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公开(公告)号：US10231986B2
公开(公告)日：2019-03-19
申请号：US14866759
申请日：2015-09-25
申请人： Centre National De La Recherche Scientifique , Universite Montpellier 2 Sciences Et Techniques , Idenix Pharmaceuticals LLC
发明人： David Dukhan , Christophe Claude Parsy , Gilles Gosselin , Jean-François Griffon , Guillaume Brandt , Cyril B. Dousson , Adel M. Moussa , Benjamin Alexander Mayes , Alistar James Stewart
IPC分类号： C07H19/073 , C07H19/10 , C07H19/173 , C07H19/20 , A61K31/7072 , C07H17/02 , A61K31/7068 , A61K45/06 , A61K9/00 , A61K31/7076
摘要： Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are 2′-cyano, azido or amino nucleosides according to Formula 1001 or 2001: or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form, or polymorphic form thereof, wherein Base, W, R1 and R2 are as described herein.
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公开(公告)号：US09309275B2
公开(公告)日：2016-04-12
申请号：US14195388
申请日：2014-03-03
申请人： Idenix Pharmaceuticals, Inc. , Centre National De La Recherche Scientifique , Universite Montpellier 2 Sciences Et Techniques
发明人： Alistair James Stewart , Adel M. Moussa , Benjamin Alexander Mayes , Francois-Rene Alexandre , Dominique Surleraux , Christophe Claude Parsy , Claire Pierra , David Dukhan , Gilles Gosselin
IPC分类号： C07H19/044 , C07H19/06 , C07H19/10 , C07H19/14 , C07H19/16 , C07H19/20 , C07H19/207 , A61K31/708 , A61K31/7068 , A61K31/7076 , A61K31/7072 , A61K45/06 , A61K31/40 , A61K31/497 , A61K31/7056 , A61K38/21
CPC分类号： C07H19/207 , A61K31/40 , A61K31/497 , A61K31/7056 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K38/212 , A61K45/06 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , A61K2300/00
摘要： Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are 3′-deoxy nucleoside compounds according to Formula 3001a or 3001b: or a pharmaceutically acceptable salts, solvates, stereoisomeric forms, tautomeric forms, or polymorphic forms thereof, wherein PD, Base1 and Base2 are as provided herein.
摘要翻译： 本文提供了用于治疗黄病毒科感染（包括HCV感染）的化合物，组合物和方法。 在某些实施方案中，公开了核苷衍生物的化合物和组合物，其可以单独施用或与其它抗病毒剂组合施用。 在某些实施方案中，化合物是根据式3001a或3001b的3'-脱氧核苷化合物：或其药学上可接受的盐，溶剂合物，立体异构形式，互变异构形式或其多晶型，其中PD，碱基和碱基2如本文所提供。
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3.发明申请AMINO ACID PHOSPHORAMIDATE PRONUCLEOTIDES OF 2'-CYANO, AZIDO AND AMINO NUCLEOSIDES FOR THE TREATMENT OF HCV 审中-公开用于治疗HCV的2'-CYANO，AZIDO和氨基酸核苷酸的氨基酸磷酸酯原核苷酸公开(公告)号：US20160113956A1
公开(公告)日：2016-04-28
申请号：US14866759
申请日：2015-09-25
申请人： Centre National De La Recherche Scientifique , Universite Montpellier 2 Sciences Et Techniques , Idenix Pharmaceuticals, Inc.
发明人： David DUKHAN , Christophe Claude PARSY , Gilles GOSSELIN , Jean-François GRIFFON , Guillaume BRANDT , Cyril B. DOUSSON , Adel M. Moussa , Benjamin Alexander Mayes , Alistair James Stewart
IPC分类号： A61K31/7072 , A61K9/00 , A61K45/06 , C07H19/20 , A61K31/7076 , C07H19/10 , A61K31/7068
CPC分类号： A61K31/7072 , A61K9/0053 , A61K31/7068 , A61K31/7076 , A61K45/06 , C07H17/02 , C07H19/073 , C07H19/10 , C07H19/173 , C07H19/20
摘要： Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are 2′-cyano, azido or amino nucleosides according to Formula 1001 or 2001: or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form, or polymorphic form thereof, wherein Base, W, R1 and R2 are as described herein.
