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    Macrocyclic beta-secretase inhibitors for the treatment of Alzheimer's disease
    2.
    发明授权
    Macrocyclic beta-secretase inhibitors for the treatment of Alzheimer's disease 有权
    用于治疗阿尔茨海默氏病的大环β-分泌酶抑制剂

    公开(公告)号：US07329746B2

    公开(公告)日：2008-02-12

    申请号：US10568153

    申请日：2004-08-10

    申请人： Craig A. Coburn ,  Shawn J. Stachel ,  Joseph P. Vacca

    发明人： Craig A. Coburn ,  Shawn J. Stachel ,  Joseph P. Vacca

    IPC分类号： C07D225/04 ,  C07D267/22 ,  A61K31/33 ,  A61K31/395 ,  A61P25/28

    CPC分类号： C07D267/00 ,  C07D225/08

    摘要： The present invention is directed to compounds of formula I which are inhibitors of the beta-secretase enzyme and that are useful in the treatment or prevention of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the beta-secretase enzyme is involved

    摘要翻译： 本发明涉及作为β-分泌酶的抑制剂并可用于治疗或预防其中涉及β-分泌酶的疾病如阿尔茨海默氏病的式I化合物。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及β-分泌酶的疾病中的用途

    HIV PROTEASE INHIBITORS
    3.
    发明申请
    HIV PROTEASE INHIBITORS 有权
    艾滋病病毒蛋白酶抑制剂

    公开(公告)号：US20120142752A1

    公开(公告)日：2012-06-07

    申请号：US13322184

    申请日：2010-05-18

    申请人： Craig A. Coburn ,  M. Katharine Holloway ,  Joseph P. Vacca

    发明人： Craig A. Coburn ,  M. Katharine Holloway ,  Joseph P. Vacca

    IPC分类号： A61K31/40 ,  A61P31/18 ,  C07D207/14

    CPC分类号： C07D207/14

    摘要： Compounds of Formula (I) are disclosed; wherein XA, k, A, B, R3A, R3B, R4 and R5 are defined herein. The compounds of Formula (I) are HIV protease inhibitors. The compounds and their pharmaceutically acceptable salts are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

    摘要翻译： 公开了式（I）的化合物; 其中XA，k，A，B，R3A，R3B，R4和R5如本文所定义。 式（I）的化合物是HIV蛋白酶抑制剂。 化合物及其药学上可接受的盐可用于预防或治疗HIV感染以及预防，治疗或延迟艾滋病的发病。 化合物及其盐可以用作药物组合物中的成分，任选与其它抗病毒剂，免疫调节剂，抗生素或疫苗组合使用。

    HIV protease inhibitors
    7.
    发明授权
    HIV protease inhibitors 有权
    HIV蛋白酶抑制剂

    公开(公告)号：US08497383B2

    公开(公告)日：2013-07-30

    申请号：US13322184

    申请日：2010-05-18

    申请人： Craig A. Coburn ,  M. Katharine Holloway ,  Joseph P. Vacca

    发明人： Craig A. Coburn ,  M. Katharine Holloway ,  Joseph P. Vacca

    IPC分类号： C07D207/14 ,  A61K31/40

    CPC分类号： C07D207/14

    摘要： Compounds of Formula (I) are disclosed; wherein XA, k, A, B, R3A, R3B, R4 and R5 are defined herein. The compounds of Formula (I) are HIV protease inhibitors. The compounds and their pharmaceutically acceptable salts are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

    摘要翻译： 公开了式（I）的化合物; 其中XA，k，A，B，R3A，R3B，R4和R5如本文所定义。 式（I）的化合物是HIV蛋白酶抑制剂。 化合物及其药学上可接受的盐可用于预防或治疗HIV感染以及预防，治疗或延迟艾滋病的发病。 化合物及其盐可以用作药物组合物中的成分，任选与其它抗病毒剂，免疫调节剂，抗生素或疫苗组合使用。