公开(公告)号：US20150140091A1

公开(公告)日：2015-05-21

申请号：US14413241

申请日：2013-07-12

Applicant: DOW GLOBAL TECHNOLOGIES LLC

Inventor： Nicholas S. Grasman ,  Steven J. Guillaudeu ,  Mark J. Hall ,  Uma Shrestha ,  Maureen L. Rose ,  William W. Porter, III ,  Wesley J. Spaulding ,  Kevin P. O'donnell ,  True L. Rogers

IPC: A61K47/38 ,  A61K9/16 ,  A61K9/14 ,  A61K9/48

CPC classification number: A61K47/38 ,  A61K9/146 ,  A61K9/1652 ,  A61K9/4891 ,  A61K31/343 ,  A61K31/4166 ,  A61K31/58

Abstract: A solid dispersion comprising at least one active ingredient in at least one hydroxyalkyl methylcellulose having a DS of from 1.0 to 2.7 and an MS of from 0.40 to 1.30, wherein DS is the degree of substitution of methoxyl groups and MS is the molar substitution of hydroxyalkoxyl groups, can be produced by extrusion or spray-drying.

Abstract translation: 一种固体分散体，其包含至少一种具有1.0至2.7的DS和0.40至1.30的DS的羟烷基甲基纤维素中的至少一种活性成分，其中DS是甲氧基的取代度，MS是羟基烷氧基 组，可以通过挤出或喷雾干燥来生产。

公开(公告)号：US20150072858A1

公开(公告)日：2015-03-12

申请号：US14540255

申请日：2014-11-13

Applicant: Dow Global Technologies LLC

Inventor： True L. Rogers ,  Debora L. Holbrook ,  Karen A. Coppens ,  Robert L. Schmitt

IPC: C09D101/28

CPC classification number: C09D101/284 ,  C08L1/26 ,  C08L1/284 ,  C09D101/26

Abstract: The present disclosure is directed to cellulose ether compositions for film-forming coating applications. A coating composition is provided which contains an aqueous solution of either a very low viscosity cellulose ether or a low-hydroxypropyl cellulose ether, the coating composition having low color. The low viscosity of the cellulose ether component enables the coating composition to contain a high concentration of cellulose ether. Provision of these high concentration cellulose ether coating solutions improves production efficiency by reducing the time required to coat a substrate.

Abstract translation: 本公开涉及用于成膜涂料应用的纤维素醚组合物。 提供一种包含非常低粘度的纤维素醚或低羟丙基纤维素醚的水溶液的涂料组合物，该涂料组合物具有低的颜色。 纤维素醚组分的低粘度使涂料组合物含有高浓度的纤维素醚。 提供这些高浓度纤维素醚涂层溶液通过减少涂布基材所需的时间来提高生产效率。

公开(公告)号：US09937258B2

公开(公告)日：2018-04-10

申请号：US14890617

申请日：2014-07-16

Applicant: Dow Global Technologies LLC

Inventor： Jaime L. Curtis-Fisk ,  Susan L. Jordan ,  True L. Rogers ,  Matthias Knarr ,  Meinolf Brackhagen ,  Roland Adden

IPC: A61K47/38 ,  A61K47/02 ,  A61K31/167 ,  A61K9/00

CPC classification number: A61K47/38 ,  A61K9/0043 ,  A61K31/167 ,  A61K47/02

Abstract: A composition designed for application to a mucosa comprises a tonicity-adjusting agent, a methylcellulose, and a liquid diluent, wherein the methylcellulose has anhydroglucose units joined by 1-4 linkages wherein hydroxy groups of anhydroglucose units are substituted with methyl groups such that s23/s26 is 0.36 or less, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 3-positions of the anhydroglucose unit are substituted with methyl groups and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 6-positions of the anhydroglucose unit are substituted with methyl groups.

公开(公告)号：US20170292010A1

公开(公告)日：2017-10-12

申请号：US15512860

申请日：2015-09-28

Applicant: Dow Global Technologies LLC

Inventor： David L. Malotky ,  Shari L. Workentine ,  True L. Rogers ,  Stacey L. Dean ,  Matthew J. Crimmins

IPC: C08L1/28 ,  A61K9/20 ,  C09D7/02 ,  C08J5/18 ,  C09D101/28 ,  C09D7/12 ,  A61K9/28 ,  A61K9/48

CPC classification number: C08L1/28 ,  A61K9/2054 ,  A61K9/28 ,  A61K9/4866 ,  A61K9/4891 ,  C08J3/05 ,  C08J5/18 ,  C08J2301/28 ,  C08J2433/02 ,  C08K5/0016 ,  C08L33/08 ,  C08L2201/50 ,  C08L2203/02 ,  C08L2203/16 ,  C09D7/45 ,  C09D7/65 ,  C09D101/28

Abstract: Provided is an aqueous composition having pH of 8 or higher and comprising (a) a solid phase comprising dispersed particles that comprise an amount of ethylcellulose polymer, (b) an amount of one or more polymeric dispersants, wherein said polymeric dispersant has a weight-average molecular weight of 5,000 daltons or higher, and wherein said polymeric dispersant has an acid value of 60 to 190 mg KOH/g of polymer. Also provided is a method of making such a composition using an extruder. Also provided is a film made by removing water from such a composition.

