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    System and Method for Patient Specific Modeling of Liver Tumor Ablation
    1.
    发明申请
    System and Method for Patient Specific Modeling of Liver Tumor Ablation 有权
    肝脏肿瘤消融患者特异性建模的系统和方法

    公开(公告)号：US20140136174A1

    公开(公告)日：2014-05-15

    申请号：US14071688

    申请日：2013-11-05

    申请人： Chloe Audigier ,  Tommaso Mansi ,  Viorel Mihalef ,  Ali Kamen ,  Dorin Comaniciu ,  Puneet Sharma ,  Saikiran Rapaka ,  Herve Delingette ,  Nicholas Ayache

    发明人： Chloe Audigier ,  Tommaso Mansi ,  Viorel Mihalef ,  Ali Kamen ,  Dorin Comaniciu ,  Puneet Sharma ,  Saikiran Rapaka ,  Herve Delingette ,  Nicholas Ayache

    IPC分类号： G06F19/12

    CPC分类号： G16H50/50 ,  G06F19/00 ,  G06F19/3481 ,  G09B23/30

    摘要： A method and system for tumor ablation planning and guidance based on a patient-specific model of liver tumor ablation is disclosed. A patient-specific anatomical model of the liver and circulatory system of the liver is estimated from 3D medical image data of a patient. Blood flow in the liver and the circulatory system of the liver is simulated based on the patient-specific anatomical model. Heat diffusion due to ablation is simulated based on a virtual ablation probe position and the simulated blood flow in the liver and the venous system of the liver. Cellular necrosis in the liver is simulated based on the simulated heat diffusion. A visualization of a simulated necrosis region is generated and displayed to the user for decision making and optimal therapy planning and guidance.

    摘要翻译： 公开了一种基于肝肿瘤消融的患者特异性模型的肿瘤消融计划和指导的方法和系统。 根据患者的3D医学图像数据估计肝脏和肝脏循环系统的患者特异性解剖模型。 根据患者特异性解剖模型模拟肝脏和肝脏循环系统的血流。 基于虚拟消融探针位置和肝脏和肝脏静脉系统中的模拟血流模拟了消融引起的热扩散。 基于模拟热扩散模拟肝脏细胞坏死。 生成模拟坏死区域的可视化，并向用户显示决策和最佳治疗计划和指导。

    Patient Specific Planning and Simulation of Ablative Procedures
    3.
    发明申请
    Patient Specific Planning and Simulation of Ablative Procedures 有权
    消融程序的患者具体规划和模拟

    公开(公告)号：US20140296842A1

    公开(公告)日：2014-10-02

    申请号：US13854991

    申请日：2013-04-02

    申请人： Tommaso Mansi ,  Puneet Sharma ,  Viorel Mihalef ,  Ali Kamen ,  Saikiran Rapaka ,  Dorin Comaniciu

    发明人： Tommaso Mansi ,  Puneet Sharma ,  Viorel Mihalef ,  Ali Kamen ,  Saikiran Rapaka ,  Dorin Comaniciu

    IPC分类号： A61B19/00 ,  G06F17/50 ,  A61B18/12

    CPC分类号： A61B19/50 ,  A61B18/1233 ,  A61B34/10 ,  A61B2018/00577 ,  A61B2034/104 ,  A61B2034/105

    摘要： Patient specific temperature distribution in organs, due to an ablative device, is simulated. The effects of ablation are modeled. The modeling is patient specific. The vessel structure for a given patient, segmented from medical images, is accounted for as a heat sink in the model of biological heat transfer. A temperature map is generated to show the effects of ablation in a pre-operative analysis. Temperature maps resulting from different ablation currents and ablation device positions may be used to determine a more optimal location of the ablative device for a given patient. Other models may be included, such as accounting for the tissue damage during the ablation.