摘要翻译： 本文提供了用于治疗黄病毒科感染（包括HCV感染）的化合物，组合物和方法。 在某些实施方案中，公开了核苷衍生物的化合物和组合物，其可以单独施用或与其它抗病毒剂组合施用。 在某些实施方案中，化合物是根据式1001或2001的2'-氰基，叠氮基或氨基核苷：或其药学上可接受的盐，溶剂合物，立体异构形式，互变异构形式或其多晶型，其中基团，W，R 1和R 2 如本文所述。
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公开(公告)号：US20160083413A1
公开(公告)日：2016-03-24
申请号：US14920830
申请日：2015-10-22
申请人： Idenix Pharmaceuticals, Inc. , Centre National De La Recherche Scientifique , Universite Montpellier 2 Sciences Et Techniques
发明人： Gilles Gosselin , Christophe Claude Parsy , François-René Alexandre , Houcine Rahali , Jean-François Griffon , Dominique Surleraux , Cyril B. Dousson , Claire Pierra , Adel M. Moussa , Benjamin Alexander Mayes , Alistair James Stewart , David Dukhan
IPC分类号： C07H19/10 , A61K45/06 , A61K31/7072
CPC分类号： C07H19/10 , A61K31/403 , A61K31/497 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K31/7105 , A61K38/212 , A61K45/06 , C07H19/06 , C07H19/11 , C07H19/12 , C07H19/14 , C07H19/16 , C07H19/20 , C07H19/213 , C07H19/23 , A61K2300/00
摘要： Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are 2′-chloro nucleosides according to Formula 2001: or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form or polymorphic form thereof, wherein B, Z and PD are as described herein.
摘要翻译： 本文提供了用于治疗黄病毒科感染（包括HCV感染）的化合物，组合物和方法。 在某些实施方案中，公开了核苷衍生物的化合物和组合物，其可以单独施用或与其它抗病毒剂组合施用。 在某些实施方案中，化合物是根据式2001的2'-氯核苷：或其药学上可接受的盐，溶剂化物，立体异构形式，互变异构形式或其多晶型，其中B，Z和PD如本文所述。
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公开(公告)号：US10513534B2
公开(公告)日：2019-12-24
申请号：US14047862
申请日：2013-10-07
申请人： IDENIX PHARMACEUTICALS LLC , Centre National De La Recherche Scientifique , UNIVERSITE DE MONTPELLIER
发明人： Gilles Gosselin , Christophe Claude Parsy , Francois-Rene Alexandre , Houcine Rahali , Jean-Francois Griffon , Dominique Surleraux , Cyril B. Dousson , Claire Pierra , Adel M. Moussa , Benjamin Alexander Mayes , Alistair James Stewart
IPC分类号： C07H19/06 , C07H19/073 , C07H19/10 , C07H19/11 , C07H19/16 , C07H19/173 , C07H19/20 , C07H19/213 , A61K31/7072 , A61K45/06 , A61K38/21 , A61K31/7076 , C07H19/14 , A61K31/7064 , C07H19/12 , A61K31/706 , A61K31/7068 , A61K31/708 , A61K31/403 , A61K31/497 , A61K31/7105 , C07H19/23
摘要： Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are 2′-chloro nucleosides according to Formula 2001: or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form or polymorphic form thereof, wherein B, Z and PD are as described herein.
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6.发明授权公开(公告)号：US10238680B2
公开(公告)日：2019-03-26
申请号：US14954815
申请日：2015-11-30
申请人： IDENIX PHARMACEUTICALS LLC , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE DE MONTPELLIER
发明人： Benjamin Alexander Mayes , Adel M. Moussa , Cyril B. Dousson , Gilles Gosselin , Claire Pierra , David Dukhan
IPC分类号： C07H19/10 , A61K31/7068 , A61K31/7072 , A61K45/06 , A61K9/00
摘要： Provided herein are compounds, compositions, and methods for the treatment of viral infections, for example, Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are D-amino acid phosphoramidate halogeno pyrimidine nucleoside analog compounds which display remarkable efficacy and bioavailability for the treatment of, for example, HCV infection in a human. In certain embodiments, the compounds are of Formula I: or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form, or polymorphic form thereof, wherein: PD, X, R1, R2, RA, and RB are as described herein.
