): Formula (I); and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with methyl modifying enzymes. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with methyl modifying enzymes.

公开(公告)号：US09745305B2

公开(公告)日：2017-08-29

申请号：US14769471

申请日：2014-03-12

Applicant: Constellation Pharmaceuticals, Inc.

Inventor： Brian K. Albrecht ,  James Edmund Audia ,  Andrew Cook ,  Alexandre Côté ,  Les A. Dakin ,  Victor S. Gehling ,  Jean-Christophe Harmange ,  Christopher G. Nasveschuk ,  Rishi G. Vaswani

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.

公开(公告)号：US11274095B2

公开(公告)日：2022-03-15

申请号：US16856454

申请日：2020-04-23

Applicant: Constellation Pharmaceuticals, Inc.

Inventor： Alexandre Côté ,  Victor S. Gehling ,  Avinash Khanna ,  Ludivine Moine ,  Jacob I. Stuckey

IPC: C07D405/14 ,  C07D405/12 ,  A61P35/00

Abstract: Provided are novel compounds of Formula (I): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with methyl modifying enzymes. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with methyl modifying enzymes.

公开(公告)号：US20200317651A1

公开(公告)日：2020-10-08

申请号：US16856454

申请日：2020-04-23

Applicant: Constellation Pharmaceuticals, Inc.

Inventor： Alexandre Côté ,  Victor S. Gehling ,  Avinash Khanna ,  Ludivine Moine ,  Jacob I. Stuckey

IPC: C07D405/14 ,  A61P35/00 ,  C07D405/12

Abstract: Provided are novel compounds of Formula (I): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with methyl modifying enzymes. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with methyl modifying enzymes.

公开(公告)号：US10526287B2

公开(公告)日：2020-01-07

申请号：US15567978

申请日：2016-04-22

Applicant: Constellation Pharmaceuticals, Inc.

Inventor： Brian K. Albrecht ,  James Edmund Audia ,  Alexandre Côté ,  Martin Duplessis ,  Victor S. Gehling ,  Jean-Christophe Harmange ,  Rishi G. Vaswani

IPC: C07D211/22 ,  C07D211/26 ,  C07D309/20 ,  C07D215/44 ,  C07D317/28 ,  C07D401/04 ,  C07D401/06 ,  C07D403/04 ,  C07D403/06 ,  C07D403/10 ,  C07D405/04 ,  C07D239/30 ,  C07C215/44 ,  C07D417/06 ,  C07D263/32 ,  C07D205/12 ,  C07D207/32 ,  C07D211/36 ,  C07D213/64 ,  C07D305/06 ,  C07C255/58 ,  C07C211/09 ,  C07C211/36 ,  C07C211/40 ,  C07C215/14 ,  C07C217/08 ,  C07C229/10 ,  C07C229/38 ,  C07C229/46 ,  C07C233/41 ,  C07C237/06 ,  C07C255/24 ,  C07C215/42 ,  C07C255/30 ,  C07D211/58 ,  C07D211/76 ,  C07D213/38 ,  C07D213/69 ,  C07D213/73 ,  C07D295/195 ,  A61P35/00

Abstract: Provided are novel compounds of Formula (I): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with LSD1. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with LSD1.