公开(公告)号：US09969897B2

公开(公告)日：2018-05-15

申请号：US14914366

申请日：2014-08-25

Applicant: Dow Global Technologies LLC ,  Union Carbide Chemicals & Plastics Technology LLC ,  Rohm and Haas Company

Inventor： True L. Rogers ,  Aslin Izmitli ,  Susan L. Jordan ,  David L. Malotky ,  Shari L. Workentine ,  Kebede Beshah

IPC: C09D101/00 ,  A61K9/10 ,  C09D101/28 ,  C08J3/03 ,  C08J3/05 ,  C08K5/09 ,  C08K5/103 ,  C08K5/11 ,  A61K9/50 ,  A61K31/4402 ,  A61K9/28 ,  A23P20/10 ,  A23P30/20 ,  C08K5/00

CPC classification number: C09D101/28 ,  A23P20/10 ,  A23P20/105 ,  A23P30/20 ,  A23V2002/00 ,  A61K9/10 ,  A61K9/2866 ,  A61K9/5078 ,  A61K31/4402 ,  C08J3/03 ,  C08J3/05 ,  C08J2301/28 ,  C08K5/0016 ,  C08K5/09 ,  C08K5/103 ,  C08K5/11 ,  C08L1/28

Abstract: A process to produce a dispersion comprising feeding ethylcellulose polymer and a dispersant into a melt and mix zone of an extruder wherein the ethylcellulose polymer and dispersant are melted and mixed together to form a melt; conveying the melt to an emulsification zone of the extruder in which the temperature and pressure are controlled; feeding a base and water into the emulsification zone wherein the melt is dispersed to form a high internal phase emulsion; conveying the emulsion to a dilution and cooling zone of the extruder; and feeding water into the dilution and cooling zone to dilute the high internal phase emulsion thereby forming an aqueous dispersion is provided.

公开(公告)号：US20170226329A1

公开(公告)日：2017-08-10

申请号：US15502804

申请日：2015-08-12

Applicant: Dow Global Technologies LLC

Inventor： David L. Malotky ,  Shari L. Workentine ,  True L. Rogers ,  Stacey L. Dean ,  Liang Chen ,  Matthew J. Crimmins

IPC: C08L1/28 ,  C08J3/18 ,  C09D101/26 ,  C08J3/12

CPC classification number: C08L1/28 ,  C08J3/122 ,  C08J3/18 ,  C08J2301/28 ,  C09D101/26

Abstract: Provided is an aqueous composition having pH of 8 or higher and comprising (i) a solid phase comprising dispersed particles that comprise ethylcellulose polymer, (ii) fatty acid, wherein 25 mole % to 100 mole % of said fatty acid is in ionic form, (iii) 0% to 0.1% colloid stabilizer, by weight based on the dry weight of said ethylcellulose polymer, (iv) 0% to 7% plasticizer, by weight based on the dry weight of said ethylcellulose polymer, and (v) one or more cations of an alkali metal or an alkaline earth, wherein the equivalent ratio of said cations to said fatty acid is 0.1:1 to 2:1. Also provided are a method of spray drying an aqueous composition and a powder composition.

公开(公告)号：US09364546B2

公开(公告)日：2016-06-14

申请号：US14389838

申请日：2013-04-08

Applicant: Dow Global Technologies LLC

Inventor： Nicholas S. Grasman ,  True L. Rogers ,  Oliver Petermann ,  Meinolf Brackhagen ,  Roland Adden

IPC: A61K9/14 ,  A61K47/38 ,  C08B11/193 ,  C08L1/28 ,  A61K9/16 ,  A61K9/20 ,  A61K31/192 ,  B29C47/00 ,  B29K1/00 ,  B29K105/00

CPC classification number: A61K47/38 ,  A61K9/1652 ,  A61K9/2095 ,  A61K31/192 ,  B29C47/004 ,  B29C47/0066 ,  B29C2793/009 ,  B29K2001/08 ,  B29K2105/0035 ,  C08B11/193 ,  C08L1/28 ,  C08L1/284

Abstract: A melt-extruded polymer composition comprising a) at least one cellulose ether, b) one or more active ingredients and c) one or more optional additives, wherein said at least one cellulose ether has an MS (hydroxyalkyl) of 0.05 to 0.55 and hydroxyl groups of anhydroglucose units are substituted with methyl groups such that [s23/s26−0.2*MS(hydroxyalkyl)] is 0.32 or less, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 3-positions of the anhydroglucose unit are substituted with a methyl group and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 6-positions of the anhydroglucose unit are substituted with a methyl group.

