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公开(公告)号：US20230167047A1
公开(公告)日：2023-06-01
申请号：US17920327
申请日：2021-04-21
Applicant: DSM IP ASSETS B.V.
Inventor： Peter Hans RIEBEL , Angela WILDERMANN
IPC: C07C201/02 , C07C67/08
CPC classification number: C07C201/02 , C07C67/08
Abstract: The invention relates to a safe and efficient process for the for the acylation of an α,ω-alkanediol, which can be used in the manufacture of ω-nitrooxy-C3-10alkane-1-ols. The process is safer to operators and allows to obtain advantageous yields on industrial scale.
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公开(公告)号：US20250161232A1
公开(公告)日：2025-05-22
申请号：US18838971
申请日：2023-02-21
Applicant: DSM IP Assets B.V.
Inventor： Linda HAENDEL , Peter Louis HOUSTON , Eileen JACKSON , Lise Anne KOHLER , Christine MENDROK-EDINGER , Fabiola PORTA , Pascal Christian SIEBER , Christos TSEKOU , Angela WILDERMANN
Abstract: The present invention relates to a new formulation, which comprises a high amount of retinol, which has a defined mixture of cis and trans isomers, in a specific solvent and in the presence of mixed tocopherol.
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公开(公告)号：US20230167048A1
公开(公告)日：2023-06-01
申请号：US17920337
申请日：2021-04-21
Applicant: DSM IP ASSETS B.V.
Inventor： Peter Hans RIEBEL , Angela WILDERMANN
IPC: C07C201/02
CPC classification number: C07C201/02
Abstract: The invention relates to a safe and efficient process for the solvent removal and recovery by distillation in a process for the preparation of ω-nitrooxy-C3-10alkane-1-ols. The process is safer to operators and allows to obtain advantageous yields on industrial scale.
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公开(公告)号：US20250032439A1
公开(公告)日：2025-01-30
申请号：US18715405
申请日：2022-12-05
Applicant: DSM IP ASSETS B.V.
Inventor： Christine MENDROK-EDINGER , Eileen JACKSON , Angela WILDERMANN , Peter Louis HOUSTON
IPC: A61K31/222 , A61K8/67 , A61Q19/00
Abstract: The present invention relates to novel compositions comprising a retinoid mixture of cis and trans isomers of a retinyl ester, particularly retinyl acetate, with a cis/trans ratio of less than 0.03 as well as the use thereof for the treatment, prevention and lessening of the symptoms of diseases and conditions which can be treated with 5-HT2B serotonin receptor antagonists, including but not limited to diseases or conditions selected from migraine headaches, anxiety, ocular hypotension, heart valve disease, irritable bowel syndrome, and MDMA (commonly called “ecstasy”) abuse.
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5.发明公开公开(公告)号：US20240216321A1
公开(公告)日：2024-07-04
申请号：US18527530
申请日：2023-12-04
Applicant: DSM IP Assets B.V.
Inventor： Adriana CARVALHO DE SOUZA , Peter Louis HOUSTON , Valmik Kanubhai VYAS , Angela WILDERMANN
IPC: A61K31/23 , A61K31/01 , A61K31/045 , A61K31/07 , A61K31/11 , A61K31/231
CPC classification number: A61K31/23 , A61K31/01 , A61K31/045 , A61K31/07 , A61K31/11 , A61K31/231
Abstract: Compositions of matter suitable for use in food, feed, pharmaceutical, and beauty care products comprising a retinoid component and a fermentative residue thereof are disclosed herein. In an embodiment, the retinoid component is present in a ratio by weight relative to the fermentative residue of 4:1 or greater, wherein the retinoid contains cis- and trans-isomers, wherein the cis-isomers are present by weight relative to the entire mixture of isomers in an amount less than 3 wt. %. Preferably, the compositions are bio-based. Also described are biotechnological methods of producing the compositions elsewhere described, along with further methods for processing such compositions into more stabilized, more commercially acceptable forms. Finally, also disclosed are food, feed, pharmaceutical, and beauty care products incorporating the compositions herein described.