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公开(公告)号：US09211300B2
公开(公告)日：2015-12-15
申请号：US14109463
申请日：2013-12-17
申请人： IDENIX PHARMACEUTICALS, INC. , Centre National De La Recherche Scientifique , Université Montpellier 2 Sciences et Techniques
IPC分类号： C07H19/00 , A61K31/70 , C07H19/10 , C07H19/20 , C07H19/213 , A61K31/708 , A61K31/7072 , A61K45/06 , C07H17/02 , C07H19/06 , C07H19/16 , A61K38/21 , A61K31/403 , A61K31/497 , A61K31/7056
CPC分类号： A61K31/708 , A61K31/403 , A61K31/497 , A61K31/7056 , A61K31/7072 , A61K38/21 , A61K38/212 , A61K45/06 , C07H17/02 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H19/213 , A61K2300/00
摘要： Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are according to Formula 1501: or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form or polymorphic form thereof, wherein B, PD, RA, RB, RC, L, M and Z are as described herein.
摘要翻译： 本文提供了用于治疗黄病毒科感染（包括HCV感染）的化合物，组合物和方法。 在某些实施方案中，公开了核苷衍生物的化合物和组合物，其可以单独施用或与其它抗病毒剂组合施用。 在某些实施方案中，化合物根据式1501：或其药学上可接受的盐，溶剂化物，立体异构形式，互变异构形式或多晶型，其中B，PD，RA，RB，RC，L，M和Z如本文所述 。
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公开(公告)号：US10717758B2
公开(公告)日：2020-07-21
申请号：US15981813
申请日：2018-05-16
IPC分类号： C07H19/20 , A61K31/403 , C07H19/10 , A61K31/7072 , A61K45/06 , A61K31/7076 , A61K31/708 , A61K31/4709 , A61K31/497 , A61K38/21 , A61K38/55 , C07H19/16 , A61K31/7056
摘要： Provided herein are compounds, compositions and methods for the treatment of liver disease and conditions, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.
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公开(公告)号：US20170066795A1
公开(公告)日：2017-03-09
申请号：US15123124
申请日：2015-03-05
发明人： John Zoltan Sulliva-Bolyai , Benjamin Alexander Mayes , Douglas Lytle Mayers , Xiao-Jian Zhou , Adel M. Moussa , Alistair James Stewart , Sindhura Ganga , Clinton Scott Shultz , Alfred Lee
IPC分类号： C07H19/10 , A61K9/48 , A61K31/7072 , A61K9/20
CPC分类号： C07H19/10 , A61K9/20 , A61K9/2018 , A61K9/2077 , A61K9/48 , A61K9/4858 , A61K31/7072 , C07B2200/13
摘要： Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are solid forms of Compound I: (Compound I)
摘要翻译： 本文提供了用于治疗黄病毒科感染（包括HCV感染）的化合物，组合物和方法。 在某些实施方案中，公开了核苷衍生物的化合物和组合物，其可以单独施用或与其它抗病毒剂组合施用。 在某些实施方案中，化合物是化合物I的固体形式：（化合物I）
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公开(公告)号：US09192621B2
公开(公告)日：2015-11-24
申请号：US14038617
申请日：2013-09-26
IPC分类号： C07H19/10 , C07H19/20 , A61K31/7076 , C07H17/02 , A61K45/06 , C07H19/16 , A61K31/403 , A61K31/497 , A61K31/7056 , A61K31/708 , A61K38/21
CPC分类号： A61K31/7076 , A61K31/403 , A61K31/497 , A61K31/7056 , A61K31/708 , A61K38/212 , A61K45/06 , C07H17/02 , C07H19/10 , C07H19/16 , C07H19/20 , A61K2300/00
摘要： Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, provided herein are compounds according to Formula 1001: or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form or polymorphic form thereof, wherein Base, Y, Z, A, RC and RD are as described herein.
摘要翻译： 本文提供了用于治疗黄病毒科感染（包括HCV感染）的化合物，组合物和方法。 在某些实施方案中，公开了核苷衍生物的化合物和组合物，其可以单独施用或与其它抗病毒剂组合施用。 在某些实施方案中，本文提供了根据式1001的化合物：或其药学上可接受的盐，溶剂化物，立体异构体形式，互变异构形式或其多晶型物，其中碱，Y，Z，A，RC和RD如本文所述。
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