    摘要翻译： 模拟了器官中由于消融装置而导致的患者特异性温度分布。 模拟消融的效果。 建模是患者特异性的。 从医学图像分割的给定患者的血管结构在生物传热模型中被认为是散热器。 生成温度图以显示术前分析中消融的效果。 可以使用由不同烧蚀电流和消融装置位置产生的温度图来确定给定患者的烧蚀装置的更优选的位置。 可能包括其他模型，例如消融期间的组织损伤。

    Patient specific planning and simulation of ablative procedures
    4.
    发明授权
    Patient specific planning and simulation of ablative procedures 有权
    消融程序的患者具体规划和模拟

    公开(公告)号：US09259287B2

    公开(公告)日：2016-02-16

    申请号：US13854991

    申请日：2013-04-02

    申请人： Tommaso Mansi ,  Puneet Sharma ,  Viorel Mihalef ,  Ali Kamen ,  Saikiran Rapaka ,  Dorin Comaniciu

    发明人： Tommaso Mansi ,  Puneet Sharma ,  Viorel Mihalef ,  Ali Kamen ,  Saikiran Rapaka ,  Dorin Comaniciu

    IPC分类号： A61B18/12 ,  A61B19/00 ,  A61B18/00

    CPC分类号： A61B19/50 ,  A61B18/1233 ,  A61B34/10 ,  A61B2018/00577 ,  A61B2034/104 ,  A61B2034/105

    摘要： Patient specific temperature distribution in organs, due to an ablative device, is simulated. The effects of ablation are modeled. The modeling is patient specific. The vessel structure for a given patient, segmented from medical images, is accounted for as a heat sink in the model of biological heat transfer. A temperature map is generated to show the effects of ablation in a pre-operative analysis. Temperature maps resulting from different ablation currents and ablation device positions may be used to determine a more optimal location of the ablative device for a given patient. Other models may be included, such as accounting for the tissue damage during the ablation.

    摘要翻译： 模拟了器官中由于消融装置而导致的患者特异性温度分布。 模拟消融的效果。 建模是患者特异性的。 从医学图像分割的给定患者的血管结构在生物传热模型中被认为是散热器。 生成温度图以显示术前分析中消融的效果。 可以使用由不同烧蚀电流和消融装置位置产生的温度图来确定给定患者的烧蚀装置的更优选的位置。 可能包括其他模型，例如消融期间的组织损伤。

    Method and system for advanced measurements computation and therapy planning from medical data and images using a multi-physics fluid-solid heart model
    5.
    发明授权
    Method and system for advanced measurements computation and therapy planning from medical data and images using a multi-physics fluid-solid heart model 有权
    使用多物理流体 - 固体心脏模型的医学数据和图像进行高级测量计算和治疗计划的方法和系统

    公开(公告)号：US09129053B2

    公开(公告)日：2015-09-08

    申请号：US13757517

    申请日：2013-02-01

    申请人： Tommaso Mansi ,  Viorel Mihalef ,  Xudong Zheng ,  Bogdan Georgescu ,  Saikiran Rapaka ,  Puneet Sharma ,  Ali Kamen ,  Dorin Comaniciu

    发明人： Tommaso Mansi ,  Viorel Mihalef ,  Xudong Zheng ,  Bogdan Georgescu ,  Saikiran Rapaka ,  Puneet Sharma ,  Ali Kamen ,  Dorin Comaniciu

    IPC分类号： G06F19/00 ,  G06T19/00

    CPC分类号： G06F19/3437 ,  G06F19/00 ,  G06T19/00 ,  G06T2210/41 ,  G16H50/50

    摘要： Method and system for computation of advanced heart measurements from medical images and data; and therapy planning using a patient-specific multi-physics fluid-solid heart model is disclosed. A patient-specific anatomical model of the left and right ventricles is generated from medical image patient data. A patient-specific computational heart model is generated based on the patient-specific anatomical model of the left and right ventricles and patient-specific clinical data. The computational model includes biomechanics, electrophysiology and hemodynamics. To generate the patient-specific computational heart model, initial patient-specific parameters of an electrophysiology model, initial patient-specific parameters of a biomechanics model, and initial patient-specific computational fluid dynamics (CFD) boundary conditions are marginally estimated. A coupled fluid-structure interaction (FSI) simulation is performed using the initial patient-specific parameters, and the initial patient-specific parameters are refined based on the coupled FSI simulation. The estimated model parameters then constitute new advanced measurements that can be used for decision making.