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Patent Agency Ranking
6.发明申请NITROGEN MONOXIDE AS CIS/TRANS ISOMERIZATION CATALYSTS FOR UNSATURATED COMPOUNDS 有权不饱和化合物的硝基一氧化碳/转异构化催化剂公开(公告)号：US20150321987A1
公开(公告)日：2015-11-12
申请号：US14652286
申请日：2013-12-18
Applicant: DSM IP ASSETS B.V.
Inventor： René Tobias STEMMLER , Nadine GREINER , Angela WILDERMANN
IPC: C07C45/67 , C07C29/56 , C07C33/02 , C07C49/203
CPC classification number: C07C43/313 , C07B2200/09 , C07C29/56 , C07C33/02 , C07C45/67 , C07C49/203
Abstract: The present invention relates to a process of a cis/trans isomerization of an unsaturated compound A being selected from the group consisting of unsaturated ketones, unsaturated ketals, unsaturated aldehydes, unsaturated acetals, unsaturated carboxylic acids, esters of an unsaturated carboxylic acid and amides of an unsaturated carboxylic acid using nitrogen monoxide as cis/trans isomerization catalyst. It has been observed that the isomerization is very efficient and fast.
Abstract translation: 本发明涉及不饱和化合物A的顺式/反式异构化方法，其选自不饱和酮，不饱和缩酮，不饱和醛，不饱和缩醛，不饱和羧酸，不饱和羧酸的酯和酰胺的酰胺 使用一氧化氮作为顺/反异构化催化剂的不饱和羧酸。 已经观察到异构化非常有效和快速。
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公开(公告)号：US20250134834A1
公开(公告)日：2025-05-01
申请号：US18838710
申请日：2023-02-21
Applicant: DSM IP Assets B.V.
Inventor： Linda HAENDEL , Peter Louis HOUSTON , Eileen JACKSON , Lise Anne KOHLER , Christine MENDROK-EDINGER , Fabiola PORTA , Pascal Christian SIEBER , Christos TSEKOU , Angela WILDERMANN
Abstract: The present invention relates to a new formulation, which comprises a high amount of retinol, which has a defined mixture of cis and trans isomers, in a specific solvent and in the presence of mixed tocopherol.
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公开(公告)号：US20230150917A1
公开(公告)日：2023-05-18
申请号：US17919939
申请日：2021-04-21
Applicant: DSM IP ASSETS B.V.
Inventor： Peter Hans RIEBEL , Angela WILDERMANN
IPC: C07C201/02 , C07C203/02
CPC classification number: C07C201/02 , C07C203/02
Abstract: The invention relates to a safe and efficient process for the hydrolysis of α,ω-C3-10alkanediol mononitrate monoacylates. The process is safer to operators and allows to obtain advantageous yields on industrial scale.
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公开(公告)号：US20230150916A1
公开(公告)日：2023-05-18
申请号：US17919932
申请日：2021-04-21
Applicant: DSM IP ASSETS B.V.
Inventor： Peter Hans RIEBEL , Angela WILDERMANN
IPC: C07C201/02
CPC classification number: C07C201/02
Abstract: The invention relates to a safe and efficient process for the nitrate ester formation of an α,ω-C3-10alkanediol monoacylate. The process is safer to operators and allows to obtain advantageous yields on industrial scale.
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公开(公告)号：US20250152493A1
公开(公告)日：2025-05-15
申请号：US18838904
申请日：2023-02-21
Applicant: DSM IP Assets B.V.
Inventor： Linda HAENDEL , Peter Louis HOUSTON , Eileen JACKSON , Lise Anne KOHLER , Christine MENDROK-EDINGER , Fabiola PORTA , Pascal Christian SIEBER , Christos TSEKOU , Angela WILDERMANN
IPC: A61K8/67
Abstract: The present invention relates to a new formulation, which comprises a high amount of retinol, which has a defined mixture of cis and trans isomers, in a specific solvent and in the presence of mixed tocopherol.
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