Abstract translation: 一种熔融挤出的聚合物组合物，其包含a）至少一种纤维素醚，b）一种或多种活性成分和c）一种或多种任选的添加剂，其中所述至少一种纤维素醚具有0.05至0.55的MS（羟烷基）和羟基 脱水葡萄糖单元的基团被甲基取代，使得[s23 / s26-0.2 * MS（羟烷基）]为0.32以下，其中s23是脱水葡萄糖单元的摩尔分数，其中只有2位和3位的两个羟基， 脱水葡萄糖单元的位置被甲基取代，其中s26是脱水葡萄糖单元的摩尔分数，其中脱水葡萄糖单元的2-和6-位上的两个羟基仅被甲基取代。

公开(公告)号：US20170209385A1

公开(公告)日：2017-07-27

申请号：US15326608

申请日：2015-07-02

Applicant: Dow Global Technologies LLC

Inventor： True L. Rogers ,  Stacey L. Dean ,  Jason J. Folkenroth ,  David L. Malotky ,  Shari L. Workentine

IPC: A61K9/50 ,  A61K47/10 ,  A61K47/14 ,  A61K9/10 ,  A61K47/38

CPC classification number: A61K9/5047 ,  A61K9/10 ,  A61K9/5015 ,  A61K47/08 ,  A61K47/10 ,  A61K47/14 ,  A61K47/38

Abstract: Provided is an aqueous composition comprising (a) dispersed particles that comprise one or more ethylcellulose polymers and (b) one or more additives having molecular weight less than 220 g/mol, Hansen hydrogen bonding parameter greater than 11 MPa1/2 and less than 17.9 MPa1/2, Hansen total solubility parameter greater than 22 MPa1/2, and solubility in water greater than 2 g/L at 25° C. Also provided is a composition comprising particles having a coating, wherein said coating comprises 0-5% water by weight based on the weight of said coating, wherein said coating additionally comprises the ingredients (a) and (b).

公开(公告)号：US20160114047A1

公开(公告)日：2016-04-28

申请号：US14890617

申请日：2014-07-16

Applicant: DOW GLOBAL TECHNOLOGIES LLC

Inventor： Jaime Curtis-Fisk ,  Susan L. Jordan ,  True L. Rogers ,  Matthias Knarr ,  Meinolf Brackhagen ,  Roland Adden

IPC: A61K47/38 ,  A61K47/02 ,  A61K31/167 ,  A61K9/00

CPC classification number: A61K47/38 ,  A61K9/0043 ,  A61K31/167 ,  A61K47/02

Abstract: A composition designed for application to a mucosa comprises a tonicity-adjusting agent, a methylcellulose, and a liquid diluent, wherein the methylcellulose has anhydroglucose units joined by 1-4 linkages wherein hydroxy groups of anhydroglucose units are substituted with methyl groups such that s23/s26 is 0.36 or less, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 3-positions of the anhydroglucose unit are substituted with methyl groups and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 6-positions of the anhydroglucose unit are substituted with methyl groups.

Abstract translation: 设计用于粘膜的组合物包括张力调节剂，甲基纤维素和液体稀释剂，其中甲基纤维素具有通过1-4键连接的脱水葡萄糖单元，其中脱水葡萄糖单元的羟基被甲基取代，使得s23 / s26为0.36以下，其中s23是脱水葡萄糖单元的摩尔分数，其中脱水葡萄糖单元的2-和3-位中的两个羟基仅被甲基取代，并且其中s26是脱水葡萄糖单元的摩尔分数，其中仅 脱水葡萄糖单元的2-和6-位上的两个羟基被甲基取代。

公开(公告)号：US09962446B2

公开(公告)日：2018-05-08

申请号：US14413241

申请日：2013-07-12

Applicant: DOW GLOBAL TECHNOLOGIES LLC

Inventor： Nicholas S. Grasman ,  Steven J. Guillaudeu ,  Mark J. Hall ,  Uma Shrestha ,  Maureen L. Rose ,  William W. Porter, III ,  Wesley J. Spaulding ,  Kevin P. O'donnell ,  True L. Rogers

IPC: A61K9/14 ,  A61K47/38 ,  A61K9/16 ,  A61K9/48 ,  A61K31/343 ,  A61K31/58 ,  A61K31/4166

CPC classification number: A61K47/38 ,  A61K9/146 ,  A61K9/1652 ,  A61K9/4891 ,  A61K31/343 ,  A61K31/4166 ,  A61K31/58

Abstract: A solid dispersion comprising at least one active ingredient in at least one hydroxyalkyl methylcellulose having a DS of from 1.0 to 2.7 and an MS of from 0.40 to 1.30, wherein DS is the degree of substitution of methoxyl groups and MS is the molar substitution of hydroxyalkoxyl groups, can be produced by extrusion or spray-drying.