    摘要翻译： 用于从医学图像和数据计算先进心脏测量的方法和系统; 并且公开了使用患者特定的多物理流体 - 固体心脏模型的治疗计划。 从医学图像患者数据生成左心室和右心室的患者特异性解剖模型。 基于左心室和右心室的患者特异性解剖模型和患者特异性临床数据生成患者特异性计算心脏模型。 计算模型包括生物力学，电生理学和血液动力学。 为了产生患者特异性计算心脏模型，电生理模型的初始患者特异性参数，生物力学模型的初始患者特异性参数和初始患者特异性计算流体动力学（CFD）边界条件被轻微估计。 使用初始患者特异性参数进行耦合的流体结构相互作用（FSI）模拟，并且基于耦合的FSI模拟来改进初始的患者特异性参数。 估计的模型参数然后构成可用于决策的新的高级测量。

    Method and System for Advanced Measurements Computation and Therapy Planning from Medical Data and Images Using a Multi-Physics Fluid-Solid Heart Model
    6.
    发明申请
    Method and System for Advanced Measurements Computation and Therapy Planning from Medical Data and Images Using a Multi-Physics Fluid-Solid Heart Model 有权
    使用多物理流体固体心脏模型的医学数据和图像的高级测量计算和治疗计划的方法和系统

    公开(公告)号：US20130197884A1

    公开(公告)日：2013-08-01

    申请号：US13757517

    申请日：2013-02-01

    申请人： Tommaso Mansi ,  Viorel Mihalef ,  Xudong Zheng ,  Bogdan Georgescu ,  Saikiran Rapaka ,  Puneet Sharma ,  Ali Kamen ,  Dorin Comaniciu

    发明人： Tommaso Mansi ,  Viorel Mihalef ,  Xudong Zheng ,  Bogdan Georgescu ,  Saikiran Rapaka ,  Puneet Sharma ,  Ali Kamen ,  Dorin Comaniciu

    IPC分类号： G06F19/00

    CPC分类号： G06F19/3437 ,  G06F19/00 ,  G06T19/00 ,  G06T2210/41 ,  G16H50/50

    摘要： Method and system for computation of advanced heart measurements from medical images and data; and therapy planning using a patient-specific multi-physics fluid-solid heart model is disclosed. A patient-specific anatomical model of the left and right ventricles is generated from medical image patient data. A patient-specific computational heart model is generated based on the patient-specific anatomical model of the left and right ventricles and patient-specific clinical data. The computational model includes biomechanics, electrophysiology and hemodynamics. To generate the patient-specific computational heart model, initial patient-specific parameters of an electrophysiology model, initial patient-specific parameters of a biomechanics model, and initial patient-specific computational fluid dynamics (CFD) boundary conditions are marginally estimated. A coupled fluid-structure interaction (FSI) simulation is performed using the initial patient-specific parameters, and the initial patient-specific parameters are refined based on the coupled FSI simulation. The estimated model parameters then constitute new advanced measurements that can be used for decision making.

    摘要翻译： 用于从医学图像和数据计算先进心脏测量的方法和系统; 并且公开了使用患者特定的多物理流体 - 固体心脏模型的治疗计划。 从医学图像患者数据生成左心室和右心室的患者特异性解剖模型。 基于左心室和右心室的患者特异性解剖模型和患者特异性临床数据生成患者特异性计算心脏模型。 计算模型包括生物力学，电生理学和血液动力学。 为了产生患者特异性计算心脏模型，电生理模型的初始患者特异性参数，生物力学模型的初始患者特异性参数和初始患者特异性计算流体动力学（CFD）边界条件被轻微估计。 使用初始患者特异性参数进行耦合的流体结构相互作用（FSI）模拟，并且基于耦合的FSI模拟来改进初始的患者特异性参数。 估计的模型参数然后构成可用于决策的新的高级测量。

    Method and system for comprehensive patient-specific modeling of the heart
    9.
    发明授权
    Method and system for comprehensive patient-specific modeling of the heart 有权
    心脏综合患者特异性建模的方法和系统

    公开(公告)号：US08682626B2

    公开(公告)日：2014-03-25

    申请号：US13091076

    申请日：2011-04-20

    申请人： Razvan Ioan Ionasec ,  Ingmar Voigt ,  Viorel Mihalef ,  Sasa Grbic ,  Dime Vitanovski ,  Yang Wang ,  Yefeng Zheng ,  Bogdan Georgescu ,  Dorin Comaniciu ,  Puneet Sharma ,  Tommaso Mansi

    发明人： Razvan Ioan Ionasec ,  Ingmar Voigt ,  Viorel Mihalef ,  Sasa Grbic ,  Dime Vitanovski ,  Yang Wang ,  Yefeng Zheng ,  Bogdan Georgescu ,  Dorin Comaniciu ,  Puneet Sharma ,  Tommaso Mansi

    IPC分类号： G06G7/48

    CPC分类号： G06T13/20 ,  G06F19/321 ,  G06T2210/24 ,  G06T2210/41 ,  G16H50/50

    摘要： A method and system for patient-specific modeling of the whole heart anatomy, dynamics, hemodynamics, and fluid structure interaction from 4D medical image data is disclosed. The anatomy and dynamics of the heart are determined by estimating patient-specific parameters of a physiological model of the heart from the 4D medical image data for a patient. The patient-specific anatomy and dynamics are used as input to a 3D Navier-Stokes solver that derives realistic hemodynamics, constrained by the local anatomy, along the entire heart cycle. Fluid structure interactions are determined iteratively over the heart cycle by simulating the blood flow at a given time step and calculating the deformation of the heart structure based on the simulated blood flow, such that the deformation of the heart structure is used in the simulation of the blood flow at the next time step. The comprehensive patient-specific model of the heart representing anatomy, dynamics, hemodynamics, and fluid structure interaction can be used for non-invasive assessment and diagnosis of the heart, as well as virtual therapy planning and cardiovascular disease management. Parameters of the comprehensive patient-specific model are changed or perturbed to simulate various conditions or treatment options, and then the patient specific model is recalculated to predict the effect of the conditions or treatment options.

    摘要翻译： 公开了一种用于针对4D医学图像数据的整个心脏解剖结构，动力学，血流动力学和流体结构相互作用的患者特异性建模的方法和系统。 通过从患者的4D医学图像数据估计心脏的生理模型的患者特异性参数来确定心脏的解剖学和动力学。 患者特异性解剖学和动力学被用作3D Navier-Stokes求解器的输入，该解算器在整个心脏周期中导出由局部解剖结构约束的现实血液动力学。 流体结构相互作用是通过在给定的时间步长模拟血液流动而在心脏周期上迭代地确定的，并且基于模拟的血液流量计算心脏结构的变形，使得心脏结构的变形用于模拟 血液流动在下一个时间步。 代表解剖学，动力学，血液动力学和流体结构相互作用的心脏综合患者特异性模型可用于心脏的非侵入性评估和诊断，以及虚拟治疗计划和心血管疾病管理。 全面的患者特异性模型的参数被改变或扰动以模拟各种条件或治疗选择，然后重新计算患者特异性模型以预测条件或治疗选择的影响。

    Method and System for Functional Assessment of Renal Artery Stenosis from Medical Images
    10.
    发明申请
    Method and System for Functional Assessment of Renal Artery Stenosis from Medical Images 有权
    医学图像肾动脉狭窄功能评估方法与系统

    公开(公告)号：US20150065864A1

    公开(公告)日：2015-03-05

    申请号：US14477770

    申请日：2014-09-04

    申请人： Puneet Sharma ,  Saikiran Rapaka ,  Viorel Mihalef ,  Ali Kamen

    发明人： Puneet Sharma ,  Saikiran Rapaka ,  Viorel Mihalef ,  Ali Kamen

    IPC分类号： A61B5/026 ,  G01R33/563 ,  A61B5/021

    CPC分类号： A61B5/0263 ,  A61B5/021 ,  A61B5/055 ,  A61B2576/023 ,  G01R33/56316 ,  G01R33/5635

    摘要： A method and system for non-invasive assessment of renal artery stenosis is disclosed. A patient-specific anatomical model of at least a portion of the renal arteries and aorta is generated from medical image data of a patient. Patient-specific boundary conditions of a computational model of blood flow in the portion of the renal arteries and aorta are estimated based on the patient-specific anatomical model. Blood flow and pressure are simulated in the portion of the renal arteries and aorta using the computational model based on the patient-specific boundary conditions. At least one hemodynamic quantity characterizing functional severity of a renal stenosis region is calculated based on the simulated blood flow and pressure in the portion of the renal arteries and aorta.

    摘要翻译： 公开了一种用于非侵入性评估肾动脉狭窄的方法和系统。 肾动脉和主动脉的至少一部分的患者特异性解剖模型由患者的医学图像数据产生。 基于患者特异性解剖模型估计肾动脉和主动脉部分血流计算模型的患者特异性边界条件。 使用基于患者特异性边界条件的计算模型在肾动脉和主动脉的部分中模拟血流和压力。 基于肾动脉和主动脉部分的模拟血流量和压力计算表征肾狭窄区域的功能严重性的至少一个血液动力学量。